YU45803A - Tetralon derivati kao sredstva protiv tumora - Google Patents

Tetralon derivati kao sredstva protiv tumora

Info

Publication number
YU45803A
YU45803A YU45803A YUP45803A YU45803A YU 45803 A YU45803 A YU 45803A YU 45803 A YU45803 A YU 45803A YU P45803 A YUP45803 A YU P45803A YU 45803 A YU45803 A YU 45803A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
amino
hydrogen
compounds
antitumor agents
Prior art date
Application number
YU45803A
Other languages
English (en)
Inventor
Guy Georges
Adelbert Grossmann
Tim Sattelkau
Wolfgang Schaefer
Ulrich Tibes
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU45803A publication Critical patent/YU45803A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Jedinjenja formule (I) gde R1,R2, R3, R4, R5, X i Y imaju znacenja data ispod, postupak za proizvodnju ovih jedinjenja i farmaceutski preparati koji sadrze takvo jedinjenje sa HDAC inhibitorskom aktivnosti. R1 je izabran od vodonika, (1-4C)alkila, COOH, COO(1-4C)alkila; R2, R3, R4, R5 su nezavisno izabrani od vodonika, halogena, (1-4C)alkil-, trifluormetil-, hidroksi-, (1-4C)alkoksi-, ariloksi-, arilalkiloksi-, nitro-, amino-, (1-4C)alkilamino-, di[(1-4C)alkil]-amino, piperidin, morfolin, pirolidin, (1-4C)alkanoilamino-, ili aril grupe, ili heteroaril grupe, ili R2 i R3 zajedno ili R3 i R4 zajedno ili R4 i R5 zajedno, sledstveno, mogu da cine (1-3C)alkilendioksi prsten, ili R2 i R3 zajedno ili R3 i R4 zajedno ili R4 i R5 zajedno, sledstveno mogu da cine (3-5C)alkilen lanac. Y je -CH2-CH2-. x je alkilen - lanac od 4 do 10 ugljenikova atoma koji moze biti zasicen ili nezasicen sa jednom ili dve dvostruke veze ili jednom ili dve trostruke veze ili jednom dvostrukom i jednom trostrukom vezom, i koji moze biti razgranat ili nerazgranat ili prekinut sa (3-7C)cikloalkil prstenom.
YU45803A 2000-12-07 2001-12-06 Tetralon derivati kao sredstva protiv tumora YU45803A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00126820 2000-12-07

Publications (1)

Publication Number Publication Date
YU45803A true YU45803A (sh) 2006-05-25

Family

ID=8170594

Family Applications (1)

Application Number Title Priority Date Filing Date
YU45803A YU45803A (sh) 2000-12-07 2001-12-06 Tetralon derivati kao sredstva protiv tumora

Country Status (26)

Country Link
US (1) US6531472B2 (sh)
EP (1) EP1349830A1 (sh)
JP (1) JP4091431B2 (sh)
KR (1) KR20030077551A (sh)
CN (1) CN100340545C (sh)
AR (1) AR035659A1 (sh)
AU (2) AU2002216074C1 (sh)
BG (1) BG107889A (sh)
BR (1) BR0115988A (sh)
CA (1) CA2430355A1 (sh)
CZ (1) CZ20031833A3 (sh)
EC (1) ECSP034642A (sh)
HK (1) HK1060875A1 (sh)
HR (1) HRP20030451A2 (sh)
HU (1) HUP0400579A2 (sh)
IL (1) IL156133A0 (sh)
MA (1) MA26972A1 (sh)
MX (1) MXPA03004947A (sh)
NO (1) NO20032531L (sh)
NZ (1) NZ526051A (sh)
PL (1) PL365324A1 (sh)
RU (1) RU2288220C2 (sh)
SK (1) SK8512003A3 (sh)
WO (1) WO2002046144A1 (sh)
YU (1) YU45803A (sh)
ZA (1) ZA200304262B (sh)

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CN102188415A (zh) 2003-08-26 2011-09-21 默克Hdac研究有限责任公司 用hdac抑制剂治疗癌症的方法
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Also Published As

Publication number Publication date
NO20032531D0 (no) 2003-06-04
NZ526051A (en) 2004-12-24
EP1349830A1 (en) 2003-10-08
ECSP034642A (es) 2003-07-25
NO20032531L (no) 2003-06-04
AU1607402A (en) 2002-06-18
CN100340545C (zh) 2007-10-03
HUP0400579A2 (hu) 2004-06-28
WO2002046144A1 (en) 2002-06-13
US20020065282A1 (en) 2002-05-30
BG107889A (bg) 2004-06-30
JP4091431B2 (ja) 2008-05-28
MXPA03004947A (es) 2003-09-10
HRP20030451A2 (en) 2005-04-30
CA2430355A1 (en) 2002-06-13
KR20030077551A (ko) 2003-10-01
MA26972A1 (fr) 2004-12-20
HK1060875A1 (en) 2004-08-27
CZ20031833A3 (cs) 2004-02-18
ZA200304262B (en) 2004-08-30
BR0115988A (pt) 2004-01-13
AU2002216074C1 (en) 2006-12-07
PL365324A1 (en) 2004-12-27
AR035659A1 (es) 2004-06-23
IL156133A0 (en) 2003-12-23
CN1478072A (zh) 2004-02-25
SK8512003A3 (en) 2004-04-06
JP2004515488A (ja) 2004-05-27
AU2002216074B2 (en) 2006-01-05
US6531472B2 (en) 2003-03-11
RU2288220C2 (ru) 2006-11-27

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