ZA200006028B - Amidino and guanidino azetidinone tryptase inhibitors. - Google Patents

Amidino and guanidino azetidinone tryptase inhibitors.

Info

Publication number
ZA200006028B
ZA200006028B ZA200006028A ZA200006028A ZA200006028B ZA 200006028 B ZA200006028 B ZA 200006028B ZA 200006028 A ZA200006028 A ZA 200006028A ZA 200006028 A ZA200006028 A ZA 200006028A ZA 200006028 B ZA200006028 B ZA 200006028B
Authority
ZA
South Africa
Prior art keywords
azetidinone
guanidino
amidino
tryptase inhibitors
tryptase
Prior art date
Application number
ZA200006028A
Other languages
English (en)
Inventor
Gregory Bisacchi
Williams A Slusarchyk
Uwe Treuner
James C Sutton
Robert Zahler
Steven Seiler
David R Kronenthal
Michael E Randazzo
Zhongmin Xu
Zhongping Shi
Mark D Schwinden
Original Assignee
Bristol Meyers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Meyers Squibb Co filed Critical Bristol Meyers Squibb Co
Publication of ZA200006028B publication Critical patent/ZA200006028B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200006028A 1998-06-25 2000-10-25 Amidino and guanidino azetidinone tryptase inhibitors. ZA200006028B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9063698P 1998-06-25 1998-06-25

Publications (1)

Publication Number Publication Date
ZA200006028B true ZA200006028B (en) 2002-09-25

Family

ID=22223632

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200006028A ZA200006028B (en) 1998-06-25 2000-10-25 Amidino and guanidino azetidinone tryptase inhibitors.

Country Status (24)

Country Link
EP (1) EP1089973B1 (ko)
JP (1) JP2002518478A (ko)
KR (1) KR20010053173A (ko)
CN (1) CN1202081C (ko)
AR (1) AR018945A1 (ko)
AT (1) ATE309211T1 (ko)
AU (1) AU752320B2 (ko)
BR (1) BR9911373A (ko)
CA (1) CA2336003A1 (ko)
DE (1) DE69928257T2 (ko)
ES (1) ES2249017T3 (ko)
HU (1) HUP0104308A3 (ko)
ID (1) ID27137A (ko)
IL (1) IL140414A0 (ko)
NO (1) NO20006380L (ko)
NZ (1) NZ507627A (ko)
PE (1) PE20000729A1 (ko)
PL (1) PL345067A1 (ko)
RU (1) RU2211832C2 (ko)
TR (1) TR200003859T2 (ko)
TW (1) TW548270B (ko)
UY (1) UY25580A1 (ko)
WO (1) WO1999067215A1 (ko)
ZA (1) ZA200006028B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063704A1 (ja) 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
WO2006062110A1 (ja) * 2004-12-06 2006-06-15 Banyu Pharmaceutical Co., Ltd. ピペラジン誘導体
US8772297B2 (en) * 2010-02-17 2014-07-08 Kyoto University TGF-β signal transduction inhibitor
AR095569A1 (es) * 2013-03-20 2015-10-28 Hoffmann La Roche Derivados de urea
WO2014173855A1 (en) 2013-04-22 2014-10-30 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
EP3036219A4 (en) * 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Novel beta lactams as modulators of glutamate uptake and methods for use thereof
ES2945905T3 (es) 2014-02-07 2023-07-10 Exithera Pharmaceuticals Inc Compuestos y composiciones terapéuticos
EP3749662A4 (en) 2018-02-07 2021-07-14 Exithera Pharmaceuticals Inc. COMPOUNDS AND THERAPEUTIC COMPOSITIONS
CN112292376A (zh) * 2018-03-30 2021-01-29 上海美悦生物科技发展有限公司 四元内酰胺类化合物及其药学用途
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
WO2020259366A1 (zh) * 2019-06-25 2020-12-30 广东东阳光药业有限公司 一种凝血因子XIa抑制剂的晶型及其制备方法
EP4055151A1 (en) 2019-11-08 2022-09-14 Coave Therapeutics Modified adeno-associated virus vectors and delivery thereof into the central nervous system
AU2021374832A1 (en) * 2020-11-06 2023-06-08 Coave Therapeutics Lactam-modified adeno-associated virus vectors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
US5959123A (en) * 1996-09-23 1999-09-28 Synphar Laboratories, Inc. 3,4-Disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators

Also Published As

Publication number Publication date
CA2336003A1 (en) 1999-12-29
HUP0104308A3 (en) 2002-06-28
UY25580A1 (es) 2001-08-27
PL345067A1 (en) 2001-12-03
RU2211832C2 (ru) 2003-09-10
NO20006380D0 (no) 2000-12-14
DE69928257D1 (de) 2005-12-15
PE20000729A1 (es) 2000-10-28
IL140414A0 (en) 2002-02-10
NO20006380L (no) 2000-12-14
EP1089973A4 (en) 2001-12-12
EP1089973B1 (en) 2005-11-09
TW548270B (en) 2003-08-21
EP1089973A1 (en) 2001-04-11
TR200003859T2 (tr) 2001-07-23
HUP0104308A2 (hu) 2002-04-29
ES2249017T3 (es) 2006-03-16
BR9911373A (pt) 2001-09-18
ID27137A (id) 2001-03-01
JP2002518478A (ja) 2002-06-25
CN1202081C (zh) 2005-05-18
AU4695099A (en) 2000-01-10
AU752320B2 (en) 2002-09-12
NZ507627A (en) 2003-12-19
DE69928257T2 (de) 2006-08-03
AR018945A1 (es) 2001-12-12
CN1307560A (zh) 2001-08-08
KR20010053173A (ko) 2001-06-25
ATE309211T1 (de) 2005-11-15
WO1999067215A1 (en) 1999-12-29

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