ZA200205265B - A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor. - Google Patents

A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor.

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Publication number
ZA200205265B
ZA200205265B ZA200205265A ZA200205265A ZA200205265B ZA 200205265 B ZA200205265 B ZA 200205265B ZA 200205265 A ZA200205265 A ZA 200205265A ZA 200205265 A ZA200205265 A ZA 200205265A ZA 200205265 B ZA200205265 B ZA 200205265B
Authority
ZA
South Africa
Prior art keywords
pyrrolo
pyrimidin
dihydro
benzoyl
oxo
Prior art date
Application number
ZA200205265A
Other languages
English (en)
Inventor
Erik Christopher Chelius
Sharon Van Den Berghe Snorek
Susan Marie Reutzel-Edens
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200205265(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA200205265B publication Critical patent/ZA200205265B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
ZA200205265A 2000-02-25 2002-07-01 A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor. ZA200205265B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25

Publications (1)

Publication Number Publication Date
ZA200205265B true ZA200205265B (en) 2003-11-11

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200205265A ZA200205265B (en) 2000-02-25 2002-07-01 A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor.

Country Status (35)

Country Link
US (1) US7138521B2 (cs)
EP (1) EP1259513B1 (cs)
JP (1) JP4846158B2 (cs)
KR (1) KR100744917B1 (cs)
CN (1) CN1183135C (cs)
AR (1) AR029471A1 (cs)
AT (1) ATE249462T1 (cs)
AU (1) AU777047B2 (cs)
BR (1) BR0108604A (cs)
CA (1) CA2400155C (cs)
CO (1) CO5261585A1 (cs)
CZ (1) CZ303772B6 (cs)
DE (1) DE60100750T2 (cs)
DK (1) DK1259513T3 (cs)
DZ (1) DZ3283A1 (cs)
EA (1) EA004684B1 (cs)
EG (1) EG24073A (cs)
ES (1) ES2206403T3 (cs)
HR (1) HRP20020701B1 (cs)
HU (1) HU229704B1 (cs)
IL (2) IL150480A0 (cs)
MX (1) MXPA02008242A (cs)
MY (1) MY124784A (cs)
NO (1) NO323422B1 (cs)
NZ (1) NZ519796A (cs)
PE (1) PE20011082A1 (cs)
PL (1) PL208061B1 (cs)
PT (1) PT1259513E (cs)
SI (1) SI1259513T1 (cs)
SK (1) SK287375B6 (cs)
SV (1) SV2002000321A (cs)
TW (1) TWI237024B (cs)
UA (1) UA72791C2 (cs)
WO (1) WO2001062760A2 (cs)
ZA (1) ZA200205265B (cs)

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CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
CN101365440A (zh) * 2005-11-04 2009-02-11 默克公司 用saha、卡铂和紫杉醇治疗癌症的方法以及其他联合治疗
CN101300015A (zh) * 2005-11-04 2008-11-05 默克公司 使用n-辛二酰苯胺异羟肟酸和厄洛替尼治疗癌症的方法
JP2008543975A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
TWI374886B (en) * 2006-08-14 2012-10-21 Sicor Inc Processes for preparing intermediates of pemetrexed
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TWI377955B (en) 2006-08-14 2012-12-01 Sicor Inc Processes for preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
EP2086323A4 (en) * 2006-11-03 2010-01-06 Univ Maryland METHOD OF USE OF SAHA AND BORTEZOMIB FOR THE TREATMENT OF MULTIPLE MYELOMA
EP2129674A2 (en) * 2007-04-03 2009-12-09 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (en) 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Stable Amorphous Form of Pemextred Disodium
EP2334685A4 (en) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr AMORPHOUS PEMETREXED DISODIUM
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
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CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
WO2011064256A1 (en) 2009-11-24 2011-06-03 Azad Pharmaceutical Ingredients Ag A new crystalline form of pemetrexed disodium
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CN103459392B (zh) * 2011-03-25 2016-08-17 台湾神隆股份有限公司 一种制备培美曲塞盐的方法
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Crystalline pemetrexed dipotassium process
CA2900088A1 (en) 2013-02-06 2014-08-14 Cipla Limited Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
EP2983649A1 (en) 2013-04-12 2016-02-17 Actavis Group PCT ehf Pemetrexed formulation
KR101485243B1 (ko) * 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
JP6248189B2 (ja) 2013-06-14 2017-12-13 シントン・ベスローテン・フェンノートシャップ 安定な抗がん剤のアルギニン塩とそれを含む組成物
EP3021849B1 (en) 2013-07-16 2019-10-09 Dr. Reddy's Laboratories Ltd. Novel crystalline forms of pemetrexed tromethamine salts
CN110051625A (zh) 2013-10-03 2019-07-26 富士胶片株式会社 注射液制剂及其制造方法
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
CA3015436C (en) 2014-10-30 2020-07-21 Scinopharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
AU2018349426B2 (en) * 2017-10-10 2024-01-18 Sun Pharmaceutical Industries Limited Intravenous infusion dosage form for pemetrexed
CN111954531A (zh) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 α聚谷氨酸化培美曲塞及其用途
JP7490239B2 (ja) 2018-02-07 2024-05-27 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化ペメトレキセドおよびその使用

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ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
BR9812524A (pt) * 1997-09-26 2000-07-25 Lilly Co Eli Processos e intermediários utilizáveis para produzir antifolatos
AU6890800A (en) * 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor

Also Published As

Publication number Publication date
HU229704B1 (en) 2014-05-28
JP4846158B2 (ja) 2011-12-28
ATE249462T1 (de) 2003-09-15
US20030216416A1 (en) 2003-11-20
HK1051856A1 (en) 2003-08-22
KR20020075449A (ko) 2002-10-04
HUP0204232A3 (en) 2006-01-30
WO2001062760A2 (en) 2001-08-30
PL356423A1 (en) 2004-06-28
DZ3283A1 (fr) 2001-08-30
MY124784A (en) 2006-07-31
WO2001062760A3 (en) 2001-12-06
MXPA02008242A (es) 2002-11-29
NO20023974D0 (no) 2002-08-21
CN1183135C (zh) 2005-01-05
CZ303772B6 (cs) 2013-05-02
AU777047B2 (en) 2004-09-30
PL208061B1 (pl) 2011-03-31
EP1259513A2 (en) 2002-11-27
EA004684B1 (ru) 2004-06-24
DE60100750D1 (de) 2003-10-16
SV2002000321A (es) 2002-07-16
NO20023974L (no) 2002-08-21
ES2206403T3 (es) 2004-05-16
EP1259513B1 (en) 2003-09-10
US7138521B2 (en) 2006-11-21
SI1259513T1 (en) 2003-12-31
KR100744917B1 (ko) 2007-08-01
AU3445101A (en) 2001-09-03
SK11862002A3 (sk) 2003-01-09
NO323422B1 (no) 2007-04-30
NZ519796A (en) 2003-01-31
CA2400155A1 (en) 2001-08-30
CZ20022875A3 (cs) 2003-02-12
BR0108604A (pt) 2002-11-19
IL150480A0 (en) 2002-12-01
CA2400155C (en) 2009-09-15
DK1259513T3 (da) 2004-01-12
DE60100750T2 (de) 2004-07-29
AR029471A1 (es) 2003-07-02
HUP0204232A2 (hu) 2003-04-28
HRP20020701A2 (en) 2003-12-31
PE20011082A1 (es) 2001-10-22
UA72791C2 (uk) 2005-04-15
TWI237024B (en) 2005-08-01
PT1259513E (pt) 2004-02-27
IL150480A (en) 2007-12-03
CO5261585A1 (es) 2003-03-31
SK287375B6 (sk) 2010-08-09
JP2003530321A (ja) 2003-10-14
EG24073A (en) 2008-05-11
CN1406238A (zh) 2003-03-26
EA200200905A1 (ru) 2003-02-27
HRP20020701B1 (en) 2011-02-28

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