ZA200309006B - Microprojection array having a beneficial agent containing coating. - Google Patents
Microprojection array having a beneficial agent containing coating. Download PDFInfo
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- ZA200309006B ZA200309006B ZA200309006A ZA200309006A ZA200309006B ZA 200309006 B ZA200309006 B ZA 200309006B ZA 200309006 A ZA200309006 A ZA 200309006A ZA 200309006 A ZA200309006 A ZA 200309006A ZA 200309006 B ZA200309006 B ZA 200309006B
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- South Africa
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- coating
- microprojections
- beneficial agent
- biocompatible carrier
- biocompatible
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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US28557601P | 2001-04-20 | 2001-04-20 |
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ZA200309006A ZA200309006B (en) | 2001-04-20 | 2003-11-19 | Microprojection array having a beneficial agent containing coating. |
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US (1) | US7963935B2 (fr) |
EP (1) | EP1392389B1 (fr) |
JP (2) | JP2004528900A (fr) |
KR (1) | KR20040020889A (fr) |
CN (2) | CN101129327A (fr) |
AT (1) | ATE444773T1 (fr) |
BR (1) | BR0209046A (fr) |
CA (1) | CA2444883A1 (fr) |
DE (1) | DE60233939D1 (fr) |
ES (1) | ES2333849T3 (fr) |
IL (1) | IL158480A0 (fr) |
MX (1) | MXPA03009603A (fr) |
NO (1) | NO20034684L (fr) |
NZ (1) | NZ529029A (fr) |
WO (1) | WO2002085447A2 (fr) |
ZA (1) | ZA200309006B (fr) |
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EP0914178B1 (fr) * | 1996-06-18 | 2003-03-12 | Alza Corporation | Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
DE60136951D1 (de) * | 2000-10-13 | 2009-01-22 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
KR20030068136A (ko) * | 2000-10-13 | 2003-08-19 | 알자 코포레이션 | 미세 돌기부로 피부를 천공하기 위한 장치 및 방법 |
US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
EP2085109A3 (fr) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Dispositifs d'approvisionnement transdermique de médicaments disposant de micro-propulsions revêtues |
US6855372B2 (en) * | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
EP1485317A2 (fr) * | 2001-11-30 | 2004-12-15 | Alza Corporation | Procedes et appareils de formation de grilles de microprojections |
EP1465535B1 (fr) * | 2001-12-20 | 2007-11-28 | ALZA Corporation | Microprojections pour le percage de la peau a regulation de la profondeur de percage |
GB0201736D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | DNA dosage forms |
TW200409657A (en) * | 2002-08-08 | 2004-06-16 | Alza Corp | Transdermal vaccine delivery device having coated microprotrusions |
CA2516547A1 (fr) * | 2002-09-30 | 2004-04-15 | Alza Corporation | Methode et dispositif d'administration de medicaments presentant des microprojections revetues comprenant des vasoconstricteurs |
AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
JP5456234B2 (ja) * | 2003-06-30 | 2014-03-26 | アルザ・コーポレーシヨン | 非揮発性の対イオンを含有する被覆された微小突起のための製剤 |
DE602004008278T2 (de) * | 2003-06-30 | 2008-02-14 | Alza Corp., Mountain View | Transdermale Abgabevorrichtung zur Abgabe eines biologisch aktiven Mittels mit hydrophober und hydrophiler Beschichtung |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
KR20060037320A (ko) * | 2003-07-02 | 2006-05-03 | 알자 코포레이션 | 미세돌출부 어레이 면역화 패치 및 방법 |
KR20060115716A (ko) * | 2003-08-04 | 2006-11-09 | 알자 코포레이션 | 경피 약물 플럭스를 개선시키기 위한 방법 및 장치 |
US8524272B2 (en) * | 2003-08-15 | 2013-09-03 | Mylan Technologies, Inc. | Transdermal patch incorporating active agent migration barrier layer |
CA2536249A1 (fr) * | 2003-08-25 | 2005-03-10 | 3M Innovative Properties Company | Administration de composes modificateurs de la reponse immunitaire |
AU2004286232A1 (en) * | 2003-10-23 | 2005-05-12 | Alza Corporation | Compositions of stabilized DNA for coating microprojections |
US20050106226A1 (en) * | 2003-10-24 | 2005-05-19 | Cormier Michel J. | Pretreatment method and system for enhancing transdermal drug delivery |
KR20060120156A (ko) * | 2003-10-28 | 2006-11-24 | 알자 코포레이션 | 담배의 이용빈도를 감소시키기 위한 방법 및 장치 |
US7097631B2 (en) | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
BRPI0416132A (pt) * | 2003-10-31 | 2007-01-02 | Alza Corp | sistema e método para liberação de vacina transdérmica |
GB0402131D0 (en) * | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
CA2560840C (fr) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Dispositif d'administration transdermique |
MXPA06011429A (es) | 2004-04-01 | 2007-04-25 | Johnson & Johnson | Aparato y metodo para el suministro transdermico de la vacuna contra la influenza. |
AU2005235990A1 (en) * | 2004-04-13 | 2005-11-03 | Alza Corporation | Apparatus and method for transdermal delivery of multiple vaccines |
EP1737434A2 (fr) * | 2004-04-13 | 2007-01-03 | Alza Corporation | Appareil et procede d'administration transdermique d'agents a base de fentanyle |
MXPA06013168A (es) * | 2004-05-13 | 2007-05-15 | Johnson & Johnson | Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea. |
US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
KR20070099540A (ko) * | 2004-09-08 | 2007-10-09 | 알자 코포레이션 | 향상된 피부 점착성 및 순응도를 갖는 미세돌출부 어레이 |
EP1833547A1 (fr) * | 2004-11-18 | 2007-09-19 | 3M Innovative Properties Company | Applicateur de jeux de micro-aiguilles a profil bas |
WO2006055799A1 (fr) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Procede de masquage pour le revetement d'un jeu de micro-aiguilles |
EP2388078B1 (fr) | 2004-11-18 | 2013-03-20 | 3M Innovative Properties Co. | Procédé de revêtement de contact d'un ensemble de micro-aiguille |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
DE602005024038D1 (de) * | 2004-12-10 | 2010-11-18 | 3M Innovative Properties Co | Medizinische vorrichtung |
AU2006214236A1 (en) * | 2005-02-16 | 2006-08-24 | Alza Corporation | Apparatus and method for transdermal delivery of erythropoetin-based agents |
US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
CA2612005C (fr) | 2005-06-17 | 2013-10-29 | Georgia Tech Research Corporation | Microstructures revetues et procede de fabrication de celles-ci |
WO2007002523A2 (fr) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Timbre repliable et son procede d'application |
US20080214952A1 (en) * | 2005-07-11 | 2008-09-04 | Jose Mir | Replaceable Cartridge for Allergy Testing System |
CN101227940A (zh) * | 2005-07-25 | 2008-07-23 | 纳米技术维多利亚有限公司 | 微阵列装置 |
JP5006196B2 (ja) | 2005-08-01 | 2012-08-22 | 久光製薬株式会社 | 経皮または経粘膜投与のためのアジュバントおよび製剤 |
CA2619452A1 (fr) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Dispositif d'administration transdermique enduisable a microprojections |
CA2629193C (fr) * | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Compositions pouvant etre revetues, revetements derives de celles-ci et micro-reseaux comprenant de tels revetements |
US7618429B2 (en) * | 2005-12-22 | 2009-11-17 | Spamedica International Srl | Skin rejuvination resurfacing method |
ES2551305T3 (es) * | 2005-12-28 | 2015-11-17 | Alza Corporation | Formulaciones terapéuticas estables |
EP1992386B1 (fr) * | 2006-02-10 | 2011-11-09 | Hisamitsu Pharmaceutical Co., Inc. | Appareil d'administration de médicament transdermale à microaiguilles |
WO2007106597A2 (fr) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Appareil et procede d'administration transdermique d'agents hormonaux parathyroidiens destines a traiter ou prevenir l'osteopenie |
US20070224252A1 (en) * | 2006-03-27 | 2007-09-27 | Trautman Joseph C | Microprojections with capillary control features and method |
EP2005990B1 (fr) | 2006-04-07 | 2013-08-28 | Hisamitsu Pharmaceutical Co., Inc. | Appareil à micro-aiguilles et appareil d'administration transdermique à micro-aiguilles |
WO2007124411A1 (fr) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Dispositif de pose d'une barrette de microaiguilles |
WO2007127811A2 (fr) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Application d'un réseau de microsaillies, les microsaillies étant groupées pour accroître la charge médicamenteuse |
WO2007127815A2 (fr) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Application d'un réseau de microprotubérances muni d'éléments de microprotubérances multicouches pour charge de médicament élevée |
US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
US20090182306A1 (en) * | 2006-07-21 | 2009-07-16 | Georgia Tech Research Corporation | Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal |
WO2008011625A2 (fr) * | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide |
EP2067482B1 (fr) | 2006-09-27 | 2012-11-28 | Asahi Kasei Pharma Corporation | Calcitonines pour la prévention de l'apparition d'une dystrophie sympathique réflexe après une attaque |
US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
WO2008091602A2 (fr) | 2007-01-22 | 2008-07-31 | Corium International, Inc. | Applicateurs pour micro-aiguilles |
US20100047327A1 (en) * | 2007-01-31 | 2010-02-25 | Tetsuji Kuwahara | Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same |
JP5241517B2 (ja) * | 2007-02-06 | 2013-07-17 | 久光製薬株式会社 | アレルギー診断用マイクロニードルデバイス |
WO2008115599A1 (fr) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Appareil et procédé d'administration transdermique d'un antagoniste 5-hydroxytrytamine |
CA2686093C (fr) | 2007-04-16 | 2018-05-08 | Corium International, Inc. | Reseaux de micro-aiguilles coulees dans un solvant contenant un actif |
WO2009048607A1 (fr) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Distribution de vaccin par l'intermédiaire de réseaux de micro-aiguilles |
US20090137945A1 (en) * | 2007-11-28 | 2009-05-28 | Claire Marquez | Electro Collagen Induction Therapy Device |
US9220678B2 (en) * | 2007-12-24 | 2015-12-29 | The University Of Queensland | Coating method |
WO2009094394A1 (fr) * | 2008-01-23 | 2009-07-30 | Georgia Tech Research Corporation | Dispositifs à micro-aiguilles et procédés d'administration de médicament ou de retrait de fluide |
EP2247527A4 (fr) | 2008-02-07 | 2014-10-29 | Univ Queensland | Fabrication de timbre transdermique |
US9381680B2 (en) | 2008-05-21 | 2016-07-05 | Theraject, Inc. | Method of manufacturing solid solution perforator patches and uses thereof |
US9387000B2 (en) | 2008-05-23 | 2016-07-12 | The University Of Queensland | Analyte detection using a needle projection patch |
US7943187B2 (en) * | 2008-05-23 | 2011-05-17 | Bakr Rabie | Paeoniflorin preparations and uses thereof for fat reduction |
US20110177297A1 (en) * | 2008-10-02 | 2011-07-21 | Nurim Wellness Co. Ltd. | Method of manufacturing solid microstructure and solid microstructure manufactured based on same |
CA2760573A1 (fr) | 2008-12-22 | 2010-07-01 | The University Of Queensland | Production de piece |
EP2383013A4 (fr) | 2008-12-26 | 2012-11-28 | Hisamitsu Pharmaceutical Co | Dispositif à micro-aiguille |
US8062568B2 (en) * | 2009-08-27 | 2011-11-22 | Korea University Research And Business Foundation | Nano pattern writer |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
WO2012006677A1 (fr) | 2010-07-14 | 2012-01-19 | The University Of Queensland | Appareil d'application de timbre transdermique |
ES2834200T3 (es) | 2011-02-25 | 2021-06-16 | Hisamitsu Pharmaceutical Co | Adyuvante para administración transdérmica o transmucosa y preparación farmacéutica que contiene el mismo |
US20120222979A1 (en) | 2011-03-04 | 2012-09-06 | Elwha LLC, a limited liability company of the State of Delaware | Glassy compositions |
AU2012323782B2 (en) * | 2011-10-12 | 2017-04-06 | Vaxxas Pty Limited | Delivery device |
CN103889497A (zh) | 2011-10-20 | 2014-06-25 | 考司美德制药株式会社 | 微针熔着法 |
CA2857501C (fr) | 2011-11-30 | 2020-06-23 | 3M Innovative Properties Company | Dispositif a micro-aiguille comprenant un agent therapeutique peptidique et un acide amine et procedes de fabrication et d'utilisation de celui-ci |
JP2013153959A (ja) * | 2012-01-30 | 2013-08-15 | Toppan Printing Co Ltd | 針状体の構造 |
US10980865B2 (en) | 2012-08-10 | 2021-04-20 | Aquavit Pharmaceuticals, Inc. | Direct application system and method for the delivery of bioactive compositions and formulations |
AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
WO2014142135A1 (fr) | 2013-03-12 | 2014-09-18 | 武田薬品工業株式会社 | Timbre à microaiguilles |
RU2674083C2 (ru) | 2013-03-12 | 2018-12-04 | Кориум Интернэшнл, Инк. | Аппликаторы с микровыступами |
CA2903459C (fr) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Applicateurs de microprojection d'impacts multiples et procedes d'utilisation |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
WO2014150293A1 (fr) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Micro-réseau ayant des microstructures sans polymère, procédés de fabrication et procédés d'utilisation |
WO2014201259A1 (fr) * | 2013-06-12 | 2014-12-18 | The Board Of Regents For Oklahoma State University | Étiquette d'oreille flottante pour vaccination de bovins |
EP3064218B1 (fr) | 2013-10-31 | 2019-06-19 | Hisamitsu Pharmaceutical Co., Inc. | Composition adjuvante |
EP3188714A1 (fr) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Matrice de microstructures, procédé de production et procédés d'utilisation |
US11147954B2 (en) | 2015-02-02 | 2021-10-19 | Vaxxas Pty Limited | Microprojection array applicator and method |
MX2017013802A (es) | 2015-04-29 | 2018-08-15 | Radius Pharmaceuticals Inc | Métodos para tratar el cáncer. |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
WO2017045031A1 (fr) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Réseaux de micro-saillies comportant des micro-saillies ayant des profils à surface élevée |
AU2016339033B2 (en) * | 2015-10-12 | 2021-04-08 | Reflow Medical, Inc. | Stents having protruding drug-delivery features and associated systems and methods |
US9918932B2 (en) | 2016-02-19 | 2018-03-20 | Zosano Pharma Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
JP2017164308A (ja) * | 2016-03-16 | 2017-09-21 | 凸版印刷株式会社 | 穿刺デバイス及びその製造方法 |
KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
CN109640963A (zh) | 2016-04-15 | 2019-04-16 | 安德玛生物科学株式会社 | 核酸膜的制备方法及利用核酸膜的药物注入装置 |
CA3020333A1 (fr) | 2016-04-18 | 2017-10-26 | Radius Health, Inc. | Formulations d'abaloparatide, timbres transdermiques les contenant, et utilisations de celles-ci |
KR102557321B1 (ko) | 2017-01-05 | 2023-07-18 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
WO2018176102A1 (fr) | 2017-03-31 | 2018-10-04 | Vaxxas Pty Limited | Dispositif et procédé de revêtement de surfaces |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
AU2018309562A1 (en) | 2017-08-04 | 2020-02-20 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
EP3672570A1 (fr) | 2017-08-23 | 2020-07-01 | Zosano Pharma Corporation | Procédé d'obtention rapide de concentrations thérapeutiques de zolmitriptan pour le traitement de migraines et de céphalées de horton |
KR102146704B1 (ko) * | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
EP3817821A1 (fr) | 2018-07-04 | 2021-05-12 | Radius Pharmaceuticals, Inc. | Formes polymorphes de rad1901-2hcl |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
US3136314A (en) | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3760984A (en) * | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
OA05448A (fr) | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
FR2474856A1 (fr) | 1980-01-31 | 1981-08-07 | Merieux Inst | Dispositif scarificateur |
US4473083A (en) * | 1981-12-14 | 1984-09-25 | Maganias Nicholas H | Device and method for allergy testing |
JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
KR970008118B1 (ko) | 1987-07-09 | 1997-05-21 | 엘테에스 로오만 테라피-지스테메 게엠베하 운트 콤파니 카게 | 피부 침투성 치료 시스템 |
CA2016900A1 (fr) | 1989-07-06 | 1991-01-06 | Ronald J. Filipski | Applicateur clinique en forme de fourchette |
EP0429842B1 (fr) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide |
US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5437656A (en) | 1991-02-27 | 1995-08-01 | Leonard Bloom | Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment |
DE4222380A1 (de) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
DE4341444C2 (de) | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
US6586006B2 (en) * | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
NZ290896A (en) * | 1994-08-04 | 1997-04-24 | Quadrant Holdings Cambridge | Solid dose delivery composition containing a glassy vehicle and at least one guest substance |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
ATE177325T1 (de) | 1994-12-09 | 1999-03-15 | Novartis Erfind Verwalt Gmbh | Transdermales system |
JP3601102B2 (ja) | 1995-03-15 | 2004-12-15 | ブラザー工業株式会社 | インクジェット式印刷記録装置と印字システム |
DE19514104C2 (de) | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
WO1996037155A1 (fr) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Dispositif micromecanique et procede pour ameliorer l'administration percutanee de composes |
AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
CN1230205C (zh) | 1995-07-03 | 2005-12-07 | 株式会社高研 | 基因制剂 |
DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
EP0914178B1 (fr) * | 1996-06-18 | 2003-03-12 | Alza Corporation | Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques |
AU3880697A (en) | 1996-07-03 | 1998-01-21 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
US5741554A (en) | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
US5738728A (en) | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
DE69718495T2 (de) | 1996-09-17 | 2003-11-20 | Deka Products Lp | System zur medikamentenabgabe durch transport |
US6197013B1 (en) * | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
DK0957972T3 (da) | 1996-12-20 | 2003-07-21 | Alza Corp | Anordning og fremgangsmåde til at forøge transdermal middelflux |
DE19654391A1 (de) | 1996-12-27 | 1998-07-02 | Basf Ag | Katalysator zur selektiven Herstellung von Propylen aus Propan |
BR9714113A (pt) | 1996-12-31 | 2000-03-21 | Shell Int Research | Plataforma de tirante |
US20020009464A1 (en) * | 1997-07-03 | 2002-01-24 | Camilo Colaco | Modified glycosides, compositions comprised thereof and methods of use thereof |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
CN1206004C (zh) | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
JP4061022B2 (ja) * | 1997-12-11 | 2008-03-12 | アルザ・コーポレーション | 経皮輸送剤の流量促進装置 |
DK1037686T3 (da) * | 1997-12-11 | 2006-01-02 | Alza Corp | Apparat til forögelse af transdermal gennemströmning af midler |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
CA2330207C (fr) | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Dispositifs a microaiguilles et procedes de fabrication et d'utilisation correspondants |
ATE280615T1 (de) * | 1998-08-31 | 2004-11-15 | Johnson & Johnson Consumer | Elektrotransportvorrichtung mit klingen |
AU2189400A (en) | 1998-12-18 | 2000-07-03 | Minimed, Inc. | Insertion sets with micro-piercing members for use with medical devices and methods of using the same |
EP1163024B1 (fr) * | 1999-01-28 | 2003-12-17 | Cyto Pulse Sciences, Inc. | Administration de macromolecules dans des cellules |
US6884427B1 (en) | 1999-02-08 | 2005-04-26 | Aderans Research Institute, Inc. | Filamentary means for introducing agents into tissue of a living host |
JP2002542183A (ja) | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 成形可能な乾燥した医薬製剤 |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
JP4412874B2 (ja) * | 1999-06-08 | 2010-02-10 | アルテア セラピューティクス コーポレイション | 薄膜組織インターフェイスデバイスを使用する生物学的膜のミクロポレーションのための装置、およびそのための方法 |
US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
SE0000363L (sv) | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
US20050008683A1 (en) | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
KR20030068136A (ko) | 2000-10-13 | 2003-08-19 | 알자 코포레이션 | 미세 돌기부로 피부를 천공하기 위한 장치 및 방법 |
DE60136951D1 (de) | 2000-10-13 | 2009-01-22 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
IL155375A0 (en) | 2000-10-13 | 2003-11-23 | Alza Corp | Microblade array impact applicator |
EP2085109A3 (fr) | 2000-10-26 | 2009-09-02 | Alza Corporation | Dispositifs d'approvisionnement transdermique de médicaments disposant de micro-propulsions revêtues |
GB0026957D0 (en) * | 2000-11-03 | 2000-12-20 | Eastman Kodak Co | Processing photographic materal |
US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
WO2002064193A2 (fr) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Appareils a microaiguilles et fabrication |
US6855372B2 (en) | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
CA2500453A1 (fr) | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Micro-aiguille a membrane |
US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
-
2002
- 2002-04-20 CA CA002444883A patent/CA2444883A1/fr not_active Abandoned
- 2002-04-20 BR BR0209046-5A patent/BR0209046A/pt not_active IP Right Cessation
- 2002-04-20 CN CNA2007101489918A patent/CN101129327A/zh active Pending
- 2002-04-20 EP EP02731464A patent/EP1392389B1/fr not_active Expired - Lifetime
- 2002-04-20 WO PCT/US2002/012730 patent/WO2002085447A2/fr active IP Right Grant
- 2002-04-20 JP JP2002583020A patent/JP2004528900A/ja not_active Ceased
- 2002-04-20 US US10/127,108 patent/US7963935B2/en active Active
- 2002-04-20 CN CNB028122518A patent/CN100349632C/zh not_active Expired - Fee Related
- 2002-04-20 NZ NZ529029A patent/NZ529029A/en unknown
- 2002-04-20 AT AT02731464T patent/ATE444773T1/de not_active IP Right Cessation
- 2002-04-20 DE DE60233939T patent/DE60233939D1/de not_active Expired - Lifetime
- 2002-04-20 IL IL15848002A patent/IL158480A0/xx unknown
- 2002-04-20 KR KR10-2003-7013728A patent/KR20040020889A/ko not_active Application Discontinuation
- 2002-04-20 MX MXPA03009603A patent/MXPA03009603A/es unknown
- 2002-04-20 ES ES02731464T patent/ES2333849T3/es not_active Expired - Lifetime
-
2003
- 2003-10-20 NO NO20034684A patent/NO20034684L/no not_active Application Discontinuation
- 2003-11-19 ZA ZA200309006A patent/ZA200309006B/en unknown
-
2011
- 2011-05-06 JP JP2011103757A patent/JP5611888B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1541126A (zh) | 2004-10-27 |
DE60233939D1 (de) | 2009-11-19 |
ATE444773T1 (de) | 2009-10-15 |
JP5611888B2 (ja) | 2014-10-22 |
EP1392389A2 (fr) | 2004-03-03 |
MXPA03009603A (es) | 2004-12-06 |
US7963935B2 (en) | 2011-06-21 |
NO20034684D0 (no) | 2003-10-20 |
NO20034684L (no) | 2003-12-11 |
CN101129327A (zh) | 2008-02-27 |
WO2002085447A3 (fr) | 2003-03-06 |
EP1392389B1 (fr) | 2009-10-07 |
NZ529029A (en) | 2005-07-29 |
JP2004528900A (ja) | 2004-09-24 |
IL158480A0 (en) | 2004-05-12 |
ES2333849T3 (es) | 2010-03-02 |
US20020177839A1 (en) | 2002-11-28 |
CA2444883A1 (fr) | 2002-10-31 |
WO2002085447A8 (fr) | 2004-05-13 |
BR0209046A (pt) | 2004-11-09 |
WO2002085447A2 (fr) | 2002-10-31 |
KR20040020889A (ko) | 2004-03-09 |
JP2011172968A (ja) | 2011-09-08 |
CN100349632C (zh) | 2007-11-21 |
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