ZA200208717B - Polyacrylamide hydrogel and its use as an endoprosthesis. - Google Patents
Polyacrylamide hydrogel and its use as an endoprosthesis. Download PDFInfo
- Publication number
- ZA200208717B ZA200208717B ZA200208717A ZA200208717A ZA200208717B ZA 200208717 B ZA200208717 B ZA 200208717B ZA 200208717 A ZA200208717 A ZA 200208717A ZA 200208717 A ZA200208717 A ZA 200208717A ZA 200208717 B ZA200208717 B ZA 200208717B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogel
- polyacrylamide
- weight
- endoprosthesis
- total weight
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title claims description 304
- 229920002401 polyacrylamide Polymers 0.000 title claims description 164
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 51
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 49
- 238000002360 preparation method Methods 0.000 claims description 43
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 39
- 238000005406 washing Methods 0.000 claims description 33
- 230000000977 initiatory effect Effects 0.000 claims description 28
- 230000002265 prevention Effects 0.000 claims description 21
- 229920000642 polymer Polymers 0.000 claims description 15
- 238000010992 reflux Methods 0.000 claims description 14
- 210000004872 soft tissue Anatomy 0.000 claims description 14
- 238000004132 cross linking Methods 0.000 claims description 11
- 206010021639 Incontinence Diseases 0.000 claims description 10
- 239000000499 gel Substances 0.000 claims description 10
- 206010003246 arthritis Diseases 0.000 claims description 9
- 230000003190 augmentative effect Effects 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 8
- 239000002537 cosmetic Substances 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- 150000003254 radicals Chemical class 0.000 claims description 7
- 230000003416 augmentation Effects 0.000 claims description 6
- 238000002316 cosmetic surgery Methods 0.000 claims description 6
- 230000007849 functional defect Effects 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 6
- 206010030216 Oesophagitis Diseases 0.000 claims description 5
- 238000002278 reconstructive surgery Methods 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- 206010046543 Urinary incontinence Diseases 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 4
- 210000000845 cartilage Anatomy 0.000 claims description 4
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 206010010356 Congenital anomaly Diseases 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 238000002513 implantation Methods 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 210000001072 colon Anatomy 0.000 claims description 2
- 230000007547 defect Effects 0.000 claims description 2
- 210000000664 rectum Anatomy 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 210000000626 ureter Anatomy 0.000 claims description 2
- 210000003708 urethra Anatomy 0.000 claims description 2
- 230000037303 wrinkles Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 23
- 239000000126 substance Substances 0.000 claims 23
- 210000003899 penis Anatomy 0.000 claims 10
- 230000032683 aging Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010068737 Facial asymmetry Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000004075 alteration Effects 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 210000000216 zygoma Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 description 8
- 230000000704 physical effect Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000003278 mimic effect Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 230000002009 allergenic effect Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 231100001223 noncarcinogenic Toxicity 0.000 description 2
- 230000002352 nonmutagenic effect Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229940127285 new chemical entity Drugs 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002265 redox agent Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F6/00—Post-polymerisation treatments
- C08F6/001—Removal of residual monomers by physical means
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F6/00—Post-polymerisation treatments
- C08F6/001—Removal of residual monomers by physical means
- C08F6/003—Removal of residual monomers by physical means from polymer solutions, suspensions, dispersions or emulsions without recovery of the polymer therefrom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F6/00—Post-polymerisation treatments
- C08F6/02—Neutralisation of the polymerisation mass, e.g. killing the catalyst also removal of catalyst residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/24—Homopolymers or copolymers of amides or imides
- C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Prostheses (AREA)
- Fire-Extinguishing Compositions (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001262 | 2000-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200208717B true ZA200208717B (en) | 2004-02-10 |
Family
ID=8159676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200208717A ZA200208717B (en) | 2000-08-25 | 2002-10-28 | Polyacrylamide hydrogel and its use as an endoprosthesis. |
Country Status (16)
| Country | Link |
|---|---|
| EP (4) | EP2272881A2 (es) |
| AT (3) | ATE294198T1 (es) |
| AU (2) | AU8176301A (es) |
| BG (1) | BG66025B1 (es) |
| DE (3) | DE60140489D1 (es) |
| DK (3) | DK1564230T3 (es) |
| EE (1) | EE05367B1 (es) |
| ES (3) | ES2362583T3 (es) |
| HK (1) | HK1054396A1 (es) |
| HU (1) | HUP0302054A3 (es) |
| IL (4) | IL152803A0 (es) |
| NO (1) | NO20025198L (es) |
| PT (1) | PT1287048E (es) |
| RU (1) | RU2301814C2 (es) |
| WO (1) | WO2002016453A1 (es) |
| ZA (1) | ZA200208717B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005951B1 (ru) | 2002-04-10 | 2005-08-25 | Общество с ограниченной ответственностью "Витагель" | Полифункциональный биосовместимый гидрогель и способ его получения |
| GB0303798D0 (en) * | 2003-02-19 | 2003-03-26 | Bioartem Ltd | Gel |
| US8663225B2 (en) | 2004-11-12 | 2014-03-04 | Medtronic, Inc. | Hydrogel bone void filler |
| FR2918476B1 (fr) * | 2007-07-02 | 2012-08-03 | Experts Enlargement Quality Exeq | Controle de conformite de donnees. |
| EP2497468A1 (en) | 2011-03-11 | 2012-09-12 | Contura A/S | Polyacrylamide hydrogel for use in the treatment and/or prevention of joint swelling and/or bone oedema in a mammal suffering from arthritis |
| UA67354U (uk) | 2011-11-24 | 2012-02-10 | Людмила Дмитрівна Желдак | Водорозчинний лінійний гетероланцюговий диполімер |
| RU2499003C1 (ru) * | 2012-03-22 | 2013-11-20 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения полиакриламидного гидрогеля |
| RU2493173C1 (ru) * | 2012-03-22 | 2013-09-20 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения полиакриламидного гидрогеля |
| US10072161B2 (en) | 2014-01-23 | 2018-09-11 | Bar Ilan University | Polyamide nanoparticles and uses thereof |
| RU2612703C1 (ru) * | 2015-11-03 | 2017-03-13 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения полимерного гидрогеля |
| HUE053532T2 (hu) * | 2016-03-31 | 2021-07-28 | Contura Int A/S | Poliakrilamid hidrogél, synovitis megelõzésére és/vagy kezelésére való alkalmazásra emlõsben |
| AU2018203714A1 (en) * | 2017-03-09 | 2018-09-27 | Colin Campbell Marshall Moore | Improved Phalloplasty Method |
| EP3615095B1 (en) * | 2017-04-24 | 2021-06-09 | Contura International A/S | Stem cell composition |
| CN108329422B (zh) * | 2018-02-07 | 2020-12-29 | 山东诺尔生物科技有限公司 | 一种水包水型微球调剖剂及其制备方法 |
| KR102129986B1 (ko) * | 2018-08-30 | 2020-07-03 | 포항공과대학교 산학협력단 | 일산화질소 감응성을 갖는 아크릴아마이드계 고분자를 포함하는 염증성 질환 예방 또는 치료용 약학 조성물 |
| CN111848877A (zh) * | 2020-07-09 | 2020-10-30 | 沈阳工大蓝金环保产业技术研究院有限公司 | 一种物理水凝胶及其制备方法和应用 |
| JP2024532952A (ja) | 2021-09-20 | 2024-09-10 | コンチュラ インターナショナル エー／エス | 変形性関節症の治療及び／又は予防に使用するポリアクリルアミドハイドロゲル |
| CN114292483B (zh) * | 2021-11-24 | 2023-02-03 | 四川大学 | 一种聚丙烯酰胺/有机硅共混水凝胶及其制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2114578B (en) | 1979-11-06 | 1984-06-27 | Ki Med I | Polyacrylamide gel for medical and biological application and method of its preparation |
| US4344193A (en) | 1980-11-28 | 1982-08-17 | Kenny Charles H | Meniscus prosthesis |
| US4502161A (en) | 1981-09-21 | 1985-03-05 | Wall W H | Prosthetic meniscus for the repair of joints |
| US4571749A (en) | 1982-09-21 | 1986-02-25 | The Johns Hopkins University | Manually actuated hydraulic sphincter |
| US4540568A (en) * | 1982-10-14 | 1985-09-10 | Trager Seymour F | Injectionable viscoelastic ophthalmic gel |
| US4969474A (en) | 1988-10-11 | 1990-11-13 | Schwarz Gerald R | Incontinence bladder control method and apparatus |
| US4919667A (en) | 1988-12-02 | 1990-04-24 | Stryker Corporation | Implant |
| US5171322A (en) | 1990-02-13 | 1992-12-15 | Kenny Charles H | Stabilized meniscus prosthesis |
| US5344459A (en) | 1991-12-03 | 1994-09-06 | Swartz Stephen J | Arthroscopically implantable prosthesis |
| JP3071926B2 (ja) | 1992-01-28 | 2000-07-31 | 第一化学薬品株式会社 | ポリアクリルアミド系電気泳動用ゲルプレートの製造方法 |
| RU2034465C1 (ru) * | 1992-08-05 | 1995-05-10 | Малое Внедренческое Предприятие "Интерфалл" | Состав для инъекции при эндопротезировании |
| UA10911C2 (uk) * | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
| US5668928A (en) | 1995-01-31 | 1997-09-16 | Kor Team International, Inc. | Speech recognition system and method with automatic syntax generation |
| US5658329A (en) * | 1995-02-14 | 1997-08-19 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| RU2127129C1 (ru) † | 1996-05-28 | 1999-03-10 | Владислав Викторович Лопатин | Способ получения гелеобразного материала для пластики мягких тканей |
| BG102375A (en) * | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
| RU2148957C1 (ru) | 1998-02-10 | 2000-05-20 | Скнар Александр Антонович | Способ лечения пузырно-мочеточникового рефлюкса |
| CA2366822C (en) | 1999-04-02 | 2008-01-29 | Barry M. Fell | Surgically implantable knee prosthesis |
| US6288043B1 (en) | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
| US6464628B1 (en) | 1999-08-12 | 2002-10-15 | Obtech Medical Ag | Mechanical anal incontinence |
| WO2001049336A1 (en) * | 1999-12-29 | 2001-07-12 | Progen S.R.L. | Biocompatible hydrogel and method of its production |
| CN101803965B (zh) | 2000-02-10 | 2014-02-26 | 厄罗洛吉卡股份公司 | 控制小便失禁的治疗 |
| US6953429B2 (en) | 2000-02-14 | 2005-10-11 | Obtech Medical Ag | Hydraulic urinary incontinence treatment apparatus |
-
2001
- 2001-08-25 AU AU8176301A patent/AU8176301A/xx active Pending
- 2001-08-25 DK DK05009167.7T patent/DK1564230T3/da active
- 2001-08-25 DK DK04002645.2T patent/DK1418188T3/da active
- 2001-08-25 DE DE60140489T patent/DE60140489D1/de not_active Expired - Lifetime
- 2001-08-25 RU RU2003107927/04A patent/RU2301814C2/ru active
- 2001-08-25 ES ES05009167T patent/ES2362583T3/es not_active Expired - Lifetime
- 2001-08-25 AU AU2001281763A patent/AU2001281763B2/en not_active Ceased
- 2001-08-25 HU HU0302054A patent/HUP0302054A3/hu unknown
- 2001-08-25 AT AT01960207T patent/ATE294198T1/de active
- 2001-08-25 DE DE60144200T patent/DE60144200D1/de not_active Expired - Lifetime
- 2001-08-25 EP EP10182169A patent/EP2272881A2/en not_active Withdrawn
- 2001-08-25 EP EP04002645A patent/EP1418188B1/en not_active Expired - Lifetime
- 2001-08-25 EP EP01960207A patent/EP1287048B2/en not_active Expired - Lifetime
- 2001-08-25 ES ES01960207T patent/ES2237588T5/es not_active Expired - Lifetime
- 2001-08-25 AT AT04002645T patent/ATE447987T1/de not_active IP Right Cessation
- 2001-08-25 AT AT05009167T patent/ATE501188T1/de not_active IP Right Cessation
- 2001-08-25 IL IL15280301A patent/IL152803A0/xx unknown
- 2001-08-25 DK DK01960207T patent/DK1287048T4/da active
- 2001-08-25 ES ES04002645T patent/ES2214988T3/es not_active Expired - Lifetime
- 2001-08-25 DE DE60110413T patent/DE60110413T3/de not_active Expired - Lifetime
- 2001-08-25 EP EP05009167A patent/EP1564230B1/en not_active Expired - Lifetime
- 2001-08-25 WO PCT/DK2001/000565 patent/WO2002016453A1/en active Application Filing
- 2001-08-25 PT PT01960207T patent/PT1287048E/pt unknown
- 2001-08-25 EE EEP200200692A patent/EE05367B1/xx not_active IP Right Cessation
-
2002
- 2002-10-28 ZA ZA200208717A patent/ZA200208717B/en unknown
- 2002-10-30 NO NO20025198A patent/NO20025198L/no not_active Application Discontinuation
- 2002-11-12 IL IL152803A patent/IL152803A/en not_active IP Right Cessation
- 2002-12-17 BG BG107397A patent/BG66025B1/bg unknown
-
2003
- 2003-09-05 HK HK03106346A patent/HK1054396A1/xx not_active IP Right Cessation
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2009
- 2009-01-28 IL IL196770A patent/IL196770A/en not_active IP Right Cessation
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2010
- 2010-12-16 IL IL210064A patent/IL210064A/en not_active IP Right Cessation
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