YU46441B - Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona - Google Patents

Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona

Info

Publication number
YU46441B
YU46441B YU36288A YU36288A YU46441B YU 46441 B YU46441 B YU 46441B YU 36288 A YU36288 A YU 36288A YU 36288 A YU36288 A YU 36288A YU 46441 B YU46441 B YU 46441B
Authority
YU
Yugoslavia
Prior art keywords
decan
aza
dione
piperazinyl
spiro
Prior art date
Application number
YU36288A
Other languages
English (en)
Other versions
YU36288A (en
Inventor
Z. Budai
L. Gregor
T. Mezei
K. Reiter
E.J. Tajthy
Original Assignee
Egis Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU71787A external-priority patent/HU198204B/hu
Priority claimed from HU71887A external-priority patent/HU198477B/hu
Priority claimed from HU71687A external-priority patent/HU197313B/hu
Application filed by Egis Gyogyszergyar filed Critical Egis Gyogyszergyar
Publication of YU36288A publication Critical patent/YU36288A/xx
Publication of YU46441B publication Critical patent/YU46441B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 8{-/4-(2-PIRIMIDINIL)-1-PIPERAZINIL/BUTIL}-8-AZA-1-SPIRO/4,5/-DEKAN-7,9-DIONA, formule I i njegove farmaceutski prihvatljive adicione soli kiseline, naznačen time, što obuhvata hidrogenovanje jedinjenja opšte formule II (gde A je -C=C- ili -CH=CH-) i, ako se želi, prevodenje jedinjenja formule I tako dobijenog u farmaceutski prihvatljivu adicionih soli kiseline. -Prijava sadrži još 9 zavisnih zahteva.
YU36288A 1987-02-25 1988-02-25 Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona YU46441B (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU71787A HU198204B (en) 1987-02-25 1987-02-25 Process for production of derivatives of piperasine
HU71887A HU198477B (en) 1987-02-25 1987-02-25 Process for producing pyrimidinyl piperazine derivatives
HU71687A HU197313B (en) 1987-02-25 1987-02-25 Process for producing 8-azaspiro <4.5> decane-7,9-dione-8-propine-/2/

Publications (2)

Publication Number Publication Date
YU36288A YU36288A (en) 1989-10-31
YU46441B true YU46441B (sh) 1993-10-20

Family

ID=27269942

Family Applications (1)

Application Number Title Priority Date Filing Date
YU36288A YU46441B (sh) 1987-02-25 1988-02-25 Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona

Country Status (20)

Country Link
KR (1) KR880009955A (sh)
CN (1) CN88100923A (sh)
AT (1) AT395851B (sh)
BE (1) BE1001464A3 (sh)
CA (1) CA1300141C (sh)
CH (1) CH677924A5 (sh)
CS (1) CS274423B2 (sh)
DE (1) DE3806009C2 (sh)
DK (1) DK99388A (sh)
ES (1) ES2009236A6 (sh)
FI (1) FI880895A (sh)
FR (1) FR2615853B1 (sh)
GB (1) GB2201417B (sh)
GR (1) GR1002245B (sh)
IL (1) IL85545A (sh)
IT (1) IT1217342B (sh)
NL (1) NL8800484A (sh)
PL (1) PL152958B1 (sh)
SE (1) SE8800651L (sh)
YU (1) YU46441B (sh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217129B (hu) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545543B1 (de) * 1964-07-03 1970-01-22 Astra Apotekarnes Kem Fab 4-Aminobutinylimide,ihre Salze und Verfahren zu deren Herstellung
SE300422B (sh) * 1964-07-03 1968-04-29 Astra Ab
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法

Also Published As

Publication number Publication date
FR2615853A1 (fr) 1988-12-02
GB2201417B (en) 1990-10-31
SE8800651D0 (sv) 1988-02-25
PL270815A1 (en) 1989-04-03
GR880100108A (el) 1988-12-16
FI880895A (fi) 1988-08-26
CN88100923A (zh) 1988-09-28
KR880009955A (ko) 1988-10-06
IT8819545A0 (it) 1988-02-25
DE3806009C2 (de) 1996-09-12
FI880895A0 (fi) 1988-02-25
GB8804385D0 (en) 1988-03-23
CS122288A2 (en) 1990-08-14
FR2615853B1 (fr) 1991-01-04
SE8800651L (sv) 1988-08-26
BE1001464A3 (fr) 1989-11-07
DE3806009A1 (de) 1988-09-08
GR1002245B (en) 1996-04-22
IL85545A0 (en) 1988-08-31
NL8800484A (nl) 1988-09-16
ATA47688A (de) 1992-08-15
GB2201417A (en) 1988-09-01
IT1217342B (it) 1990-03-22
CA1300141C (en) 1992-05-05
CS274423B2 (en) 1991-04-11
PL152958B1 (en) 1991-02-28
DK99388A (da) 1988-08-26
ES2009236A6 (es) 1989-09-16
CH677924A5 (sh) 1991-07-15
YU36288A (en) 1989-10-31
DK99388D0 (da) 1988-02-25
IL85545A (en) 1992-05-25
AT395851B (de) 1993-03-25

Similar Documents

Publication Publication Date Title
RS49531B (sr) Estrogen agonisti/antagonisti
BE900038A (fr) Agents antidepression a base de 1,2,4-triazol-3-one.
DE69329296T2 (de) Pyrazolopyrimidine als crf antagonisten
NO303223B1 (no) AnalogifremgangsmÕte for fremstilling av terapeutisk aktive bis-benzo- eller benzopyridocykloheptapiperiden-, piperidyliden- og piperazinforbindelser
GR930100279A (el) Μέ?οδος για την παρασκευή Ν-με?ύλ-3-φαινύλ-3-[4-(τριφ?οριομε?υλ) φαινοξύ] προπυλαμίνης και αλάτων δια προσ?ήκης οξέος αυτής.
CA2096611A1 (en) 4-benzylpiperidine derivatives and process for their production
ES2004386A6 (es) Un procedimiento para producir un nuevo derivado de difluorohalometoxifenilo
EG19361A (en) A process for the preparation of piperidine compound having local anaesthetica and analgetic
ES8607218A1 (es) Un procedimiento para preparar compuestos de amidina
AU541413B2 (en) 2-(1,4-benzodioxan-2-ylalicyl)imidazoles
YU46441B (sh) Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona
AU2001293856A1 (en) A process for the preparation of pantoprazole and intermediates therefor
IL88085A (en) Pyrimidinyl-piperazine propanes and anti-anxiety compositions comprising them
EP0331078A3 (en) Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
ES8801615A1 (es) Un procedimiento para preparar esteres de acidos ciclopropanocarboxolico que contienen fluor.
EA199900667A1 (ru) Замещенный 4-(6-фтор-(1h)-индол-3-ил)-1,2,3,6-тетрагидропиридин для лечения нарушений цнс
AU3694997A (en) The preparation of 3-pyrroline-2-carboxylic acid derivatives
EP0245004A3 (en) Antihypercholesterolemic compounds
MY116365A (en) Process for the preparation of the (-)-n-methyl-n [4-(4-phenyl-4-acetyl-aminopiperidin-1-yl)-2-(3,4-dichlorophenyl) butyl]-benzamide and its pharmaceutically acceptable salts
ES2150564T3 (es) Proceso para la preparacion de derivados de 5,6-dihidroxi-2-amino-1,2,3,4-tetrahidronaftaleno.
CA2042473A1 (en) Piperidino-nmda antagonists
AU585378B2 (en) Process for preparing 2-acyl-3,4-dialkoxyanilines
ATE129702T1 (de) Sulfonamidderivat und dieses enthaltende arzneimittel.
ES8706663A1 (es) Procedimiento para la obtencion de 2-tiocromenilidenacetoacetatos
ES2162550A1 (es) Procedimiento de preparacion de 3-hidroximetilquinuclidina.