ES8705363A1 - Un procedimiento para preparar derivados de tetrahidronaftaleno - Google Patents

Un procedimiento para preparar derivados de tetrahidronaftaleno

Info

Publication number
ES8705363A1
ES8705363A1 ES552087A ES552087A ES8705363A1 ES 8705363 A1 ES8705363 A1 ES 8705363A1 ES 552087 A ES552087 A ES 552087A ES 552087 A ES552087 A ES 552087A ES 8705363 A1 ES8705363 A1 ES 8705363A1
Authority
ES
Spain
Prior art keywords
hydrogen
hypertension
treatment
alkyl
tetrahydronaphthalenols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552087A
Other languages
English (en)
Other versions
ES552087A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES552087A0 publication Critical patent/ES552087A0/es
Publication of ES8705363A1 publication Critical patent/ES8705363A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE TETRAHIDRONAFTALENO. CONSISTE EN HACER REACCIONAR EL ISOMERO CIS DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA OBTENER DERIVADOS DE TETRAHIDRONAFTALENO DE FORMULA (I) DONDE R1 ES H O METILO; R3 Y R4 SON CADA UNO ARILO O CICLOALQUILO, O R3 ES H O ALQUILO Y R4 ES CICLOALQUILO O 9H-FLUOREN-9-ILO, O R3 ES H O ALQUILO Y R4 ES HETEROARILO; R5 Y R6 SON IGUALES O DIFERENTES Y SON CADA UNO H, HIDROXI, ALCOXI O ALCANOILO; Y N ES 1, 2, 3 O 4. TIENEN APLICACIONES FARMACOLOGICAS PARA DISMINUIR LA TENSION SANGUINEA DE UN HUESPED HIPERTENSO.
ES552087A 1984-05-17 1986-02-17 Un procedimiento para preparar derivados de tetrahidronaftaleno Expired ES8705363A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61125884A 1984-05-17 1984-05-17

Publications (2)

Publication Number Publication Date
ES552087A0 ES552087A0 (es) 1987-05-01
ES8705363A1 true ES8705363A1 (es) 1987-05-01

Family

ID=24448300

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543242A Expired ES8701144A1 (es) 1984-05-17 1985-05-17 Un procedimiento para preparar un derivado de tetrahidronaf-taleno
ES552087A Expired ES8705363A1 (es) 1984-05-17 1986-02-17 Un procedimiento para preparar derivados de tetrahidronaftaleno

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES543242A Expired ES8701144A1 (es) 1984-05-17 1985-05-17 Un procedimiento para preparar un derivado de tetrahidronaf-taleno

Country Status (13)

Country Link
EP (1) EP0163458A1 (es)
JP (1) JPS60260546A (es)
KR (1) KR910002944B1 (es)
AU (1) AU573828B2 (es)
DK (1) DK219885A (es)
ES (2) ES8701144A1 (es)
FI (1) FI851969L (es)
GR (1) GR851204B (es)
HU (1) HUT38298A (es)
IL (1) IL75224A (es)
NZ (1) NZ212112A (es)
PT (1) PT80481B (es)
ZA (1) ZA853759B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3765206D1 (de) * 1986-07-28 1990-10-31 Whitby Research Inc Substituierte 2-aminotetraline.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267373A (en) * 1972-07-03 1981-05-12 E. R. Squibb & Sons, Inc. 5,6,7,8-Tetrahydronaphthalene hypotensive agents
US3930022A (en) * 1972-07-03 1975-12-30 Squibb & Sons Inc Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia
GB1442851A (en) * 1973-07-09 1976-07-14 Squibb & Sons Inc Substituted cyclic polymethylene phenols
AU8194275A (en) * 1974-06-17 1976-12-16 Takeda Chemical Industries Ltd Aminotetralin compounds
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
NZ213651A (en) * 1984-10-11 1989-07-27 Hoffmann La Roche Tetrahydronapthalene derivatives and medicaments

Also Published As

Publication number Publication date
KR910002944B1 (ko) 1991-05-11
FI851969A0 (fi) 1985-05-17
EP0163458A1 (en) 1985-12-04
JPS60260546A (ja) 1985-12-23
AU573828B2 (en) 1988-06-23
IL75224A0 (en) 1985-09-29
PT80481A (en) 1985-06-01
ES543242A0 (es) 1986-11-16
FI851969L (fi) 1985-11-18
ES552087A0 (es) 1987-05-01
DK219885D0 (da) 1985-05-17
PT80481B (en) 1987-01-15
ZA853759B (en) 1986-01-29
ES8701144A1 (es) 1986-11-16
AU4254785A (en) 1985-11-21
NZ212112A (en) 1988-10-28
GR851204B (es) 1985-11-25
HUT38298A (en) 1986-05-28
IL75224A (en) 1988-11-15
DK219885A (da) 1985-11-18
KR850008659A (ko) 1985-12-21

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