ZA200410046B - Molecular antigen arrays using a virus like particle derived from the AP205 coat protein. - Google Patents

Molecular antigen arrays using a virus like particle derived from the AP205 coat protein. Download PDF

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Publication number
ZA200410046B
ZA200410046B ZA200410046A ZA200410046A ZA200410046B ZA 200410046 B ZA200410046 B ZA 200410046B ZA 200410046 A ZA200410046 A ZA 200410046A ZA 200410046 A ZA200410046 A ZA 200410046A ZA 200410046 B ZA200410046 B ZA 200410046B
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South Africa
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seq
composition
protein
amino acid
antigen
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ZA200410046A
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English (en)
Inventor
Martin F Bachmann
Alain Tissot
Paul Pumpens
Indulis Cielens
Regina Renhofa
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Cytos Biotechnology Ag
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Publication of ZA200410046B publication Critical patent/ZA200410046B/en

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ZA200410046A 2002-07-17 2004-12-13 Molecular antigen arrays using a virus like particle derived from the AP205 coat protein. ZA200410046B (en)

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US (3) US7138252B2 (fr)
EP (2) EP1532167B1 (fr)
JP (3) JP4726483B2 (fr)
CN (2) CN102061288A (fr)
AT (1) ATE542828T1 (fr)
AU (1) AU2003246690B2 (fr)
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NZ (1) NZ538083A (fr)
RU (2) RU2324704C2 (fr)
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US7094409B2 (en) * 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
EP1513552B1 (fr) * 2002-06-20 2010-12-01 Cytos Biotechnology AG Particules pseudo-virales enveloppees combinees au cpg destinees a etre utilisees en tant qu'adjuvants avec des allergenes: procede de preparation et utilisation de celles-ci
EP1532167B1 (fr) * 2002-07-17 2012-01-25 Cytos Biotechnology AG Reseaux d'antigenes moleculaires utilisant une pseudoparticule virale derivee de la proteine d'enveloppe virale ap205
KR101228376B1 (ko) * 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
RU2450827C2 (ru) * 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
CA2575997A1 (fr) * 2004-08-04 2006-03-16 Cytos Biotechnology Ag Conjugues vecteurs des peptides de gonadoliberine (gnrh)
JP2008513035A (ja) * 2004-09-21 2008-05-01 サイトス バイオテクノロジー アーゲー Ａｐ２０５のコートタンパク質と抗原性ポリペプチドとの融合タンパク質を含んでなるウイルス粒子
CN101052411B (zh) * 2004-10-05 2011-04-06 赛托斯生物技术公司 Vlp-抗原偶联物及其作为疫苗的用途
JP2008517975A (ja) * 2004-10-25 2008-05-29 サイトス バイオテクノロジー アーゲー 胃酸分泌抑制ポリペプチド（ｇｉｐ）抗原アッセイ及びその使用
EP1804829A1 (fr) * 2004-10-29 2007-07-11 Cytos Biotechnology AG Reseaux d'antigenes de la t-cadherine et utilisations
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
NZ555590A (en) * 2004-12-13 2009-07-31 Cytos Biotechnology Ag Compositions comprising a VLP and IL-15 protein
US7767212B2 (en) * 2005-03-18 2010-08-03 Cytos Biotechnology Ag CAT allergen conjugates and uses thereof
EP1746165A1 (fr) 2005-07-21 2007-01-24 Cytos Biotechnology AG Procédé de fermentation échelonnable
WO2006125821A2 (fr) * 2005-05-26 2006-11-30 Cytos Biotechnology Ag Procede de fermentation extensible
BRPI0612293A2 (pt) * 2005-06-14 2010-11-03 Cytos Biotechnology Ag conjugados antigênicos e usos dos mesmos
EP1736538A1 (fr) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Procédé pour la purification préparative de particules pseudo-virales (VLPs)
ES2310062B1 (es) 2005-07-15 2009-11-13 Bionostra, S.L. Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones.
CN103230590A (zh) * 2005-09-28 2013-08-07 赛托斯生物技术公司 白介素-1偶联物及其用途
CA2632662A1 (fr) * 2005-12-08 2007-06-14 South Dakota State University Procedes de propagation in vitro et de detection de prions infectieux
EP1973608A1 (fr) 2005-12-14 2008-10-01 Cytos Biotechnology AG Particules emballees avec des acides nucleiques immunostimulateurs pour le traitement de l hypersensibilite
WO2007144150A1 (fr) 2006-06-12 2007-12-21 Cytos Biotechnology Ag Procédé pour le conditionnement d'oligonucléotides dans des particules analogues à des virus de bactériophages à arn
US7534595B2 (en) * 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
EP2066347A1 (fr) * 2006-09-28 2009-06-10 Cytos Biotechnology AG Mutéines de l'interleukine-1 liées à des particules de type viral destinées au traitement de maladies associées à l'il-1
US7998487B2 (en) * 2007-02-16 2011-08-16 The Salk Institute For Biological Studies Antitoxin and vaccine platform based on nodavirus VLPs
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
AU2008288283B2 (en) * 2007-08-15 2013-01-31 Circassia Limited Peptides for desensibilization against allergens
US8222206B2 (en) * 2008-03-04 2012-07-17 Taiwan Advance Bio-Pharm Inc. Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H
BRPI0910476A2 (pt) * 2008-04-22 2018-03-27 Cytios Biotechnology Ag composições de vacinas para tratamento de febre do dengue e seus usos
CN102245198B (zh) 2008-12-09 2016-08-17 辉瑞疫苗有限责任公司 IgE CH3肽疫苗
WO2010122164A1 (fr) 2009-04-23 2010-10-28 Cytos Biotechnology Ag Pseudo-particules virales du bactériophage φcb5
NZ596058A (en) * 2009-04-30 2013-08-30 Cytos Biotechnology Ag Influenza hemagglutinin compositions and uses thereof
RU2518291C2 (ru) 2009-07-30 2014-06-10 Пфайзер Вэксинс ЭлЭлСи Антигенные tau-пептиды и их применения
SG178447A1 (en) * 2009-09-03 2012-03-29 Pfizer Vaccines Llc Pcsk9 vaccine
US20110200574A1 (en) * 2010-02-02 2011-08-18 Jolly James F Use of proteases for gluten intolerance
EP2942061A3 (fr) 2010-06-07 2016-01-13 Pfizer Vaccines LLC Vaccin peptidique ige ch3
WO2012131504A1 (fr) 2011-03-02 2012-10-04 Pfizer Inc. Vaccin à base de pcsk9
EA201490381A1 (ru) 2011-07-29 2014-06-30 Селекта Байосайенсиз, Инк. Синтетические наноносители, которые стимулируют формирование гуморального иммунного ответа и иммунного ответа, опосредованного цитотоксическими т-лимфоцитами (ctl)
JP2015503907A (ja) 2011-12-22 2015-02-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 真核細胞のための全長抗体提示システムおよびその使用
AU2013224027B2 (en) 2012-02-23 2019-01-24 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US20210320597A1 (en) * 2012-05-11 2021-10-14 The Regents Of The University Of California Virus-Based Piezoelectric Energy Generation
DE102013105144A1 (de) * 2013-05-17 2014-11-20 Arno Thaller Pharmazeutisches Kombinationspräparat mit einem anti-idiotypischen Antikörperfragment
WO2015017280A1 (fr) 2013-07-28 2015-02-05 Qantu Therapeutics, Inc. Formulation de vaccins induisant une réponse immunitaire de type th2
EP3104877B1 (fr) 2014-02-11 2020-01-22 The USA, as represented by The Secretary, Department of Health and Human Services Vaccin à base de pcsk9 et méthodes d'utilisation dudit vaccin
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP3244915A1 (fr) 2015-01-15 2017-11-22 University of Copenhagen Pseudo-particule virale à présentation efficace des épitopes
EP3347046B1 (fr) * 2015-09-08 2022-10-19 Universität Zürich Compositions contre une allergie aux chats
EP3141600A1 (fr) 2015-09-11 2017-03-15 Institut National de la Recherche Agronomique Polypeptides de fusion de la proteine d'enveloppe de nepovirus et leurs utilisations
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
RU2021134624A (ru) 2015-10-22 2022-03-15 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
US11129882B2 (en) 2015-10-30 2021-09-28 University Of Copenhagen Virus like particle with efficient epitope display
KR20190056382A (ko) * 2016-09-02 2019-05-24 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 안정화된 그룹 2 인플루엔자 헤마글루티닌 줄기 영역 삼량체 및 그의 용도
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12084655B2 (en) 2018-04-09 2024-09-10 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
EP3781689A1 (fr) 2018-04-19 2021-02-24 Checkmate Pharmaceuticals, Inc. Agonistes de récepteur de type rig-i synthétique
US20220072120A1 (en) * 2019-02-08 2022-03-10 The Usa, As Represented By The Secretary, Department Of Health And Human Services Nanoparticle-based influenza virus vaccines and uses thereof
CA3138094A1 (fr) 2019-04-17 2020-10-22 Compass Pathfinder Limited Procedes de traitement des troubles de l'anxiete, des troubles de la cephalee et des troubles de l'alimentation au moyen de psilocybine
JP2022554175A (ja) 2019-10-23 2022-12-28 チェックメイト ファーマシューティカルズ， インコーポレイテッド 合成ｒｉｇ－ｉ様受容体アゴニスト
US20230063876A1 (en) * 2020-03-02 2023-03-02 Unm Rainforest Innovations Virus-Like Particle Vaccines for Opioid Drugs
EP4141110A1 (fr) 2020-04-24 2023-03-01 Obshchestvo S Ogranichennoy Otvetstvennost'yu "Ingenik" Procédé de production de particules de bactériophages de la famille levivirus
IL312785A (en) 2020-05-19 2024-07-01 Cybin Irl Ltd Denatured Tryptamine Derivatives and Methods of Use
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN114634578B (zh) * 2020-12-15 2024-04-02 榕森生物科技(北京)有限公司 针对新型冠状病毒感染的疫苗组合物
CN114632148B (zh) * 2020-12-15 2024-08-09 榕森生物科技(北京)有限公司 病原样抗原疫苗及其制备方法
CN112480245B (zh) * 2020-12-19 2023-08-18 上海佰君生物科技有限公司 一种疏水性环状肽配基纯化人免疫球蛋白g的应用
US20240189407A1 (en) 2021-04-12 2024-06-13 Saiba AG Modified virus-like particles of bacteriophage ap205
WO2022229817A1 (fr) 2021-04-28 2022-11-03 Bavarian Nordic A/S Vaccins comprenant des particules pseudo-virales présentant des antigènes du sars-cov-2 et leurs méthodes d'utilisation
US12121574B2 (en) 2021-09-28 2024-10-22 Unm Rainforest Innovations Malaria immunogen and methods for using same
WO2024068265A2 (fr) 2022-09-30 2024-04-04 Bavarian Nordic A/S Particules de type virus présentant des antigènes du sars-cov-2 utilisées en tant que vaccins de rappel et leurs utilisations
CN116987700B (zh) * 2023-07-13 2024-02-20 杭州赛基生物科技有限公司 一种人白细胞介素-5重组蛋白及其制备方法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334A (en) * 1847-10-16 Improvement in cutter-heads for plan ing-machines
US394A (en) * 1837-09-21 Mode of regulating the temperature of inkiwg-rollers and ink used
US4722840A (en) 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
CA1319101C (fr) 1986-09-03 1993-06-15 Marta Iris Sabara Proteine de capside nucleique de rotavirus avec ou sans peptides liants comme porteurs de macromolecules immunologiques
ATE108067T1 (de) 1986-09-22 1994-07-15 Univ Emory Impfstoff und verfahren zur herstellung.
US5143726A (en) 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
US4918166A (en) 1987-04-10 1990-04-17 Oxford Gene Systems Limited Particulate hybrid HIV antigens
GB8903313D0 (en) 1989-02-14 1989-04-05 Wellcome Found Conjugates
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DE69018926T2 (de) 1989-09-04 1995-08-24 Wellcome Found Vakzine gegen Bordetella.
WO1991010741A1 (fr) 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation d'anticorps xenogeniques
US5334394A (en) 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
US5178882A (en) 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
SE9003978D0 (sv) 1990-12-13 1990-12-13 Henrik Garoff Dna expressionssystem baserade paa ett virus replikon
WO1992011291A1 (fr) 1990-12-20 1992-07-09 Smithkline Beecham Biologicals (S.A.) VACCINS A BASE DE l'ANTIGENE D'ENVELOPPE DU VIRUS DE L'HEPATITE B
GB9114003D0 (en) 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
JPH08505625A (ja) 1993-01-11 1996-06-18 ダナ−ファーバー キャンサー インスティチュート 細胞毒性ｔリンパ球応答の誘導
WO1994017813A1 (fr) 1993-02-08 1994-08-18 Paravax, Inc. VECTEURS DU VIRUS SINDBIS DEFECTIF QUI EXPRIMENT DES ANTIGENES P30 $i(TOXOPLASMA GONDII)
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
AT402898B (de) 1994-08-08 1997-09-25 Int Centre Genetic Eng & Bio Molekulares präsentiersystem
WO1996030523A2 (fr) 1995-03-31 1996-10-03 Hans Wolf Systeme de presentation d'antigenes fonde sur des particules similaires a des retrovirus
US5792462A (en) 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
IL125590A (en) 1996-03-01 2001-08-26 Novartis Ag Peptide immunogens, process for their preparation and use thereof as vaccines against allergies
US5770380A (en) 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
DK0996717T3 (da) 1997-08-05 2006-04-10 Vlaams Interuniv Inst Biotech Immunbeskyttende influenzaantigen og anvendelse deraf til vaccination
US6169175B1 (en) 1997-08-06 2001-01-02 Centers For Disease Control And Prevention Preparation and use of recombinant influenza A virus M2 construct vaccines
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
US6231864B1 (en) 1998-02-12 2001-05-15 Immune Complex Corporation Strategically modified hepatitis B core proteins and their derivatives
US5990085A (en) 1998-05-04 1999-11-23 Michigan State University Inhibin-HBc fusion protein
TWI227241B (en) 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
CA2347411C (fr) 1998-10-21 2012-04-03 The Government Of The United States Of America Particules assimilees a des virus pour l'induction d'anticorps
US6380364B1 (en) 1998-11-23 2002-04-30 Loyola University Of Chicago Chimeric biotin-binding papillomavirus protein
EP1135162B1 (fr) 1998-11-30 2008-10-29 Cytos Biotechnology AG Presentation moleculaire ordonnee d'allergenes, procede de preparation et utilisation
KR100715954B1 (ko) 1998-12-04 2007-05-09 바이오겐 아이덱 엠에이 인코포레이티드 펩티드 리간드에 의하여 부착된 다중 면역원성 성분을보유한 ｈｂｖ 코어 항원 입자
CN1520423A (zh) 1999-02-25 2004-08-11 ʷ��˿�������ȳ�ķ���޹�˾ 来源于IgE的Cε3或Cε4区的抗原决定基或拟表位,其拮抗物,及其治疗用途
EP1173467A4 (fr) 1999-04-07 2005-12-28 Univ Jefferson Peptides synthetiques issus de chimiokines
JP5025871B2 (ja) 2000-02-21 2012-09-12 エイチ．リュンドベック エイ／エス アミロイドの新規なダウン−レギュレート方法
CA2407897A1 (fr) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Jeu ordonne d'antigenes moleculaires
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7128911B2 (en) * 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
DE60222917T2 (de) 2001-09-21 2008-08-07 Coloplast A/S Vorrichtung zur verabreichung eines wirkstoffes an die menschliche haut
US7115266B2 (en) * 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
WO2003039225A2 (fr) * 2001-11-07 2003-05-15 Cytos Biotechnology Ag Ensemble ordonne d'antigenes destines au traitement de maladies osseuses
JP3787697B2 (ja) 2002-01-08 2006-06-21 独立行政法人理化学研究所 重イオンビーム照射によるキメラ植物の作出方法
EP1532167B1 (fr) * 2002-07-17 2012-01-25 Cytos Biotechnology AG Reseaux d'antigenes moleculaires utilisant une pseudoparticule virale derivee de la proteine d'enveloppe virale ap205
KR101228376B1 (ko) * 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
RU2450827C2 (ru) * 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
US7537767B2 (en) * 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
RU2351362C2 (ru) * 2003-03-26 2009-04-10 Цитос Байотекнолоджи Аг КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ
CA2533660C (fr) 2003-07-25 2013-04-23 Agroplast Aps Procede et dispositif pour traiter les excrements animaux contenant de l'uree
JP2008517975A (ja) * 2004-10-25 2008-05-29 サイトス バイオテクノロジー アーゲー 胃酸分泌抑制ポリペプチド（ｇｉｐ）抗原アッセイ及びその使用
US7767212B2 (en) * 2005-03-18 2010-08-03 Cytos Biotechnology Ag CAT allergen conjugates and uses thereof

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