YU48583B - Postupak za pripremanje formulacije u obliku pilule za oralno davanje - Google Patents

Postupak za pripremanje formulacije u obliku pilule za oralno davanje

Info

Publication number
YU48583B
YU48583B YU215090A YU215090A YU48583B YU 48583 B YU48583 B YU 48583B YU 215090 A YU215090 A YU 215090A YU 215090 A YU215090 A YU 215090A YU 48583 B YU48583 B YU 48583B
Authority
YU
Yugoslavia
Prior art keywords
pill
formulation
preparation
oral dosage
crohn
Prior art date
Application number
YU215090A
Other languages
English (en)
Other versions
YU215090A (sr
Inventor
Ulmius Jan
Original Assignee
Aktiebolaget Draco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20377544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48583(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aktiebolaget Draco filed Critical Aktiebolaget Draco
Priority to SI9012150A priority Critical patent/SI9012150A/sl
Priority to HRP-2150/90A priority patent/HRP920632B1/xx
Publication of YU215090A publication Critical patent/YU215090A/sh
Publication of YU48583B publication Critical patent/YU48583B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Postupak za pripremanje formulacije u obliku pilule za kontrolisano davanje, koja sadrzi: I) jezgro koje se sastoji od tvrdog zrnca secera, ili nekog zrnca na kome je budesonid, ili njegov 22-R epimer, ravnomerno rasporeden, i II) u slucaju jezgra koje se sastoji od tvrdog zrnca secera, a) sloj budesonida ili njegovog 22R epimera, i b) farmaceutski prihvatljiv tanki sloj koji obrazuje vodonerastvorljiv ili vodorastvorljiv polimer, ili u slucaju jezgra koje se sastoji od zrnca u kome je budesonid, ili njegov 22R epimer, homogeno rasporeden, po zelji jedan sloj farmaceutski prihvatljivog vodonerastvorljivog polimera koji obrazuje tanak sloj, ili mecavinu vodonerastvorljivih polimera, ili mesavinu vodorastvorljivih i vodonerastvorljivih polimera i iii) membranu koja okruzuje pomenuto jezgro i sloj, i koja sadrzi jedan farmaceutski prihvatljiv anjonski karboksilni polimer koji obrazuje tanak sloj, koji se tesko rastvara pri malim pH, ali koji je rastvorljiv pri vecim pH bilo sam, bilo u kombinaciji sa nekim farmaceutski prihvatljivim vodonerastvorljivim polimerom koji obrazuje tanak sloj, pri cemu je debljina tog sloja ili pomenute membrane i/ili odnos anjonskog karboksilnog polimera prema nerastvorljivom polimeru takav da sprecava ispustanje budesonida, ili njegovog 22R epimera, iz pomenute formulacije pri malim pH vrednostima, ali da omogucuje ispustanje budesonida, ili njegovog 22R epimera, iz pomenute formulacije pri visim pH vrednostima, nazn acen time, sto se obrazuje jezgro od farmaceutski prihvatljivih neutralnih sastojaka sa budesonidom, ili njegovim 22R epimerom, homogeno rasporedenim unutar jezgra, i eventualno to jezgro oblaze vodonerastvorljivim polimerom, ili smesom vodonerastvorljivih polimera, ili smesom vodorastvorljivih i vodonerastvorljivih polimera, ili zatvara jezgro od tvrdog zrnca secera u sloj budesonida, ili njegovog 22R epimera, i vodorastvorljivog ili vodonerastvorljivog polimera, i potom se zatvara ovako oblozeno jezgro u jednu membranu, ili u anjonski karboksilni polimer koji obrazuje tanak sloj, bilo sam bilo u kombinaciji sa vodonerastvorljivim polimerom, tako da formulacija omogucuje ispustanje budesonida, ili njegovog 22R epimera, na nacin iznet u ovom zahtevu. - Prijava sadrzi jos 12 zavisnih zahteva.
YU215090A 1989-11-22 1990-11-13 Postupak za pripremanje formulacije u obliku pilule za oralno davanje YU48583B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012150A SI9012150A (sl) 1989-11-22 1990-11-13 Oralni pripravek za zdravljenje vnetnih črevesnih bolezni
HRP-2150/90A HRP920632B1 (en) 1989-11-22 1992-09-30 Oral composition for the treatment of inflammatory bowel deseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8903914A SE8903914D0 (sv) 1989-11-22 1989-11-22 Oral composition for the treatment of inflammatory bowel diseases

Publications (2)

Publication Number Publication Date
YU215090A YU215090A (sr) 1996-01-09
YU48583B true YU48583B (sh) 1998-12-23

Family

ID=20377544

Family Applications (1)

Application Number Title Priority Date Filing Date
YU215090A YU48583B (sh) 1989-11-22 1990-11-13 Postupak za pripremanje formulacije u obliku pilule za oralno davanje

Country Status (36)

Country Link
US (1) US6423340B1 (sh)
EP (1) EP0502092B1 (sh)
JP (1) JP3145111B2 (sh)
KR (1) KR0179042B1 (sh)
AT (1) ATE125445T1 (sh)
AU (1) AU643021B2 (sh)
CA (1) CA2071518C (sh)
DE (1) DE69021214T2 (sh)
DK (1) DK0502092T3 (sh)
EG (1) EG19642A (sh)
ES (1) ES2074698T3 (sh)
FI (2) FI104949B (sh)
GR (1) GR3017691T3 (sh)
HK (1) HK51897A (sh)
HR (1) HRP920632B1 (sh)
HU (2) HU216836B (sh)
IE (1) IE74854B1 (sh)
IL (1) IL96415A (sh)
IS (1) IS1858B (sh)
LT (1) LT3696B (sh)
LV (1) LV10183B (sh)
MY (1) MY104535A (sh)
NO (1) NO304010B1 (sh)
NZ (1) NZ235807A (sh)
PL (1) PL166506B1 (sh)
PT (1) PT95946A (sh)
RU (1) RU2134104C1 (sh)
SA (1) SA90110123B1 (sh)
SE (1) SE8903914D0 (sh)
SG (1) SG54210A1 (sh)
SI (1) SI9012150A (sh)
TW (1) TW250435B (sh)
UA (1) UA37196C2 (sh)
WO (1) WO1991007172A1 (sh)
YU (1) YU48583B (sh)
ZA (1) ZA908777B (sh)

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BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
US5914132A (en) * 1993-02-26 1999-06-22 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
DE4332394A1 (de) * 1993-09-23 1995-03-30 Falk Pharma Gmbh Budesonid-Pellets mit kontrolliertem Freigabeprofil und Verfahren zu ihrer Herstellung
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
CA2271560C (en) * 1996-11-15 2003-09-23 Mayo Foundation For Medical Education And Research Pharmaceutical dosage form for colonic delivery
SE9604751D0 (sv) 1996-12-20 1996-12-20 Astra Ab New therapy
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
US6239120B1 (en) 1998-03-17 2001-05-29 Pharmalink Ab Method and means for treating glomerulonephritis
GB9824604D0 (en) 1998-11-11 1999-01-06 Hewlett Healthcare Limited Treatment of allergic conditions
SE9902673D0 (sv) * 1999-07-12 1999-07-12 Astra Ab New composition
DK1392321T3 (da) * 2001-03-15 2010-11-29 Soligenix Inc Fremgangsmåde til behandling af inflammatoriske sygdomme i mave-tarm-kanalen ved anvendelse af topisk aktive corticosteroider
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform
US7879833B2 (en) 2002-12-12 2011-02-01 Nycomed Gmbh Combination medicament
US20060188563A1 (en) * 2003-03-27 2006-08-24 Hisamitsu Pharmaceutical Co., Inc. Medicinal oral preparations for colon delivery, medicinal oral preparations for treating colon cancer and medicinal oral preparations for treating colitis
ATE476185T1 (de) * 2003-09-15 2010-08-15 Nycomed Gmbh Verwendung von ciclesonid zur behandlung von entzündlichen darmerkrankungen
EP1670482B2 (en) 2003-09-16 2022-06-29 Covis Pharma B.V. Use of ciclesonide for the treatment of respiratory diseases
CA2570916C (en) 2004-06-16 2013-06-11 Tap Pharmaceutical Products, Inc. Pulsed release dosage form of a ppi
WO2007056539A2 (en) * 2005-11-08 2007-05-18 Medarex, Inc. Prophylaxis and treatment of enterocolitis associated with anti-ctla-4 antibody therapy
JPWO2008117814A1 (ja) * 2007-03-26 2010-07-15 帝國製薬株式会社 大腸送達用経口製剤
GB0808537D0 (en) * 2008-05-12 2008-06-18 Archimedes Dev Ltd Compositions
EP2334178A4 (en) * 2008-10-03 2012-04-11 Falk Pharma Gmbh COMPOSITIONS AND METHODS OF TREATING THERAPEUTIC DISEASES WITH GRANULATED MESALAMINE
US8945615B2 (en) * 2009-02-17 2015-02-03 Mylan Pharmaceuticals Inc. Controlled release budesonide minitablets
US8945616B2 (en) * 2009-02-17 2015-02-03 Mylan Pharmaceuticals Inc. Controlled release budesonide minitablets
AU2012211968A1 (en) * 2011-02-04 2013-08-29 Optimer Pharmaceuticals, Inc. Treatment of bacterial infections
MD480Z5 (ro) * 2011-07-07 2012-09-30 Эльвира АНДОН Metodă de tratament al colitei ulceroase nespecifice acute
JOP20200144A1 (ar) 2012-04-30 2017-06-16 Tillotts Pharma Ag تركيبة عقار ذو إطلاق متأخر
EP3062776A1 (en) 2013-10-29 2016-09-07 Tillotts Pharma AG A delayed release drug formulation
US9707182B2 (en) * 2015-09-11 2017-07-18 Sun Pharmaceutical Industries Ltd. Oral pharmaceutical dosage forms of budesonide
CN105663091A (zh) * 2016-01-28 2016-06-15 上海信谊百路达药业有限公司 一种布地奈德肠溶缓释胶囊及其制备方法
CN108601744B (zh) * 2016-02-09 2022-01-04 阿尔比里奥公司 口服考来烯胺制剂及其用途
RU2750937C2 (ru) * 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
EP3613414A1 (de) 2018-08-24 2020-02-26 Dr. Falk Pharma Gmbh Pellets mit mehrschichtiger struktur zur verzögerten freisetzung des wirkstoffs im distalen kolon
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Also Published As

Publication number Publication date
HRP920632A2 (en) 1995-04-30
IS3644A7 (is) 1991-05-23
HK51897A (en) 1997-05-02
EP0502092B1 (en) 1995-07-26
PL287844A1 (en) 1991-12-02
WO1991007172A1 (en) 1991-05-30
UA37196C2 (uk) 2001-05-15
US6423340B1 (en) 2002-07-23
HUT60630A (en) 1992-10-28
DE69021214T2 (de) 1996-01-04
JPH05501705A (ja) 1993-04-02
HU216836B (hu) 1999-09-28
SG54210A1 (en) 1998-11-16
LV10183A (lv) 1994-10-20
SE8903914D0 (sv) 1989-11-22
HU9201700D0 (en) 1992-08-28
NZ235807A (en) 1993-02-25
NO922004D0 (no) 1992-05-21
ZA908777B (en) 1991-07-31
AU643021B2 (en) 1993-11-04
AU7786491A (en) 1991-06-13
DK0502092T3 (da) 1995-12-27
FI19991893A (fi) 1999-09-06
RU2134104C1 (ru) 1999-08-10
IL96415A0 (en) 1991-08-16
GR3017691T3 (en) 1996-01-31
IS1858B (is) 2003-03-27
LV10183B (en) 1995-08-20
TW250435B (sh) 1995-07-01
LT3696B (en) 1996-02-26
JP3145111B2 (ja) 2001-03-12
FI922325A0 (fi) 1992-05-21
FI922325A (fi) 1992-05-21
NO304010B1 (no) 1998-10-12
CA2071518A1 (en) 1991-05-23
DE69021214D1 (de) 1995-08-31
MY104535A (en) 1994-04-30
YU215090A (sr) 1996-01-09
EP0502092A1 (en) 1992-09-09
PL166506B1 (pl) 1995-05-31
SA90110123B1 (ar) 1999-06-06
CA2071518C (en) 2002-11-12
HRP920632B1 (en) 1999-10-31
FI104949B (fi) 2000-05-15
IL96415A (en) 1995-11-27
EG19642A (en) 1995-08-30
SI9012150A (sl) 1998-08-31
NO922004L (no) 1992-05-21
KR0179042B1 (ko) 1999-03-20
ES2074698T3 (es) 1995-09-16
PT95946A (pt) 1991-09-13
LTIP1751A (en) 1995-07-25
IE904170A1 (en) 1991-05-22
IE74854B1 (en) 1997-08-13
ATE125445T1 (de) 1995-08-15
KR920703025A (ko) 1992-12-17

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