ZA200307588B - Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides. - Google Patents

Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides.

Info

Publication number
ZA200307588B
ZA200307588B ZA200307588A ZA200307588A ZA200307588B ZA 200307588 B ZA200307588 B ZA 200307588B ZA 200307588 A ZA200307588 A ZA 200307588A ZA 200307588 A ZA200307588 A ZA 200307588A ZA 200307588 B ZA200307588 B ZA 200307588B
Authority
ZA
South Africa
Prior art keywords
beta
halo
preparation
arabinofuranosyl
arabinofuranosyl nucleosides
Prior art date
Application number
ZA200307588A
Other languages
English (en)
Inventor
Marcos Sznaidman
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ZA200307588B publication Critical patent/ZA200307588B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307588A 2001-03-30 2003-09-29 Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides. ZA200307588B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28030701P 2001-03-30 2001-03-30

Publications (1)

Publication Number Publication Date
ZA200307588B true ZA200307588B (en) 2004-06-30

Family

ID=23072521

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307588A ZA200307588B (en) 2001-03-30 2003-09-29 Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides.

Country Status (17)

Country Link
US (2) US6870048B2 (fr)
EP (1) EP1373288B1 (fr)
JP (1) JP4430307B2 (fr)
KR (1) KR100910791B1 (fr)
CN (2) CN101117346B (fr)
AT (1) ATE298759T1 (fr)
AU (1) AU2002303187C1 (fr)
BR (1) BR0208517A (fr)
CA (1) CA2442979C (fr)
DE (1) DE60204859T2 (fr)
ES (1) ES2243726T3 (fr)
HK (1) HK1117169A1 (fr)
IL (2) IL158185A0 (fr)
MX (1) MXPA03008870A (fr)
NZ (1) NZ528575A (fr)
WO (1) WO2002079213A1 (fr)
ZA (1) ZA200307588B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法
KR20040094692A (ko) * 2002-02-14 2004-11-10 파마셋, 리미티드 변형된 불소화 뉴클레오사이드 유사체
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
WO2008022469A1 (fr) * 2006-08-23 2008-02-28 Mcgill University 2'-DÉSOXY-2'-FLUORO-β-D-ARABINONUCLÉOSIDE-5'-TRIPHOSPHATES ET UTILISATION DE CEUX-CI EN SYNTHÈSE ENZYMATIQUE D'ACIDES NUCLÉIQUES
CN101469012B (zh) * 2007-12-26 2013-03-27 杭州容立医药科技有限公司 2-氨基-6-甲氧基-9-(β-D-阿拉伯糖基)-9H-嘌呤的合成方法
WO2011003018A2 (fr) * 2009-07-01 2011-01-06 Cornell University 2-désoxy-lactones halogénées, 2'-désoxy-nucléosides, et leurs dérivés
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
CN102344427B (zh) * 2011-08-10 2013-07-31 济南圣泉集团股份有限公司 一种烯糖的合成方法
CN102863479B (zh) * 2011-11-04 2015-06-17 济南圣泉唐和唐生物科技有限公司 一种制备全乙酰溴代-l-阿拉伯糖的方法
CN103694279B (zh) * 2013-12-23 2015-12-02 江西苏克尔新材料有限公司 一种制备2-脱氧-l-核糖的方法
CN105732732B (zh) * 2016-04-14 2018-04-06 四川理工学院 一种制备2‑脱氧‑d‑核糖的方法
WO2022008025A1 (fr) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority Nucléosides et dérivés de 2-hydroxyiminopyrimidine et utilisations antivirales de ceux-ci

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008384A (en) * 1988-07-12 1991-04-16 Pfizer Inc. Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
CN1039121C (zh) * 1994-10-18 1998-07-15 北京医科大学药学院 具有嘧啶或嘌呤取代基的氢化呋喃衍生物及其制法
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法

Also Published As

Publication number Publication date
IL158185A (en) 2009-09-22
DE60204859D1 (de) 2005-08-04
DE60204859T2 (de) 2006-04-27
CN1330660C (zh) 2007-08-08
WO2002079213A1 (fr) 2002-10-10
BR0208517A (pt) 2005-02-01
US20050187384A1 (en) 2005-08-25
EP1373288B1 (fr) 2005-06-29
CN101117346B (zh) 2012-12-12
ES2243726T3 (es) 2005-12-01
AU2002303187B2 (en) 2007-11-08
ATE298759T1 (de) 2005-07-15
US20030060622A1 (en) 2003-03-27
IL158185A0 (en) 2004-03-28
CN101117346A (zh) 2008-02-06
EP1373288A1 (fr) 2004-01-02
KR20030092037A (ko) 2003-12-03
JP2004526743A (ja) 2004-09-02
JP4430307B2 (ja) 2010-03-10
CA2442979A1 (fr) 2002-10-10
MXPA03008870A (es) 2004-01-29
HK1117169A1 (fr) 2009-01-09
NZ528575A (en) 2006-04-28
KR100910791B1 (ko) 2009-08-04
AU2002303187C1 (en) 2008-06-12
US6870048B2 (en) 2005-03-22
CN1571792A (zh) 2005-01-26
US7291726B2 (en) 2007-11-06
CA2442979C (fr) 2010-02-16
AU2002303187B8 (en) 2002-10-15

Similar Documents

Publication Publication Date Title
HK1117169A1 (fr)
EP0861262A4 (fr) Fractions de capture d'acide nucleique
ATE277068T1 (de) 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind
AU8695901A (en) Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
WO1997026270A3 (fr) Synthese de methoxy nucleosides et de molecules d'acide nucleique enzymatique
AP2000001777A0 (en) High temperature heap bioleaching process
WO1999055857A3 (fr) Nucleoside triphosphates et leur integration aux ribozymes
YU76100A (sh) Pirolo(2,3-d) pirimidin preparati i njihova primena
HUP0401291A3 (en) 4'-substituted nucleosides
EP1020534A4 (fr) Procede de synthese d'acide nucleique
EP0893496A3 (fr) Histidyl ARNt synthétase de Chlamydia trachomatis
WO1996034107A3 (fr) Proteines antivirales, sequences d'adn codant pour ces proteines et utilisations
HU9501963D0 (en) 7-deazapurine modified oligonucleotides
EP1070084A4 (fr) Piperazines utilisees en tant qu'inhibiteurs de fructose-1,6-bisphosphatase (fbpase)
WO1998028317A3 (fr) Synthese chimique d'analogues de nucleosides et leur incorporation dans des polynucleotides
IL112329A (en) Sucrose isomerase, dna sequences coding therefor and processes for the preparation of non-cariogenic sugars utilizing the same
EP0876149A4 (fr) Procede de traitement des troubles caracterises par une surexpression de la cytidine-desaminase ou de la desoxycytidine-desaminase
ZA974952B (en) 2'-substituted nucleosides and oligonucleotide derivatives.
IL135284A (en) Method and reagents for n-alkylating ureides
AU6409399A (en) Improved process for oligonucleotide synthesis
EP0749439A4 (fr) Anticorps modifies par des composes de photoaffinite nucleotidiques ou nucleosidiques, leurs procedes de fabrication et d'utilisation
AU2375600A (en) High throughput assay system using mass spectrometry
EP0948512A4 (fr) Methode pour synthetiser des oligonucleotides phosphorothioates
EP0953572A3 (fr) Peptides de liaison d'antigene des cellules de stroma de moelle osseuse
CA2227491A1 (fr) Preparation in situ de phosphoramidites de nucleosides et synthese d'oligonucleotides