YU47728B - Azaoksindol derivati - Google Patents
Azaoksindol derivatiInfo
- Publication number
- YU47728B YU47728B YU791A YU791A YU47728B YU 47728 B YU47728 B YU 47728B YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A YU 47728 B YU47728 B YU 47728B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituted
- phenyl
- alkyl
- heteroaryl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
AZAOKSINDOL DERIVATI formule, naznaceno time, u kojoj jedan A, B, D i E je N i drugi su C; X i Y su nezavisno odabrani iz grupe koju sacinjavaju vodonik, OR3, hidroksi (C1-C6)alkil, CF3,COR3, halogen COOR3, CONR3R3, CN, NO", SR3, SOR3, SO2R3R3; R1 je (C1-C6)alkil ili CONHR4; R2 je (C1-C8)alkil, (Ch2)nR5 gde je n 0 ili1, ili NHR6; R3 je (C1-C6) alkil, fenil, benzil, alil ili vodonik, pri cemu pomenuti fenil i fenil ostatak pomenutog benzila moze opciono biti supstituisan sa jednim ili vise supstituenata nezavisno odabrani od fluoro, hloro, bromo, jodo, hidroksi, (C1-C3)alkoksi i CF3 grupe; R4 je vodonik, (C1-C6)alkil, (C2-C6)hidroksialkil, (C3-C8)-cikloalkil, COR3 gde R3 je kao sto je gore definisano, fenil, supstituisani fenil, heteroaril ili supstituisani heteroaril, pri cemu heteroaril ostatak svake od pomenutih heteroaril i supstituisanih heteroaril grupa je odabran od tiofena i furana, i pri cemu svaki pomenuti fenil i supstituisani heteroaril grupa je supstituisan sa jednim ili dva supstituenta nezavisno odabranih od fluoro, hloro, bromo, jodo, hidroksi, (C1-C3)alkil, (C1-C3)alkoksi i CF3; R5 je (C3-C8)cikloalkil, vodonik, fenil, supstituisani fenil, heteroaril i supstituisani heteroaril, pri cemu heteroaril ostatak svake od pomenutih heteroaril i supstituisane heteroaril grupa je odabran od tiofena i furana, i svaki od pomenutih supstituisanih fenil i supstituisanih heteroaril grupa je supstituisan sa jednim ili dva supstituenta nezavisno odabrani od fluoro, hloro, bromo, jodo, hidroksi, (C1-C3) alkil, (C1-C3)alkoksi i trifluorometil grupe; R6 je fenil, tiofen ili furan, pri cemu svaki fenil, tiofen i furan mogu biti opciono supstituisani sa jednim ili vise supstituenata nezavisno odabrani od fluoro, hloro, bromo, jodo, hidroksi, (C1-C3) alkil, (C1-C3)alkoksi i trifluorometil grupe; i W je vodonik, (C2-C10)alkonil, (C5-C7)cikloaliklkarbonil, (C7-C10)fenilakanoilm hlorobenzoil, tenoil, omega-(C2-C4)alkoksikarbonil-(C3-C5)alkanoil, (C2-C10)alkoksikarbonil, fenoksikarbonil, 1/(C1C4)aciloksi/-(C2-C4)alkil;pod uslovom sto (a) kada E je azot, tada najmanje jedan X i Y se razlikuje od vodonika; (b) kada ili R2 je NHR6 ili R1 je (C1-C6)alkil, atada W je vodonik; ili njegova farmaceutski prihvatljiva so. Prijava sadrzi jos 4 zavisna patenta.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1990/000107 WO1991009598A1 (en) | 1990-01-05 | 1990-01-05 | Azaoxindole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU791A YU791A (sh) | 1994-01-20 |
| YU47728B true YU47728B (sh) | 1996-01-08 |
Family
ID=22220612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU791A YU47728B (sh) | 1990-01-05 | 1991-01-04 | Azaoksindol derivati |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0436333A3 (sh) |
| JP (1) | JPH0826018B2 (sh) |
| KR (1) | KR930005447B1 (sh) |
| CN (1) | CN1031053C (sh) |
| AU (1) | AU635593B2 (sh) |
| BR (1) | BR9100046A (sh) |
| CA (1) | CA2033531C (sh) |
| CS (1) | CS991A2 (sh) |
| FI (1) | FI922347A (sh) |
| IE (1) | IE910022A1 (sh) |
| IL (1) | IL96819A0 (sh) |
| MY (1) | MY109722A (sh) |
| NO (1) | NO922634D0 (sh) |
| NZ (1) | NZ236582A (sh) |
| PL (2) | PL166512B1 (sh) |
| PT (1) | PT96411B (sh) |
| WO (1) | WO1991009598A1 (sh) |
| YU (1) | YU47728B (sh) |
| ZA (1) | ZA9172B (sh) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101860A0 (en) * | 1991-05-31 | 1992-12-30 | Ici Plc | Heterocyclic derivatives |
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| US5618819A (en) * | 1994-07-07 | 1997-04-08 | Adir Et Compagnie | 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds |
| FR2722195B1 (fr) * | 1994-07-07 | 1996-08-23 | Adir | Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2722196B1 (fr) * | 1994-07-07 | 1996-08-23 | Adir | Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent |
| US5939069A (en) | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| BR9916324A (pt) | 1998-12-17 | 2001-10-02 | Hoffmann La Roche | 4,5-pirazinoxindóis como inibidores de proteìna quinase |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| ES2192877T3 (es) * | 1998-12-17 | 2003-10-16 | Hoffmann La Roche | 4-alquenil (y alquinil) oxindoles como inhibidores de kinasas ciclina-dependientes, en particular cdk2. |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| DE60021423T2 (de) | 1999-12-21 | 2006-04-13 | Sugen, Inc., San Diego | 4-substituierte 7-aza-indolin-2-one und ihre verwendung als proteinkinaseinhibitoren |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| DE10053275A1 (de) * | 2000-10-27 | 2002-05-02 | Dresden Arzneimittel | Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
| TWI262920B (en) | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| DE60331219D1 (de) * | 2002-03-28 | 2010-03-25 | Eisai R&D Man Co Ltd | Azaindole als hemmstoffe von c-jun n-terminalen kinasen |
| PE20060430A1 (es) | 2004-06-09 | 2006-05-25 | Glaxo Group Ltd | Derivados de pirrolopiridina como moduladores de los receptores cannabinoides |
| US7906528B2 (en) * | 2004-10-05 | 2011-03-15 | Novartis International Pharmaceutical Ltd. | Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds |
| WO2009147476A1 (en) * | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| EP0208510B1 (en) * | 1985-07-09 | 1991-09-11 | Pfizer Inc. | 1-substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents |
| KR900701784A (ko) * | 1988-06-14 | 1990-12-04 | 스타이너 브이. 캔스타드 | 소염 활성을 갖는 헤테로비사이클릭 화합물 |
-
1990
- 1990-01-05 WO PCT/US1990/000107 patent/WO1991009598A1/en active Application Filing
- 1990-12-14 EP EP19900313669 patent/EP0436333A3/en not_active Withdrawn
- 1990-12-20 NZ NZ236582A patent/NZ236582A/xx unknown
- 1990-12-25 JP JP2419301A patent/JPH0826018B2/ja not_active Expired - Fee Related
- 1990-12-28 IL IL96819A patent/IL96819A0/xx unknown
- 1990-12-31 MY MYPI90002304A patent/MY109722A/en unknown
-
1991
- 1991-01-03 PT PT96411A patent/PT96411B/pt not_active IP Right Cessation
- 1991-01-03 PL PL91303916A patent/PL166512B1/pl not_active IP Right Cessation
- 1991-01-03 CA CA002033531A patent/CA2033531C/en not_active Expired - Fee Related
- 1991-01-03 AU AU68606/91A patent/AU635593B2/en not_active Ceased
- 1991-01-03 PL PL91288598A patent/PL165653B1/pl not_active IP Right Cessation
- 1991-01-04 CS CS919A patent/CS991A2/cs unknown
- 1991-01-04 YU YU791A patent/YU47728B/sh unknown
- 1991-01-04 ZA ZA9172A patent/ZA9172B/xx unknown
- 1991-01-04 CN CN91100034A patent/CN1031053C/zh not_active Expired - Fee Related
- 1991-01-04 KR KR1019910000020A patent/KR930005447B1/ko not_active IP Right Cessation
- 1991-01-04 IE IE002291A patent/IE910022A1/en unknown
- 1991-01-07 BR BR919100046A patent/BR9100046A/pt not_active Application Discontinuation
-
1992
- 1992-05-22 FI FI922347A patent/FI922347A/fi not_active Application Discontinuation
- 1992-07-03 NO NO1992922634A patent/NO922634D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04210981A (ja) | 1992-08-03 |
| BR9100046A (pt) | 1991-10-22 |
| CN1053065A (zh) | 1991-07-17 |
| PT96411A (pt) | 1991-10-15 |
| PT96411B (pt) | 1999-04-30 |
| KR910014375A (ko) | 1991-08-31 |
| JPH0826018B2 (ja) | 1996-03-13 |
| CA2033531C (en) | 1998-06-23 |
| MY109722A (en) | 1997-05-31 |
| AU635593B2 (en) | 1993-03-25 |
| FI922347A0 (fi) | 1992-05-22 |
| EP0436333A3 (en) | 1992-05-27 |
| CA2033531A1 (en) | 1991-07-06 |
| CS991A2 (en) | 1991-09-15 |
| PL165653B1 (pl) | 1995-01-31 |
| WO1991009598A1 (en) | 1991-07-11 |
| PL166512B1 (pl) | 1995-05-31 |
| KR930005447B1 (ko) | 1993-06-22 |
| NO922634L (no) | 1992-07-03 |
| FI922347A (fi) | 1992-05-22 |
| NO922634D0 (no) | 1992-07-03 |
| NZ236582A (en) | 1993-10-26 |
| IE910022A1 (en) | 1991-07-17 |
| CN1031053C (zh) | 1996-02-21 |
| EP0436333A2 (en) | 1991-07-10 |
| IL96819A0 (en) | 1991-09-16 |
| PL288598A1 (en) | 1991-12-02 |
| YU791A (sh) | 1994-01-20 |
| AU6860691A (en) | 1992-03-05 |
| ZA9172B (en) | 1992-10-28 |
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