ES2001166A6 - Procedimiento para preparar nuevos prostadienoatos - Google Patents

Procedimiento para preparar nuevos prostadienoatos

Info

Publication number
ES2001166A6
ES2001166A6 ES8600630A ES8600630A ES2001166A6 ES 2001166 A6 ES2001166 A6 ES 2001166A6 ES 8600630 A ES8600630 A ES 8600630A ES 8600630 A ES8600630 A ES 8600630A ES 2001166 A6 ES2001166 A6 ES 2001166A6
Authority
ES
Spain
Prior art keywords
methyl
prostadienoates
dihydroxy
oxo
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600630A
Other languages
English (en)
Inventor
Brawner Floyd Middleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES2001166A6 publication Critical patent/ES2001166A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS PROTADIENOATOS, DE FORMULA EN DONDE N Y M REPRESENTAN ENTEROS DE 2 A 4 INCLUSIVE Y R3 ES UN RADICAL MONOVALENTE SELECCIONADO ENTRE HIDROGENO, TRIALQUIL (1-4C) SILILO Y ALQUILO 1-6C, TRATANDO DIALQUILACETAL DE FURFURILO DE FORMULA EN DONDE R1 SE ELIGE ENTRE HIDROGENO Y ALQUILO 1-4C, CON BROMURO DE PROPARGIL ALUMINO, HACIENDOLE REACCIONAR CON UNA AMIDA DE METAL ALCALINO EN AMONIACO LIQUIDO PARA LUEGO SOMETERLE DE METAL ALCALINO EN AMONIACO LIQUIDO PARA LUEGO SOMETERLE A HIDROLISIS; ISOMORIZANDO A CONTINUACION LA 3-HIDROXICICLOPENTENONA OBTENIDA Y ESTERIFICANDO EL ACIDO CARBOXILICO PRODUCIDO, PROTEGIENDO EL GRUPO HIDROXI DEL COMPUESTO OBTENIDO CON UN GRUPO BLOQUEANTE PARA LUEGO SOMETERLE A HIDROGENACION CATALITICA PARCIAL Y A HIDROLISIS. ESTOS COMPUESTOS SON APTOS COMO AGENTES HIPOTENSIVOS Y VASODILATADORES. PROCEDIMIENTO PARA PREPARAR NUEVOS PROSTADIENOATOS.
ES8600630A 1985-07-29 1986-07-28 Procedimiento para preparar nuevos prostadienoatos Expired ES2001166A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76002385A 1985-07-29 1985-07-29

Publications (1)

Publication Number Publication Date
ES2001166A6 true ES2001166A6 (es) 1988-05-01

Family

ID=25057818

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600630A Expired ES2001166A6 (es) 1985-07-29 1986-07-28 Procedimiento para preparar nuevos prostadienoatos

Country Status (6)

Country Link
EP (1) EP0213313A3 (es)
JP (1) JPS6229568A (es)
AU (1) AU591920B2 (es)
DK (1) DK355786A (es)
ES (1) ES2001166A6 (es)
HU (1) HU196778B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6256469A (ja) * 1985-09-06 1987-03-12 ジ−．デイ．サ−ル　アンド　コンパニ− 新規プロスタグランジン誘導体
JPH0731026B2 (ja) * 1993-06-25 1995-04-10 昭和アルミニウム株式会社 ヒート・パイプ
DK1224168T3 (da) * 1999-10-07 2006-12-11 Phytera Inc Antifungale enediyner

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5422342A (en) * 1977-07-19 1979-02-20 American Cyanamid Co 155deoxyy166hydroxyy166substitutedd prostanate homologue thereof and imtermediate and process for preparing same
US4254278A (en) * 1979-09-27 1981-03-03 American Cyanamid Company 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins
US4529812A (en) * 1983-02-02 1985-07-16 G. D. Searle & Co. 3-Oxaprostaglandins
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins

Also Published As

Publication number Publication date
HUT44024A (en) 1988-01-28
HU196778B (en) 1989-01-30
DK355786A (da) 1987-01-30
EP0213313A3 (en) 1988-09-14
EP0213313A2 (en) 1987-03-11
AU591920B2 (en) 1989-12-21
DK355786D0 (da) 1986-07-25
JPS6229568A (ja) 1987-02-07
AU6062086A (en) 1987-02-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19940729