ZA200102566B - Novel salts of pyridopyrazine compound and crystals thereof. - Google Patents
Novel salts of pyridopyrazine compound and crystals thereof. Download PDFInfo
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- ZA200102566B ZA200102566B ZA200102566A ZA200102566A ZA200102566B ZA 200102566 B ZA200102566 B ZA 200102566B ZA 200102566 A ZA200102566 A ZA 200102566A ZA 200102566 A ZA200102566 A ZA 200102566A ZA 200102566 B ZA200102566 B ZA 200102566B
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- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000692870 Inachis io Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000001907 Mushroom Poisoning Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
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- 238000002447 crystallographic data Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 1
- BGCNBOFPABQGNG-UHFFFAOYSA-N ethyl 2-(dimethylamino)acetate Chemical compound CCOC(=O)CN(C)C BGCNBOFPABQGNG-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011554 guinea pig model Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000004434 industrial solvent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 231100000824 inhalation exposure Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000022023 interleukin-5 production Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 description 1
- UAAKJEVCDBPTQS-UHFFFAOYSA-N methanesulfonic acid;dihydrate Chemical compound O.O.CS(O)(=O)=O UAAKJEVCDBPTQS-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- PEMGGJDINLGTON-UHFFFAOYSA-N n-(3-aminophenyl)acetamide Chemical compound CC(=O)NC1=CC=CC(N)=C1 PEMGGJDINLGTON-UHFFFAOYSA-N 0.000 description 1
- DBMDUQWYBBRSTN-UHFFFAOYSA-N n-[3-[(3-aminopyridin-2-yl)amino]phenyl]-3,5-dichlorobenzamide Chemical compound NC1=CC=CN=C1NC1=CC=CC(NC(=O)C=2C=C(Cl)C=C(Cl)C=2)=C1 DBMDUQWYBBRSTN-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27444098 | 1998-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200102566B true ZA200102566B (en) | 2002-07-18 |
Family
ID=17541719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200102566A ZA200102566B (en) | 1998-09-29 | 2001-03-28 | Novel salts of pyridopyrazine compound and crystals thereof. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1118615A4 (fr) |
| KR (1) | KR20010075287A (fr) |
| CN (1) | CN1328555A (fr) |
| AU (1) | AU5758199A (fr) |
| BR (1) | BR9914399A (fr) |
| CA (1) | CA2345362A1 (fr) |
| CZ (1) | CZ20011164A3 (fr) |
| HK (1) | HK1042896A1 (fr) |
| HU (1) | HUP0103947A3 (fr) |
| IL (1) | IL142147A0 (fr) |
| TR (2) | TR200200971T2 (fr) |
| WO (1) | WO2000018768A1 (fr) |
| ZA (1) | ZA200102566B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| EP1511516B1 (fr) * | 2002-05-28 | 2008-12-17 | Nycomed GmbH | Preparation pharmaceutique topique |
| JP2006501269A (ja) * | 2002-09-16 | 2006-01-12 | アルコン マニュファクチャリング，リミティド | 血管新生を処置するためのｐｄｅｉｖインヒビターの使用 |
| EA009985B1 (ru) | 2003-03-10 | 2008-04-28 | Никомед Гмбх | Новый способ получения рофлумиласта |
| CA2601250C (fr) | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Forme posologique a gout masque |
| KR20120073300A (ko) * | 2009-09-30 | 2012-07-04 | 뗑따마르 에스아에스 | 휴대 가방 또는 조끼 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (fr) * | 1978-08-15 | 1980-03-19 | FISONS plc | Dérivés de la pyridopyrazine et de la quinoxaline, procédés pour leur préparation, et compositions pharmaceutiques les contenant |
| AU594512B2 (en) * | 1986-09-16 | 1990-03-08 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Hydroxy indole derivatives |
| GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
-
1999
- 1999-09-22 TR TR2002/00971T patent/TR200200971T2/xx unknown
- 1999-09-22 WO PCT/JP1999/005182 patent/WO2000018768A1/fr not_active Application Discontinuation
- 1999-09-22 AU AU57581/99A patent/AU5758199A/en not_active Abandoned
- 1999-09-22 BR BR9914399-2A patent/BR9914399A/pt not_active IP Right Cessation
- 1999-09-22 KR KR1020017003667A patent/KR20010075287A/ko not_active Application Discontinuation
- 1999-09-22 CA CA002345362A patent/CA2345362A1/fr not_active Abandoned
- 1999-09-22 IL IL14214799A patent/IL142147A0/xx unknown
- 1999-09-22 EP EP99944776A patent/EP1118615A4/fr not_active Withdrawn
- 1999-09-22 CN CN99813617A patent/CN1328555A/zh active Pending
- 1999-09-22 HU HU0103947A patent/HUP0103947A3/hu unknown
- 1999-09-22 TR TR2001/00893T patent/TR200100893T2/xx unknown
- 1999-09-22 CZ CZ20011164A patent/CZ20011164A3/cs unknown
-
2001
- 2001-03-28 ZA ZA200102566A patent/ZA200102566B/en unknown
-
2002
- 2002-06-11 HK HK02104375.5A patent/HK1042896A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1328555A (zh) | 2001-12-26 |
| WO2000018768A1 (fr) | 2000-04-06 |
| EP1118615A4 (fr) | 2002-02-27 |
| BR9914399A (pt) | 2002-01-22 |
| CA2345362A1 (fr) | 2000-04-06 |
| HUP0103947A3 (en) | 2002-06-28 |
| KR20010075287A (ko) | 2001-08-09 |
| HUP0103947A2 (hu) | 2002-04-29 |
| IL142147A0 (en) | 2002-03-10 |
| EP1118615A1 (fr) | 2001-07-25 |
| HK1042896A1 (zh) | 2002-08-30 |
| AU5758199A (en) | 2000-04-17 |
| TR200100893T2 (tr) | 2001-11-21 |
| CZ20011164A3 (cs) | 2001-12-12 |
| TR200200971T2 (tr) | 2002-06-21 |
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