ZA200305118B - Pharmaceutically activity piperidine derivatives. - Google Patents
Pharmaceutically activity piperidine derivatives. Download PDFInfo
- Publication number
- ZA200305118B ZA200305118B ZA200305118A ZA200305118A ZA200305118B ZA 200305118 B ZA200305118 B ZA 200305118B ZA 200305118 A ZA200305118 A ZA 200305118A ZA 200305118 A ZA200305118 A ZA 200305118A ZA 200305118 B ZA200305118 B ZA 200305118B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- piperidinetriol
- hydroxymethyl
- phenylmethoxy
- methyl
- Prior art date
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Landscapes
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| JP2005532274A (ja) * | 2002-03-13 | 2005-10-27 | ユニザー ファーマシューティカルズ インコーポレーティッド | 雄避妊のための非ホルモン的アプローチ |
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| JP4585851B2 (ja) | 2002-07-17 | 2010-11-24 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
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| EP1528056A1 (en) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| EP1680112B1 (en) * | 2003-10-29 | 2010-12-15 | Genzyme Corporation | N-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin or a pharmaceutically salt thereof for use in the treatment of insulin resistance |
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| EP1746992A2 (en) * | 2004-03-25 | 2007-01-31 | United Therapeutics | Use of n-substituted imino sugars for appetite suppression |
| US20070248591A1 (en) * | 2004-09-08 | 2007-10-25 | Takeda Pharmaceutical Company Limited | Preventive/Therapeutic Drug for Arteriosclerosis |
| JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| EP2023927B1 (en) * | 2006-05-24 | 2015-02-25 | United Therapeutics Corporation | Deoxynojirimycin and d-arabinitol analogs and methods of using |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| EP2167485B1 (en) | 2007-05-31 | 2015-09-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| MX2010003603A (es) | 2007-10-05 | 2010-06-02 | Genzyme Corp | Metodo para el tratamiento de enfermedades de riñon poliquisticas con derivados de ceramida. |
| CA2731685A1 (en) * | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| MX2011003517A (es) * | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
| CA2747230C (en) | 2008-12-16 | 2019-06-11 | Genzyme Corporation | Oligosaccharide-protein conjugates |
| CN102655746B (zh) | 2009-02-23 | 2016-08-03 | 联合治疗公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
| KR101787434B1 (ko) * | 2009-02-24 | 2017-11-15 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법 |
| EP2440205B1 (en) * | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
| CA2772813A1 (en) * | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating filoviral diseases |
| CN102625796B (zh) * | 2009-09-04 | 2015-03-11 | 联合治疗公司 | 治疗正粘病毒感染的方法 |
| KR101459530B1 (ko) * | 2009-09-04 | 2014-11-07 | 유나이티드 세러퓨틱스 코오포레이션 | 폭스바이러스 감염의 치료 방법 |
| CA2783405A1 (en) * | 2009-12-07 | 2011-06-16 | The Chancellor, Masters And Scholars Of The University Of Oxford | N-substituted deoxynojirimycin compounds for use in inhibiting osteoclastogenesis and/or osteoclast activation |
| ES2371398B1 (es) * | 2010-06-04 | 2013-05-20 | Bioglane, S.L.N.E. | Uso de un iminoazúcar como inhibidor de la adherencia a células epiteliales. |
| EP2394667A1 (en) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vectors and sequences for the treatment of diseases |
| WO2013079580A1 (en) | 2011-11-29 | 2013-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of darier disease |
| JP2016513729A (ja) | 2013-03-15 | 2016-05-16 | ユニザー ヴィロロジー，エルエルシー | 抗菌化合物 |
| WO2014179438A2 (en) * | 2013-05-02 | 2014-11-06 | The Chancellor, Masters And Scholars Of The University Of Oxford | Glycolipid inhibition using iminosugars |
| TWI770184B (zh) | 2017-06-01 | 2022-07-11 | 瑞士商愛杜西亞製藥有限公司 | N-丁基脫氧半乳糖野尻黴素(N-butyldeoxygalactonojirimycin)之結晶型 |
| WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
| US20220213058A1 (en) * | 2019-05-10 | 2022-07-07 | Alectos Therapeutics Inc. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| EP4146624A4 (en) * | 2020-05-07 | 2024-06-19 | Alectos Therapeutics Inc. | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF |
| MX2022013954A (es) * | 2020-05-07 | 2022-11-30 | Alectos Therapeutics Inc | Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos. |
| EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
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| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| JPH02306962A (ja) | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
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-
2001
- 2001-01-12 GB GBGB0100889.5A patent/GB0100889D0/en not_active Ceased
-
2002
- 2002-01-11 WO PCT/GB2002/000106 patent/WO2002055498A1/en active IP Right Grant
- 2002-01-11 RU RU2003124756/04A patent/RU2279425C2/ru active
- 2002-01-11 KR KR1020037009309A patent/KR100879651B1/ko active IP Right Grant
- 2002-01-11 BR BR0206433-2 patent/BRPI0206433B8/pt not_active IP Right Cessation
- 2002-01-11 HU HU0303891A patent/HU229428B1/hu unknown
- 2002-01-11 CA CA2433675A patent/CA2433675C/en not_active Expired - Lifetime
- 2002-01-11 ES ES02729458T patent/ES2304439T3/es not_active Expired - Lifetime
- 2002-01-11 AU AU2002219363A patent/AU2002219363B2/en not_active Expired
- 2002-01-11 CN CNB028062264A patent/CN1267420C/zh not_active Expired - Lifetime
- 2002-01-11 AT AT02729458T patent/ATE389635T1/de active
- 2002-01-11 DE DE60225671T patent/DE60225671T2/de not_active Expired - Lifetime
- 2002-01-11 PT PT02729458T patent/PT1362031E/pt unknown
- 2002-01-11 JP JP2002556170A patent/JP4313572B2/ja not_active Expired - Lifetime
- 2002-01-11 MX MXPA03006185A patent/MXPA03006185A/es active IP Right Grant
- 2002-01-11 EP EP02729458A patent/EP1362031B1/en not_active Expired - Lifetime
- 2002-01-11 IL IL15687302A patent/IL156873A0/xx active IP Right Grant
-
2003
- 2003-07-01 ZA ZA200305118A patent/ZA200305118B/en unknown
- 2003-07-11 US US10/618,165 patent/US20040097551A1/en not_active Abandoned
-
2005
- 2005-08-03 US US11/196,153 patent/US8729099B2/en not_active Expired - Lifetime
-
2014
- 2014-04-07 US US14/246,879 patent/US9199935B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002219363B2 (en) | 2007-11-01 |
| HUP0303891A3 (en) | 2010-01-28 |
| BRPI0206433B8 (pt) | 2021-05-25 |
| CA2433675A1 (en) | 2002-07-18 |
| HU229428B1 (en) | 2013-12-30 |
| JP2004517869A (ja) | 2004-06-17 |
| US8729099B2 (en) | 2014-05-20 |
| US9199935B2 (en) | 2015-12-01 |
| EP1362031B1 (en) | 2008-03-19 |
| RU2003124756A (ru) | 2005-01-10 |
| KR20030081383A (ko) | 2003-10-17 |
| DE60225671D1 (de) | 2008-04-30 |
| ES2304439T3 (es) | 2008-10-16 |
| WO2002055498A1 (en) | 2002-07-18 |
| CN1496351A (zh) | 2004-05-12 |
| HUP0303891A2 (hu) | 2004-03-29 |
| BRPI0206433B1 (pt) | 2020-01-07 |
| MXPA03006185A (es) | 2004-12-03 |
| US20060074107A1 (en) | 2006-04-06 |
| CA2433675C (en) | 2011-03-22 |
| DE60225671T2 (de) | 2009-04-16 |
| PT1362031E (pt) | 2008-06-12 |
| US20040097551A1 (en) | 2004-05-20 |
| ATE389635T1 (de) | 2008-04-15 |
| IL156873A0 (en) | 2004-02-08 |
| CN1267420C (zh) | 2006-08-02 |
| RU2279425C2 (ru) | 2006-07-10 |
| BR0206433A (pt) | 2003-12-30 |
| JP4313572B2 (ja) | 2009-08-12 |
| EP1362031A1 (en) | 2003-11-19 |
| US20140303208A1 (en) | 2014-10-09 |
| KR100879651B1 (ko) | 2009-01-20 |
| GB0100889D0 (en) | 2001-02-21 |
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