ZA200102759B - Expandable gatroretentive therapeutical system with prolonged stomach retention time. - Google Patents
Expandable gatroretentive therapeutical system with prolonged stomach retention time. Download PDFInfo
- Publication number
- ZA200102759B ZA200102759B ZA200102759A ZA200102759A ZA200102759B ZA 200102759 B ZA200102759 B ZA 200102759B ZA 200102759 A ZA200102759 A ZA 200102759A ZA 200102759 A ZA200102759 A ZA 200102759A ZA 200102759 B ZA200102759 B ZA 200102759B
- Authority
- ZA
- South Africa
- Prior art keywords
- expandable
- active compound
- component
- gastric juice
- present
- Prior art date
Links
- 210000002784 stomach Anatomy 0.000 title description 8
- 230000014759 maintenance of location Effects 0.000 title description 4
- 230000002035 prolonged effect Effects 0.000 title description 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 19
- 229920000642 polymer Polymers 0.000 claims description 17
- 210000004051 gastric juice Anatomy 0.000 claims description 6
- 239000012982 microporous membrane Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000013270 controlled release Methods 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 238000005187 foaming Methods 0.000 claims 1
- 239000011148 porous material Substances 0.000 description 11
- 210000004913 chyme Anatomy 0.000 description 10
- 239000007789 gas Substances 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- -1 hydronium ions Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000001187 pylorus Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000009172 bursting Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000002060 circadian Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19850309A DE19850309A1 (de) | 1998-10-30 | 1998-10-30 | Expandierbares gastroretensives Therapiesystem mit verlängerter Magenverweildauer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200102759B true ZA200102759B (en) | 2001-10-22 |
Family
ID=7886319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200102759A ZA200102759B (en) | 1998-10-30 | 2001-04-04 | Expandable gatroretentive therapeutical system with prolonged stomach retention time. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6776999B1 (es) |
| EP (1) | EP1124534B1 (es) |
| JP (1) | JP2002528482A (es) |
| KR (1) | KR100654482B1 (es) |
| CN (1) | CN1222274C (es) |
| AR (1) | AR021009A1 (es) |
| AT (1) | ATE257694T1 (es) |
| AU (1) | AU758112B2 (es) |
| BR (1) | BR9914841A (es) |
| CA (1) | CA2344672C (es) |
| CZ (1) | CZ293951B6 (es) |
| DE (2) | DE19850309A1 (es) |
| DK (1) | DK1124534T3 (es) |
| ES (1) | ES2214915T3 (es) |
| HK (1) | HK1040197B (es) |
| IL (1) | IL142846A0 (es) |
| NZ (1) | NZ510340A (es) |
| PL (1) | PL194337B1 (es) |
| RU (1) | RU2242219C2 (es) |
| TR (1) | TR200101173T2 (es) |
| TW (1) | TWI226246B (es) |
| WO (1) | WO2000025742A1 (es) |
| ZA (1) | ZA200102759B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19920838A1 (de) * | 1999-05-06 | 2000-11-16 | Lohmann Therapie Syst Lts | Gastroretentives System mit Kapillaren |
| FR2827502B1 (fr) * | 2001-07-17 | 2004-04-09 | Univ Joseph Fourier | Micromuscle en milieu biologique |
| US20080089933A1 (en) * | 2006-10-16 | 2008-04-17 | Amir Alon | Device and method for reducing calorie intake |
| TW200533391A (en) | 2004-03-25 | 2005-10-16 | Sun Pharmaceutical Ind Ltd | Gastric retention drug delivery system |
| RU2491075C2 (ru) | 2006-12-22 | 2013-08-27 | Айронвуд Фармасьютикалз, Инк. | Способы и композиции для лечения расстройств пищевода |
| US7925351B2 (en) * | 2007-06-13 | 2011-04-12 | Betastim, Ltd. | Gastrointestinal device for treating obesity and diabetes |
| US20090259246A1 (en) * | 2008-04-14 | 2009-10-15 | Sherif Eskaros | Intragastric Volume-Occupying Device |
| WO2010110882A1 (en) * | 2009-03-23 | 2010-09-30 | Paolo Costa | Absorption barrier and method of using the same |
| US8414559B2 (en) | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
| US9421169B2 (en) * | 2009-11-20 | 2016-08-23 | Covidien Lp | Oral dosage forms for delivery of therapeutic agents |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US8722066B2 (en) | 2011-03-29 | 2014-05-13 | Primigenia, LLC | Devices and methods for weight control and weight loss |
| WO2013183058A2 (en) | 2012-06-07 | 2013-12-12 | Tulip Medical Ltd. | Expanded device |
| CA2932574C (en) | 2013-12-05 | 2023-03-07 | Tulip Medical Ltd. | Retentive devices and systems for in-situ release of pharmaceutical active agents |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| CN106714893B (zh) | 2014-06-11 | 2021-01-01 | 麻省理工学院 | 自组装的驻留装置及相关方法 |
| AU2016342374B2 (en) | 2015-10-23 | 2022-08-04 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| WO2017100367A1 (en) | 2015-12-08 | 2017-06-15 | Lyndra, Inc. | Geometric configurations for gastric residence systems |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| WO2018064630A1 (en) | 2016-09-30 | 2018-04-05 | Lyndra, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| CN110035718B (zh) * | 2016-12-02 | 2021-04-06 | 克雷西奥生物科技有限公司 | 胃内滞留系统 |
| CN112618094B (zh) * | 2020-12-15 | 2021-12-10 | 上海澎立生技医药研究有限公司 | 一种脑梗的颈静脉插管给药装置 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901232A (en) * | 1973-10-26 | 1975-08-26 | Alza Corp | Integrated device for administering beneficial drug at programmed rate |
| US3944064A (en) * | 1973-10-26 | 1976-03-16 | Alza Corporation | Self-monitored device for releasing agent at functional rate |
| US4036228A (en) * | 1975-09-11 | 1977-07-19 | Alza Corporation | Osmotic dispenser with gas generating means |
| GB1518364A (en) | 1976-05-05 | 1978-07-19 | Beecham Group Ltd | Pharmaceutical composition |
| US4207890A (en) * | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| US4235236A (en) | 1979-02-12 | 1980-11-25 | Alza Corporation | Device for dispensing drug by combined diffusional and osmotic operations |
| GB8305797D0 (en) | 1983-03-02 | 1983-04-07 | Graham N B | Hydrogel-containing envelopes |
| EP0147780A3 (en) | 1984-01-03 | 1987-03-11 | Merck & Co. Inc. | Drug delivery device |
| JPS6143108A (ja) | 1984-08-03 | 1986-03-01 | Nippon Shinyaku Co Ltd | 医薬品製剤及びその製造法 |
| JPS6226215A (ja) * | 1985-05-10 | 1987-02-04 | メルク エンド カムパニ− インコ−ポレ−テツド | 一定に制御した時間内胃中に保持できる薬剤移送装置 |
| US4758436A (en) | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4767627A (en) * | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| JPS6251141A (ja) * | 1985-08-29 | 1987-03-05 | Hitachi Ltd | Ｘ線発生装置 |
| JPS62195323A (ja) * | 1986-02-24 | 1987-08-28 | Eisai Co Ltd | 胃内滞留型粒子 |
| JPS62207209A (ja) | 1986-03-07 | 1987-09-11 | Teijin Ltd | 経口徐放性製剤 |
| US4847093A (en) * | 1986-06-19 | 1989-07-11 | Alza Corporation | Dosage form with means for governing rate of gas formation |
| IL87710A (en) * | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| JPH0261934A (ja) * | 1988-08-29 | 1990-03-01 | Hitachi Ltd | カラー受像管用パネルの製造方法 |
| JPH03163011A (ja) * | 1989-08-31 | 1991-07-15 | Yamanouchi Pharmaceut Co Ltd | 胃内滞留デバイス |
| JP3012667B2 (ja) * | 1990-06-04 | 2000-02-28 | 大日本製薬株式会社 | 液体浮遊性中空材料 |
| DE59803511D1 (de) * | 1997-01-14 | 2002-05-02 | Lohmann Therapie Syst Lts | Expandierbares gastroretentives therapie-system mit kontrollierter wirkstofffreisetzung im gastrointestinaltrakt |
| SE9702533D0 (sv) * | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
-
1998
- 1998-10-30 DE DE19850309A patent/DE19850309A1/de not_active Withdrawn
-
1999
- 1999-10-23 KR KR1020017005286A patent/KR100654482B1/ko not_active IP Right Cessation
- 1999-10-23 CA CA002344672A patent/CA2344672C/en not_active Expired - Fee Related
- 1999-10-23 WO PCT/EP1999/008043 patent/WO2000025742A1/de active IP Right Grant
- 1999-10-23 NZ NZ510340A patent/NZ510340A/xx not_active IP Right Cessation
- 1999-10-23 JP JP2000579186A patent/JP2002528482A/ja not_active Ceased
- 1999-10-23 EP EP99971306A patent/EP1124534B1/de not_active Expired - Lifetime
- 1999-10-23 RU RU2001114501/15A patent/RU2242219C2/ru not_active IP Right Cessation
- 1999-10-23 BR BR9914841-2A patent/BR9914841A/pt not_active Application Discontinuation
- 1999-10-23 DE DE59908319T patent/DE59908319D1/de not_active Expired - Lifetime
- 1999-10-23 TR TR2001/01173T patent/TR200101173T2/xx unknown
- 1999-10-23 CN CNB998125873A patent/CN1222274C/zh not_active Expired - Fee Related
- 1999-10-23 DK DK99971306T patent/DK1124534T3/da active
- 1999-10-23 IL IL14284699A patent/IL142846A0/xx not_active IP Right Cessation
- 1999-10-23 AU AU11537/00A patent/AU758112B2/en not_active Ceased
- 1999-10-23 US US09/830,533 patent/US6776999B1/en not_active Expired - Fee Related
- 1999-10-23 ES ES99971306T patent/ES2214915T3/es not_active Expired - Lifetime
- 1999-10-23 PL PL99348155A patent/PL194337B1/pl not_active IP Right Cessation
- 1999-10-23 CZ CZ20011478A patent/CZ293951B6/cs not_active IP Right Cessation
- 1999-10-23 AT AT99971306T patent/ATE257694T1/de active
- 1999-10-28 TW TW088118706A patent/TWI226246B/zh not_active IP Right Cessation
- 1999-10-28 AR ARP990105450A patent/AR021009A1/es active IP Right Grant
-
2001
- 2001-04-04 ZA ZA200102759A patent/ZA200102759B/en unknown
-
2002
- 2002-03-14 HK HK02101963.9A patent/HK1040197B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI226246B (en) | 2005-01-11 |
| DK1124534T3 (da) | 2004-05-03 |
| BR9914841A (pt) | 2001-07-10 |
| CZ20011478A3 (cs) | 2001-08-15 |
| KR100654482B1 (ko) | 2006-12-05 |
| AU1153700A (en) | 2000-05-22 |
| IL142846A0 (en) | 2002-03-10 |
| HK1040197A1 (en) | 2002-05-31 |
| US6776999B1 (en) | 2004-08-17 |
| CZ293951B6 (cs) | 2004-08-18 |
| ATE257694T1 (de) | 2004-01-15 |
| HK1040197B (zh) | 2006-02-17 |
| AR021009A1 (es) | 2002-06-12 |
| NZ510340A (en) | 2003-01-31 |
| AU758112B2 (en) | 2003-03-13 |
| EP1124534B1 (de) | 2004-01-14 |
| ES2214915T3 (es) | 2004-09-16 |
| CA2344672C (en) | 2008-07-29 |
| CN1222274C (zh) | 2005-10-12 |
| TR200101173T2 (tr) | 2001-10-22 |
| KR20010082259A (ko) | 2001-08-29 |
| DE19850309A1 (de) | 2000-05-04 |
| CA2344672A1 (en) | 2000-05-11 |
| DE59908319D1 (de) | 2004-02-19 |
| RU2242219C2 (ru) | 2004-12-20 |
| CN1324232A (zh) | 2001-11-28 |
| PL348155A1 (en) | 2002-05-06 |
| JP2002528482A (ja) | 2002-09-03 |
| WO2000025742A1 (de) | 2000-05-11 |
| PL194337B1 (pl) | 2007-05-31 |
| EP1124534A1 (de) | 2001-08-22 |
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