YU90503A - Supstituisani pirazinoni, piridini i pirimidini kao faktor oslobađanja kortikotropina - Google Patents

Supstituisani pirazinoni, piridini i pirimidini kao faktor oslobađanja kortikotropina

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Publication number
YU90503A
YU90503A YU90503A YUP90503A YU90503A YU 90503 A YU90503 A YU 90503A YU 90503 A YU90503 A YU 90503A YU P90503 A YUP90503 A YU P90503A YU 90503 A YU90503 A YU 90503A
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YU
Yugoslavia
Prior art keywords
pyridines
pyrimidines
releasing factor
corticotropin releasing
factor ligands
Prior art date
Application number
YU90503A
Other languages
English (en)
Inventor
Argyrios G. Arvanitis
Paul J. Gilligan
Richard A. Hartz
Original Assignee
Bristol-Myers Squibb Pharma Company
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Filing date
Publication date
Application filed by Bristol-Myers Squibb Pharma Company filed Critical Bristol-Myers Squibb Pharma Company
Publication of YU90503A publication Critical patent/YU90503A/sh

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P25/32—Alcohol-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
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  • Transplantation (AREA)
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Abstract

Sadašnji pronalazak odnosi se na jedinjenja koja predstavljaju nove supstituisane pirazinone, piridine i pirimidine formule (I) i (II). Takva jedinjenja posebno su korisna kao CRF receptorski ligandi, i stoga, korisna su u lečenju različitih neurološki povezanih oboljenja kao što su ona izazvana osećanjima, anksioznost i depresija.[Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II):[Insert Formula (1) and Formula (II)]Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.
YU90503A 2001-05-14 2002-05-14 Supstituisani pirazinoni, piridini i pirimidini kao faktor oslobađanja kortikotropina YU90503A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29070601P 2001-05-14 2001-05-14

Publications (1)

Publication Number Publication Date
YU90503A true YU90503A (sh) 2006-03-03

Family

ID=23117196

Family Applications (1)

Application Number Title Priority Date Filing Date
YU90503A YU90503A (sh) 2001-05-14 2002-05-14 Supstituisani pirazinoni, piridini i pirimidini kao faktor oslobađanja kortikotropina

Country Status (23)

Country Link
US (2) US7205306B2 (sh)
EP (1) EP1392309B1 (sh)
JP (1) JP2004533447A (sh)
KR (1) KR20030094410A (sh)
CN (1) CN1527710A (sh)
BG (1) BG108425A (sh)
BR (1) BR0209575A (sh)
CA (1) CA2446980A1 (sh)
CZ (1) CZ20033053A3 (sh)
DE (1) DE60217669D1 (sh)
EE (1) EE200300546A (sh)
HK (1) HK1059220A1 (sh)
HU (1) HUP0304048A2 (sh)
IL (1) IL158669A0 (sh)
IS (1) IS7017A (sh)
MX (1) MXPA03010324A (sh)
NO (1) NO20035055D0 (sh)
PL (1) PL366577A1 (sh)
RU (1) RU2003135424A (sh)
SK (1) SK13752003A3 (sh)
WO (1) WO2002092090A1 (sh)
YU (1) YU90503A (sh)
ZA (1) ZA200308729B (sh)

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WO2000011003A1 (en) 1998-08-21 2000-03-02 Du Pont Pharmaceuticals Company ISOXAZOLO[4,5-d]PYRIMIDINES AS CRF ANTAGONISTS

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