ZA200201557B - Pyrimidine derivatives. - Google Patents
Pyrimidine derivatives. Download PDFInfo
- Publication number
- ZA200201557B ZA200201557B ZA200201557A ZA200201557A ZA200201557B ZA 200201557 B ZA200201557 B ZA 200201557B ZA 200201557 A ZA200201557 A ZA 200201557A ZA 200201557 A ZA200201557 A ZA 200201557A ZA 200201557 B ZA200201557 B ZA 200201557B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- pyrrolidin
- alkyl
- piperidin
- amino
- Prior art date
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- 150000003230 pyrimidines Chemical class 0.000 title claims abstract description 37
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 127
- 150000002148 esters Chemical class 0.000 claims abstract description 73
- 150000003839 salts Chemical class 0.000 claims abstract description 72
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 54
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 41
- 125000005843 halogen group Chemical group 0.000 claims abstract description 33
- 125000003118 aryl group Chemical group 0.000 claims abstract description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
- 102000004127 Cytokines Human genes 0.000 claims abstract description 24
- 108090000695 Cytokines Proteins 0.000 claims abstract description 24
- 201000010099 disease Diseases 0.000 claims abstract description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 23
- 239000001257 hydrogen Substances 0.000 claims abstract description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 21
- 238000011282 treatment Methods 0.000 claims abstract description 17
- 230000001404 mediated effect Effects 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 4
- -1 cyano, mercapto, nitro, amino, carboxy, carbamoyl Chemical group 0.000 claims description 961
- 125000001424 substituent group Chemical group 0.000 claims description 157
- 150000001875 compounds Chemical class 0.000 claims description 112
- 239000000203 mixture Substances 0.000 claims description 61
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 55
- 125000000623 heterocyclic group Chemical group 0.000 claims description 48
- 125000003545 alkoxy group Chemical group 0.000 claims description 46
- 125000003282 alkyl amino group Chemical group 0.000 claims description 46
- 125000001153 fluoro group Chemical group F* 0.000 claims description 38
- 229910052760 oxygen Inorganic materials 0.000 claims description 36
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 34
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 34
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 30
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 30
- 125000005236 alkanoylamino group Chemical group 0.000 claims description 29
- 238000006243 chemical reaction Methods 0.000 claims description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims description 28
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 27
- 238000004519 manufacturing process Methods 0.000 claims description 27
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 125000006239 protecting group Chemical group 0.000 claims description 22
- 125000001246 bromo group Chemical group Br* 0.000 claims description 20
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 18
- 125000000524 functional group Chemical group 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 16
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 15
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 15
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 15
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 14
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- 125000004423 acyloxy group Chemical group 0.000 claims description 13
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- 125000006325 2-propenyl amino group Chemical group [H]C([H])=C([H])C([H])([H])N([H])* 0.000 claims description 12
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- 125000002947 alkylene group Chemical group 0.000 claims description 12
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- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 11
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 9
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- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 6
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 6
- 238000007254 oxidation reaction Methods 0.000 claims description 6
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 6
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- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
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- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 4
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
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- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
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- IYXXHXAZYORMBJ-UHFFFAOYSA-N n-[4-methyl-3-[[2-(1-methylpiperidin-4-yl)oxypyrimidin-4-yl]amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound C1CN(C)CCC1OC1=NC=CC(NC=2C(=CC=C(NC(=O)C=3C=C(N=CC=3)N3CCOCC3)C=2)C)=N1 IYXXHXAZYORMBJ-UHFFFAOYSA-N 0.000 claims description 3
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- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000004627 thianthrenyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3SC12)* 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000013389 whole blood assay Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9924092.1A GB9924092D0 (en) | 1999-10-13 | 1999-10-13 | Pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
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ZA200201557B true ZA200201557B (en) | 2003-07-30 |
Family
ID=10862569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200201557A ZA200201557B (en) | 1999-10-13 | 2002-02-25 | Pyrimidine derivatives. |
Country Status (18)
Country | Link |
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US (1) | US6846827B1 (ko) |
EP (1) | EP1226126B1 (ko) |
JP (1) | JP2003511442A (ko) |
KR (1) | KR100738862B1 (ko) |
CN (1) | CN100415724C (ko) |
AT (1) | ATE286501T1 (ko) |
AU (1) | AU772293B2 (ko) |
BR (1) | BR0014596A (ko) |
CA (1) | CA2382605A1 (ko) |
DE (1) | DE60017279T2 (ko) |
GB (1) | GB9924092D0 (ko) |
HK (1) | HK1045511B (ko) |
IL (2) | IL148428A0 (ko) |
MX (1) | MXPA02003533A (ko) |
NO (1) | NO322808B1 (ko) |
NZ (1) | NZ517572A (ko) |
WO (1) | WO2001027089A1 (ko) |
ZA (1) | ZA200201557B (ko) |
Families Citing this family (75)
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PT1077930E (pt) | 1998-05-15 | 2005-03-31 | Astrazeneca Ab | Derivados de benzamida para o tratamento de doencas mediadas por citocinas |
JP2002522421A (ja) | 1998-08-04 | 2002-07-23 | アストラゼネカ アクチボラグ | サイトカイン産生の阻害剤として有用なアミド誘導体 |
ID28267A (id) | 1998-09-25 | 2001-05-10 | Astrazeneca Ab | Turunan benzamida dan penggunaannya sebagai inhibitor sitokina |
BR0009083B1 (pt) | 1999-03-17 | 2011-11-01 | derivado de amida compreendendo um núcleo de quinazolinona, processo para a preparação de um derivado de amida, composição farmacêutica, e, uso de um derivado de amida. | |
JP2002539187A (ja) | 1999-03-17 | 2002-11-19 | アストラゼネカ アクチボラグ | アミド誘導体 |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
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ATE517872T1 (de) | 2003-06-26 | 2011-08-15 | Novartis Ag | Fünfgliedrige p38-kinaseinhibitoren auf heterocyclusbasis |
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US7504521B2 (en) | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
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PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
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CA2633980A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
BRPI0708644A2 (pt) | 2006-03-07 | 2011-06-07 | Bristol-Myers Squibb Company | compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase |
US20070293494A1 (en) * | 2006-06-15 | 2007-12-20 | Djung Jane F | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines |
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EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
AU2008314632B2 (en) * | 2007-10-19 | 2015-05-28 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
US20100015708A1 (en) * | 2008-06-18 | 2010-01-21 | Mdrna, Inc. | Ribonucleic acids with non-standard bases and uses thereof |
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WO2010120963A1 (en) * | 2009-04-16 | 2010-10-21 | Bristol-Myers Squibb Company | Tablet formulation for p38 inhibitor and method |
DK2477629T3 (en) * | 2009-09-17 | 2016-08-22 | Univ Vanderbilt | SUBSTITUTED HETEROARYLAMIDANALOGER AS mGluR5 allosteric modulators NEGATIVE AND METHODS OF MAKING AND USE THEREOF |
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UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
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LT2970218T (lt) | 2013-03-12 | 2019-03-12 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitoriai |
SG11201602962PA (en) | 2013-10-17 | 2016-05-30 | Vertex Pharma | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
EP3071568A1 (en) | 2013-11-19 | 2016-09-28 | Vanderbilt University | Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5 |
US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
KR20190062485A (ko) | 2016-09-27 | 2019-06-05 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-손상제 및 dna-pk 저해제의 조합을 사용한 암 치료 방법 |
EP3749649A1 (en) | 2018-02-08 | 2020-12-16 | ENYO Pharma | Non-fused thiophene derivatives and their uses |
AU2019435745A1 (en) * | 2019-03-18 | 2021-10-14 | The Council Of The Queensland Institute Of Medical Research | Cardiomyocyte proliferation |
CA3166746A1 (en) * | 2020-02-28 | 2021-09-02 | Nathanael S. Gray | Map kinase kinase (mkk7) inhibitors and uses thereof |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
WO1997033883A1 (en) * | 1996-03-13 | 1997-09-18 | Smithkline Beecham Corporation | Novel pyrimidine compounds useful in treating cytokine mediated diseases |
GB9623833D0 (en) | 1996-11-16 | 1997-01-08 | Zeneca Ltd | Chemical compound |
WO1999001439A1 (en) | 1997-07-03 | 1999-01-14 | Du Pont Pharmaceuticals Company | Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists |
WO1999015164A1 (en) | 1997-09-23 | 1999-04-01 | Zeneca Limited | Amide derivatives for the treatment of diseases mediated by cytokines |
KR100699514B1 (ko) | 1998-03-27 | 2007-03-26 | 얀센 파마슈티카 엔.브이. | Hiv를 억제하는 피리미딘 유도체 |
SK286123B6 (sk) | 1998-05-15 | 2008-04-07 | Astrazeneca Ab | Benzamidové deriváty, spôsob ich prípravy, farmaceutická kompozícia a ich použitie na prípravu liečiva na liečenie chorôb sprostredkovaných cytokínmi |
PT1077930E (pt) | 1998-05-15 | 2005-03-31 | Astrazeneca Ab | Derivados de benzamida para o tratamento de doencas mediadas por citocinas |
JP2002522421A (ja) | 1998-08-04 | 2002-07-23 | アストラゼネカ アクチボラグ | サイトカイン産生の阻害剤として有用なアミド誘導体 |
ATE267175T1 (de) | 1998-08-27 | 2004-06-15 | Sumitomo Pharma | Pyrimidin derivate |
DE69932828T2 (de) | 1998-08-29 | 2007-10-18 | Astrazeneca Ab | Pyrimidine verbindungen |
AU5438299A (en) | 1998-08-29 | 2000-03-21 | Astrazeneca Ab | Pyrimidine compounds |
ID28267A (id) | 1998-09-25 | 2001-05-10 | Astrazeneca Ab | Turunan benzamida dan penggunaannya sebagai inhibitor sitokina |
EP1117653B1 (en) | 1998-10-01 | 2003-02-05 | AstraZeneca AB | Quinoline and quinazoline derivatives and their use as inhibitors of cytokine mediated diseases |
JP2002539187A (ja) | 1999-03-17 | 2002-11-19 | アストラゼネカ アクチボラグ | アミド誘導体 |
BR0009083B1 (pt) | 1999-03-17 | 2011-11-01 | derivado de amida compreendendo um núcleo de quinazolinona, processo para a preparação de um derivado de amida, composição farmacêutica, e, uso de um derivado de amida. | |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-10-13 GB GBGB9924092.1A patent/GB9924092D0/en not_active Ceased
-
2000
- 2000-10-10 JP JP2001530109A patent/JP2003511442A/ja active Pending
- 2000-10-10 US US10/070,360 patent/US6846827B1/en not_active Expired - Fee Related
- 2000-10-10 KR KR1020027004779A patent/KR100738862B1/ko not_active IP Right Cessation
- 2000-10-10 WO PCT/GB2000/003929 patent/WO2001027089A1/en active IP Right Grant
- 2000-10-10 CN CNB008141452A patent/CN100415724C/zh not_active Expired - Fee Related
- 2000-10-10 DE DE60017279T patent/DE60017279T2/de not_active Expired - Fee Related
- 2000-10-10 CA CA002382605A patent/CA2382605A1/en not_active Abandoned
- 2000-10-10 EP EP00968084A patent/EP1226126B1/en not_active Expired - Lifetime
- 2000-10-10 AT AT00968084T patent/ATE286501T1/de not_active IP Right Cessation
- 2000-10-10 BR BR0014596-3A patent/BR0014596A/pt not_active Application Discontinuation
- 2000-10-10 AU AU78042/00A patent/AU772293B2/en not_active Ceased
- 2000-10-10 NZ NZ517572A patent/NZ517572A/en unknown
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- 2000-10-10 MX MXPA02003533A patent/MXPA02003533A/es active IP Right Grant
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2002
- 2002-02-25 ZA ZA200201557A patent/ZA200201557B/en unknown
- 2002-02-27 IL IL148428A patent/IL148428A/en not_active IP Right Cessation
- 2002-04-12 NO NO20021728A patent/NO322808B1/no not_active IP Right Cessation
- 2002-09-25 HK HK02107003.8A patent/HK1045511B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20021728L (no) | 2002-06-12 |
MXPA02003533A (es) | 2002-08-20 |
ATE286501T1 (de) | 2005-01-15 |
EP1226126A1 (en) | 2002-07-31 |
CN1378537A (zh) | 2002-11-06 |
CA2382605A1 (en) | 2001-04-19 |
BR0014596A (pt) | 2002-06-11 |
HK1045511B (zh) | 2005-06-03 |
NZ517572A (en) | 2003-11-28 |
WO2001027089A1 (en) | 2001-04-19 |
HK1045511A1 (en) | 2002-11-29 |
IL148428A0 (en) | 2002-09-12 |
KR20020091830A (ko) | 2002-12-06 |
IL148428A (en) | 2006-12-10 |
DE60017279D1 (en) | 2005-02-10 |
US6846827B1 (en) | 2005-01-25 |
NO20021728D0 (no) | 2002-04-12 |
AU772293B2 (en) | 2004-04-22 |
GB9924092D0 (en) | 1999-12-15 |
EP1226126B1 (en) | 2005-01-05 |
JP2003511442A (ja) | 2003-03-25 |
DE60017279T2 (de) | 2005-12-08 |
AU7804200A (en) | 2001-04-23 |
CN100415724C (zh) | 2008-09-03 |
NO322808B1 (no) | 2006-12-11 |
KR100738862B1 (ko) | 2007-07-13 |
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