YU791A - Azaoksindol derivati - Google Patents

Azaoksindol derivati

Info

Publication number
YU791A
YU791A YU791A YU791A YU791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
azaoksindol
diseases
inflammatory
azooxindole
Prior art date
Application number
YU791A
Other languages
English (en)
Other versions
YU47728B (sh
Inventor
R.P. Robinson
A. Marfat
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU791A publication Critical patent/YU791A/sh
Publication of YU47728B publication Critical patent/YU47728B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Opisani su azaoksindol derivati, bliže rečeno novi 4-, 5-, 6-, i 7-azaoksindol derivati, jedinjenja koja su antiinflamatorna i analgetička sredstva i inhibitori jedne ili više od prostaglandin H2 sintaze, 5-lipoksigenaze i interleukin-1 biosinteza, koja se upotrebljavaju za tretiranje hroničnih inflamatornih oboljenja, alergije, psorijaze, različitih oboljenja kostiju, i imunih disfunkcija kao što je sistemski lupus erithematozis.
YU791A 1990-01-05 1991-01-04 Azaoksindol derivati YU47728B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000107 WO1991009598A1 (en) 1990-01-05 1990-01-05 Azaoxindole derivatives

Publications (2)

Publication Number Publication Date
YU791A true YU791A (sh) 1994-01-20
YU47728B YU47728B (sh) 1996-01-08

Family

ID=22220612

Family Applications (1)

Application Number Title Priority Date Filing Date
YU791A YU47728B (sh) 1990-01-05 1991-01-04 Azaoksindol derivati

Country Status (19)

Country Link
EP (1) EP0436333A3 (sh)
JP (1) JPH0826018B2 (sh)
KR (1) KR930005447B1 (sh)
CN (1) CN1031053C (sh)
AU (1) AU635593B2 (sh)
BR (1) BR9100046A (sh)
CA (1) CA2033531C (sh)
CS (1) CS991A2 (sh)
FI (1) FI922347A (sh)
IE (1) IE910022A1 (sh)
IL (1) IL96819A0 (sh)
MY (1) MY109722A (sh)
NO (1) NO922634L (sh)
NZ (1) NZ236582A (sh)
PL (2) PL166512B1 (sh)
PT (1) PT96411B (sh)
WO (1) WO1991009598A1 (sh)
YU (1) YU47728B (sh)
ZA (1) ZA9172B (sh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
FR2722196B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent
FR2722195B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5939069A (en) 1996-08-23 1999-08-17 University Of Florida Materials and methods for detection and treatment of immune system dysfunctions
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
TR200101756T2 (tr) 1998-12-17 2001-10-22 F.Hoffmann-La Roche Ag Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller.
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
PT1157019E (pt) * 1998-12-17 2003-06-30 Hoffmann La Roche 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2
KR20010101266A (ko) 1998-12-17 2001-11-14 프리돌린 클라우스너, 롤란드 비. 보레르 Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
JP2003518123A (ja) 1999-12-21 2003-06-03 スージェン・インコーポレーテッド ４−置換７−アザ−インドリン−２−オンおよびその蛋白質キナーゼ阻害剤としての使用
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI262920B (en) 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
AU2003214414B2 (en) * 2002-03-28 2008-10-09 Eisai R & D Management Co., Ltd. Azaindoles as inhibitors of c-Jun N-terminal kinases
PT1753764E (pt) 2004-06-09 2009-01-28 Glaxo Group Ltd Derivados de pirrolopiridina
WO2006042102A2 (en) * 2004-10-05 2006-04-20 Neurogen Corporation Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
WO2009147476A1 (en) * 2008-06-02 2009-12-10 Matrix Laboratories Ltd. Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
ATE67185T1 (de) * 1985-07-09 1991-09-15 Pfizer Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
KR900701784A (ko) * 1988-06-14 1990-12-04 스타이너 브이. 캔스타드 소염 활성을 갖는 헤테로비사이클릭 화합물

Also Published As

Publication number Publication date
CS991A2 (en) 1991-09-15
EP0436333A2 (en) 1991-07-10
PT96411B (pt) 1999-04-30
PT96411A (pt) 1991-10-15
MY109722A (en) 1997-05-31
NO922634D0 (no) 1992-07-03
WO1991009598A1 (en) 1991-07-11
JPH04210981A (ja) 1992-08-03
AU6860691A (en) 1992-03-05
CA2033531A1 (en) 1991-07-06
PL288598A1 (en) 1991-12-02
FI922347A0 (fi) 1992-05-22
NZ236582A (en) 1993-10-26
ZA9172B (en) 1992-10-28
EP0436333A3 (en) 1992-05-27
FI922347A (fi) 1992-05-22
PL165653B1 (pl) 1995-01-31
YU47728B (sh) 1996-01-08
AU635593B2 (en) 1993-03-25
KR910014375A (ko) 1991-08-31
KR930005447B1 (ko) 1993-06-22
CN1053065A (zh) 1991-07-17
BR9100046A (pt) 1991-10-22
CN1031053C (zh) 1996-02-21
JPH0826018B2 (ja) 1996-03-13
CA2033531C (en) 1998-06-23
NO922634L (no) 1992-07-03
IL96819A0 (en) 1991-09-16
PL166512B1 (pl) 1995-05-31
IE910022A1 (en) 1991-07-17

Similar Documents

Publication Publication Date Title
YU791A (sh) Azaoksindol derivati
AR002267A1 (es) Compuestos de imidazol utiles para el tratamiento de patologias mediadas por citoquinas; composicion farmaceutica que los contiene; proceso para preparar dichos compuestos; uso del mismo para preparar dichas composiciones; compuestos intermediarios y procesos para su preparacion.
YU6602A (sh) Pirimidin-2,4,6-trion metaloproteinazni inhibitori
YU64701A (sh) Jedinjenja upotrebljiva kao anti-inflamatorna sredstva
ES2133807T3 (es) Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
NO20032254L (no) Forbindelser for inhibering av ekspresjon av VACM-I
DE60027016D1 (de) Verwendung von konjugierten linolensaüren zur topischen behandlung von zellulitis
YU44398A (sh) Derivati supstituisanog benzensulfonamida kao prolekovi cox-2 inhibitora
EA200300508A1 (ru) Противовоспалительные агенты
BG103518A (en) 2-(purin-9-yl)tetrahydrofuran-3,4-diol derivatives
DE68905863T2 (de) Zusammensetzungen essentieller fettsaeuren.
ATE215366T1 (de) 3-benzoylphenylessigsäure-derivate enthaltende topische zusammensetzungen zur behandlung der ophthalmischen entzündungserkrankungen
YU47100A (sh) Novi derivati dihidroksiheksanoinske kiseline
IL152961A0 (en) Inhibitors of alpha beta 2 mediated cell adhesion
ES2138595T3 (es) Inhibidores de citoquinas.
NO20003868L (no) Hydroksam- og karboksylsyrederivater
CA1270834C (en) DIHYDROBENZOPYRAN SUBSTITUTES
DE69525740D1 (de) Spezielle halofantrinhaltige Zusammensetzungen
ATE221780T1 (de) Fenbendazolformulierungen
MXPA03007413A (es) Composicion y metodo para tratar enfermedades inflamatorias.
FI950842A (fi) Enkefalinaasin inhibiittoreina käyttökelpoisia uusia 2-substituoituja trisyklisiä indaani-2-merkaptoasetyyliamidijohdannaisia
ES2056983T3 (es) Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa.
PT841933E (pt) Composicoes do inibidor bowman-birk para tratamento de doencas inflamatorias
CO4920227A1 (es) Histidina-n-bencil glicinamida sustituida con cicloalquilos .
NZ336042A (en) Farnesyl transferase inhibitors