YU791A - AZAOKSINDOL DERIVATIVES - Google Patents
AZAOKSINDOL DERIVATIVESInfo
- Publication number
- YU791A YU791A YU791A YU791A YU791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A YU 791 A YU791 A YU 791A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- derivatives
- azaoksindol
- diseases
- inflammatory
- azooxindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Opisani su azaoksindol derivati, bliže rečeno novi 4-, 5-, 6-, i 7-azaoksindol derivati, jedinjenja koja su antiinflamatorna i analgetička sredstva i inhibitori jedne ili više od prostaglandin H2 sintaze, 5-lipoksigenaze i interleukin-1 biosinteza, koja se upotrebljavaju za tretiranje hroničnih inflamatornih oboljenja, alergije, psorijaze, različitih oboljenja kostiju, i imunih disfunkcija kao što je sistemski lupus erithematozis.Described are azooxindole derivatives, in particular novel 4-, 5-, 6-, and 7-azaoxindole derivatives, compounds that are anti-inflammatory and analgesic agents, and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase, and interleukin-1 biosynthesis, which are used to treat chronic inflammatory diseases, allergies, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosus.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1990/000107 WO1991009598A1 (en) | 1990-01-05 | 1990-01-05 | Azaoxindole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
YU791A true YU791A (en) | 1994-01-20 |
YU47728B YU47728B (en) | 1996-01-08 |
Family
ID=22220612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU791A YU47728B (en) | 1990-01-05 | 1991-01-04 | AZAOKSINDOL DERIVATIVES |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0436333A3 (en) |
JP (1) | JPH0826018B2 (en) |
KR (1) | KR930005447B1 (en) |
CN (1) | CN1031053C (en) |
AU (1) | AU635593B2 (en) |
BR (1) | BR9100046A (en) |
CA (1) | CA2033531C (en) |
CS (1) | CS991A2 (en) |
FI (1) | FI922347A0 (en) |
IE (1) | IE910022A1 (en) |
IL (1) | IL96819A0 (en) |
MY (1) | MY109722A (en) |
NO (1) | NO922634L (en) |
NZ (1) | NZ236582A (en) |
PL (2) | PL166512B1 (en) |
PT (1) | PT96411B (en) |
WO (1) | WO1991009598A1 (en) |
YU (1) | YU47728B (en) |
ZA (1) | ZA9172B (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1625192A (en) * | 1991-05-31 | 1992-12-03 | Zeneca Limited | Heterocyclic derivatives |
GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
US5618819A (en) * | 1994-07-07 | 1997-04-08 | Adir Et Compagnie | 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds |
FR2722195B1 (en) * | 1994-07-07 | 1996-08-23 | Adir | NOVEL 1,3-DIHYDRO-2H-PYRROLO (2,3-B) PYRIDIN-2-ONES AND OXAZOLO (4,5-B) PYRIDIN-2 (3H) -ONES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS WHO CONTAIN THEM |
FR2722196B1 (en) * | 1994-07-07 | 1996-08-23 | Adir | NOVEL AMINO DERIVATIVES OF 1,3-DIHYDRO-2H-PYRROLO (2,3-B) PYRIDIN-2-ONES AND OXAZOLO (4,5-B) PYRIDIN-2 (3H) -ONES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS PHARMACEUTICAL CONTAINING THEM |
US5939069A (en) * | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
KR20010101266A (en) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 4-aryloxindoles as inhibitors of jnk protein kinases |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
JP2002532503A (en) | 1998-12-17 | 2002-10-02 | エフ.ホフマン−ラ ロシュ アーゲー | 4,5-Pyrazinooxindole as a protein kinase inhibitor |
WO2000035908A1 (en) * | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2 |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
JP2003518123A (en) | 1999-12-21 | 2003-06-03 | スージェン・インコーポレーテッド | 4-Substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
DE10053275A1 (en) * | 2000-10-27 | 2002-05-02 | Dresden Arzneimittel | New 7-aza-indole-3-carboxamides or glyoxylamides, useful e.g. for treating rheumatoid arthritis, osteoporosis, sepsis, asthma or multiple sclerosis are phosphodiesterase-4 and tumor necrosis factor-alpha inhibitors |
TWI262920B (en) | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
WO2002070478A1 (en) | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
US7291630B2 (en) * | 2002-03-28 | 2007-11-06 | Eisai Co., Ltd. | Azaindoles as inhibitors of c-Jun N-terminal kinases |
KR20070034049A (en) | 2004-06-09 | 2007-03-27 | 글락소 그룹 리미티드 | Pyrrolopyridine derivatives |
US7906528B2 (en) * | 2004-10-05 | 2011-03-15 | Novartis International Pharmaceutical Ltd. | Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds |
WO2009147476A1 (en) * | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
DE3681358D1 (en) * | 1985-07-09 | 1991-10-17 | Pfizer | SUBSTITUTED OXINDOL-3-CARBOXAMINE AS AN ANTI-INFLAMMATORY AND PAIN-RELEASING AGENT. |
WO1989012637A1 (en) * | 1988-06-14 | 1989-12-28 | Schering Corporation | Heterobicyclic compounds having antiinflammatory activity |
-
1990
- 1990-01-05 WO PCT/US1990/000107 patent/WO1991009598A1/en active Application Filing
- 1990-12-14 EP EP19900313669 patent/EP0436333A3/en not_active Withdrawn
- 1990-12-20 NZ NZ236582A patent/NZ236582A/en unknown
- 1990-12-25 JP JP2419301A patent/JPH0826018B2/en not_active Expired - Fee Related
- 1990-12-28 IL IL96819A patent/IL96819A0/en unknown
- 1990-12-31 MY MYPI90002304A patent/MY109722A/en unknown
-
1991
- 1991-01-03 AU AU68606/91A patent/AU635593B2/en not_active Ceased
- 1991-01-03 PL PL91303916A patent/PL166512B1/en not_active IP Right Cessation
- 1991-01-03 PL PL91288598A patent/PL165653B1/en not_active IP Right Cessation
- 1991-01-03 CA CA002033531A patent/CA2033531C/en not_active Expired - Fee Related
- 1991-01-03 PT PT96411A patent/PT96411B/en not_active IP Right Cessation
- 1991-01-04 IE IE002291A patent/IE910022A1/en unknown
- 1991-01-04 CN CN91100034A patent/CN1031053C/en not_active Expired - Fee Related
- 1991-01-04 ZA ZA9172A patent/ZA9172B/en unknown
- 1991-01-04 CS CS919A patent/CS991A2/en unknown
- 1991-01-04 YU YU791A patent/YU47728B/en unknown
- 1991-01-04 KR KR1019910000020A patent/KR930005447B1/en not_active IP Right Cessation
- 1991-01-07 BR BR919100046A patent/BR9100046A/en not_active Application Discontinuation
-
1992
- 1992-05-22 FI FI922347A patent/FI922347A0/en not_active Application Discontinuation
- 1992-07-03 NO NO92922634A patent/NO922634L/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT96411A (en) | 1991-10-15 |
FI922347A (en) | 1992-05-22 |
JPH04210981A (en) | 1992-08-03 |
AU6860691A (en) | 1992-03-05 |
IE910022A1 (en) | 1991-07-17 |
CS991A2 (en) | 1991-09-15 |
EP0436333A2 (en) | 1991-07-10 |
PL288598A1 (en) | 1991-12-02 |
JPH0826018B2 (en) | 1996-03-13 |
EP0436333A3 (en) | 1992-05-27 |
NZ236582A (en) | 1993-10-26 |
YU47728B (en) | 1996-01-08 |
CA2033531C (en) | 1998-06-23 |
AU635593B2 (en) | 1993-03-25 |
PL165653B1 (en) | 1995-01-31 |
KR930005447B1 (en) | 1993-06-22 |
IL96819A0 (en) | 1991-09-16 |
FI922347A0 (en) | 1992-05-22 |
PT96411B (en) | 1999-04-30 |
CA2033531A1 (en) | 1991-07-06 |
CN1031053C (en) | 1996-02-21 |
PL166512B1 (en) | 1995-05-31 |
ZA9172B (en) | 1992-10-28 |
NO922634D0 (en) | 1992-07-03 |
BR9100046A (en) | 1991-10-22 |
KR910014375A (en) | 1991-08-31 |
CN1053065A (en) | 1991-07-17 |
WO1991009598A1 (en) | 1991-07-11 |
MY109722A (en) | 1997-05-31 |
NO922634L (en) | 1992-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU791A (en) | AZAOKSINDOL DERIVATIVES | |
AR002267A1 (en) | IMIDAZOLE COMPOUNDS USEFUL FOR THE TREATMENT OF PATHOLOGIES MEDIATED BY CYTOKINES; PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM; PROCESS TO PREPARE SUCH COMPOUNDS; USE OF THE SAME TO PREPARE SUCH COMPOSITIONS; INTERMEDIATE COMPOUNDS AND PROCESSES FOR ITS PREPARATION. | |
YU6602A (en) | Pyrimidine-2,4,6-trione metalloproteinase inhibitors | |
YU64701A (en) | Compounds useful as anti-inflamatory agents | |
NO20032254L (en) | Compounds for Inhibition of Expression of VACM-I | |
DE60027016D1 (en) | USE OF CONJUGATED LINOL ATTACHMENTS FOR THE TOPIC TREATMENT OF CELLULITIS | |
YU44398A (en) | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors | |
BG103518A (en) | 2-(purin-9-yl)tetrahydrofuran-3,4-diol derivatives | |
DE68905863T2 (en) | COMPOSITIONS OF ESSENTIAL FATTY ACIDS. | |
ATE215366T1 (en) | TOPICAL COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC INFLAMMATORY DISEASES | |
MXPA05005314A (en) | Novel lapachone compounds and methods of use thereof. | |
YU47100A (en) | Novel dihydroxahexanoic acid derivatives | |
ES2138595T3 (en) | CYTOKIN INHIBITORS. | |
DE60129132D1 (en) | INHIBITORS OF ALPHA-L BETA-2 MEDIATED CELL ADHESION | |
NO20003868D0 (en) | Hydroxamic and carboxylic acid derivatives | |
CA1270834C (en) | Substituted dihydrobenzopyrans | |
ES2150705T3 (en) | USEFUL STEROID NITRITE ESTER DERIVATIVES AS ANTI-INFLAMMATORY PHARMACES. | |
BR0309386A (en) | Triaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinases inhibitors | |
DE69525740T2 (en) | Special compositions containing halofantrine | |
DK0727996T3 (en) | Fendazole formulations | |
MXPA03007413A (en) | Composition and method for treating inflammatory disorders. | |
FI950842A (en) | Novel 2-substituted tricyclic indan-2-mercaptoacetylamide derivatives useful as enkephalinase inhibitors | |
ES2056983T3 (en) | COMPOUNDS TO INHIBIT THE BIOSYNTHESIS OF METABOLITES OF ARACHIDONIC ACID DERIVED FROM LIPOXIGENASE. | |
PT841933E (en) | BOWMAN-BIRK INHIBITOR COMPOSITIONS FOR TREATMENT OF INFLAMMATORY DISEASES | |
CO4920227A1 (en) | HISTIDINA-N-BENCIL GLICINAMIDA SUBSTITUTED WITH CYCLLOALKYL. |