NO933723L - Prodrug-estere av fenoliske 2-piperidino-1-alkanoler - Google Patents

Prodrug-estere av fenoliske 2-piperidino-1-alkanoler

Info

Publication number
NO933723L
NO933723L NO933723A NO933723A NO933723L NO 933723 L NO933723 L NO 933723L NO 933723 A NO933723 A NO 933723A NO 933723 A NO933723 A NO 933723A NO 933723 L NO933723 L NO 933723L
Authority
NO
Norway
Prior art keywords
prodrug esters
piperidino
phenolic
alkanols
esters
Prior art date
Application number
NO933723A
Other languages
English (en)
Other versions
NO933723D0 (no
Inventor
Bertrand L Chenard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO933723D0 publication Critical patent/NO933723D0/no
Publication of NO933723L publication Critical patent/NO933723L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Abstract

Det beskrives fenoliske prodrug-estere av visse 1- (hydroksyfenyl)-2-piperidino-l-alkanolderivater som er egnet ved behandlingen av slag, traumatiske hodeskader og CNS- degenerativ sykdom; samt mellomprodukter egnet for deres syntese. Foreliggende oppfinnelse angår de såkalte prodrug-estere med formel (I) og (II)
NO933723A 1991-04-18 1993-10-15 Prodrug-estere av fenoliske 2-piperidino-1-alkanoler NO933723L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68727391A 1991-04-18 1991-04-18
PCT/US1992/002131 WO1992018502A1 (en) 1991-04-18 1992-03-24 Prodrug esters of phenolic 2-piperidino-1-alkanols

Publications (2)

Publication Number Publication Date
NO933723D0 NO933723D0 (no) 1993-10-15
NO933723L true NO933723L (no) 1993-10-15

Family

ID=24759771

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933723A NO933723L (no) 1991-04-18 1993-10-15 Prodrug-estere av fenoliske 2-piperidino-1-alkanoler

Country Status (19)

Country Link
US (3) US5455250A (no)
EP (1) EP0584192A1 (no)
JP (1) JPH0788355B2 (no)
CN (1) CN1065866A (no)
AU (1) AU654554B2 (no)
BR (1) BR9205893A (no)
CA (1) CA2108557A1 (no)
CZ (1) CZ390792A3 (no)
DE (1) DE9290042U1 (no)
FI (1) FI934566A0 (no)
HU (1) HUT65836A (no)
IE (1) IE921215A1 (no)
IL (1) IL101546A0 (no)
NO (1) NO933723L (no)
NZ (1) NZ242391A (no)
PT (1) PT100394A (no)
WO (1) WO1992018502A1 (no)
YU (1) YU40592A (no)
ZA (1) ZA922811B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
KR100224961B1 (ko) * 1994-08-18 1999-10-15 디. 제이. 우드 신경보호성 3-(피페리디닐-1)-크로만-4,7-디올 및 1-(4-하이드로페닐)-2-(피페리디닐-1)-알칸올 유도체
RU2176145C2 (ru) 1995-05-26 2001-11-27 Пфайзер Инк. Синергическое лечение паркинсонизма
TW450807B (en) * 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
AU1201101A (en) 1999-10-15 2001-04-30 Du Pont Pharmaceuticals Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US6784200B2 (en) 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
JP2003512422A (ja) 1999-10-29 2003-04-02 メルク シャープ エンド ドーム リミテッド ベンズイミダゾールｎｍｄａ／ｎｒ２ｂアンタゴニストを使用する疼痛の治療方法
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1379520B2 (en) 2001-02-23 2014-04-09 Merck Sharp & Dohme Corp. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
US8648198B2 (en) 2011-01-19 2014-02-11 Cold Spring Harbor Laboratory Phenylethanolamine-based NMDA receptor antagonists
US11931428B2 (en) 2019-08-23 2024-03-19 Wake Forest University Health Sciences Selective hydrogen sulfide probe and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (no) * 1966-09-27 1968-01-22
DE3045688A1 (de) * 1980-12-04 1982-07-08 C.H. Boehringer Sohn, 6507 Ingelheim Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
SK232890A3 (en) * 1989-05-17 1998-11-04 Pfizer 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
RU2099339C1 (ru) * 1990-02-06 1997-12-20 Пфайзер Инк. Производные пиперидина
ES2146578T3 (es) * 1990-05-10 2000-08-16 Pfizer Indolona neuroprotectora y derivados relacionados.

Also Published As

Publication number Publication date
AU654554B2 (en) 1994-11-10
HU9302928D0 (en) 1993-12-28
FI934566A (fi) 1993-10-15
FI934566A0 (fi) 1993-10-15
US5654302A (en) 1997-08-05
CA2108557A1 (en) 1992-10-19
EP0584192A1 (en) 1994-03-02
YU40592A (sh) 1994-12-28
AU1783992A (en) 1992-11-17
NO933723D0 (no) 1993-10-15
WO1992018502A1 (en) 1992-10-29
JPH06501022A (ja) 1994-01-27
ZA922811B (en) 1993-10-18
IL101546A0 (en) 1992-12-30
JPH0788355B2 (ja) 1995-09-27
US5455250A (en) 1995-10-03
CZ390792A3 (en) 1994-04-13
IE921215A1 (en) 1992-10-21
NZ242391A (en) 1993-12-23
PT100394A (pt) 1993-06-30
HUT65836A (en) 1994-07-28
CN1065866A (zh) 1992-11-04
BR9205893A (pt) 1994-11-08
US5696126A (en) 1997-12-09
DE9290042U1 (de) 1993-12-16

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