ZA200101824B - Substituted phenyl derivatives, their preparation and use. - Google Patents
Substituted phenyl derivatives, their preparation and use. Download PDFInfo
- Publication number
- ZA200101824B ZA200101824B ZA200101824A ZA200101824A ZA200101824B ZA 200101824 B ZA200101824 B ZA 200101824B ZA 200101824 A ZA200101824 A ZA 200101824A ZA 200101824 A ZA200101824 A ZA 200101824A ZA 200101824 B ZA200101824 B ZA 200101824B
- Authority
- ZA
- South Africa
- Prior art keywords
- urea
- tetrazol
- phenyl
- bromo
- alkyl
- Prior art date
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- 238000002360 preparation method Methods 0.000 title description 18
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- -1 -CO2R® Chemical group 0.000 claims description 63
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- 239000001257 hydrogen Substances 0.000 claims description 30
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- 125000005842 heteroatom Chemical group 0.000 claims description 28
- 229910052736 halogen Inorganic materials 0.000 claims description 27
- 150000002367 halogens Chemical class 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
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- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 125000002252 acyl group Chemical group 0.000 claims description 15
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- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Ophthalmology & Optometry (AREA)
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- Pain & Pain Management (AREA)
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- Oncology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| DKPA199801362 | 1998-10-22 |
Publications (1)
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| ZA200101824B true ZA200101824B (en) | 2002-03-05 |
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| ZA200101824A ZA200101824B (en) | 1998-10-22 | 1999-10-19 | Substituted phenyl derivatives, their preparation and use. |
Country Status (28)
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| EP (2) | EP1514867A3 (sk) |
| JP (2) | JP3960754B2 (sk) |
| KR (1) | KR100799892B1 (sk) |
| CN (1) | CN1263733C (sk) |
| AP (1) | AP2001002103A0 (sk) |
| AT (1) | ATE286021T1 (sk) |
| AU (1) | AU759275B2 (sk) |
| BR (1) | BR9914638A (sk) |
| CA (1) | CA2342626A1 (sk) |
| DE (1) | DE69922986T2 (sk) |
| EE (1) | EE04849B1 (sk) |
| ES (1) | ES2235522T3 (sk) |
| HK (1) | HK1040699A1 (sk) |
| HU (1) | HUP0103673A3 (sk) |
| IL (2) | IL141479A0 (sk) |
| IS (1) | IS2215B (sk) |
| NO (1) | NO20011956L (sk) |
| NZ (1) | NZ510098A (sk) |
| OA (1) | OA11665A (sk) |
| PL (1) | PL198852B1 (sk) |
| PT (1) | PT1123274E (sk) |
| RU (1) | RU2218328C2 (sk) |
| SK (1) | SK5222001A3 (sk) |
| TR (1) | TR200101126T2 (sk) |
| UA (1) | UA73284C2 (sk) |
| WO (1) | WO2000024707A1 (sk) |
| ZA (1) | ZA200101824B (sk) |
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| EP2212303A1 (en) * | 2007-11-26 | 2010-08-04 | NeuroSearch AS | Novel benzamide derivatives useful as potassium channel modulators |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| RS57110B1 (sr) | 2008-10-28 | 2018-06-29 | Arena Pharm Inc | Sastavi modulatora 5-ht2a serotoninskog receptora korisni za tretiranje poremećaja povezanih sa njim |
| US20120136033A1 (en) * | 2009-05-18 | 2012-05-31 | President And Fellows Of Harvard College | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof |
| GB0915196D0 (en) | 2009-09-01 | 2009-10-07 | King S College London | Therapeutic compounds and their use |
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| CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
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| US11103481B2 (en) | 2016-05-17 | 2021-08-31 | Scandion Oncology A/S | Combination treatment of cancer |
| TW201920081A (zh) | 2017-07-11 | 2019-06-01 | 美商維泰克斯製藥公司 | 作為鈉通道調節劑的羧醯胺 |
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| CA3221557A1 (en) | 2021-06-14 | 2022-12-22 | Peter Michael Vestlev | Combination treatments for cancer patients and methods for identifying same |
| EP4104834A1 (en) | 2021-06-14 | 2022-12-21 | Scandion Oncology A/S | Combination treatments for cancer patients and methods for identifying same |
| CA3221558A1 (en) | 2021-06-14 | 2022-12-22 | Peter Michael Vestlev | Methods of increasing the plasma drug exposure of anticancer agents |
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| CN117229258A (zh) * | 2022-06-07 | 2023-12-15 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
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| BR9808938A (pt) * | 1997-04-22 | 2000-08-01 | Neurosearch As | Composto, composição farmacêutica, uso de um composto, processos para o tratamento de um distúrbio ou doença de um corpo de animal vivo e para a preparação de um composto, e, uso de bloqueadores de canal de cloreto |
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1999
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2001
- 2001-02-16 IL IL141479A patent/IL141479A/en not_active IP Right Cessation
- 2001-03-02 IS IS5875A patent/IS2215B/is unknown
- 2001-04-19 US US09/837,166 patent/US6706749B2/en not_active Expired - Fee Related
- 2001-04-20 NO NO20011956A patent/NO20011956L/no not_active Application Discontinuation
-
2002
- 2002-03-19 HK HK02102082A patent/HK1040699A1/xx not_active IP Right Cessation
-
2003
- 2003-01-30 JP JP2003022576A patent/JP2003246773A/ja not_active Abandoned
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