ZA200402265B - Antibody inhibitors of GDF-8 and uses thereof - Google Patents
Antibody inhibitors of GDF-8 and uses thereof Download PDFInfo
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- ZA200402265B ZA200402265B ZA200402265A ZA200402265A ZA200402265B ZA 200402265 B ZA200402265 B ZA 200402265B ZA 200402265 A ZA200402265 A ZA 200402265A ZA 200402265 A ZA200402265 A ZA 200402265A ZA 200402265 B ZA200402265 B ZA 200402265B
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32452801P | 2001-09-26 | 2001-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402265B true ZA200402265B (en) | 2007-03-28 |
Family
ID=23263987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200402265A ZA200402265B (en) | 2001-09-26 | 2004-03-23 | Antibody inhibitors of GDF-8 and uses thereof |
| ZA200606082A ZA200606082B (en) | 2001-09-26 | 2006-07-21 | Antibody inhibitors of GDF-8 and BMP-11 and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200606082A ZA200606082B (en) | 2001-09-26 | 2006-07-21 | Antibody inhibitors of GDF-8 and BMP-11 and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7320789B2 (fr) |
| EP (2) | EP2316851A1 (fr) |
| JP (2) | JP4452077B2 (fr) |
| AU (1) | AU2002347773B2 (fr) |
| BR (1) | BR0212809A (fr) |
| CA (1) | CA2469230C (fr) |
| DK (1) | DK1438068T3 (fr) |
| ES (1) | ES2481165T3 (fr) |
| HK (1) | HK1064284A1 (fr) |
| MX (1) | MXPA04002834A (fr) |
| NO (1) | NO336528B1 (fr) |
| NZ (1) | NZ532034A (fr) |
| PL (1) | PL374221A1 (fr) |
| PT (1) | PT1438068E (fr) |
| WO (1) | WO2003027248A2 (fr) |
| ZA (2) | ZA200402265B (fr) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329129B (en) * | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP4429729B2 (ja) | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
| WO2003072714A2 (fr) * | 2002-02-21 | 2003-09-04 | Wyeth | Domaine follistatine contenant des proteines |
| US20040138118A1 (en) * | 2002-09-16 | 2004-07-15 | Neil Wolfman | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| ATE496938T1 (de) | 2002-12-20 | 2011-02-15 | Amgen Inc | Myostatin hemmende bindungsstoffe |
| EP1635870A2 (fr) * | 2003-06-02 | 2006-03-22 | Wyeth | Utilisation des inhibiteurs du myostatin (gdf8) avec des corticosteroides pour le traitement des desordres neuromusculaires |
| EP1699820A2 (fr) * | 2003-12-31 | 2006-09-13 | Schering-Plough Ltd. | Vaccin stimulant la croissance a base d'un epitope neutralisant |
| JP2007526337A (ja) | 2004-03-02 | 2007-09-13 | アクセルロン ファーマ インコーポレーテッド | Ａｌｋ７およびミオスタチン阻害剤ならびにその使用 |
| WO2005094446A2 (fr) * | 2004-03-23 | 2005-10-13 | Eli Lilly And Company | Anticorps diriges contre la myostatine |
| DK2332977T3 (en) * | 2004-07-23 | 2016-02-29 | Acceleron Pharma Inc | ActRII receptor polypeptides |
| BRPI0514253A (pt) * | 2004-08-12 | 2008-06-03 | Wyeth Corp | terapia de combinação para diabetes, obesidade e doenças cardiovasculares usando composições contendo inibidores de gdf-8 |
| TWI364458B (en) | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
| RU2451082C2 (ru) * | 2004-08-27 | 2012-05-20 | Вайет Рисёрч Айрлэнд Лимитед | Производство полипептидов |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| EP1831372A2 (fr) | 2004-12-30 | 2007-09-12 | Schering-Plough Ltd. | Vaccins favorisant la croissance a base d'epitopes neutralisants |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| JP2008537488A (ja) * | 2005-03-23 | 2008-09-18 | ワイス | Ｇｄｆ−８モジュレート物質の検出 |
| CA2601086A1 (fr) * | 2005-03-23 | 2006-10-12 | Wyeth | Detection d'une reponse immunitaire contre les agents de modulation gdf-8 |
| MX2007013217A (es) * | 2005-04-25 | 2008-03-11 | Pfizer | Anticuerpos contra miostatina. |
| CA2538208A1 (fr) * | 2005-05-04 | 2006-11-04 | Universite Laval | Modulation de la myostatine et utilisation de celle-ci dans le traitement de maladies musculaires axe sur la greffe de cellules |
| CN103450359B (zh) | 2005-08-19 | 2018-07-24 | 惠氏有限责任公司 | 抗gdf-8的拮抗剂抗体以及在als和其他gdf-8-相关病症治疗中的用途 |
| EP1951756B1 (fr) * | 2005-10-06 | 2015-01-07 | Eli Lilly And Company | Anticorps anti-myostatine |
| UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| CA3045808C (fr) | 2005-11-23 | 2022-08-16 | Acceleron Pharma, Inc. | Antagonistes de l'activine-actriia et utilisations pour activer la croissance osseuse |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
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| PT2066695E (pt) * | 2006-09-05 | 2013-05-23 | Lilly Co Eli | Anticorpos anti-miostatina |
| CN104524548A (zh) * | 2006-12-18 | 2015-04-22 | 阿塞勒隆制药公司 | 活化素-actrii拮抗剂及在提高红细胞水平中的用途 |
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| ES2415666T3 (es) * | 2007-02-01 | 2013-07-26 | Acceleron Pharma, Inc. | Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama |
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2002
- 2002-09-25 US US10/253,532 patent/US7320789B2/en active Active
- 2002-09-26 WO PCT/US2002/030452 patent/WO2003027248A2/fr active Application Filing
- 2002-09-26 DK DK02783984.4T patent/DK1438068T3/da active
- 2002-09-26 BR BR0212809-8A patent/BR0212809A/pt not_active IP Right Cessation
- 2002-09-26 ES ES02783984.4T patent/ES2481165T3/es not_active Expired - Lifetime
- 2002-09-26 AU AU2002347773A patent/AU2002347773B2/en not_active Ceased
- 2002-09-26 PL PL02374221A patent/PL374221A1/xx not_active Application Discontinuation
- 2002-09-26 NZ NZ532034A patent/NZ532034A/en not_active IP Right Cessation
- 2002-09-26 CA CA2469230A patent/CA2469230C/fr not_active Expired - Lifetime
- 2002-09-26 JP JP2003530820A patent/JP4452077B2/ja not_active Expired - Fee Related
- 2002-09-26 PT PT2783984T patent/PT1438068E/pt unknown
- 2002-09-26 EP EP10183355A patent/EP2316851A1/fr not_active Withdrawn
- 2002-09-26 EP EP02783984.4A patent/EP1438068B1/fr not_active Expired - Lifetime
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- 2004-03-23 ZA ZA200402265A patent/ZA200402265B/en unknown
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- 2004-04-19 NO NO20041582A patent/NO336528B1/no not_active IP Right Cessation
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- 2008-10-09 JP JP2008263289A patent/JP2009067798A/ja not_active Withdrawn
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| BR0212809A (pt) | 2005-12-13 |
| US9505831B2 (en) | 2016-11-29 |
| NO336528B1 (no) | 2015-09-21 |
| NZ532034A (en) | 2006-06-30 |
| WO2003027248A8 (fr) | 2004-04-22 |
| WO2003027248A3 (fr) | 2003-05-30 |
| US7320789B2 (en) | 2008-01-22 |
| PT1438068E (pt) | 2014-07-24 |
| ZA200606082B (en) | 2008-10-29 |
| JP4452077B2 (ja) | 2010-04-21 |
| CA2469230C (fr) | 2017-02-21 |
| WO2003027248A2 (fr) | 2003-04-03 |
| AU2002347773B2 (en) | 2008-03-13 |
| US20120107928A1 (en) | 2012-05-03 |
| EP1438068A2 (fr) | 2004-07-21 |
| JP2009067798A (ja) | 2009-04-02 |
| NO20041582L (no) | 2004-04-19 |
| MXPA04002834A (es) | 2005-09-28 |
| EP2316851A1 (fr) | 2011-05-04 |
| US20030138422A1 (en) | 2003-07-24 |
| US8092798B2 (en) | 2012-01-10 |
| EP1438068A4 (fr) | 2005-11-16 |
| CA2469230A1 (fr) | 2003-04-03 |
| DK1438068T3 (da) | 2014-06-30 |
| US8710202B2 (en) | 2014-04-29 |
| EP1438068B1 (fr) | 2014-05-21 |
| PL374221A1 (en) | 2005-10-03 |
| US7731961B1 (en) | 2010-06-08 |
| ES2481165T3 (es) | 2014-07-29 |
| HK1064284A1 (en) | 2005-01-28 |
| US20150024484A1 (en) | 2015-01-22 |
| JP2005510212A (ja) | 2005-04-21 |
| US20110020330A1 (en) | 2011-01-27 |
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