ZA200108527B - Preventives/remedies/progression inhibitors for simplex retinopathy or preproliferating retinopathy. - Google Patents
Preventives/remedies/progression inhibitors for simplex retinopathy or preproliferating retinopathy. Download PDFInfo
- Publication number
- ZA200108527B ZA200108527B ZA200108527A ZA200108527A ZA200108527B ZA 200108527 B ZA200108527 B ZA 200108527B ZA 200108527 A ZA200108527 A ZA 200108527A ZA 200108527 A ZA200108527 A ZA 200108527A ZA 200108527 B ZA200108527 B ZA 200108527B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- angiotensin
- antagonistic activity
- retinopathy
- composition according
- Prior art date
Links
- 208000017442 Retinal disease Diseases 0.000 title claims description 19
- 206010038923 Retinopathy Diseases 0.000 title claims description 19
- 239000003112 inhibitor Substances 0.000 title 1
- 230000003449 preventive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 49
- 230000003042 antagnostic effect Effects 0.000 claims description 35
- 102000005862 Angiotensin II Human genes 0.000 claims description 34
- 101800000733 Angiotensin-2 Proteins 0.000 claims description 34
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims description 34
- 229950006323 angiotensin ii Drugs 0.000 claims description 34
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 7
- 201000010183 Papilledema Diseases 0.000 claims description 7
- 206010038886 Retinal oedema Diseases 0.000 claims description 7
- 150000001450 anions Chemical class 0.000 claims description 7
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 201000011195 retinal edema Diseases 0.000 claims description 7
- 230000002207 retinal effect Effects 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 239000000651 prodrug Substances 0.000 claims description 6
- 229940002612 prodrug Drugs 0.000 claims description 6
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 6
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 229960000651 tasosartan Drugs 0.000 claims description 4
- ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 claims description 4
- 229960004699 valsartan Drugs 0.000 claims description 4
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims description 4
- VVQNAFBGAWCMLU-UHFFFAOYSA-N 1h-benzimidazole-4-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1N=CN2 VVQNAFBGAWCMLU-UHFFFAOYSA-N 0.000 claims description 3
- 239000002083 C09CA01 - Losartan Substances 0.000 claims description 3
- 239000002080 C09CA02 - Eprosartan Substances 0.000 claims description 3
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 3
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 3
- 239000002081 C09CA05 - Tasosartan Substances 0.000 claims description 3
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims description 3
- 239000005537 C09CA07 - Telmisartan Substances 0.000 claims description 3
- 229960000932 candesartan Drugs 0.000 claims description 3
- 229960004349 candesartan cilexetil Drugs 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229960004563 eprosartan Drugs 0.000 claims description 3
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 229960002198 irbesartan Drugs 0.000 claims description 3
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 3
- 229960004773 losartan Drugs 0.000 claims description 3
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical group CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 3
- 125000006850 spacer group Chemical group 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 229960005187 telmisartan Drugs 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 description 12
- 206010038934 Retinopathy proliferative Diseases 0.000 description 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 7
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 7
- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 206010020772 Hypertension Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 102000015427 Angiotensins Human genes 0.000 description 3
- 108010064733 Angiotensins Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 150000002460 imidazoles Chemical class 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 3
- 230000008728 vascular permeability Effects 0.000 description 3
- 102000008873 Angiotensin II receptor Human genes 0.000 description 2
- 108050000824 Angiotensin II receptor Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 206010038848 Retinal detachment Diseases 0.000 description 2
- 206010047139 Vasoconstriction Diseases 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000000649 photocoagulation Effects 0.000 description 2
- 230000036454 renin-angiotensin system Effects 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 230000004264 retinal detachment Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 230000025033 vasoconstriction Effects 0.000 description 2
- 230000004382 visual function Effects 0.000 description 2
- -1 1- (cyclohexyloxycarbonyloxy)ethyl Chemical group 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- MJABXZWILYUAEB-UHFFFAOYSA-N benzimidazole-1-carboxylic acid Chemical compound C1=CC=C2N(C(=O)O)C=NC2=C1 MJABXZWILYUAEB-UHFFFAOYSA-N 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000003450 growing effect Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000002577 ophthalmoscopy Methods 0.000 description 1
- ZVTQYRVARPYRRE-UHFFFAOYSA-N oxadiazol-4-one Chemical group O=C1CON=N1 ZVTQYRVARPYRRE-UHFFFAOYSA-N 0.000 description 1
- JNGDFYLGDPAEBY-UHFFFAOYSA-N oxadiazole-4-thione Chemical group S=C1CON=N1 JNGDFYLGDPAEBY-UHFFFAOYSA-N 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000003668 pericyte Anatomy 0.000 description 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 150000008512 pyrimidinediones Chemical class 0.000 description 1
- 150000008318 pyrimidones Chemical class 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- XWMXMWHHTIEXRE-UHFFFAOYSA-N thiadiazole 1-oxide Chemical group O=S1C=CN=N1 XWMXMWHHTIEXRE-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12149899 | 1999-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108527B true ZA200108527B (en) | 2002-10-17 |
Family
ID=14812676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108527A ZA200108527B (en) | 1999-04-28 | 2001-10-17 | Preventives/remedies/progression inhibitors for simplex retinopathy or preproliferating retinopathy. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7064141B1 (no) |
| EP (1) | EP1197223B1 (no) |
| KR (1) | KR100865059B1 (no) |
| CN (1) | CN1172719C (no) |
| AT (1) | ATE289204T1 (no) |
| AU (1) | AU774799B2 (no) |
| BR (1) | BR0010084A (no) |
| CA (1) | CA2371554C (no) |
| CZ (1) | CZ301913B6 (no) |
| DE (1) | DE60018186T2 (no) |
| DK (1) | DK1197223T3 (no) |
| ES (1) | ES2233362T3 (no) |
| HU (1) | HU226948B1 (no) |
| MX (1) | MXPA01010923A (no) |
| NO (1) | NO327446B1 (no) |
| NZ (1) | NZ514855A (no) |
| PL (1) | PL196895B1 (no) |
| PT (1) | PT1197223E (no) |
| RU (1) | RU2239454C2 (no) |
| SI (1) | SI1197223T1 (no) |
| SK (1) | SK286859B6 (no) |
| WO (1) | WO2000066161A1 (no) |
| ZA (1) | ZA200108527B (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2468827A1 (en) * | 2001-12-03 | 2003-06-12 | Takeda Chemical Industries, Ltd. | Insulin resistance improving agents |
| JP4484427B2 (ja) * | 2001-12-03 | 2010-06-16 | 武田薬品工業株式会社 | インスリン抵抗性改善剤 |
| TW200304812A (en) * | 2002-03-08 | 2003-10-16 | Sankyo Co | An eye drop containing a tetrazole derivative |
| US8980870B2 (en) | 2002-09-24 | 2015-03-17 | Boehringer Ingelheim International Gmbh | Solid telmisartan pharmaceutical formulations |
| DE10335027A1 (de) * | 2003-07-31 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Angiotensin II Rezeptor Antagonisten |
| EP1614428A4 (en) * | 2003-04-15 | 2010-01-06 | Sankyo Co | MEDICAMENT FOR THE PREVENTION OR TREATMENT OF ANGIOGENIC OCULAR DISEASES |
| US20050038093A1 (en) * | 2003-05-02 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Treating diabetic retinopathy with angiotensin II receptor blockers |
| PT1784181E (pt) | 2004-08-31 | 2013-08-26 | Newsouth Innovations Pty Ltd | Inibição do vegf |
| EA013053B1 (ru) * | 2004-11-05 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Двуслойная таблетка, содержащая телмисартан и амлодипин |
| PT1872783E (pt) * | 2005-04-21 | 2012-01-16 | Santen Pharmaceutical Co Ltd | Agente terapêutico para distúrbio queratoconjuntivo |
| WO2007066678A1 (ja) * | 2005-12-06 | 2007-06-14 | Santen Pharmaceutical Co., Ltd. | 角結膜障害治療剤 |
| CL2008000868A1 (es) * | 2007-03-28 | 2008-10-10 | Takeda Pharmaceutical | Composicion farmaceutica solida que comprende un compuesto derivado de benzimidazol y un agente de control de ph; metodo de estabilizacion y de mejoramiento de la disolucion; uso de un agente de control de ph. |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027211D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
| US5591762A (en) | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
| DE4201554A1 (de) | 1992-01-22 | 1993-07-29 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB9110635D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| IL104755A0 (en) | 1992-02-17 | 1993-06-10 | Ciba Geigy Ag | Treatment of glaucoma |
| GB9223860D0 (en) * | 1992-11-13 | 1993-01-06 | Glaxo Group Ltd | Chemical compounds |
| CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
| JPH0789957A (ja) * | 1993-09-22 | 1995-04-04 | Nissan Chem Ind Ltd | ビフェニルメチルアミン誘導体 |
| CA2181461A1 (en) | 1994-02-08 | 1995-08-17 | Alica Huxley | Treatment of normotensive glaucoma with angiotensin ii antagonists |
| JPH09210183A (ja) * | 1996-01-31 | 1997-08-12 | Suzuki Motor Corp | 動力伝達装置 |
| DK0889880T3 (da) * | 1996-03-29 | 2003-09-01 | Smithkline Beecham Corp | Eprosartan-dihydrat og fremgangsmåde til fremstilling deraf samt formulering |
| KR19990087076A (ko) * | 1996-04-05 | 1999-12-15 | 다께다 구니오 | 안지오텐신 ⅱ 및 길항 활성을 갖는 화합물을 함유하는 약제학적 배합물 |
| TW416953B (en) * | 1996-09-25 | 2001-01-01 | Takeda Chemical Industries Ltd | Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use |
| EP0855392A3 (de) * | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| CA2294515C (en) * | 1997-06-27 | 2007-08-28 | Smithkline Beecham Corporation | Eprosartan monohydrate |
| IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
| ES2273433T3 (es) * | 1997-08-06 | 2007-05-01 | Smithkline Beecham Corporation | Complejo por neutralizacion de cargas con arginilo de eprosartan y procedimiento para su produccion y formulacion. |
| BR9908474A (pt) | 1998-03-04 | 2000-12-05 | Takeda Chemical Industries Ltd | Preparação de liberação prolongada, processo para a produção de uma preparação de liberação prolongada, e, composição farmacêutica |
| SG142116A1 (en) * | 1998-07-10 | 2008-05-28 | Novartis Ag | Antihypersensitive combination of valsartan and calcium channel blocker |
| FR2783422A1 (fr) * | 1998-09-21 | 2000-03-24 | Sanofi Sa | Composition pharmaceutique contenant un antagoniste des recepteurs at1 de l'angiotensine ii et un antiagregant plaquettaire |
| JP2000159671A (ja) * | 1998-12-01 | 2000-06-13 | Takeda Chem Ind Ltd | 血管新生阻害剤 |
-
2000
- 2000-04-27 EP EP00921056A patent/EP1197223B1/en not_active Expired - Lifetime
- 2000-04-27 HU HU0200890A patent/HU226948B1/hu not_active IP Right Cessation
- 2000-04-27 SI SI200030651T patent/SI1197223T1/xx unknown
- 2000-04-27 AT AT00921056T patent/ATE289204T1/de not_active IP Right Cessation
- 2000-04-27 NZ NZ514855A patent/NZ514855A/xx not_active IP Right Cessation
- 2000-04-27 DE DE60018186T patent/DE60018186T2/de not_active Expired - Lifetime
- 2000-04-27 PL PL350554A patent/PL196895B1/pl not_active IP Right Cessation
- 2000-04-27 WO PCT/JP2000/002766 patent/WO2000066161A1/ja active IP Right Grant
- 2000-04-27 KR KR1020017013765A patent/KR100865059B1/ko not_active IP Right Cessation
- 2000-04-27 MX MXPA01010923A patent/MXPA01010923A/es active IP Right Grant
- 2000-04-27 AU AU41434/00A patent/AU774799B2/en not_active Ceased
- 2000-04-27 RU RU2001132073/15A patent/RU2239454C2/ru not_active IP Right Cessation
- 2000-04-27 CA CA002371554A patent/CA2371554C/en not_active Expired - Fee Related
- 2000-04-27 BR BR0010084-6A patent/BR0010084A/pt not_active Application Discontinuation
- 2000-04-27 US US09/958,740 patent/US7064141B1/en not_active Expired - Fee Related
- 2000-04-27 ES ES00921056T patent/ES2233362T3/es not_active Expired - Lifetime
- 2000-04-27 DK DK00921056T patent/DK1197223T3/da active
- 2000-04-27 SK SK1545-2001A patent/SK286859B6/sk not_active IP Right Cessation
- 2000-04-27 CN CNB008067783A patent/CN1172719C/zh not_active Expired - Fee Related
- 2000-04-27 PT PT00921056T patent/PT1197223E/pt unknown
- 2000-04-27 CZ CZ20013804A patent/CZ301913B6/cs not_active IP Right Cessation
-
2001
- 2001-10-17 ZA ZA200108527A patent/ZA200108527B/en unknown
- 2001-10-26 NO NO20015257A patent/NO327446B1/no not_active IP Right Cessation
-
2006
- 2006-04-19 US US11/406,345 patent/US20060189669A1/en not_active Abandoned
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