ZA200303061B - A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride. - Google Patents
A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride. Download PDFInfo
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- ZA200303061B ZA200303061B ZA200303061A ZA200303061A ZA200303061B ZA 200303061 B ZA200303061 B ZA 200303061B ZA 200303061 A ZA200303061 A ZA 200303061A ZA 200303061 A ZA200303061 A ZA 200303061A ZA 200303061 B ZA200303061 B ZA 200303061B
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- compound
- estrogen
- methanol
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- 238000001959 radiotherapy Methods 0.000 description 1
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- 230000001850 reproductive effect Effects 0.000 description 1
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- 239000003340 retarding agent Substances 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 description 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
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- 239000008247 solid mixture Substances 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- 229960001603 tamoxifen Drugs 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
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- 229960001600 xylazine Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24225200P | 2000-10-20 | 2000-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200303061B true ZA200303061B (en) | 2004-07-19 |
Family
ID=22914051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200303061A ZA200303061B (en) | 2000-10-20 | 2003-04-17 | A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20040014672A1 (fr) |
| EP (1) | EP1328521A2 (fr) |
| JP (1) | JP2004512333A (fr) |
| KR (1) | KR20030037690A (fr) |
| CN (1) | CN1268624C (fr) |
| AR (1) | AR035355A1 (fr) |
| AU (1) | AU2002214534A1 (fr) |
| BR (1) | BR0114792A (fr) |
| CA (1) | CA2426007A1 (fr) |
| CZ (1) | CZ20031098A3 (fr) |
| EA (1) | EA005116B1 (fr) |
| EC (1) | ECSP034560A (fr) |
| HK (1) | HK1061857A1 (fr) |
| HR (1) | HRP20030296A2 (fr) |
| HU (1) | HUP0301403A3 (fr) |
| IL (1) | IL155487A0 (fr) |
| MX (1) | MXPA03003432A (fr) |
| MY (1) | MY125009A (fr) |
| NO (1) | NO20031753D0 (fr) |
| NZ (1) | NZ525364A (fr) |
| PE (1) | PE20020588A1 (fr) |
| PL (1) | PL360946A1 (fr) |
| SK (1) | SK4902003A3 (fr) |
| UA (1) | UA76124C2 (fr) |
| WO (1) | WO2002034741A2 (fr) |
| ZA (1) | ZA200303061B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553853B2 (en) * | 2003-10-10 | 2009-06-30 | Synthon Bv | Solid-state montelukast |
| ES2349798T3 (es) * | 2004-07-22 | 2011-01-11 | Eli Lilly And Company | Hidrato variable cristalino de la sal hemisuccinato de (s)-6-(4-(2-((3-(9h-carbazol-4-iloxi)-2-hidroxipropil)amino)-2-metilpropil)fenoxi)-3-piridinocarboxamida. |
| CA2709227A1 (fr) * | 2007-12-19 | 2009-07-09 | Spectrum Pharmaceuticals, Inc. | Formulations de sel d'elsamitrucine stables |
| DK2305238T3 (da) | 2009-09-25 | 2012-03-26 | Iasomai Aktiebolag | N-acetyl-L-cystein til behandling af endometriose |
| PL236889B1 (pl) * | 2017-10-03 | 2021-02-22 | Univ Warszawski Medyczny | Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE44597A1 (es) * | 1995-02-28 | 1997-10-13 | Lilly Co Eli | Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos |
| ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
| EP1204656A2 (fr) * | 1999-07-29 | 2002-05-15 | Eli Lilly And Company | NOUVELLE FORME CRISTALLINE DE CHLORHYDRATE DE 6-HYDROXY-3-(4- 2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO b]THIOPHENE |
| ES2208384T3 (es) * | 1999-07-29 | 2004-06-16 | Eli Lilly And Company | Forma cristalina de clorhidrato de 6 hidroxi-3-(4-(2-(piperidin-1-il)-etoxi)-fenoxi)2--(4-metoxifenil)-benzo(b)tiofeno. |
-
2001
- 2001-10-18 BR BR0114792-7A patent/BR0114792A/pt not_active IP Right Cessation
- 2001-10-18 HU HU0301403A patent/HUP0301403A3/hu unknown
- 2001-10-18 NZ NZ525364A patent/NZ525364A/en unknown
- 2001-10-18 AU AU2002214534A patent/AU2002214534A1/en not_active Abandoned
- 2001-10-18 CA CA002426007A patent/CA2426007A1/fr not_active Abandoned
- 2001-10-18 EP EP01983079A patent/EP1328521A2/fr not_active Withdrawn
- 2001-10-18 JP JP2002537732A patent/JP2004512333A/ja active Pending
- 2001-10-18 UA UA2003043576A patent/UA76124C2/uk unknown
- 2001-10-18 PL PL01360946A patent/PL360946A1/xx unknown
- 2001-10-18 US US10/399,523 patent/US20040014672A1/en not_active Abandoned
- 2001-10-18 WO PCT/US2001/027773 patent/WO2002034741A2/fr active IP Right Grant
- 2001-10-18 IL IL15548701A patent/IL155487A0/xx unknown
- 2001-10-18 AR ARP010104895A patent/AR035355A1/es unknown
- 2001-10-18 SK SK490-2003A patent/SK4902003A3/sk not_active Application Discontinuation
- 2001-10-18 EA EA200300491A patent/EA005116B1/ru not_active IP Right Cessation
- 2001-10-18 CN CNB018175813A patent/CN1268624C/zh not_active Expired - Fee Related
- 2001-10-18 MX MXPA03003432A patent/MXPA03003432A/es not_active Application Discontinuation
- 2001-10-18 CZ CZ20031098A patent/CZ20031098A3/cs unknown
- 2001-10-18 MY MYPI20014862A patent/MY125009A/en unknown
- 2001-10-18 KR KR10-2003-7005501A patent/KR20030037690A/ko not_active Application Discontinuation
- 2001-10-18 PE PE2001001040A patent/PE20020588A1/es not_active Application Discontinuation
-
2003
- 2003-04-15 HR HR20030296A patent/HRP20030296A2/hr not_active Application Discontinuation
- 2003-04-15 NO NO20031753A patent/NO20031753D0/no not_active Application Discontinuation
- 2003-04-16 EC EC2003004560A patent/ECSP034560A/es unknown
- 2003-04-17 ZA ZA200303061A patent/ZA200303061B/en unknown
-
2004
- 2004-07-06 HK HK04104903A patent/HK1061857A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002214534A1 (en) | 2002-05-06 |
| NO20031753L (no) | 2003-04-15 |
| IL155487A0 (en) | 2003-11-23 |
| CN1268624C (zh) | 2006-08-09 |
| EA005116B1 (ru) | 2004-10-28 |
| MXPA03003432A (es) | 2003-08-07 |
| EP1328521A2 (fr) | 2003-07-23 |
| CZ20031098A3 (cs) | 2003-08-13 |
| BR0114792A (pt) | 2003-08-12 |
| KR20030037690A (ko) | 2003-05-14 |
| NO20031753D0 (no) | 2003-04-15 |
| JP2004512333A (ja) | 2004-04-22 |
| PE20020588A1 (es) | 2002-07-06 |
| ECSP034560A (es) | 2003-06-25 |
| NZ525364A (en) | 2005-09-30 |
| UA76124C2 (en) | 2006-07-17 |
| EA200300491A1 (ru) | 2003-08-28 |
| MY125009A (en) | 2006-07-31 |
| CN1469872A (zh) | 2004-01-21 |
| CA2426007A1 (fr) | 2002-05-02 |
| WO2002034741A3 (fr) | 2003-01-03 |
| WO2002034741A2 (fr) | 2002-05-02 |
| HUP0301403A2 (hu) | 2003-10-28 |
| PL360946A1 (en) | 2004-09-20 |
| HK1061857A1 (en) | 2004-10-08 |
| HUP0301403A3 (en) | 2009-05-28 |
| HRP20030296A2 (en) | 2003-06-30 |
| US20040014672A1 (en) | 2004-01-22 |
| SK4902003A3 (en) | 2003-10-07 |
| AR035355A1 (es) | 2004-05-12 |
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