ZA200107081B - Lyophilisates with improved reconstitutibility. - Google Patents

Lyophilisates with improved reconstitutibility.

Info

Publication number
ZA200107081B
ZA200107081B ZA200107081A ZA200107081A ZA200107081B ZA 200107081 B ZA200107081 B ZA 200107081B ZA 200107081 A ZA200107081 A ZA 200107081A ZA 200107081 A ZA200107081 A ZA 200107081A ZA 200107081 B ZA200107081 B ZA 200107081B
Authority
ZA
South Africa
Prior art keywords
lyophilisates
improved
reconstitutibility
reconstituted
warming
Prior art date
Application number
ZA200107081A
Other languages
English (en)
Inventor
Thekla Kurz
Brigitte Hesse
Ludwig Krueger
Amd Kamatz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200107081B publication Critical patent/ZA200107081B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Waveguide Aerials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA200107081A 1999-01-28 2001-08-27 Lyophilisates with improved reconstitutibility. ZA200107081B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19903275A DE19903275A1 (de) 1999-01-28 1999-01-28 Lyophilisate mit verbesserter Rekonstituierbarkeit

Publications (1)

Publication Number Publication Date
ZA200107081B true ZA200107081B (en) 2003-02-26

Family

ID=7895601

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200107081A ZA200107081B (en) 1999-01-28 2001-08-27 Lyophilisates with improved reconstitutibility.

Country Status (21)

Country Link
US (1) US6770678B1 (xx)
EP (1) EP1146863B1 (xx)
JP (2) JP4562288B2 (xx)
KR (1) KR20010108136A (xx)
AT (1) ATE266387T1 (xx)
AU (1) AU757781B2 (xx)
BR (1) BRPI0007714B8 (xx)
CA (1) CA2361237C (xx)
CZ (1) CZ20012693A3 (xx)
DE (2) DE19903275A1 (xx)
DK (1) DK1146863T3 (xx)
ES (1) ES2220404T3 (xx)
HU (1) HU226585B1 (xx)
NO (1) NO331321B1 (xx)
PL (1) PL351140A1 (xx)
PT (1) PT1146863E (xx)
RU (1) RU2225709C2 (xx)
SK (1) SK10542001A3 (xx)
UA (1) UA70351C2 (xx)
WO (1) WO2000044354A1 (xx)
ZA (1) ZA200107081B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4508646B2 (ja) * 2002-01-09 2010-07-21 エミスフェアー・テクノロジーズ・インク ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AU2009243749B2 (en) 2008-05-09 2013-11-21 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
US8183267B2 (en) * 2008-06-09 2012-05-22 Awd. Pharma Gmbh & Co. Kg Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
TW201920174A (zh) * 2017-09-27 2019-06-01 瑞士商羅氏大藥廠股份有限公司 二氮雜雙環辛烷衍生物之醫藥形式及其製法
EP3733182A4 (en) * 2017-12-28 2021-09-01 FUJIFILM Toyama Chemical Co., Ltd. PROCESS FOR PREPARING A FREEZE-DRIED FORMULATION

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002748A (en) * 1976-01-19 1977-01-11 Eli Lilly And Company Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration
JPH07114946B2 (ja) * 1988-10-24 1995-12-13 株式会社奈良機械製作所 難溶性物質の処理方法
US5066647A (en) * 1989-04-20 1991-11-19 Erbamont, Inc. Cyclophosphamide - alanine lyophilizates
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
JP2747967B2 (ja) * 1993-07-23 1998-05-06 雪印乳業株式会社 シアル酸粉末
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
JPH09183729A (ja) * 1995-12-29 1997-07-15 Meiji Milk Prod Co Ltd 凍結乾燥ウラシルを含有する抗腫瘍医薬組成物

Also Published As

Publication number Publication date
UA70351C2 (en) 2004-10-15
WO2000044354A1 (de) 2000-08-03
ES2220404T3 (es) 2004-12-16
BR0007714B1 (pt) 2014-09-30
HUP0105493A2 (en) 2002-06-29
DE50006404D1 (de) 2004-06-17
CA2361237A1 (en) 2000-08-03
JP2010264249A (ja) 2010-11-25
PL351140A1 (en) 2003-03-24
JP2002535089A (ja) 2002-10-22
BR0007714A (pt) 2001-11-27
NO20013703L (no) 2001-07-27
HUP0105493A3 (en) 2006-07-28
NO20013703D0 (no) 2001-07-27
BRPI0007714B8 (pt) 2021-05-25
SK10542001A3 (sk) 2002-01-07
HU226585B1 (en) 2009-04-28
KR20010108136A (ko) 2001-12-07
PT1146863E (pt) 2004-10-29
JP4562288B2 (ja) 2010-10-13
NO331321B1 (no) 2011-11-21
AU757781B2 (en) 2003-03-06
DK1146863T3 (da) 2004-08-30
EP1146863B1 (de) 2004-05-12
CA2361237C (en) 2008-07-15
US6770678B1 (en) 2004-08-03
AU2798600A (en) 2000-08-18
RU2225709C2 (ru) 2004-03-20
CZ20012693A3 (cs) 2002-01-16
ATE266387T1 (de) 2004-05-15
EP1146863A1 (de) 2001-10-24
DE19903275A1 (de) 2000-08-03

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