ZA200107501B - Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease. - Google Patents
Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease.Info
- Publication number
- ZA200107501B ZA200107501B ZA200107501A ZA200107501A ZA200107501B ZA 200107501 B ZA200107501 B ZA 200107501B ZA 200107501 A ZA200107501 A ZA 200107501A ZA 200107501 A ZA200107501 A ZA 200107501A ZA 200107501 B ZA200107501 B ZA 200107501B
- Authority
- ZA
- South Africa
- Prior art keywords
- halo
- hydroxy
- amino
- hydrogen
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9906566.6A GB9906566D0 (en) | 1999-03-23 | 1999-03-23 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200107501B true ZA200107501B (en) | 2003-02-26 |
Family
ID=10850125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200107501A ZA200107501B (en) | 1999-03-23 | 2001-09-11 | Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease. |
Country Status (20)
Country | Link |
---|---|
US (1) | US6784174B1 (ko) |
EP (1) | EP1165566B1 (ko) |
JP (1) | JP2002540112A (ko) |
KR (1) | KR20010103798A (ko) |
CN (3) | CN1308329C (ko) |
AT (1) | ATE247661T1 (ko) |
AU (1) | AU757028B2 (ko) |
BR (1) | BR0009223A (ko) |
CA (1) | CA2367866A1 (ko) |
DE (1) | DE60004655T2 (ko) |
DK (1) | DK1165566T3 (ko) |
ES (1) | ES2204539T3 (ko) |
GB (1) | GB9906566D0 (ko) |
HK (2) | HK1041886A1 (ko) |
IL (1) | IL145303A0 (ko) |
NO (1) | NO20014589L (ko) |
NZ (1) | NZ514042A (ko) |
PT (1) | PT1165566E (ko) |
WO (1) | WO2000056738A1 (ko) |
ZA (1) | ZA200107501B (ko) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
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US7772432B2 (en) * | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
NZ507144A (en) | 1998-05-15 | 2002-10-25 | Astrazeneca Ab | Benzamide derivatives useful for the treatment of diseases mediated by cytokines |
US6432949B1 (en) | 1998-08-04 | 2002-08-13 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines |
WO2000018738A1 (en) | 1998-09-25 | 2000-04-06 | Astrazeneca Ab | Benzamide derivatives and their use as cytokine inhibitors |
CZ20013276A3 (cs) | 1999-03-17 | 2001-12-12 | Astrazeneca Ab | Nové amidové deriváty, způsob jejich přípravy a farmaceutická kompozice, která je obsahuje |
CZ300293B6 (cs) | 1999-03-17 | 2009-04-15 | Astrazeneca Ab | Nové amidové deriváty, zpusob jejich prípravy a farmaceutická kompozice, která je obsahuje |
GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
US6943161B2 (en) | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
ATE375980T1 (de) | 2002-02-12 | 2007-11-15 | Smithkline Beecham Corp | Nicotinamide und deren verwendung als p38 inhibitoren |
EP1487436A4 (en) | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
US6900208B2 (en) | 2002-03-28 | 2005-05-31 | Bristol Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
US7388009B2 (en) | 2002-04-23 | 2008-06-17 | Bristol-Myers Squibb Company | Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors |
EP1503996B1 (en) | 2002-04-23 | 2008-12-24 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
PT1497019E (pt) | 2002-04-23 | 2015-09-10 | Bristol Myers Squibb Co | Compostos de pirrolotriazina anilina úteis como inibidores de quinase |
TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
EP1707205A2 (en) | 2002-07-09 | 2006-10-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
CL2003002287A1 (es) * | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
US7276519B2 (en) | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
US7030112B2 (en) | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
PT1635824E (pt) | 2003-06-03 | 2009-11-24 | Novartis Ag | Inibidores de p-38 à base de heterociclos de 5 membros |
DK1641764T3 (da) | 2003-06-26 | 2011-11-21 | Novartis Ag | P38-kinasehæmmere på grundlag af 5-leddede heterocykliske forbindelser |
ES2315703T3 (es) | 2003-07-25 | 2009-04-01 | Novartis Ag | Inhibidores de la quinasa p-38. |
GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
US7419978B2 (en) | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
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US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
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US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
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PE20060421A1 (es) | 2004-08-12 | 2006-06-01 | Bristol Myers Squibb Co | Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
WO2008041053A2 (en) * | 2005-05-20 | 2008-04-10 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
TWI522337B (zh) | 2005-06-22 | 2016-02-21 | 普雷辛肯公司 | 用於激酶調節的化合物及方法及其適應症 |
EP1899353A1 (en) * | 2005-06-22 | 2008-03-19 | DeveloGen Aktiengesellschaft | Thienopyrimidines for pharmaceutical compositions |
US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
AR056200A1 (es) * | 2005-09-27 | 2007-09-26 | Wyeth Corp | Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa |
WO2007059905A2 (en) * | 2005-11-25 | 2007-05-31 | Develogen Aktiengesellschaft | Thienopyrimidines treating inflammatory diseases |
EP1971611B1 (en) | 2005-12-21 | 2012-10-10 | Abbott Laboratories | Anti-viral compounds |
NZ569817A (en) * | 2005-12-21 | 2011-10-28 | Abbott Lab | Anti-viral compounds |
WO2007076035A2 (en) | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
CN101374941A (zh) | 2005-12-29 | 2009-02-25 | 人类起源公司 | 采集和保存胎盘干细胞的改良组合物及其使用方法 |
US7723330B2 (en) | 2006-03-07 | 2010-05-25 | Array Biopharma Inc. | Heterobicyclic pyrazole compounds and methods of use |
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-
1999
- 1999-03-23 GB GBGB9906566.6A patent/GB9906566D0/en not_active Ceased
-
2000
- 2000-03-17 ES ES00912750T patent/ES2204539T3/es not_active Expired - Lifetime
- 2000-03-17 IL IL14530300A patent/IL145303A0/xx unknown
- 2000-03-17 NZ NZ514042A patent/NZ514042A/en unknown
- 2000-03-17 CA CA002367866A patent/CA2367866A1/en not_active Abandoned
- 2000-03-17 CN CNB2004100821917A patent/CN1308329C/zh not_active Expired - Fee Related
- 2000-03-17 PT PT00912750T patent/PT1165566E/pt unknown
- 2000-03-17 DK DK00912750T patent/DK1165566T3/da active
- 2000-03-17 JP JP2000606599A patent/JP2002540112A/ja active Pending
- 2000-03-17 WO PCT/GB2000/001006 patent/WO2000056738A1/en active IP Right Grant
- 2000-03-17 BR BR0009223-1A patent/BR0009223A/pt not_active IP Right Cessation
- 2000-03-17 CN CNB008077983A patent/CN1222527C/zh not_active Expired - Fee Related
- 2000-03-17 CN CNA200610101846XA patent/CN1911931A/zh active Pending
- 2000-03-17 KR KR1020017012093A patent/KR20010103798A/ko active IP Right Grant
- 2000-03-17 EP EP00912750A patent/EP1165566B1/en not_active Expired - Lifetime
- 2000-03-17 DE DE60004655T patent/DE60004655T2/de not_active Expired - Fee Related
- 2000-03-17 US US09/937,018 patent/US6784174B1/en not_active Expired - Fee Related
- 2000-03-17 AU AU34401/00A patent/AU757028B2/en not_active Ceased
- 2000-03-17 AT AT00912750T patent/ATE247661T1/de not_active IP Right Cessation
-
2001
- 2001-09-11 ZA ZA200107501A patent/ZA200107501B/xx unknown
- 2001-09-21 NO NO20014589A patent/NO20014589L/no not_active Application Discontinuation
-
2002
- 2002-05-21 HK HK02103787.9A patent/HK1041886A1/zh unknown
-
2005
- 2005-11-23 HK HK05110610A patent/HK1078849A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20014589D0 (no) | 2001-09-21 |
WO2000056738A1 (en) | 2000-09-28 |
NZ514042A (en) | 2003-10-31 |
NO20014589L (no) | 2001-11-21 |
IL145303A0 (en) | 2002-06-30 |
CA2367866A1 (en) | 2000-09-28 |
BR0009223A (pt) | 2001-12-26 |
DK1165566T3 (da) | 2003-11-24 |
CN1351604A (zh) | 2002-05-29 |
HK1078849A1 (en) | 2006-03-24 |
EP1165566B1 (en) | 2003-08-20 |
EP1165566A1 (en) | 2002-01-02 |
DE60004655T2 (de) | 2004-04-15 |
US6784174B1 (en) | 2004-08-31 |
PT1165566E (pt) | 2004-01-30 |
HK1041886A1 (zh) | 2002-07-26 |
JP2002540112A (ja) | 2002-11-26 |
ATE247661T1 (de) | 2003-09-15 |
AU757028B2 (en) | 2003-01-30 |
CN1222527C (zh) | 2005-10-12 |
AU3440100A (en) | 2000-10-09 |
CN1660849A (zh) | 2005-08-31 |
CN1308329C (zh) | 2007-04-04 |
CN1911931A (zh) | 2007-02-14 |
ES2204539T3 (es) | 2004-05-01 |
KR20010103798A (ko) | 2001-11-23 |
DE60004655D1 (de) | 2003-09-25 |
GB9906566D0 (en) | 1999-05-19 |
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