ZA200105060B - Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications. - Google Patents
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications. Download PDFInfo
- Publication number
- ZA200105060B ZA200105060B ZA200105060A ZA200105060A ZA200105060B ZA 200105060 B ZA200105060 B ZA 200105060B ZA 200105060 A ZA200105060 A ZA 200105060A ZA 200105060 A ZA200105060 A ZA 200105060A ZA 200105060 B ZA200105060 B ZA 200105060B
- Authority
- ZA
- South Africa
- Prior art keywords
- amount
- combination
- inhibiting compound
- bile acid
- acid transport
- Prior art date
Links
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title description 22
- 230000002526 effect on cardiovascular system Effects 0.000 title description 3
- 229940077672 Ileal bile acid transport inhibitor Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 40
- 230000002401 inhibitory effect Effects 0.000 claims description 23
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 claims description 22
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 claims description 22
- 239000003613 bile acid Substances 0.000 claims description 20
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 13
- 238000011321 prophylaxis Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 230000001225 therapeutic effect Effects 0.000 claims description 8
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 230000003143 atherosclerotic effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 230000000879 anti-atherosclerotic effect Effects 0.000 claims 3
- 230000000326 anti-hypercholesterolaemic effect Effects 0.000 claims 3
- 230000001315 anti-hyperlipaemic effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 20
- 235000012000 cholesterol Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 201000001320 Atherosclerosis Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 108010010234 HDL Lipoproteins Proteins 0.000 description 7
- 102000015779 HDL Lipoproteins Human genes 0.000 description 7
- 238000008214 LDL Cholesterol Methods 0.000 description 7
- 230000000055 hyoplipidemic effect Effects 0.000 description 7
- -1 cholesteryl ester Chemical class 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 description 5
- 108010007622 LDL Lipoproteins Proteins 0.000 description 5
- 102000007330 LDL Lipoproteins Human genes 0.000 description 5
- 208000029078 coronary artery disease Diseases 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 150000007657 benzothiazepines Chemical class 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 description 4
- 150000003222 pyridines Chemical class 0.000 description 4
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 238000002648 combination therapy Methods 0.000 description 3
- 229960003765 fluvastatin Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical compound S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 description 2
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 2
- KUEUWHJGRZKESU-UHFFFAOYSA-N Niceritrol Chemical compound C=1C=CN=CC=1C(=O)OCC(COC(=O)C=1C=NC=CC=1)(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 KUEUWHJGRZKESU-UHFFFAOYSA-N 0.000 description 2
- 208000018262 Peripheral vascular disease Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000010235 enterohepatic circulation Effects 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229960000827 niceritrol Drugs 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- VGSSUFQMXBFFTM-UHFFFAOYSA-N (24R)-24-ethyl-5alpha-cholestane-3beta,5,6beta-triol Natural products C1C(O)C2(O)CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 VGSSUFQMXBFFTM-UHFFFAOYSA-N 0.000 description 1
- SJKXQWZJYOQHJG-PGMWNZCJSA-N 3-[(e)-[(2s,8as)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-2h-naphthalen-1-ylidene]methyl]-4-methoxybenzene-1,2-diol Chemical compound COC1=CC=C(O)C(O)=C1\C=C/1[C@@]2(C)CCCC(C)(C)C2CC[C@@H]\1C SJKXQWZJYOQHJG-PGMWNZCJSA-N 0.000 description 1
- UWJFOBFXVGMJMW-AVKWCDSFSA-N 3-[[(8as)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]methyl]-4-methoxybenzene-1,2-diol Chemical compound COC1=CC=C(O)C(O)=C1CC1=C(C)CCC2[C@]1(C)CCCC2(C)C UWJFOBFXVGMJMW-AVKWCDSFSA-N 0.000 description 1
- DJQOOSBJCLSSEY-UHFFFAOYSA-N Acipimox Chemical compound CC1=CN=C(C(O)=O)C=[N+]1[O-] DJQOOSBJCLSSEY-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002911 Colestipol Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 description 1
- 229940125922 IBAT inhibitor Drugs 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001504519 Papio ursinus Species 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-JFBKYFIKSA-N Sitostanol Natural products O[C@@H]1C[C@H]2[C@@](C)([C@@H]3[C@@H]([C@H]4[C@@](C)([C@@H]([C@@H](CC[C@H](C(C)C)CC)C)CC4)CC3)CC2)CC1 LGJMUZUPVCAVPU-JFBKYFIKSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960003526 acipimox Drugs 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003529 anticholesteremic agent Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 108091022863 bile acid binding Proteins 0.000 description 1
- 102000030904 bile acid binding Human genes 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001906 cholesterol absorption Effects 0.000 description 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 description 1
- 229960002604 colestipol Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- ICFXZZFWRWNZMA-UHFFFAOYSA-N diethylpropion hydrochloride Chemical compound [Cl-].CC[NH+](CC)C(C)C(=O)C1=CC=CC=C1 ICFXZZFWRWNZMA-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000004129 fatty acid metabolism Effects 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 102000052454 human CETP Human genes 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000000871 hypocholesterolemic effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 108010022197 lipoprotein cholesterol Proteins 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
- 239000003264 margarine Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- XXEBDPRHFAWOND-UHFFFAOYSA-M p-chloromercuribenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C([Hg]Cl)C=C1 XXEBDPRHFAWOND-UHFFFAOYSA-M 0.000 description 1
- 230000008068 pathophysiological alteration Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229960002965 pravastatin Drugs 0.000 description 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
- 208000000876 primary bile acid malabsorption Diseases 0.000 description 1
- 239000012268 protein inhibitor Substances 0.000 description 1
- 229940121649 protein inhibitor Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229940034887 tenuate Drugs 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11395598P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105060B true ZA200105060B (en) | 2002-09-20 |
Family
ID=22352512
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105059A ZA200105059B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications. |
| ZA200105062A ZA200105062B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and nicotinic acid derivatives for cardiovascular indications. |
| ZA200105060A ZA200105060B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications. |
| ZA200105061A ZA200105061B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications. |
| ZA200105056A ZA200105056B (en) | 1998-12-23 | 2001-06-20 | Combinations for cardiovascular indications. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105059A ZA200105059B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications. |
| ZA200105062A ZA200105062B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and nicotinic acid derivatives for cardiovascular indications. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105061A ZA200105061B (en) | 1998-12-23 | 2001-06-20 | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications. |
| ZA200105056A ZA200105056B (en) | 1998-12-23 | 2001-06-20 | Combinations for cardiovascular indications. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20040058908A1 (cs) |
| EP (2) | EP1140187B1 (cs) |
| JP (1) | JP2002533411A (cs) |
| KR (1) | KR20020002367A (cs) |
| CN (1) | CN1342091A (cs) |
| AR (1) | AR037482A1 (cs) |
| AT (1) | ATE248606T1 (cs) |
| AU (1) | AU779264B2 (cs) |
| BR (1) | BR9916564A (cs) |
| CA (1) | CA2356515A1 (cs) |
| CZ (1) | CZ20012344A3 (cs) |
| DE (1) | DE69911058T2 (cs) |
| DK (1) | DK1140187T3 (cs) |
| EA (1) | EA200100704A1 (cs) |
| ES (1) | ES2207330T3 (cs) |
| HU (1) | HUP0104655A2 (cs) |
| IL (1) | IL143944A0 (cs) |
| MX (1) | MXPA01006468A (cs) |
| NO (1) | NO20013157L (cs) |
| NZ (1) | NZ512532A (cs) |
| PT (1) | PT1140187E (cs) |
| WO (1) | WO2000038725A1 (cs) |
| ZA (5) | ZA200105059B (cs) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| KR100396171B1 (ko) * | 1998-08-10 | 2003-08-27 | 아사히 가세이 가부시키가이샤 | 염산 파수딜의 경구 서방성 제제 |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| AU2001247331A1 (en) * | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| AR030414A1 (es) * | 2000-04-03 | 2003-08-20 | Astrazeneca Ab | Combinacion farmaceutica que comprende un beta bloqueante y un inhibidor de hmg-coa reductasa , formulacion farmaceutica, equipo transportable de partes , uso de esta combinacion y de esta formulacion para preparar medicamentos |
| PL357674A1 (en) * | 2000-04-19 | 2004-07-26 | Thomas Julius Borody | Compositions and therapies for hyperlipidaemia-associated disorders |
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- 1999-12-17 EP EP03016600A patent/EP1354604A1/en not_active Withdrawn
- 1999-12-17 CZ CZ20012344A patent/CZ20012344A3/cs unknown
- 1999-12-17 WO PCT/US1999/027946 patent/WO2000038725A1/en not_active Application Discontinuation
- 1999-12-17 AU AU21577/00A patent/AU779264B2/en not_active Ceased
- 1999-12-17 AT AT99965901T patent/ATE248606T1/de not_active IP Right Cessation
- 1999-12-17 CA CA002356515A patent/CA2356515A1/en not_active Abandoned
- 1999-12-17 MX MXPA01006468A patent/MXPA01006468A/es unknown
- 1999-12-17 CN CN99816302A patent/CN1342091A/zh active Pending
- 1999-12-17 NZ NZ512532A patent/NZ512532A/en unknown
- 1999-12-17 ES ES99965901T patent/ES2207330T3/es not_active Expired - Lifetime
- 1999-12-17 HU HU0104655A patent/HUP0104655A2/hu unknown
- 1999-12-17 JP JP2000590676A patent/JP2002533411A/ja active Pending
- 1999-12-17 DK DK99965901T patent/DK1140187T3/da active
- 1999-12-17 DE DE69911058T patent/DE69911058T2/de not_active Expired - Fee Related
- 1999-12-17 IL IL14394499A patent/IL143944A0/xx unknown
- 1999-12-23 AR ARP990106756A patent/AR037482A1/es not_active Application Discontinuation
-
2001
- 2001-06-20 ZA ZA200105059A patent/ZA200105059B/en unknown
- 2001-06-20 ZA ZA200105062A patent/ZA200105062B/en unknown
- 2001-06-20 ZA ZA200105060A patent/ZA200105060B/en unknown
- 2001-06-20 ZA ZA200105061A patent/ZA200105061B/en unknown
- 2001-06-20 ZA ZA200105056A patent/ZA200105056B/en unknown
- 2001-06-22 NO NO20013157A patent/NO20013157L/no not_active Application Discontinuation
-
2002
- 2002-10-09 US US10/266,743 patent/US20040058908A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200105056B (en) | 2002-06-20 |
| AU779264B2 (en) | 2005-01-13 |
| IL143944A0 (en) | 2002-04-21 |
| ES2207330T3 (es) | 2004-05-16 |
| EP1140187B1 (en) | 2003-09-03 |
| KR20020002367A (ko) | 2002-01-09 |
| BR9916564A (pt) | 2002-01-29 |
| AR037482A1 (es) | 2004-11-17 |
| PT1140187E (pt) | 2004-01-30 |
| WO2000038725A1 (en) | 2000-07-06 |
| MXPA01006468A (es) | 2004-03-10 |
| ZA200105059B (en) | 2002-06-20 |
| HUP0104655A2 (hu) | 2002-04-29 |
| AU2157700A (en) | 2000-07-31 |
| NO20013157D0 (no) | 2001-06-22 |
| NZ512532A (en) | 2003-12-19 |
| ZA200105061B (en) | 2002-06-20 |
| CZ20012344A3 (cs) | 2002-01-16 |
| ZA200105062B (en) | 2002-08-28 |
| DE69911058D1 (de) | 2003-10-09 |
| CA2356515A1 (en) | 2000-07-06 |
| ATE248606T1 (de) | 2003-09-15 |
| CN1342091A (zh) | 2002-03-27 |
| NO20013157L (no) | 2001-08-22 |
| EP1354604A1 (en) | 2003-10-22 |
| DK1140187T3 (da) | 2003-12-22 |
| JP2002533411A (ja) | 2002-10-08 |
| US20040058908A1 (en) | 2004-03-25 |
| EP1140187A1 (en) | 2001-10-10 |
| DE69911058T2 (de) | 2004-06-03 |
| EA200100704A1 (ru) | 2002-02-28 |
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