ZA200106971B - Covalently bridged insulin dimers. - Google Patents
Covalently bridged insulin dimers. Download PDFInfo
- Publication number
- ZA200106971B ZA200106971B ZA200106971A ZA200106971A ZA200106971B ZA 200106971 B ZA200106971 B ZA 200106971B ZA 200106971 A ZA200106971 A ZA 200106971A ZA 200106971 A ZA200106971 A ZA 200106971A ZA 200106971 B ZA200106971 B ZA 200106971B
- Authority
- ZA
- South Africa
- Prior art keywords
- insulin
- analogues
- group
- analogue
- des
- Prior art date
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 131
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19908041A DE19908041A1 (de) | 1999-02-24 | 1999-02-24 | Kovalent verbrückte Insulindimere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200106971B true ZA200106971B (en) | 2003-01-29 |
Family
ID=7898750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200106971A ZA200106971B (en) | 1999-02-24 | 2001-08-23 | Covalently bridged insulin dimers. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6908897B2 (es) |
| EP (1) | EP1161452B1 (es) |
| JP (1) | JP4519324B2 (es) |
| KR (1) | KR100658961B1 (es) |
| CN (1) | CN1200949C (es) |
| AT (1) | ATE428729T1 (es) |
| AU (1) | AU765076B2 (es) |
| CA (1) | CA2363639C (es) |
| CY (1) | CY1109241T1 (es) |
| DE (2) | DE19908041A1 (es) |
| DK (1) | DK1161452T3 (es) |
| ES (1) | ES2324093T3 (es) |
| HK (1) | HK1042710B (es) |
| PT (1) | PT1161452E (es) |
| WO (1) | WO2000050456A2 (es) |
| ZA (1) | ZA200106971B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067969A2 (en) * | 2001-02-21 | 2002-09-06 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| CA2580313C (en) | 2004-07-19 | 2016-03-15 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| CN101062948B (zh) * | 2006-04-29 | 2010-05-12 | 上海生物泰生命科学研究有限公司 | 单体速效胰岛素及其制法和用途 |
| CA2652989A1 (en) * | 2006-06-08 | 2007-12-13 | Diabecore Medical Inc. | Derivatized insulin oligomers |
| BRPI0818004B8 (pt) | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
| CN101983066B (zh) | 2008-01-30 | 2016-06-29 | 印第安那大学科技研究公司 | 基于酯的胰岛素前药 |
| WO2010043566A2 (de) | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem insulin und einem glp-1-agonisten |
| KR20110110174A (ko) | 2008-12-19 | 2011-10-06 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 아미드 기반 글루카곤 슈퍼패밀리 펩티드 프로드럭 |
| US8697632B2 (en) | 2008-12-19 | 2014-04-15 | Indiana University Research And Technology Corporation | Amide based insulin prodrugs |
| CA2747490C (en) | 2008-12-19 | 2017-02-14 | Indiana University Research And Technology Corporation | Insulin analogs |
| ES2855146T3 (es) | 2009-11-13 | 2021-09-23 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
| US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
| EP2582719B1 (en) | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| CA2803164C (en) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| PT2750699E (pt) | 2011-08-29 | 2015-11-03 | Sanofi Aventis Deutschland | Acelerómetro pendular |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| AU2013323669B2 (en) | 2012-09-26 | 2018-03-01 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| RU2678134C2 (ru) | 2013-03-14 | 2019-01-23 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты инсулин-инкретин |
| US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| EP3197912B1 (en) | 2014-09-24 | 2023-01-04 | Indiana University Research & Technology Corporation | Lipidated amide-based insulin prodrugs |
| ES2946247T3 (es) * | 2014-11-21 | 2023-07-14 | Merck Sharp & Dohme Llc | Agonistas parciales del receptor de insulina |
| CN107206058A (zh) | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US11058775B2 (en) | 2016-04-26 | 2021-07-13 | Merck Sharp & Dohme Corp. | Insulin dimer-incretin conjugates |
| EP3922260A3 (en) | 2016-05-24 | 2022-06-15 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists and glp-1 analogues |
| EP3463413A4 (en) | 2016-05-25 | 2020-03-04 | Merck Sharp & Dohme Corp. | PARTIAL INSULIN RECEPTOR AGONISTS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
-
1999
- 1999-02-24 DE DE19908041A patent/DE19908041A1/de not_active Withdrawn
-
2000
- 2000-02-24 PT PT00909247T patent/PT1161452E/pt unknown
- 2000-02-24 WO PCT/EP2000/001530 patent/WO2000050456A2/de active IP Right Grant
- 2000-02-24 JP JP2000601034A patent/JP4519324B2/ja not_active Expired - Fee Related
- 2000-02-24 DK DK00909247T patent/DK1161452T3/da active
- 2000-02-24 EP EP00909247A patent/EP1161452B1/de not_active Expired - Lifetime
- 2000-02-24 KR KR1020017010815A patent/KR100658961B1/ko not_active IP Right Cessation
- 2000-02-24 CN CNB008041989A patent/CN1200949C/zh not_active Expired - Fee Related
- 2000-02-24 DE DE50015623T patent/DE50015623D1/de not_active Expired - Lifetime
- 2000-02-24 ES ES00909247T patent/ES2324093T3/es not_active Expired - Lifetime
- 2000-02-24 CA CA2363639A patent/CA2363639C/en not_active Expired - Fee Related
- 2000-02-24 AU AU31601/00A patent/AU765076B2/en not_active Ceased
- 2000-02-24 AT AT00909247T patent/ATE428729T1/de active
-
2001
- 2001-08-23 US US09/934,766 patent/US6908897B2/en not_active Expired - Fee Related
- 2001-08-23 ZA ZA200106971A patent/ZA200106971B/en unknown
-
2002
- 2002-05-31 HK HK02104089.2A patent/HK1042710B/zh not_active IP Right Cessation
-
2009
- 2009-07-14 CY CY20091100747T patent/CY1109241T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE50015623D1 (de) | 2009-05-28 |
| AU765076B2 (en) | 2003-09-11 |
| KR100658961B1 (ko) | 2006-12-21 |
| ATE428729T1 (de) | 2009-05-15 |
| EP1161452B1 (de) | 2009-04-15 |
| PT1161452E (pt) | 2009-07-08 |
| JP2003525864A (ja) | 2003-09-02 |
| HK1042710B (zh) | 2006-01-13 |
| DE19908041A1 (de) | 2000-08-31 |
| CA2363639C (en) | 2010-04-13 |
| JP4519324B2 (ja) | 2010-08-04 |
| CN1200949C (zh) | 2005-05-11 |
| WO2000050456A3 (de) | 2000-12-07 |
| US6908897B2 (en) | 2005-06-21 |
| EP1161452A2 (de) | 2001-12-12 |
| CN1341122A (zh) | 2002-03-20 |
| HK1042710A1 (en) | 2002-08-23 |
| US20020160938A1 (en) | 2002-10-31 |
| KR20010103772A (ko) | 2001-11-23 |
| CA2363639A1 (en) | 2000-08-31 |
| DK1161452T3 (da) | 2009-08-17 |
| CY1109241T1 (el) | 2014-07-02 |
| AU3160100A (en) | 2000-09-14 |
| WO2000050456A2 (de) | 2000-08-31 |
| ES2324093T3 (es) | 2009-07-30 |
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