FI934566A0 - Prodrug-estrar av fenol-2-piperidino-1-alkanoler - Google Patents

Prodrug-estrar av fenol-2-piperidino-1-alkanoler

Info

Publication number
FI934566A0
FI934566A0 FI934566A FI934566A FI934566A0 FI 934566 A0 FI934566 A0 FI 934566A0 FI 934566 A FI934566 A FI 934566A FI 934566 A FI934566 A FI 934566A FI 934566 A0 FI934566 A0 FI 934566A0
Authority
FI
Finland
Prior art keywords
alkanoler
estrar
piperidino
prodrug
phenol
Prior art date
Application number
FI934566A
Other languages
English (en)
Other versions
FI934566A (fi
Inventor
Bertrand Leo Chenard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI934566A0 publication Critical patent/FI934566A0/fi
Publication of FI934566A publication Critical patent/FI934566A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI934566A 1991-04-18 1993-10-15 Prodrug-estrar av fenol-2-piperidino-1-alkanoler FI934566A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68727391A 1991-04-18 1991-04-18
PCT/US1992/002131 WO1992018502A1 (en) 1991-04-18 1992-03-24 Prodrug esters of phenolic 2-piperidino-1-alkanols

Publications (2)

Publication Number Publication Date
FI934566A0 true FI934566A0 (fi) 1993-10-15
FI934566A FI934566A (fi) 1993-10-15

Family

ID=24759771

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934566A FI934566A (fi) 1991-04-18 1993-10-15 Prodrug-estrar av fenol-2-piperidino-1-alkanoler

Country Status (19)

Country Link
US (3) US5455250A (fi)
EP (1) EP0584192A1 (fi)
JP (1) JPH0788355B2 (fi)
CN (1) CN1065866A (fi)
AU (1) AU654554B2 (fi)
BR (1) BR9205893A (fi)
CA (1) CA2108557A1 (fi)
CZ (1) CZ390792A3 (fi)
DE (1) DE9290042U1 (fi)
FI (1) FI934566A (fi)
HU (1) HUT65836A (fi)
IE (1) IE921215A1 (fi)
IL (1) IL101546A0 (fi)
NO (1) NO933723D0 (fi)
NZ (1) NZ242391A (fi)
PT (1) PT100394A (fi)
WO (1) WO1992018502A1 (fi)
YU (1) YU40592A (fi)
ZA (1) ZA922811B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
PT777652E (pt) * 1994-08-18 2003-11-28 Pfizer Derivados neuroptotectores de 3-(piperidinil-1)-croman-4.7-diol e de 1-(4-hidrofenil)-2-(piperidinil-1)-alcanol
JPH11505828A (ja) 1995-05-26 1999-05-25 ファイザー・インコーポレーテッド パーキンソン症候群の治療用の選択的ｎｍｄａアンタゴニスト含有組合せ
TW450807B (en) * 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6784200B2 (en) 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
CA2386049A1 (en) 1999-10-15 2001-04-26 Daniel S. Gardner Bicyclic and tricyclic amines as modulators of chemokine receptor activity
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1379520B2 (en) 2001-02-23 2014-04-09 Merck Sharp & Dohme Corp. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
CA2443108A1 (en) 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
US8648198B2 (en) 2011-01-19 2014-02-11 Cold Spring Harbor Laboratory Phenylethanolamine-based NMDA receptor antagonists
US11931428B2 (en) 2019-08-23 2024-03-19 Wake Forest University Health Sciences Selective hydrogen sulfide probe and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (fi) * 1966-09-27 1968-01-22
DE3045688A1 (de) * 1980-12-04 1982-07-08 C.H. Boehringer Sohn, 6507 Ingelheim Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
SK232890A3 (en) * 1989-05-17 1998-11-04 Pfizer 2-piperidino and 2-pyrrolidino-1-alkanols derivatives and preparation method thereof
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1991012005A1 (en) * 1990-02-06 1991-08-22 Pfizer Inc. Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs
ES2146578T3 (es) * 1990-05-10 2000-08-16 Pfizer Indolona neuroprotectora y derivados relacionados.

Also Published As

Publication number Publication date
JPH0788355B2 (ja) 1995-09-27
PT100394A (pt) 1993-06-30
EP0584192A1 (en) 1994-03-02
JPH06501022A (ja) 1994-01-27
US5654302A (en) 1997-08-05
HU9302928D0 (en) 1993-12-28
ZA922811B (en) 1993-10-18
DE9290042U1 (de) 1993-12-16
NO933723L (no) 1993-10-15
US5455250A (en) 1995-10-03
NO933723D0 (no) 1993-10-15
CN1065866A (zh) 1992-11-04
CA2108557A1 (en) 1992-10-19
CZ390792A3 (en) 1994-04-13
HUT65836A (en) 1994-07-28
IL101546A0 (en) 1992-12-30
YU40592A (sh) 1994-12-28
AU654554B2 (en) 1994-11-10
FI934566A (fi) 1993-10-15
US5696126A (en) 1997-12-09
NZ242391A (en) 1993-12-23
AU1783992A (en) 1992-11-17
BR9205893A (pt) 1994-11-08
IE921215A1 (en) 1992-10-21
WO1992018502A1 (en) 1992-10-29

Similar Documents

Publication Publication Date Title
FI921369A (fi) Anvaendarfoerbindelse foer kontrollsystem av anlaeggningskomponenter
FI922273A (fi) Framstaellning av additionspolymerisationskatalysatorer
FI921599A (fi) Kodingsfoerfarande och -anordning foer foerutsaegning av roerelsekompensation
FI920875A (fi) Foerfarande foer avfaergning av avfallspapper
FI921828A (fi) Dehalogenisering av foereningar innehaollande organohalogener
FI921299A (fi) Laongspaltpress saerskilt foer avvattning av en fiberaemnesbana
FI921749A (fi) Tillverkning av tryckkaerl
FI921290A (fi) Skenlaeggningsmaskin foer kontrollerad nedsaenkning av en skena
FI921149A (fi) Reaktivering av hydroformyleringskatalysatorer
FI934566A0 (fi) Prodrug-estrar av fenol-2-piperidino-1-alkanoler
FI921202A (fi) Foerfarande foer instaellning av rasterpunktstorleken foer en offset-rotationstryckmaskin
FI920993A (fi) Foerfarande foer framstaellning av galliumfoereningar
FI921037A (fi) Vaermesensor av kompensationstyp
FI921721A (fi) Foerfarande foer isynnerhet foersnabbad aerobisk mikrobiologisk nedbrytning av biologiska aemnen
FI921458A (fi) Hjaelpmedel foer svetsning av ytterst korrosionsbestaendiga austenitiska staol
FI88701B (fi) Foerfarande foer producering av vaeteperoxid
FI922381A (fi) Foerfarande foer framstaellning av amorfa provkroppar
FI914586A (fi) Foerfarande foer foerminskning av asklasten av en cellufabriks pannanlaeggning
FI921103A (fi) Foerfarande foer framstaellning av oxamid
FI921404A (fi) Foerfarande foer framstaellning av elektrolumisescens tunnfolie
FI922125A (fi) Mikrobidogiskt foerfarande foer framstaellning av 5-hydroxipyrazinkarboxylsyra
FI920422A (fi) Foerfarande foer ytfoerening av kiselhalvledarskivor
FI920926A (fi) Foerfarande foer foerbaettring av stabiliteten foer hoegalkaliska proteaser
FI922138A (fi) Anordning foer belysning av en hisskorgs innerrum
FI912871A (fi) Foerfarande foer boejning av glasskivor