ZA200101110B - Incorporation of exogenous lactic bacteria into the oral microflora. - Google Patents
Incorporation of exogenous lactic bacteria into the oral microflora. Download PDFInfo
- Publication number
- ZA200101110B ZA200101110B ZA200101110A ZA200101110A ZA200101110B ZA 200101110 B ZA200101110 B ZA 200101110B ZA 200101110 A ZA200101110 A ZA 200101110A ZA 200101110 A ZA200101110 A ZA 200101110A ZA 200101110 B ZA200101110 B ZA 200101110B
- Authority
- ZA
- South Africa
- Prior art keywords
- lactic bacteria
- teeth
- pellicle
- mouth
- composition
- Prior art date
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- 235000013024 sodium fluoride Nutrition 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
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- 108010005406 variacin Proteins 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 238000005406 washing Methods 0.000 description 1
- 239000008256 whipped cream Substances 0.000 description 1
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- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1236—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt using Leuconostoc, Pediococcus or Streptococcus sp. other than Streptococcus Thermophilus; Artificial sour buttermilk in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Confectionery (AREA)
- Dairy Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP98202707 | 1998-08-12 |
Publications (1)
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ZA200101110B true ZA200101110B (en) | 2002-02-08 |
Family
ID=8234030
Family Applications (1)
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ZA200101110A ZA200101110B (en) | 1998-08-12 | 2001-02-08 | Incorporation of exogenous lactic bacteria into the oral microflora. |
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US (3) | US6942849B2 (pl) |
EP (1) | EP1104281B1 (pl) |
JP (1) | JP4564169B2 (pl) |
KR (2) | KR100727338B1 (pl) |
CN (1) | CN1240372C (pl) |
AR (1) | AR020169A1 (pl) |
AT (1) | ATE501640T1 (pl) |
AU (1) | AU773799B2 (pl) |
BG (1) | BG105188A (pl) |
BR (1) | BR9912946A (pl) |
CA (1) | CA2337082C (pl) |
DE (1) | DE69943283D1 (pl) |
ES (1) | ES2363201T3 (pl) |
HU (1) | HUP0103229A3 (pl) |
ID (1) | ID28917A (pl) |
IL (1) | IL140641A (pl) |
IN (1) | IN2001CH00156A (pl) |
NZ (1) | NZ509722A (pl) |
PL (1) | PL201312B1 (pl) |
RO (1) | RO121005B1 (pl) |
TR (1) | TR200100406T2 (pl) |
TW (1) | TW552142B (pl) |
WO (1) | WO2000009080A1 (pl) |
ZA (1) | ZA200101110B (pl) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1159951A1 (en) * | 2000-06-02 | 2001-12-05 | Societe Des Produits Nestle S.A. | Use of exogenous lactic bacteria strain against Actinomyces naeslundii-related diseases |
IL140641A (en) | 1998-08-12 | 2007-07-04 | Nestle Sa | Incorporation of exogenous lactic bacteria into the oral microflora |
JP4528472B2 (ja) * | 2001-11-29 | 2010-08-18 | ビオフェルミン製薬株式会社 | 歯周病の予防または治療剤 |
AU2003285875A1 (en) | 2002-10-11 | 2004-05-04 | Walker Digital, Llc | Method and apparatus for outputting a message at a game machine |
US6872565B2 (en) * | 2003-01-29 | 2005-03-29 | Biogaia Ab | Product containing Lactobacillus reuteri strain ATTC PTA-4965 or PTA-4964 for inhibiting bacteria causing dental caries |
JP4656288B2 (ja) * | 2004-08-19 | 2011-03-23 | ライオン商事株式会社 | 動物用オーラルケア用ペットフードの製造方法 |
EP1634948A1 (en) * | 2004-09-10 | 2006-03-15 | Basf Aktiengesellschaft | Means and methods for preventing and/or treating caries |
US8038990B2 (en) * | 2005-06-01 | 2011-10-18 | The Ohio State University | Compositions and methods for the prevention and removal of biofilms on inert and biological surfaces |
TW200808191A (en) | 2006-08-09 | 2008-02-16 | Genmont Biotech Inc | Product containing Lactobacillus paracasei |
CN101273738B (zh) * | 2007-03-28 | 2011-06-01 | 哈尔滨正方科技有限公司 | 在常温下保持高活菌数的调配型酸性乳饮料的制备方法 |
GB0709162D0 (en) * | 2007-05-11 | 2007-06-20 | Jagotec Ag | Dosage foam |
KR100898491B1 (ko) * | 2007-10-10 | 2009-05-19 | 주식회사한국야쿠르트 | 사람의 구강 충치균에 저해능이 있는 스트렙토코커스써머필러스 에이취와이9012 및 이를 이용한 식품 |
AU2009271287A1 (en) * | 2008-06-24 | 2010-01-21 | Wm. Wrigley Jr. Company | Probiotic chewing gum method of manufacture |
RU2011129693A (ru) * | 2008-12-16 | 2013-01-27 | Нестек С.А. | Композиции и способы улучшения здоровья полости рта |
WO2011057336A1 (en) * | 2009-11-11 | 2011-05-19 | Oral Health Australia Pty Ltd | Antibiofilm glycopeptides |
JP2014506923A (ja) | 2011-03-01 | 2014-03-20 | クオラム イノベーションズ リミテッド ライアビリティ カンパニー | 病原性バイオフィルムと関連した状態を治療するための物質および方法 |
CA2828583A1 (en) * | 2011-03-04 | 2012-09-13 | Tufts University | Oral bacteria and uses thereof |
WO2014047625A1 (en) | 2012-09-24 | 2014-03-27 | Montana State University | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
RS63856B1 (sr) * | 2013-07-05 | 2023-01-31 | Stellar Biome Inc | Probiotički sojevi bakterija za prevenciju i lečenje bolesti u usnoj duplji |
KR101523205B1 (ko) * | 2013-08-28 | 2015-05-28 | 한국식품연구원 | 페디오코쿠스 펜토사세우스 kft-18 및 이를 이용하여 세포외다당류를 대량 생산하는 방법 |
EP3086796B1 (en) * | 2013-12-27 | 2018-10-24 | Colgate-Palmolive Company | Prebiotic oral care methods using a saccharide |
EP3100614A1 (en) * | 2015-06-02 | 2016-12-07 | Universiteit van Amsterdam | Compositions comprising anti-cariogenic bacteria and fermentable saccharides |
EP3196318A1 (en) | 2016-01-19 | 2017-07-26 | Symrise AG | Probiotics for altering the composition of oral biofilms |
KR101833727B1 (ko) * | 2016-05-13 | 2018-02-28 | 정규헌 | 세균의 소독이 가능한 물치약과 그 조성물 |
EP3351259A1 (en) | 2017-01-18 | 2018-07-25 | Symrise AG | Probiotics for aggregation with disease-associated species in the oral cavity |
CN110267641A (zh) | 2017-02-10 | 2019-09-20 | 赢创德固赛有限公司 | 含有至少一种生物表面活性剂和氟化物的口腔护理组合物 |
CN110237024B (zh) * | 2019-07-22 | 2022-04-19 | 佛山卡丝生物科技有限公司 | 一种美白益生菌牙膏及其制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135739A (en) * | 1983-02-15 | 1992-08-04 | Kitasato Kenkyusho | Non-cariogenic composition and drink |
JPS59220191A (ja) * | 1983-04-07 | 1984-12-11 | Kitasato Inst:The | 非う蝕性組成物および飲料 |
US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
JPS61291413A (ja) | 1985-06-18 | 1986-12-22 | Shin Nippon Kagaku Kogyo Co Ltd | 水酸化マグネシウム懸濁液の製造法 |
CH671879A5 (pl) * | 1987-02-26 | 1989-10-13 | Nestle Sa | |
JPH0687776B2 (ja) * | 1990-02-20 | 1994-11-09 | 愛三 松代 | 新規形質転換株およびその製造方法 |
JPH0421633A (ja) | 1990-05-17 | 1992-01-24 | Saikon Medics:Kk | 生体下口腔内有用微生物叢の維持管理法および維持管理組成物 |
FR2672494A1 (fr) | 1991-02-13 | 1992-08-14 | Madinier Isabelle | Ferments prophylactiques favorisant la prevention de la carie dentaire. |
DE4117782C2 (de) * | 1991-05-28 | 1997-07-17 | Diagnostikforschung Inst | Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel |
JPH054927A (ja) | 1991-06-28 | 1993-01-14 | Aizo Matsushiro | 乳酸菌含有組成物及びその製造方法 |
DE69219768T2 (de) | 1992-07-06 | 1997-08-28 | Societe Des Produits Nestle S.A., Vevey | Milchbakterien |
GB9224598D0 (en) | 1992-11-24 | 1993-01-13 | Smithkline Beecham Plc | Novel compositions |
CH684773A5 (fr) | 1992-12-28 | 1994-12-30 | Nestle Sa | Composition alimentaire anti-cariogène. |
CO4560537A1 (es) | 1992-12-28 | 1998-02-10 | Nestle Sa | Composicion lactea y procedimiento de preparacion |
US5368845A (en) | 1993-01-07 | 1994-11-29 | Colgate Palmolive Company | Oral composition |
JP3078431B2 (ja) * | 1993-09-27 | 2000-08-21 | 富士写真フイルム株式会社 | 黒白ハロゲン化銀写真感光材料の現像方法 |
US5358858A (en) * | 1994-03-17 | 1994-10-25 | National Science Council | Process for preparing phycoerythrin from bangia atropurpurea and porphyra angusta |
DE69421921T2 (de) * | 1994-08-19 | 2000-05-11 | Societe Des Produits Nestle S.A., Vevey | Verzweigtes Polysaccharide, es produzierender Mikroorganismus und Zusammensetzungen welche sie enthalten |
JP3101173B2 (ja) * | 1995-03-22 | 2000-10-23 | 雪印乳業株式会社 | フローズンヨーグルトの製造法 |
ATE206877T1 (de) | 1995-06-16 | 2001-11-15 | Nestle Sa | Fluorierte kasein-mizellen |
PT759469E (pt) * | 1995-08-07 | 2003-08-29 | Nestle Sa | Bacteriocina |
JP3356599B2 (ja) * | 1995-09-22 | 2002-12-16 | 雪印乳業株式会社 | 低酸度型フローズンヨーグルトの製造法 |
KR19990024297A (ko) * | 1997-08-07 | 1999-04-06 | 오종석 | 인체 구강내 치태형성을 억제하는 신규한 유산균 |
IL140641A (en) | 1998-08-12 | 2007-07-04 | Nestle Sa | Incorporation of exogenous lactic bacteria into the oral microflora |
-
1999
- 1999-07-26 IL IL140641A patent/IL140641A/en not_active IP Right Cessation
- 1999-07-26 ID IDW20010308A patent/ID28917A/id unknown
- 1999-07-26 HU HU0103229A patent/HUP0103229A3/hu unknown
- 1999-07-26 DE DE69943283T patent/DE69943283D1/de not_active Expired - Lifetime
- 1999-07-26 AU AU54159/99A patent/AU773799B2/en not_active Ceased
- 1999-07-26 CA CA2337082A patent/CA2337082C/en not_active Expired - Fee Related
- 1999-07-26 ES ES99940086T patent/ES2363201T3/es not_active Expired - Lifetime
- 1999-07-26 CN CNB99809496XA patent/CN1240372C/zh not_active Expired - Fee Related
- 1999-07-26 WO PCT/EP1999/005473 patent/WO2000009080A1/en not_active Application Discontinuation
- 1999-07-26 KR KR20017001841A patent/KR100727338B1/ko not_active IP Right Cessation
- 1999-07-26 JP JP2000564584A patent/JP4564169B2/ja not_active Expired - Fee Related
- 1999-07-26 BR BR9912946-9A patent/BR9912946A/pt not_active Application Discontinuation
- 1999-07-26 EP EP99940086A patent/EP1104281B1/en not_active Expired - Lifetime
- 1999-07-26 TR TR2001/00406T patent/TR200100406T2/xx unknown
- 1999-07-26 RO ROA200100152A patent/RO121005B1/ro unknown
- 1999-07-26 AT AT99940086T patent/ATE501640T1/de not_active IP Right Cessation
- 1999-07-26 KR KR1020077005001A patent/KR20070035111A/ko not_active Application Discontinuation
- 1999-08-12 AR ARP990104042A patent/AR020169A1/es unknown
- 1999-08-12 TW TW088113807A patent/TW552142B/zh not_active IP Right Cessation
-
2001
- 2001-01-11 PL PL345890A patent/PL201312B1/pl not_active IP Right Cessation
- 2001-01-11 NZ NZ509722A patent/NZ509722A/en not_active IP Right Cessation
- 2001-01-26 BG BG105188A patent/BG105188A/bg unknown
- 2001-02-01 IN IN156CH2001 patent/IN2001CH00156A/en unknown
- 2001-02-08 ZA ZA200101110A patent/ZA200101110B/en unknown
- 2001-02-09 US US09/779,596 patent/US6942849B2/en not_active Expired - Fee Related
-
2005
- 2005-03-23 US US11/087,523 patent/US20050186148A1/en not_active Abandoned
- 2005-06-23 US US11/166,605 patent/US20050238590A1/en not_active Abandoned
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