HRP970393A2 - N-(4-aryl-thiazol-2-yl)-sulfonamide derivatives and their use - Google Patents

N-(4-aryl-thiazol-2-yl)-sulfonamide derivatives and their use

Info

Publication number
HRP970393A2
HRP970393A2 HR96111661.3A HRP970393A HRP970393A2 HR P970393 A2 HRP970393 A2 HR P970393A2 HR P970393 A HRP970393 A HR P970393A HR P970393 A2 HRP970393 A2 HR P970393A2
Authority
HR
Croatia
Prior art keywords
thiazol
aryl
sulfonamide derivatives
sulfonamide
derivatives
Prior art date
Application number
HR96111661.3A
Other languages
English (en)
Inventor
Andrea Cesura
Stephan Roever
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HRP970393A2 publication Critical patent/HRP970393A2/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR96111661.3A 1996-07-19 1997-07-18 N-(4-aryl-thiazol-2-yl)-sulfonamide derivatives and their use HRP970393A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96111661 1996-07-19

Publications (1)

Publication Number Publication Date
HRP970393A2 true HRP970393A2 (en) 1998-04-30

Family

ID=8223010

Family Applications (1)

Application Number Title Priority Date Filing Date
HR96111661.3A HRP970393A2 (en) 1996-07-19 1997-07-18 N-(4-aryl-thiazol-2-yl)-sulfonamide derivatives and their use

Country Status (23)

Country Link
US (2) US5877193A (xx)
EP (1) EP0819681A3 (xx)
JP (1) JP2991679B2 (xx)
KR (1) KR100247672B1 (xx)
CN (1) CN1176101A (xx)
AU (1) AU725496B2 (xx)
BR (1) BR9704023A (xx)
CA (1) CA2210613A1 (xx)
CO (1) CO4900053A1 (xx)
CZ (1) CZ227397A3 (xx)
HR (1) HRP970393A2 (xx)
HU (1) HUP9701193A3 (xx)
IL (1) IL121298A (xx)
MA (1) MA24273A1 (xx)
MX (1) MX9705385A (xx)
NO (1) NO973338L (xx)
NZ (1) NZ328331A (xx)
PE (1) PE91298A1 (xx)
PL (1) PL321203A1 (xx)
SG (1) SG91796A1 (xx)
TR (1) TR199700653A2 (xx)
YU (1) YU30297A (xx)
ZA (1) ZA976222B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725138D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Thiophenesulfonamide compounds
GB9725141D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
US6211185B1 (en) * 1999-05-05 2001-04-03 Veterinary Pharmacy Corporation Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
CA2436526C (en) * 2000-12-13 2010-10-19 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production
RS44304A (xx) 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
WO2005054216A1 (ja) * 2003-12-01 2005-06-16 Reverse Proteomics Research Institute Co., Ltd. 新規抗癌剤「スルコキシン」
EP2054056A4 (en) * 2006-08-16 2010-08-25 J David Gladstone Inst A Testa SMALL MOLECULAR INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
US7994338B2 (en) 2006-08-16 2011-08-09 The J. David Gladstone Institutes Small molecule inhibitors of kynurenine-3-monooxygenase
CA2712071A1 (en) * 2008-01-15 2009-10-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
WO2009124086A2 (en) * 2008-04-04 2009-10-08 Siga Technologies, Inc. Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections
UA103319C2 (xx) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Сполуки бензенсульфонамідтіазолу та -оксазолу$соединения бензенсульфонамидтиазола и -оксазола
CN101602687A (zh) * 2008-06-13 2009-12-16 上海特化医药科技有限公司 6-硝基苯乙酮类化合物、其制备方法及用途
ES2629194T3 (es) * 2011-08-30 2017-08-07 Chdi Foundation, Inc. Inhibidores de kinurenina-3-monoxigenasa, composiciones farmacéuticas y métodos de utilización del mismo
CN102633687B (zh) * 2012-04-05 2016-06-08 天津瑞岭化工有限公司 一种对位取代烷基苯磺酰氯的制备方法和工艺
CN102633695A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种4-异丙基苯磺酰氯的制备方法和工艺
CN102633696A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种两步合成制备对位取代烷基苯磺酰氯的方法和工艺
CN102627589A (zh) * 2012-04-05 2012-08-08 天津理工大学 一种两步合成制备4-异丙基苯磺酰氯的方法和工艺
EP3345596B1 (en) * 2012-09-21 2021-01-20 Rhode Island Hospital Inhibitors of beta-hydrolase for treatment of cancer
RU2769827C2 (ru) 2016-05-20 2022-04-06 Ксенон Фармасьютикалз Инк. Соединения бензолсульфонамида и их применение в качестве терапевтических средств
US20180162868A1 (en) 2016-12-09 2018-06-14 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
MX2020013317A (es) 2018-06-13 2021-04-13 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y su uso como agentes terapeuticos.
KR20210054510A (ko) 2018-08-31 2021-05-13 제논 파마슈티칼스 인크. 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도
WO2020047312A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
CN114516807B (zh) * 2022-02-24 2023-11-17 南京大学 一种含硝基多取代芳香二胺单体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
WO1996016650A1 (fr) * 1994-11-29 1996-06-06 Hisamitsu Pharmaceutical Co., Inc. Antibacterien et bactericide comprenant un derive de 2-aminothiazole et sels de ce derive
GB9702194D0 (en) * 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives

Also Published As

Publication number Publication date
IL121298A (en) 2001-03-19
CZ227397A3 (cs) 1998-02-18
EP0819681A3 (de) 1998-02-04
BR9704023A (pt) 1998-11-17
MA24273A1 (fr) 1998-04-01
NZ328331A (en) 1999-05-28
US5958910A (en) 1999-09-28
KR100247672B1 (ko) 2000-04-01
YU30297A (sh) 2000-10-30
IL121298A0 (en) 1998-01-04
NO973338L (no) 1998-01-20
SG91796A1 (en) 2002-10-15
HUP9701193A3 (en) 2000-08-28
US5877193A (en) 1999-03-02
AU725496B2 (en) 2000-10-12
HU9701193D0 (en) 1997-09-29
KR980008228A (ko) 1998-04-30
CN1176101A (zh) 1998-03-18
MX9705385A (es) 1998-04-30
JP2991679B2 (ja) 1999-12-20
TR199700653A2 (xx) 1998-02-21
EP0819681A2 (de) 1998-01-21
CO4900053A1 (es) 2000-03-27
PE91298A1 (es) 1998-12-31
ZA976222B (en) 1998-01-19
CA2210613A1 (en) 1998-01-19
NO973338D0 (no) 1997-07-18
JPH1067761A (ja) 1998-03-10
PL321203A1 (en) 1998-02-02
HUP9701193A2 (hu) 1999-02-01
AU2875297A (en) 1998-01-29

Similar Documents

Publication Publication Date Title
HU9701193D0 (en) N-(4-aryl-thiazol-2-yl)-sulfonamide derivatives and their use
HU9701096D0 (en) Sulfonamides and their use
ZA9711141B (en) Novel ketobenzamides and their use
EP1032377A4 (en) SUBSTITUTED 2-AMINOACETAMIDES AND APPLICATION THEREOF
IS4481A (is) Díhýdrópyramídín og notkun þeirra
EP1021185A4 (en) DIHYDROPYRIMIDINE AND ITS USES.
ZA9710569B (en) Novel benzamides and their application
ZA9710979B (en) Novel heterocyclically substituted benzamides and their use
HRP970225A2 (en) Benzofuryl derivatives and their use
GB9719493D0 (en) Hinge construction and parts used therewith
HUP9700446A3 (en) Oilsuspension-concentrate and using thereof
ZA978876B (en) Oxazolone derivatives and their use
IL127068A0 (en) Substituted benzamide derivatives and their use as anticonvulsants
PL331523A1 (en) Azolotrizines and azolopyrimidines
IL123535A0 (en) Benzoxazindione derivatives and their use
EP0744125A3 (en) Iodine complex and its application
GB9712811D0 (en) Amido furandione derivatives
SG44332A1 (en) Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas
IL134499A0 (en) Pyrimidin-2- oxy-4-one and pyrimidin-2-oxy- 4-thione derivatives
GB9617308D0 (en) Benzamide derivatives
GB9617307D0 (en) Benzamide derivatives
GB9421887D0 (en) Benzodioxanylimidazoline and bensodioxanyllimidazole derivatives
IL130921A0 (en) Tetrahydroisoindole and hexahydroisoindole derivatives
GB9715323D0 (en) Piperidinecarboxamides and their use
GB9417415D0 (en) Hinge arrangements, their construction and use

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODBI Application refused