YU47372B - Kondenzovani diazepinoni i postupak za njihovo dobijanje - Google Patents
Kondenzovani diazepinoni i postupak za njihovo dobijanjeInfo
- Publication number
- YU47372B YU47372B YU171590A YU171590A YU47372B YU 47372 B YU47372 B YU 47372B YU 171590 A YU171590 A YU 171590A YU 171590 A YU171590 A YU 171590A YU 47372 B YU47372 B YU 47372B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- carbon atoms
- chlorine
- atom
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Kondenzovani diazepinoni opšte formule I gde je B jedan od dvovalentnih ostataka X, R, R4, R5, R6, R7, R8, m, n, o, i p imaju sledeće značenje: X je = CH - grupa ili azotov atom, R je ravan ili razgranat alkil ostatak sa 1 do 4 atoma ugljenika, koji u datom primeru može da bude supstituisan sa hlorom, bromom, fluorom, metil ili metoksi grupom, mono ili dis-supstituisanom fenil grupom. R4 i R5, koji mogu da budu isti ili različiti jedan od drugog, predstavlfjaju vodonikov, fluorov, hlorov ili bromov atom ili alkil grupu sa 1 do 4 atoma ugljenika, R6 je atom vodonika ili hlora ili metil grupa, R7 i R8, koji su jednaki ili različiti jedan od drugog, predstavljaju atome vodonika ili alkil grupe sa 1 do 4 atoma ugljenika, tada R8 može dodatno da bude i atom halogena, m, n, o i p imaju vrednost 1 do 2 pri čemu zbir m+n+o+p mora biti jednak ili manji od 6, njihovi izomeri i njihove fiziološki prihvatljive soli sa neorganskim ili organskim kiselinama. Prijava sadrži još 1 nezavisan i 4 zavisna zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3930262A DE3930262A1 (de) | 1989-09-11 | 1989-09-11 | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
YU171590A YU171590A (sh) | 1993-05-28 |
YU47372B true YU47372B (sh) | 1995-01-31 |
Family
ID=6389152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU171590A YU47372B (sh) | 1989-09-11 | 1990-09-10 | Kondenzovani diazepinoni i postupak za njihovo dobijanje |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0417631A3 (sh) |
JP (1) | JPH03209382A (sh) |
KR (1) | KR910006286A (sh) |
AU (1) | AU626452B2 (sh) |
CA (1) | CA2025005A1 (sh) |
DD (1) | DD299308A5 (sh) |
DE (1) | DE3930262A1 (sh) |
FI (1) | FI904469A0 (sh) |
HU (1) | HU206882B (sh) |
IL (1) | IL95622A (sh) |
NO (1) | NO903941L (sh) |
NZ (1) | NZ235270A (sh) |
PL (1) | PL165197B1 (sh) |
PT (1) | PT95259A (sh) |
RU (1) | RU2017740C1 (sh) |
YU (1) | YU47372B (sh) |
ZA (1) | ZA907199B (sh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3930266A1 (de) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
JP4749715B2 (ja) | 2002-07-05 | 2011-08-17 | ターガセプト,インコーポレイテッド | N−アリールジアザスピロ環式化合物、並びにその製造及び使用方法 |
SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
EA201492223A1 (ru) | 2012-06-13 | 2015-03-31 | Ф. Хоффманн-Ля Рош Аг | Новые диазаспироциклоалканы и азаспироциклоалканы |
CN104684915B (zh) | 2012-09-25 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
PE20160845A1 (es) | 2013-11-26 | 2016-09-10 | Hoffmann La Roche | Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo |
DK3122750T3 (da) | 2014-03-26 | 2019-11-04 | Hoffmann La Roche | Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere |
JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | オートタキシン(atx)及びリゾホスファチジン酸(lpa)産生の阻害剤としての縮合[1,4]ジアゼピン化合物 |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
KR20180043837A (ko) | 2015-09-04 | 2018-04-30 | 에프. 호프만-라 로슈 아게 | 페녹시메틸 유도체 |
CN107922412B (zh) | 2015-09-24 | 2021-02-23 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
RU2018114289A (ru) | 2015-09-24 | 2019-10-24 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов аутотаксина (atx) |
CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
WO2018167001A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
CA3072766A1 (en) * | 2017-09-05 | 2019-03-14 | Blackthorn Therapeutics, Inc. | 2,6-diazaspiro[3.3]hepatan-2-yl derivatives and pharmaceutical compostions thereof useful as vasopressin receptor antagonists |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4210648A (en) * | 1977-05-31 | 1980-07-01 | Boehringer Ingelheim Gmbh | II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and salts thereof |
DE3204153A1 (de) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
DE3204403A1 (de) * | 1982-02-09 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
DE3726908A1 (de) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3930266A1 (de) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1989
- 1989-09-11 DE DE3930262A patent/DE3930262A1/de not_active Withdrawn
-
1990
- 1990-09-05 EP EP19900117078 patent/EP0417631A3/de not_active Withdrawn
- 1990-09-10 IL IL9562290A patent/IL95622A/en not_active IP Right Cessation
- 1990-09-10 DD DD90343932A patent/DD299308A5/de not_active IP Right Cessation
- 1990-09-10 CA CA002025005A patent/CA2025005A1/en not_active Abandoned
- 1990-09-10 NO NO90903941A patent/NO903941L/no unknown
- 1990-09-10 HU HU905852A patent/HU206882B/hu not_active IP Right Cessation
- 1990-09-10 YU YU171590A patent/YU47372B/sh unknown
- 1990-09-10 PT PT95259A patent/PT95259A/pt not_active Application Discontinuation
- 1990-09-11 NZ NZ235270A patent/NZ235270A/xx unknown
- 1990-09-11 FI FI904469A patent/FI904469A0/fi not_active Application Discontinuation
- 1990-09-11 AU AU62352/90A patent/AU626452B2/en not_active Ceased
- 1990-09-11 ZA ZA907199A patent/ZA907199B/xx unknown
- 1990-09-11 PL PL90286835A patent/PL165197B1/pl unknown
- 1990-09-11 KR KR1019900014616A patent/KR910006286A/ko not_active Application Discontinuation
- 1990-09-11 JP JP2241064A patent/JPH03209382A/ja active Pending
-
1992
- 1992-03-18 RU SU925011116A patent/RU2017740C1/ru active
Also Published As
Publication number | Publication date |
---|---|
ZA907199B (en) | 1992-05-27 |
CA2025005A1 (en) | 1991-03-12 |
KR910006286A (ko) | 1991-04-29 |
EP0417631A3 (en) | 1991-12-11 |
AU626452B2 (en) | 1992-07-30 |
PT95259A (pt) | 1991-05-22 |
RU2017740C1 (ru) | 1994-08-15 |
DD299308A5 (de) | 1992-04-09 |
IL95622A0 (en) | 1991-06-30 |
YU171590A (sh) | 1993-05-28 |
AU6235290A (en) | 1991-03-14 |
HU206882B (en) | 1993-01-28 |
PL165197B1 (pl) | 1994-11-30 |
DE3930262A1 (de) | 1991-03-21 |
NZ235270A (en) | 1991-11-26 |
IL95622A (en) | 1994-04-12 |
HU905852D0 (en) | 1991-03-28 |
FI904469A0 (fi) | 1990-09-11 |
EP0417631A2 (de) | 1991-03-20 |
HUT55393A (en) | 1991-05-28 |
PL286835A1 (en) | 1991-08-26 |
NO903941L (no) | 1991-03-12 |
JPH03209382A (ja) | 1991-09-12 |
NO903941D0 (no) | 1990-09-10 |
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