YU17092A - Derivati 2,4-diaminohinazolina - Google Patents
Derivati 2,4-diaminohinazolinaInfo
- Publication number
- YU17092A YU17092A YU17092A YU17092A YU17092A YU 17092 A YU17092 A YU 17092A YU 17092 A YU17092 A YU 17092A YU 17092 A YU17092 A YU 17092A YU 17092 A YU17092 A YU 17092A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- derivatives
- diaminohinazolina
- potentiators
- cancer
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
DERIVATI 2,4-DIAMINOHINAZOLINA, opisano je jedinjenje fomule: u kojoj X predstavlja C1-C3alkil, C1-C3 alkoksi, hloro fluoro, amino, C1-C3alkilamino, C2-C6dialkilamino ili trifluorometil; X1 je vodonik, C1-C3alkil, fluoro, hloro ili C2-C6 dialkilamino; X2 je vodonik, C1-C3alkil, C1-C3alkoksi; R1 je vodonik ili C1-C3alkil; R2 je C1-C10alkil ili aralkil; R3 je vodonik ili C1-C3alkil; R4 je aralkil; i njegova farmaceutski prihvatljiva adiciona so sa kiselinom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65792291A | 1991-02-20 | 1991-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU17092A true YU17092A (sh) | 1994-12-28 |
Family
ID=24639196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU17092A YU17092A (sh) | 1991-02-20 | 1992-02-19 | Derivati 2,4-diaminohinazolina |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0572437B1 (sh) |
| JP (1) | JPH06500117A (sh) |
| KR (1) | KR930703270A (sh) |
| CN (1) | CN1064271A (sh) |
| AT (1) | ATE121735T1 (sh) |
| AU (1) | AU655798B2 (sh) |
| BR (1) | BR9205645A (sh) |
| CA (1) | CA2101542A1 (sh) |
| CZ (1) | CZ387292A3 (sh) |
| DE (2) | DE9290018U1 (sh) |
| DK (1) | DK0572437T3 (sh) |
| ES (1) | ES2071484T3 (sh) |
| FI (1) | FI933656A0 (sh) |
| HU (1) | HUT64755A (sh) |
| IE (1) | IE920522A1 (sh) |
| IL (1) | IL100942A0 (sh) |
| MX (1) | MX9200675A (sh) |
| NO (1) | NO932954L (sh) |
| NZ (1) | NZ241627A (sh) |
| PT (1) | PT100132A (sh) |
| WO (1) | WO1992014716A1 (sh) |
| YU (1) | YU17092A (sh) |
| ZA (1) | ZA921911B (sh) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| ES2049659B1 (es) * | 1992-10-08 | 1994-10-16 | Ici Plc | Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena. |
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| DE4429026C2 (de) * | 1994-08-16 | 1995-11-16 | Mueller Wolfgang | Inlay-Entfernungsinstrumentarium für Totalendoprothese |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| DE69613367T2 (de) * | 1995-04-27 | 2002-04-18 | Astrazeneca Ab | Chinazolin derivate |
| AU7692896A (en) * | 1995-12-01 | 1997-06-27 | Novartis Ag | Quinazolin-2,4-diazirines as NPY receptor antagonist |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
| GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| MXPA02004366A (es) | 1999-11-05 | 2002-11-07 | Astrazeneca Ab | Derivados de quinazolina como inhibidores vegf. |
| AU2001240150A1 (en) * | 2000-03-13 | 2001-09-24 | Chemrx Advanced Technologies, Inc. | Quinazoline synthesis |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| WO2005003100A2 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| JP2007269629A (ja) * | 2004-06-21 | 2007-10-18 | Astellas Pharma Inc | キナゾリン誘導体 |
| CN101031551A (zh) * | 2004-07-06 | 2007-09-05 | 安吉永生物制药公司 | 针对癌症治疗的肝细胞生长因子/c－met活性的喹唑啉调节剂 |
| CA2592900A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833511A4 (en) * | 2005-01-03 | 2011-01-19 | Myriad Genetics Inc | METHOD OF TREATING BRAIN CANCER |
| JP2009518359A (ja) * | 2005-12-07 | 2009-05-07 | ノイロサーチ アクティーゼルスカブ | 新規なキナゾリン−２，４−ジアミン誘導体及び小コンダクタンスカルシウム依存性カリウムチャネルの調節剤としてのそれらの使用 |
| CN101100466B (zh) | 2006-07-05 | 2013-12-25 | 天津和美生物技术有限公司 | 不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用 |
| US20090004185A1 (en) * | 2007-01-11 | 2009-01-01 | Wyeth | Amino-substituted quinazoline derivatives as inhibitors of beta-catenin/tcf-4 pathway and cancer treatment agents |
| EP2173346A2 (en) * | 2007-06-27 | 2010-04-14 | Summit Corporation Plc | Use of compounds for preparing anti-tuberculosis agents |
| JP2013530942A (ja) | 2010-05-07 | 2013-08-01 | カリフォルニア・インスティチュート・オブ・テクノロジー | 移行型小胞体ａｔｐアーゼの阻害のための方法および組成物 |
| WO2018212774A1 (en) * | 2017-05-17 | 2018-11-22 | Vanderbilt University | Quinazoline compounds as modulators of ras signaling |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635979A (en) * | 1969-09-29 | 1972-01-18 | Pfizer | Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines |
| IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
| AU610328B2 (en) * | 1987-12-03 | 1991-05-16 | Smithkline Beckman Intercredit B.V. | 2,4- diaminoquinazoline derivatives |
-
1992
- 1992-01-08 AT AT92903632T patent/ATE121735T1/de not_active IP Right Cessation
- 1992-01-08 DE DE9290018U patent/DE9290018U1/de not_active Expired - Lifetime
- 1992-01-08 JP JP4503777A patent/JPH06500117A/ja active Pending
- 1992-01-08 WO PCT/US1992/000028 patent/WO1992014716A1/en active IP Right Grant
- 1992-01-08 AU AU11848/92A patent/AU655798B2/en not_active Expired - Fee Related
- 1992-01-08 KR KR1019930702481A patent/KR930703270A/ko not_active Application Discontinuation
- 1992-01-08 HU HU9302384A patent/HUT64755A/hu unknown
- 1992-01-08 ES ES92903632T patent/ES2071484T3/es not_active Expired - Lifetime
- 1992-01-08 CA CA002101542A patent/CA2101542A1/en not_active Abandoned
- 1992-01-08 EP EP92903632A patent/EP0572437B1/en not_active Expired - Lifetime
- 1992-01-08 DK DK92903632.5T patent/DK0572437T3/da active
- 1992-01-08 CZ CS923872A patent/CZ387292A3/cs unknown
- 1992-01-08 DE DE69202243T patent/DE69202243T2/de not_active Expired - Fee Related
- 1992-01-08 BR BR9205645A patent/BR9205645A/pt not_active Application Discontinuation
- 1992-02-13 IL IL100942A patent/IL100942A0/xx unknown
- 1992-02-17 NZ NZ241627A patent/NZ241627A/xx unknown
- 1992-02-18 PT PT100132A patent/PT100132A/pt not_active Application Discontinuation
- 1992-02-18 MX MX9200675A patent/MX9200675A/es unknown
- 1992-02-19 CN CN92101113A patent/CN1064271A/zh active Pending
- 1992-02-19 ZA ZA921191A patent/ZA921911B/xx unknown
- 1992-02-19 YU YU17092A patent/YU17092A/sh unknown
- 1992-02-19 IE IE052292A patent/IE920522A1/en not_active Application Discontinuation
-
1993
- 1993-08-19 FI FI933656A patent/FI933656A0/fi not_active Application Discontinuation
- 1993-08-19 NO NO93932954A patent/NO932954L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69202243D1 (de) | 1995-06-01 |
| NO932954D0 (no) | 1993-08-19 |
| DE69202243T2 (de) | 1995-08-31 |
| IE920522A1 (en) | 1992-08-26 |
| AU655798B2 (en) | 1995-01-12 |
| CA2101542A1 (en) | 1992-08-21 |
| PT100132A (pt) | 1993-05-31 |
| DE9290018U1 (de) | 1993-10-14 |
| FI933656A (fi) | 1993-08-19 |
| ZA921911B (en) | 1993-08-19 |
| AU1184892A (en) | 1992-09-15 |
| HUT64755A (en) | 1994-02-28 |
| FI933656A0 (fi) | 1993-08-19 |
| MX9200675A (es) | 1992-08-01 |
| JPH06500117A (ja) | 1994-01-06 |
| EP0572437A1 (en) | 1993-12-08 |
| BR9205645A (pt) | 1994-06-07 |
| ATE121735T1 (de) | 1995-05-15 |
| WO1992014716A1 (en) | 1992-09-03 |
| KR930703270A (ko) | 1993-11-29 |
| ES2071484T3 (es) | 1995-06-16 |
| EP0572437B1 (en) | 1995-04-26 |
| HU9302384D0 (en) | 1993-11-29 |
| NO932954L (no) | 1993-08-19 |
| CZ387292A3 (en) | 1994-04-13 |
| CN1064271A (zh) | 1992-09-09 |
| IL100942A0 (en) | 1992-11-15 |
| NZ241627A (en) | 1993-06-25 |
| DK0572437T3 (da) | 1995-07-03 |
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