ZA200208967B - Hepatitis B core antigen fusion proteins. - Google Patents

Hepatitis B core antigen fusion proteins. Download PDF

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Publication number
ZA200208967B
ZA200208967B ZA200208967A ZA200208967A ZA200208967B ZA 200208967 B ZA200208967 B ZA 200208967B ZA 200208967 A ZA200208967 A ZA 200208967A ZA 200208967 A ZA200208967 A ZA 200208967A ZA 200208967 B ZA200208967 B ZA 200208967B
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ZA
South Africa
Prior art keywords
protein
hbcag
copies
nucleic acid
protein according
Prior art date
Application number
ZA200208967A
Other languages
English (en)
Inventor
Annick Gehin
Robert Gilbert
David Stuart
David Rowlands
Original Assignee
Univ Leeds Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leeds Innovations Ltd filed Critical Univ Leeds Innovations Ltd
Publication of ZA200208967B publication Critical patent/ZA200208967B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/02Hepadnaviridae, e.g. hepatitis B virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200208967A 2000-04-07 2002-11-05 Hepatitis B core antigen fusion proteins. ZA200208967B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00107118 2000-04-07

Publications (1)

Publication Number Publication Date
ZA200208967B true ZA200208967B (en) 2003-10-08

Family

ID=8168351

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200208967A ZA200208967B (en) 2000-04-07 2002-11-05 Hepatitis B core antigen fusion proteins.

Country Status (18)

Country Link
US (1) US7270821B2 (fr)
EP (1) EP1268530B1 (fr)
JP (1) JP4713809B2 (fr)
KR (1) KR100808313B1 (fr)
CN (1) CN100360556C (fr)
AP (1) AP1836A (fr)
AT (1) ATE336502T1 (fr)
AU (1) AU784345B2 (fr)
BR (1) BR0109919A (fr)
CA (1) CA2405438C (fr)
DE (1) DE60122300T2 (fr)
DK (1) DK1268530T3 (fr)
EA (1) EA200201077A1 (fr)
ES (1) ES2269371T3 (fr)
MX (1) MXPA02009895A (fr)
PT (1) PT1268530E (fr)
WO (1) WO2001077158A1 (fr)
ZA (1) ZA200208967B (fr)

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DE60027581T2 (de) * 1999-10-08 2007-05-10 Celltech Pharma Europe Ltd., Slough Design von immunogene
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
WO2003024481A2 (fr) 2001-09-14 2003-03-27 Cytos Biotechnology Ag Emballage de substances immunnostimulatrices dans des particules de type virus : procede de preparation et utilisation correspondants
KR100465643B1 (ko) * 2001-09-28 2005-01-13 (주) 에이프로젠 비형 간염 바이러스 프리에쓰1 항원 유래의 에피토프 태그및 이에 대한 항체를 이용한 폴리펩티드의 검출 및 정제방법
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
BR0213117A (pt) 2001-10-05 2004-09-21 Cytos Biotechnology Ag Conjugados peptìdeo angiotensina-veìculo e seus usos
IN2008CN05409A (fr) 2002-07-18 2015-10-02 Cytos Biotechnology Ag
WO2004016282A1 (fr) 2002-07-19 2004-02-26 Cytos Biotechnology Ag Matrices d'antigenes amyloides $g(b)1-6
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
EP1606398A1 (fr) 2003-03-26 2005-12-21 Cytos Biotechnology AG Conjugues de particules d'aspect viral d'analogues du peptide melan-a
CN100537762C (zh) * 2004-06-24 2009-09-09 中国人民解放军军事医学科学院野战输血研究所 一种嵌合型病毒样颗粒疫苗载体蛋白及其制备方法与应用
KR100687653B1 (ko) * 2005-05-13 2007-02-27 유기현 스타-델타 결선용 전자개폐기의 제어방법
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
KR101644221B1 (ko) 2008-12-09 2016-07-29 화이자 백신스 엘엘씨 IgE CH3 펩티드 백신
NZ598356A (en) 2009-07-30 2014-06-27 Pfizer Vaccines Llc Antigenic tau peptides and uses thereof
MX2012002639A (es) 2009-09-03 2012-03-14 Pfizer Vaccines Llc Vacuna de pcsk9.
GB0918679D0 (en) * 2009-10-23 2009-12-09 Iqur Ltd Influenza vaccine
EP2547695B1 (fr) * 2010-03-16 2018-05-09 Biontech Protein Therapeutics GmbH Vaccination anti-tumeur impliquant une réponse immunitaire humorale contre la protéine endogène CLDN18.2
EP2942061A3 (fr) 2010-06-07 2016-01-13 Pfizer Vaccines LLC Vaccin peptidique ige ch3
EP2680883B1 (fr) 2011-03-02 2018-09-05 Pfizer Inc Vaccin à base de pcsk9
CN102199217B (zh) * 2011-04-01 2013-03-27 中国人民解放军第三军医大学 乙型肝炎病毒多表位融合蛋白及其制备方法和应用
ES2668672T3 (es) 2011-04-15 2018-05-21 Osaka University Vacuna de ADN
WO2014034735A1 (fr) * 2012-08-31 2014-03-06 国立大学法人 大阪大学 Vaccin à base d'adn contenant un épitope spécifique du vegf et/ou un épitope spécifique de l'angiopoïétine-2
RU2677799C2 (ru) * 2012-12-11 2019-01-21 Озивакс Сас Модифицированные суперспиральные белки с улучшенными свойствами
JP2016528176A (ja) * 2013-06-06 2016-09-15 ジェイ ローランズ、デビッド シングルドメイン抗体ディスプレイ
CN104341506A (zh) * 2013-07-30 2015-02-11 复旦大学 一种重组融合蛋白及其用途
WO2015123291A1 (fr) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Vaccin à base de pcsk9 et méthodes d'utilisation dudit vaccin
GB201402890D0 (en) * 2014-02-18 2014-04-02 Iqur Ltd Vaccines based on hepatitis B Core antigens
GB201421692D0 (en) * 2014-12-05 2015-01-21 Iquar Ltd Vaccines based on hepatitis B core antigens
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CA3041888A1 (fr) * 2016-11-11 2018-05-17 Fraunhofer Usa, Inc. Proteines de capside virale fusionnees de maniere covalente destinees a la mise en evidence de molecules cibles
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Also Published As

Publication number Publication date
ATE336502T1 (de) 2006-09-15
KR20030009429A (ko) 2003-01-29
DK1268530T3 (da) 2006-11-13
JP2003530123A (ja) 2003-10-14
DE60122300D1 (de) 2006-09-28
PT1268530E (pt) 2006-12-29
ES2269371T3 (es) 2007-04-01
MXPA02009895A (es) 2004-09-06
DE60122300T2 (de) 2007-08-30
EP1268530A1 (fr) 2003-01-02
JP4713809B2 (ja) 2011-06-29
WO2001077158A1 (fr) 2001-10-18
EA200201077A1 (ru) 2003-04-24
AU4670601A (en) 2001-10-23
CA2405438A1 (fr) 2001-10-18
AP2002002658A0 (en) 2002-12-31
CN1441807A (zh) 2003-09-10
AP1836A (en) 2008-03-14
US20040223965A1 (en) 2004-11-11
US7270821B2 (en) 2007-09-18
AU784345B2 (en) 2006-03-16
KR100808313B1 (ko) 2008-02-27
BR0109919A (pt) 2003-03-11
EP1268530B1 (fr) 2006-08-16
CA2405438C (fr) 2011-07-12
CN100360556C (zh) 2008-01-09

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