YU40592A - Estri fenolnih 2-piperidino-1-alkanola - Google Patents
Estri fenolnih 2-piperidino-1-alkanolaInfo
- Publication number
- YU40592A YU40592A YU40592A YU40592A YU40592A YU 40592 A YU40592 A YU 40592A YU 40592 A YU40592 A YU 40592A YU 40592 A YU40592 A YU 40592A YU 40592 A YU40592 A YU 40592A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkanols
- esters
- piperidino
- phenol
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Abstract
ESTRI FENOLNIH 2-PIPERADINO-1-ALKANOLA, opisana su jedinjenja fomula gde E predstavlja R je H, (C1-C6)alkil, (C2-C6)alkenil ili (C2-C6)alkinil; X je fenil, benzil, (C1-C3)alkoksi ili fenoksi; kada ili su Y i Y1 ili Y2 i Y3 uzeti zajedno, predstavljaju gde je n = 0, 1, 2 ili 3; X1 je H, (C1-C3)alkil, (C1-C3)alkoksi ili halo, Q je S ili CH=CH; ili kada su Y i Y1 uzeti odvojeno, Y je H ili OH, a Y1 je gde je m = 0, 1, 2, 3 ili 4; a X1 i Q kao što je definisano; ili Y je vodonik i Y1 je gde Z je O, S, SO ili SO2, a X1 i Q kao što je definisano, kada su Y2 i Y3 uzeti odvojeno, a Y2 je OH i Y3 je Y9 je gde m, X1 i Q su kao što je definisano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68727391A | 1991-04-18 | 1991-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU40592A true YU40592A (sh) | 1994-12-28 |
Family
ID=24759771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU40592A YU40592A (sh) | 1991-04-18 | 1992-04-17 | Estri fenolnih 2-piperidino-1-alkanola |
Country Status (19)
Country | Link |
---|---|
US (3) | US5455250A (sh) |
EP (1) | EP0584192A1 (sh) |
JP (1) | JPH0788355B2 (sh) |
CN (1) | CN1065866A (sh) |
AU (1) | AU654554B2 (sh) |
BR (1) | BR9205893A (sh) |
CA (1) | CA2108557A1 (sh) |
CZ (1) | CZ390792A3 (sh) |
DE (1) | DE9290042U1 (sh) |
FI (1) | FI934566A0 (sh) |
HU (1) | HUT65836A (sh) |
IE (1) | IE921215A1 (sh) |
IL (1) | IL101546A0 (sh) |
NO (1) | NO933723L (sh) |
NZ (1) | NZ242391A (sh) |
PT (1) | PT100394A (sh) |
WO (1) | WO1992018502A1 (sh) |
YU (1) | YU40592A (sh) |
ZA (1) | ZA922811B (sh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594007A (en) * | 1991-04-18 | 1997-01-14 | Pfizer Inc. | Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols |
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
KR100224961B1 (ko) * | 1994-08-18 | 1999-10-15 | 디. 제이. 우드 | 신경보호성 3-(피페리디닐-1)-크로만-4,7-디올 및 1-(4-하이드로페닐)-2-(피페리디닐-1)-알칸올 유도체 |
RU2176145C2 (ru) | 1995-05-26 | 2001-11-27 | Пфайзер Инк. | Синергическое лечение паркинсонизма |
TW450807B (en) * | 1995-09-15 | 2001-08-21 | Pfizer | Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents |
US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
AU1201101A (en) | 1999-10-15 | 2001-04-30 | Du Pont Pharmaceuticals Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US6784200B2 (en) | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
JP2003512422A (ja) | 1999-10-29 | 2003-04-02 | メルク シャープ エンド ドーム リミテッド | ベンズイミダゾールnmda/nr2bアンタゴニストを使用する疼痛の治療方法 |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
EP1379520B2 (en) | 2001-02-23 | 2014-04-09 | Merck Sharp & Dohme Corp. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
AU2002338334B8 (en) | 2001-04-03 | 2008-09-18 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists |
US8648198B2 (en) | 2011-01-19 | 2014-02-11 | Cold Spring Harbor Laboratory | Phenylethanolamine-based NMDA receptor antagonists |
US11931428B2 (en) | 2019-08-23 | 2024-03-19 | Wake Forest University Health Sciences | Selective hydrogen sulfide probe and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3294804A (en) * | 1961-01-27 | 1966-12-27 | Sterling Drug Inc | 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine |
FR5733M (sh) * | 1966-09-27 | 1968-01-22 | ||
DE3045688A1 (de) * | 1980-12-04 | 1982-07-08 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung |
FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
SK232890A3 (en) * | 1989-05-17 | 1998-11-04 | Pfizer | 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof |
US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
RU2099339C1 (ru) * | 1990-02-06 | 1997-12-20 | Пфайзер Инк. | Производные пиперидина |
ES2146578T3 (es) * | 1990-05-10 | 2000-08-16 | Pfizer | Indolona neuroprotectora y derivados relacionados. |
-
1992
- 1992-03-24 HU HU9302928A patent/HUT65836A/hu unknown
- 1992-03-24 US US08/119,122 patent/US5455250A/en not_active Expired - Fee Related
- 1992-03-24 WO PCT/US1992/002131 patent/WO1992018502A1/en not_active Application Discontinuation
- 1992-03-24 JP JP4509961A patent/JPH0788355B2/ja not_active Expired - Fee Related
- 1992-03-24 CA CA002108557A patent/CA2108557A1/en not_active Abandoned
- 1992-03-24 BR BR9205893A patent/BR9205893A/pt not_active Application Discontinuation
- 1992-03-24 CZ CS923907A patent/CZ390792A3/cs unknown
- 1992-03-24 AU AU17839/92A patent/AU654554B2/en not_active Ceased
- 1992-03-24 DE DE9290042U patent/DE9290042U1/de not_active Expired - Lifetime
- 1992-03-24 EP EP92911061A patent/EP0584192A1/en not_active Withdrawn
- 1992-04-09 IL IL101546A patent/IL101546A0/xx unknown
- 1992-04-16 NZ NZ242391A patent/NZ242391A/en not_active IP Right Cessation
- 1992-04-16 CN CN92102845A patent/CN1065866A/zh active Pending
- 1992-04-16 IE IE121592A patent/IE921215A1/en not_active Application Discontinuation
- 1992-04-16 ZA ZA922811A patent/ZA922811B/xx unknown
- 1992-04-16 PT PT100394A patent/PT100394A/pt not_active Application Discontinuation
- 1992-04-17 YU YU40592A patent/YU40592A/sh unknown
-
1993
- 1993-10-15 FI FI934566A patent/FI934566A0/fi unknown
- 1993-10-15 NO NO933723A patent/NO933723L/no unknown
-
1995
- 1995-04-07 US US08/418,718 patent/US5696126A/en not_active Expired - Fee Related
- 1995-04-07 US US08/418,713 patent/US5654302A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU654554B2 (en) | 1994-11-10 |
HU9302928D0 (en) | 1993-12-28 |
FI934566A (fi) | 1993-10-15 |
FI934566A0 (fi) | 1993-10-15 |
US5654302A (en) | 1997-08-05 |
CA2108557A1 (en) | 1992-10-19 |
EP0584192A1 (en) | 1994-03-02 |
AU1783992A (en) | 1992-11-17 |
NO933723D0 (no) | 1993-10-15 |
WO1992018502A1 (en) | 1992-10-29 |
JPH06501022A (ja) | 1994-01-27 |
ZA922811B (en) | 1993-10-18 |
NO933723L (no) | 1993-10-15 |
IL101546A0 (en) | 1992-12-30 |
JPH0788355B2 (ja) | 1995-09-27 |
US5455250A (en) | 1995-10-03 |
CZ390792A3 (en) | 1994-04-13 |
IE921215A1 (en) | 1992-10-21 |
NZ242391A (en) | 1993-12-23 |
PT100394A (pt) | 1993-06-30 |
HUT65836A (en) | 1994-07-28 |
CN1065866A (zh) | 1992-11-04 |
BR9205893A (pt) | 1994-11-08 |
US5696126A (en) | 1997-12-09 |
DE9290042U1 (de) | 1993-12-16 |
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