YU43866B - Process for obtaining 1,3-disubstituted 2-oxindoles - Google Patents

Process for obtaining 1,3-disubstituted 2-oxindoles

Info

Publication number
YU43866B
YU43866B YU180/85A YU18085A YU43866B YU 43866 B YU43866 B YU 43866B YU 180/85 A YU180/85 A YU 180/85A YU 18085 A YU18085 A YU 18085A YU 43866 B YU43866 B YU 43866B
Authority
YU
Yugoslavia
Prior art keywords
oxindoles
disubstituted
obtaining
Prior art date
Application number
YU180/85A
Other languages
English (en)
Other versions
YU18085A (en
Inventor
S B Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of YU18085A publication Critical patent/YU18085A/xx
Publication of YU43866B publication Critical patent/YU43866B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
YU180/85A 1984-02-07 1985-02-06 Process for obtaining 1,3-disubstituted 2-oxindoles YU43866B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57790384A 1984-02-07 1984-02-07

Publications (2)

Publication Number Publication Date
YU18085A YU18085A (en) 1988-04-30
YU43866B true YU43866B (en) 1989-12-31

Family

ID=24310612

Family Applications (3)

Application Number Title Priority Date Filing Date
YU180/85A YU43866B (en) 1984-02-07 1985-02-06 Process for obtaining 1,3-disubstituted 2-oxindoles
YU129087A YU46320B (sh) 1984-02-07 1987-07-09 Postupak za dobijanje 3-supstituisanih 2-oksindola
YU1981/87A YU44062B (en) 1984-02-07 1987-10-30 Process for obtaining 1,3-disubstituted 2-oxindols

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU129087A YU46320B (sh) 1984-02-07 1987-07-09 Postupak za dobijanje 3-supstituisanih 2-oksindola
YU1981/87A YU44062B (en) 1984-02-07 1987-10-30 Process for obtaining 1,3-disubstituted 2-oxindols

Country Status (14)

Country Link
US (1) US4658037A (ko)
JP (1) JPS60248669A (ko)
KR (2) KR880000433B1 (ko)
BG (3) BG44204A3 (ko)
CS (1) CS252480B2 (ko)
DD (2) DD234417A5 (ko)
HU (1) HU194166B (ko)
IN (1) IN163263B (ko)
MW (1) MW185A1 (ko)
PL (3) PL145196B1 (ko)
RO (2) RO93218B (ko)
YU (3) YU43866B (ko)
ZA (1) ZA85888B (ko)
ZM (1) ZM785A1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5086186A (en) * 1989-05-25 1992-02-04 Pfizer Inc. N-trichloroacetyl-2-oxindole-1-carboxamides
US4952703A (en) * 1989-05-25 1990-08-28 Pfizer Inc. Intermediates for making 2-oxindole-1-carboxamides
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
ES2097025T3 (es) * 1993-02-09 1997-03-16 Pfizer Oxindol 1-(n-(alcoxicarbonil))carboxamidas y 1-(n-carboxamido)carboxamidas como agentes antiinflamatorios.
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP2009040790A (ja) * 2008-08-29 2009-02-26 Ube Ind Ltd ５−フルオロオキシインドールの製造法
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103570604B (zh) * 2012-07-21 2015-10-07 重庆圣华曦药业股份有限公司 齐拉西酮中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462450A (en) * 1966-06-29 1969-08-19 Merck & Co Inc Chemical compounds
GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
US3631177A (en) * 1967-04-18 1971-12-28 Smith Kline French Lab 3-phenacyl-2-oxoindolines
US3519592A (en) * 1967-04-18 1970-07-07 Smithkline Corp Indole compounds
BE714717A (ko) * 1967-05-12 1968-09-30
FR7337M (ko) * 1968-01-11 1969-10-13
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones

Also Published As

Publication number Publication date
IN163263B (ko) 1988-08-27
ZM785A1 (en) 1985-08-22
KR880000433B1 (ko) 1988-03-24
CS252480B2 (en) 1987-09-17
RO93218A (ro) 1987-12-31
BG40963A3 (en) 1987-03-14
PL255465A1 (en) 1986-07-15
CS78585A2 (en) 1987-01-15
KR850005824A (ko) 1985-09-26
RO93218B (ro) 1988-01-01
YU18085A (en) 1988-04-30
YU46320B (sh) 1993-05-28
DD234417A5 (de) 1986-04-02
YU198187A (en) 1988-10-31
KR880000434B1 (ko) 1988-03-24
JPS60248669A (ja) 1985-12-09
YU129087A (en) 1988-02-29
MW185A1 (en) 1986-04-09
BG43865A3 (en) 1988-08-15
HU194166B (en) 1988-01-28
BG44204A3 (en) 1988-10-14
DD244133A5 (de) 1987-03-25
PL145196B1 (en) 1988-08-31
RO90621A2 (ro) 1986-12-10
JPH0413340B2 (ko) 1992-03-09
US4658037A (en) 1987-04-14
ZA85888B (en) 1986-09-24
YU44062B (en) 1990-02-28
PL251869A1 (en) 1985-12-17
PL145230B1 (en) 1988-08-31
PL145310B1 (en) 1988-09-30

Similar Documents

Publication Publication Date Title
GB2159520B (en) 1, 24-dihydroxy- 22-vitamin d3 and process for preparing same
YU43866B (en) Process for obtaining 1,3-disubstituted 2-oxindoles
PT81018B (en) Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3--benzazepine
PT80956A (en) Process for preparing 1,4-dihydropyridines
YU45251B (en) Process for obtaining hydroxi-4-2h-1-benzothiopyran-2 one
HUT39168A (en) Process for preparing 1,3-oxazolidin-2-one-derivatives
HUT39410A (en) Process for preparing 2,4-dichloro-5-fluoro-benzoic acid
YU18185A (en) Process for preparing new 1,3,2-dioxaborinanes
YU167087A (en) Process for obtaining 4,4-dialkyl-2-azetidinone
DE3568327D1 (en) Process for the preparation of 2,3,5-trimethylbenzoquinone
YU69785A (en) Process for obtaining l-carnityne
EP0174375A4 (en) PRODUCTION PROCESS FOR N-ACYLPHENYLALANINE.
YU43585B (en) Process for making 1,1-dioxopenicilano-iloximethyl-6-(2-amino-2-phenylacetamido) penicilanate
HUT39442A (en) Process for preparing 1,3-disubstituted tetrahydro-pyridines
DE3564940D1 (en) Method for preparing 2,2,6,6-tetramethyl-4-oxopiperidine
DE3569366D1 (en) Process for producing 4,4'-dihydroxydiphenyls
PT80104A (en) Process for preparing 1,2,4-triazacycloalkadiene derivatives
DE3560069D1 (en) Process for preparing 2,6-dichloro-4-nitro-aniline
HUT38906A (en) Process for preparing 1,3-oxyacyl-2-oxindole derivatives
GB2185035B (en) Process for preparing 1,4-diaminoanthraquinone-2,3-disubstituted compound
YU192682A (en) Process for obtaining new 1,2,3-thiadiazole-5-yl-carbamides
GB2158434B (en) Process for preparing2,2-bishalomethylpenam derivatives
DE3264300D1 (en) Process for making substituted 1,11-diaminoundecanes
DE3566539D1 (en) Process for preparing 2,2,6,6-tetramethyl-4-oxopiperidine
YU102587A (en) Process for obtaining substituted ethandiimidamides