YU30297A - Derivati n-(4-aril-tiazol-2-il)-sulfonamida i njihova primena - Google Patents

Derivati n-(4-aril-tiazol-2-il)-sulfonamida i njihova primena

Info

Publication number
YU30297A
YU30297A YU30297A YU30297A YU30297A YU 30297 A YU30297 A YU 30297A YU 30297 A YU30297 A YU 30297A YU 30297 A YU30297 A YU 30297A YU 30297 A YU30297 A YU 30297A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
nitro
amino
trifluoromethyl
alkoxy
Prior art date
Application number
YU30297A
Other languages
English (en)
Inventor
Andrea Cesura
Stephan Rover
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU30297A publication Critical patent/YU30297A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ovaj pronalazak se odnosi na primenu derivata sulfonamida opšte formule u kojoj R označava niži-alkil, fenil, benzil, naftil, piridil ili tienil, koji su opciono supstituisani sa jednim ili više niži-alkil-, niži-alkoksi-, niži-alkilkarbonilamino-, halogen-, cikloalkil-, nitro-, amino-, metilendioksi-, fenoksi- ili benziloksi-supstituenata, i aromatični prstenovi, sa svoje strane, mogu biti supstituisani nitrogrupom, halogenom ili amino-grupom, R1-R4 označava vodonik, halgoen, hidroksi, niži-alkil, nitro, cijan, amino, niži-alkoksi, benziloksi, trifluorometil ili fenil, koji je opciono supstituisan sa jednim ili više niži-alkil-, trifluormetil-, nitro-, amino-ili hidroksi-supstituenata, i u kojoj R1 i R2 ili R2 i R3 zajedno mogu formirati benzenski prsten koji opciono može biti supstituisan halogenom, trifluormetil-, nitro-, niži-alkil- ili niži-alkoksi-grupom, i njihova farmaceutski prihvatljivih soli kao inhibitora kinurenin-3-hidroksilaze u suzbijanju ili sprečavanju neurodegenerativnih poremećaja, neuroloških poremećaja koji rezultiraju iz aktivacije imunog sistema ili psihijatrijskih oboljenja i, odnosno, za proizvodnju odgovarajućih lekova.
YU30297A 1996-07-19 1997-07-11 Derivati n-(4-aril-tiazol-2-il)-sulfonamida i njihova primena YU30297A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96111661 1996-07-19

Publications (1)

Publication Number Publication Date
YU30297A true YU30297A (sh) 2000-10-30

Family

ID=8223010

Family Applications (1)

Application Number Title Priority Date Filing Date
YU30297A YU30297A (sh) 1996-07-19 1997-07-11 Derivati n-(4-aril-tiazol-2-il)-sulfonamida i njihova primena

Country Status (23)

Country Link
US (2) US5877193A (sh)
EP (1) EP0819681A3 (sh)
JP (1) JP2991679B2 (sh)
KR (1) KR100247672B1 (sh)
CN (1) CN1176101A (sh)
AU (1) AU725496B2 (sh)
BR (1) BR9704023A (sh)
CA (1) CA2210613A1 (sh)
CO (1) CO4900053A1 (sh)
CZ (1) CZ227397A3 (sh)
HR (1) HRP970393A2 (sh)
HU (1) HUP9701193A3 (sh)
IL (1) IL121298A (sh)
MA (1) MA24273A1 (sh)
MX (1) MX9705385A (sh)
NO (1) NO973338L (sh)
NZ (1) NZ328331A (sh)
PE (1) PE91298A1 (sh)
PL (1) PL321203A1 (sh)
SG (1) SG91796A1 (sh)
TR (1) TR199700653A2 (sh)
YU (1) YU30297A (sh)
ZA (1) ZA976222B (sh)

Families Citing this family (29)

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GB9725138D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Thiophenesulfonamide compounds
GB9725141D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
US6211185B1 (en) 1999-05-05 2001-04-03 Veterinary Pharmacy Corporation Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
JP2004517892A (ja) * 2000-12-13 2004-06-17 ワイス β−アミロイド産生の複素環スルホンアミド阻害剤
RS44304A (en) 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
WO2005054216A1 (ja) * 2003-12-01 2005-06-16 Reverse Proteomics Research Institute Co., Ltd. 新規抗癌剤「スルコキシン」
DK2420494T3 (en) * 2006-08-16 2015-01-12 J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone Use of thiadiazole compounds as inhibitors of kynurenine 3-monooxygenase
WO2008022281A1 (en) 2006-08-16 2008-02-21 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Small molecule inhibitors of kynurenine-3-monooxygenase
CA2712071A1 (en) * 2008-01-15 2009-10-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
WO2009124086A2 (en) * 2008-04-04 2009-10-08 Siga Technologies, Inc. Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN101602687A (zh) * 2008-06-13 2009-12-16 上海特化医药科技有限公司 6-硝基苯乙酮类化合物、其制备方法及用途
AU2012302144B2 (en) * 2011-08-30 2017-06-15 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CN102633696A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种两步合成制备对位取代烷基苯磺酰氯的方法和工艺
CN102627589A (zh) * 2012-04-05 2012-08-08 天津理工大学 一种两步合成制备4-异丙基苯磺酰氯的方法和工艺
CN102633695A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种4-异丙基苯磺酰氯的制备方法和工艺
CN102633687B (zh) * 2012-04-05 2016-06-08 天津瑞岭化工有限公司 一种对位取代烷基苯磺酰氯的制备方法和工艺
US9771356B2 (en) * 2012-09-21 2017-09-26 Rhode Island Hospital Inhibitors of beta-hydroxylase for treatment of cancer
CA3023465A1 (en) 2016-05-20 2017-11-23 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
BR112019011121A2 (pt) 2016-12-09 2019-10-01 Xenon Pharmaceuticals Inc compostos de benzenossulfonamida e seu uso como agentes terapêuticos
CA3103600A1 (en) 2018-06-13 2019-12-19 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
CN112638879B (zh) 2018-08-31 2024-06-18 泽农医药公司 杂芳基取代的磺酰胺化合物及其作为治疗剂的用途
EP3844158A1 (en) 2018-08-31 2021-07-07 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
JP2022500499A (ja) * 2018-09-07 2022-01-04 ピク セラピューティクス， インコーポレイテッド Ｅｉｆ４ｅ阻害剤およびその使用
CN114516807B (zh) * 2022-02-24 2023-11-17 南京大学 一种含硝基多取代芳香二胺单体及其制备方法

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US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
US5856347A (en) * 1994-11-29 1999-01-05 Hisamitsu Pharmaceutical Co., Inc. Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
GB9702194D0 (en) * 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives

Also Published As

Publication number Publication date
SG91796A1 (en) 2002-10-15
AU2875297A (en) 1998-01-29
CA2210613A1 (en) 1998-01-19
EP0819681A2 (de) 1998-01-21
MA24273A1 (fr) 1998-04-01
PE91298A1 (es) 1998-12-31
CZ227397A3 (cs) 1998-02-18
JP2991679B2 (ja) 1999-12-20
HRP970393A2 (en) 1998-04-30
HU9701193D0 (en) 1997-09-29
US5877193A (en) 1999-03-02
KR100247672B1 (ko) 2000-04-01
BR9704023A (pt) 1998-11-17
EP0819681A3 (de) 1998-02-04
IL121298A0 (en) 1998-01-04
CO4900053A1 (es) 2000-03-27
PL321203A1 (en) 1998-02-02
ZA976222B (en) 1998-01-19
HUP9701193A2 (hu) 1999-02-01
IL121298A (en) 2001-03-19
JPH1067761A (ja) 1998-03-10
NO973338L (no) 1998-01-20
AU725496B2 (en) 2000-10-12
MX9705385A (es) 1998-04-30
HUP9701193A3 (en) 2000-08-28
CN1176101A (zh) 1998-03-18
US5958910A (en) 1999-09-28
TR199700653A2 (xx) 1998-02-21
KR980008228A (ko) 1998-04-30
NO973338D0 (no) 1997-07-18
NZ328331A (en) 1999-05-28

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