ATE221886T1 - Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress - Google Patents

Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress

Info

Publication number
ATE221886T1
ATE221886T1 AT98942330T AT98942330T ATE221886T1 AT E221886 T1 ATE221886 T1 AT E221886T1 AT 98942330 T AT98942330 T AT 98942330T AT 98942330 T AT98942330 T AT 98942330T AT E221886 T1 ATE221886 T1 AT E221886T1
Authority
AT
Austria
Prior art keywords
antagonists
stress
treatment
corticotropin releasing
crh
Prior art date
Application number
AT98942330T
Other languages
English (en)
Inventor
Argyrios G Arvanitis
Paul J Gilligan
James P Beck
Rajagopal Bakthavatchalam
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of ATE221886T1 publication Critical patent/ATE221886T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98942330T 1997-09-02 1998-09-01 Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress ATE221886T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5743297P 1997-09-02 1997-09-02
PCT/US1998/018080 WO1999011643A1 (en) 1997-09-02 1998-09-01 Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders

Publications (1)

Publication Number Publication Date
ATE221886T1 true ATE221886T1 (de) 2002-08-15

Family

ID=22010535

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942330T ATE221886T1 (de) 1997-09-02 1998-09-01 Heterocyclyl-substituierte annellierte pyridine und pyrimidine als antagonisten des corticotropin freisetzenden hormons (crh), verwendbar für die behandlung von cns und stress

Country Status (11)

Country Link
US (2) US6245769B1 (de)
EP (1) EP1012151B1 (de)
JP (1) JP2001514260A (de)
CN (1) CN1278819A (de)
AT (1) ATE221886T1 (de)
AU (1) AU9041198A (de)
BR (1) BR9814458A (de)
CA (1) CA2303280A1 (de)
DE (1) DE69807085D1 (de)
IL (1) IL134748A0 (de)
WO (1) WO1999011643A1 (de)

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Also Published As

Publication number Publication date
US6525056B2 (en) 2003-02-25
EP1012151A1 (de) 2000-06-28
IL134748A0 (en) 2001-04-30
EP1012151B1 (de) 2002-08-07
CN1278819A (zh) 2001-01-03
US20010025042A1 (en) 2001-09-27
AU9041198A (en) 1999-03-22
US6245769B1 (en) 2001-06-12
DE69807085D1 (de) 2002-09-12
JP2001514260A (ja) 2001-09-11
CA2303280A1 (en) 1999-03-11
WO1999011643A1 (en) 1999-03-11
BR9814458A (pt) 2001-10-23

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