YU33730B - Process for preparing a novel antibiotic substance and salts thereof - Google Patents

Process for preparing a novel antibiotic substance and salts thereof

Info

Publication number
YU33730B
YU33730B YU715/68A YU71568A YU33730B YU 33730 B YU33730 B YU 33730B YU 715/68 A YU715/68 A YU 715/68A YU 71568 A YU71568 A YU 71568A YU 33730 B YU33730 B YU 33730B
Authority
YU
Yugoslavia
Prior art keywords
salts
preparing
antibiotic substance
novel antibiotic
novel
Prior art date
Application number
YU715/68A
Other languages
English (en)
Other versions
YU71568A (en
Inventor
Arcanone Federico
Federico Arcanone
Cassinelli Giuseppe
Giuseppe Cassinelli
Di Marco Aurelio
Marco Aurelio Di
Gaetani Marcello
Marcello Gaetani
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of YU71568A publication Critical patent/YU71568A/xx
Publication of YU33730B publication Critical patent/YU33730B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/886Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
YU715/68A 1967-04-18 1968-03-29 Process for preparing a novel antibiotic substance and salts thereof YU33730B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1505667 1967-04-18

Publications (2)

Publication Number Publication Date
YU71568A YU71568A (en) 1977-08-31
YU33730B true YU33730B (en) 1978-02-28

Family

ID=11146217

Family Applications (1)

Application Number Title Priority Date Filing Date
YU715/68A YU33730B (en) 1967-04-18 1968-03-29 Process for preparing a novel antibiotic substance and salts thereof

Country Status (15)

Country Link
US (1) US3590028A (forum.php)
AT (1) AT276630B (forum.php)
BE (1) BE713773A (forum.php)
CH (1) CH496091A (forum.php)
DE (1) DE1770204B1 (forum.php)
DK (1) DK118652B (forum.php)
ES (1) ES352842A1 (forum.php)
FR (2) FR1583289A (forum.php)
GB (1) GB1161278A (forum.php)
IL (1) IL29813A (forum.php)
NL (1) NL6804925A (forum.php)
NO (1) NO124883B (forum.php)
SE (1) SE333126B (forum.php)
SU (1) SU378026A3 (forum.php)
YU (1) YU33730B (forum.php)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
US3965088A (en) * 1967-10-18 1976-06-22 Rhone-Poulenc S.A. Naphthacene derivatives
FR2160716A1 (en) * 1971-11-23 1973-07-06 Rhone Poulenc Sa Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin
JPS5233639B1 (forum.php) * 1971-01-20 1977-08-30
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
US3976667A (en) * 1975-06-19 1976-08-24 The Upjohn Company Steffimycinone, 7-deoxysteffimycinone and derivatives
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin
ES444380A1 (es) * 1976-01-16 1977-06-16 Gosalvez Mario Un procedimiento para preparar derivados metalicos antraci- clinicos.
US4039736A (en) * 1976-04-15 1977-08-02 Bristol-Myers Company Antibiotic compounds marcellomycin and musettamycin
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4192915A (en) * 1976-08-16 1980-03-11 Bristol-Myers Company Anthracycline glycosides from streptomyces
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
NL176004C (nl) * 1976-10-05 1985-02-01 Microbial Chem Res Found Werkwijze ter bereiding van geneesmiddelen met antitumorwerking op basis van anthracycline glycosiden en werkwijze ter bereiding van daartoe dienende anthracycline glycosiden.
US4112071A (en) * 1977-01-10 1978-09-05 Bristol-Myers Company Antibiotic complex
US4089872A (en) * 1977-03-09 1978-05-16 The Upjohn Company Antibiotics steffimycinol and 7-deoxysteffimycinol and process for preparing the same
US4246399A (en) * 1977-03-21 1981-01-20 Interx Research Corporation Complexes of doxorubicin exhibiting enhanced stability
US4077844A (en) * 1977-03-30 1978-03-07 The Upjohn Company Process for preparing steffimycinol
NL7900869A (nl) * 1978-02-09 1979-08-13 Erba Farmitalia Anthracyclinenantibiotica.
US4248970A (en) * 1978-05-30 1981-02-03 Bristol-Myers Company Antibiotic complex producing bacterial culture
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4303785A (en) * 1978-08-05 1981-12-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor anthracycline antibiotics
IT1196402B (it) * 1978-11-21 1988-11-16 Erba Farmitalia Antibiotici antitumorali
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
GB2125030B (en) * 1982-08-13 1986-11-26 Erba Farmitalia Naphthacenequinone synthesis
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4548927A (en) * 1983-05-25 1985-10-22 Eaton John W Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ,ザ・ユニバーシティ・オブ・テキサス・システム 3’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
GB8812697D0 (en) * 1988-05-27 1988-06-29 Erba Carlo Spa Isolation & characterisation of genes resistant to anthracycline antibiotics
US5220001A (en) * 1989-10-25 1993-06-15 Zaidan Hojim Biseibutsu Dong-A Pharm Co. Anthracycline glycoside derivatives
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
WO1996035451A1 (en) 1995-05-10 1996-11-14 Kyowa Hakko Kogyo Co., Ltd. Novel toxin complex
HU227564B1 (en) 1996-10-15 2011-08-29 Searle & Co Use of cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia for producing pharmaceutical compositions
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
MY122499A (en) 1997-11-10 2006-04-29 Searle & Co Use of alkylated iminosugars to treat multidrug resistance
GB9727546D0 (en) * 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides
BR9907882A (pt) 1998-02-12 2000-10-17 Searle & Co Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
NZ511093A (en) * 1998-10-16 2003-04-29 Mercian Corp Crystallization of doxorubicin hydrochloride
CA2362785A1 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
ES2311921T3 (es) * 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
JP2003522791A (ja) * 2000-02-14 2003-07-29 ファルマシア コーポレイション 肝炎ウイルス感染症治療用n‐置換‐1,5‐ジデオキシ‐1,5‐イミノ‐d‐グルシトール化合物の使用
US20060079463A1 (en) * 2003-05-20 2006-04-13 Zhong Hong J Anticancer compositions comprising methenamine
JP2007507523A (ja) * 2003-10-02 2007-03-29 セフアロン・インコーポレーテツド 置換インドール誘導体
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CA2606390A1 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
CA2665692A1 (en) * 2006-10-06 2008-04-17 Yoshikazu Ohta Combination drug
KR101502267B1 (ko) 2007-11-09 2015-03-18 페레그린 파마수티컬즈, 인크 항-vegf 항체 조성물 및 방법
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2189158A1 (en) 2008-11-20 2010-05-26 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer
TW201026716A (en) * 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside analogs
TW201026715A (en) 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside phosphoramidates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
EP3327148B1 (en) 2010-06-18 2021-03-17 Myriad Genetics, Inc. Methods of predicting the status of brca1 and brca2 genes in a cancer cell
CA2807823C (en) 2010-08-24 2023-02-07 The Brigham And Women's Hospital, Inc. Methods for predicting anti-cancer response
CN102363755B (zh) * 2011-05-21 2013-04-03 浙江海正药业股份有限公司 一种链霉菌及其生产阿霉素的方法
WO2012174378A2 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
AU2012358244A1 (en) 2011-12-21 2014-06-12 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
EP4462120A3 (en) 2012-02-23 2025-01-08 Children's Medical Center Corporation Methods for predicting response to parp inhibitors
JP6104287B2 (ja) * 2012-03-06 2017-03-29 天津和美生物技術有限公司 四環系アントラキノン誘導体
US11091808B2 (en) 2012-06-07 2021-08-17 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
WO2014160080A1 (en) 2013-03-14 2014-10-02 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
AU2014240950B2 (en) 2013-03-29 2018-11-01 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
PT2981624T (pt) 2013-04-05 2020-03-23 Myriad Genetics Inc Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro
US11149316B2 (en) 2013-12-09 2021-10-19 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
CN104774229A (zh) * 2014-01-10 2015-07-15 浙江华谱新创科技有限公司 一种阿霉素及其衍生物的制备方法
ES3039109T3 (en) 2014-08-15 2025-10-17 Myriad Genetics Inc Methods and materials for assessing homologous recombination deficiency
WO2017189865A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
CN107773556B (zh) * 2016-08-26 2020-08-18 广州安好医药科技有限公司 一种具有抗肿瘤药物功效的联合用药物
EP4141127B1 (en) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Method for assessing homologous recombination deficiency in ovarian cancer cells

Also Published As

Publication number Publication date
FR1583289A (fr) 1969-10-24
SU378026A3 (forum.php) 1973-04-17
GB1161278A (en) 1969-08-13
NO124883B (forum.php) 1972-06-19
IL29813A0 (en) 1968-06-20
YU71568A (en) 1977-08-31
BE713773A (fr) 1968-10-17
DE1770204B1 (de) 1971-12-23
CH496091A (de) 1970-09-15
FR7406M (fr) 1969-11-03
NL6804925A (forum.php) 1968-10-21
SE333126B (sv) 1971-03-08
IL29813A (en) 1971-04-28
ES352842A1 (es) 1969-08-01
AT276630B (de) 1969-11-25
US3590028A (en) 1971-06-29
DK118652B (da) 1970-09-21

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