NO973338L - N-(4-aryl-tiazol-2-yl)-sulfonamid-derivater og deres anvendelse - Google Patents

N-(4-aryl-tiazol-2-yl)-sulfonamid-derivater og deres anvendelse

Info

Publication number
NO973338L
NO973338L NO973338A NO973338A NO973338L NO 973338 L NO973338 L NO 973338L NO 973338 A NO973338 A NO 973338A NO 973338 A NO973338 A NO 973338A NO 973338 L NO973338 L NO 973338L
Authority
NO
Norway
Prior art keywords
nitro
lower alkyl
halogen
amino
trifluoromethyl
Prior art date
Application number
NO973338A
Other languages
English (en)
Other versions
NO973338D0 (no
Inventor
Andrea Cesura
Stephan Roever
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO973338D0 publication Critical patent/NO973338D0/no
Publication of NO973338L publication Critical patent/NO973338L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen vedrører anvendelsen av derivater med den generelle formel hvor R betyr lavere alkyl, fenyl, benzyl, naftyl, pyridyl eller tienyl, eventuelt substituert med en eller flere lavere alkyl-, lavere alkoksy-, lavere alkylkarbonylamino-, halogen-, cykloalkyl-, nitro-, amino-, metylendioksy-, fenoksy- eller benzyloksy- substituenter, og de aromatiske ringer kan i sin tur være substituert med nitro, halogen eller amino; R1- R4 betyr hydrogen, halogen, hydroksy, lavere alkyl, nitro, cyano, amino, lavere alkoksy, benzyloksy, trifluormetyl eller fenyl, eventuelt substituert med en eller flere lavere alkyl-, trifluormetyl-, nitro-, amino- eller hydroksysubstituenter, og hvor R1 og R2 eller R2 og R3 sammen kan danne en benzenring som eventuelt kan være substituert med halogen, trifluor- metyl, nitro, lavere alkyl eller lavere alkoksy; og deres farmasøytisk akseptable salter som kynurenin-3- hydroksylaseinhibitorer ved kontroll eller forebyg- gelse av nevrodegenerative forstyrrelser, nevrolog- iske forstyrrelser som et resultat av en aktivering av immunsystemet, eller psykiatriske sykdommer og henholdsvis for produksjon av tilsvarende medika- menter.
NO973338A 1996-07-19 1997-07-18 N-(4-aryl-tiazol-2-yl)-sulfonamid-derivater og deres anvendelse NO973338L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96111661 1996-07-19

Publications (2)

Publication Number Publication Date
NO973338D0 NO973338D0 (no) 1997-07-18
NO973338L true NO973338L (no) 1998-01-20

Family

ID=8223010

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973338A NO973338L (no) 1996-07-19 1997-07-18 N-(4-aryl-tiazol-2-yl)-sulfonamid-derivater og deres anvendelse

Country Status (23)

Country Link
US (2) US5877193A (no)
EP (1) EP0819681A3 (no)
JP (1) JP2991679B2 (no)
KR (1) KR100247672B1 (no)
CN (1) CN1176101A (no)
AU (1) AU725496B2 (no)
BR (1) BR9704023A (no)
CA (1) CA2210613A1 (no)
CO (1) CO4900053A1 (no)
CZ (1) CZ227397A3 (no)
HR (1) HRP970393A2 (no)
HU (1) HUP9701193A3 (no)
IL (1) IL121298A (no)
MA (1) MA24273A1 (no)
MX (1) MX9705385A (no)
NO (1) NO973338L (no)
NZ (1) NZ328331A (no)
PE (1) PE91298A1 (no)
PL (1) PL321203A1 (no)
SG (1) SG91796A1 (no)
TR (1) TR199700653A2 (no)
YU (1) YU30297A (no)
ZA (1) ZA976222B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725141D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
GB9725138D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Thiophenesulfonamide compounds
US6211185B1 (en) * 1999-05-05 2001-04-03 Veterinary Pharmacy Corporation Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
SI1341779T1 (sl) * 2000-12-13 2006-12-31 Wyeth Corp Heterociklicni sulfonamidni inhibitorji produkcije beta amiloida
EA200400707A1 (ru) 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
WO2005054216A1 (ja) * 2003-12-01 2005-06-16 Reverse Proteomics Research Institute Co., Ltd. 新規抗癌剤「スルコキシン」
DK2054397T3 (en) * 2006-08-16 2016-01-18 J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone SMALL MOLECULAR INHIBITORS OF KYNURENIN-3-MONOOXYGENASE
EP2054056A4 (en) * 2006-08-16 2010-08-25 J David Gladstone Inst A Testa SMALL MOLECULAR INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
WO2009123776A2 (en) * 2008-01-15 2009-10-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
WO2009124086A2 (en) * 2008-04-04 2009-10-08 Siga Technologies, Inc. Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN101602687A (zh) * 2008-06-13 2009-12-16 上海特化医药科技有限公司 6-硝基苯乙酮类化合物、其制备方法及用途
EA027451B1 (ru) * 2011-08-30 2017-07-31 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и их применение
CN102627589A (zh) * 2012-04-05 2012-08-08 天津理工大学 一种两步合成制备4-异丙基苯磺酰氯的方法和工艺
CN102633687B (zh) * 2012-04-05 2016-06-08 天津瑞岭化工有限公司 一种对位取代烷基苯磺酰氯的制备方法和工艺
CN102633695A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种4-异丙基苯磺酰氯的制备方法和工艺
CN102633696A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种两步合成制备对位取代烷基苯磺酰氯的方法和工艺
CN104902889A (zh) * 2012-09-21 2015-09-09 罗得岛医院 用于治疗癌症的β-水解酶抑制剂
EP3458449A1 (en) 2016-05-20 2019-03-27 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
EP3551626B1 (en) 2016-12-09 2023-10-25 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
JP7371029B2 (ja) 2018-06-13 2023-10-30 ゼノン・ファーマシューティカルズ・インコーポレイテッド ベンゼンスルホンアミド化合物および治療剤としてのその使用
CA3104913A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
EP3844150A1 (en) 2018-08-31 2021-07-07 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
CN114516807B (zh) * 2022-02-24 2023-11-17 南京大学 一种含硝基多取代芳香二胺单体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
AU689972B2 (en) * 1994-11-29 1998-04-09 Hisamitsu Pharmaceutical Co., Inc. Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
GB9702194D0 (en) * 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives

Also Published As

Publication number Publication date
AU725496B2 (en) 2000-10-12
HU9701193D0 (en) 1997-09-29
CA2210613A1 (en) 1998-01-19
SG91796A1 (en) 2002-10-15
NO973338D0 (no) 1997-07-18
KR100247672B1 (ko) 2000-04-01
HRP970393A2 (en) 1998-04-30
HUP9701193A2 (hu) 1999-02-01
IL121298A (en) 2001-03-19
JPH1067761A (ja) 1998-03-10
HUP9701193A3 (en) 2000-08-28
JP2991679B2 (ja) 1999-12-20
MA24273A1 (fr) 1998-04-01
CZ227397A3 (cs) 1998-02-18
IL121298A0 (en) 1998-01-04
EP0819681A3 (de) 1998-02-04
PL321203A1 (en) 1998-02-02
US5877193A (en) 1999-03-02
CN1176101A (zh) 1998-03-18
BR9704023A (pt) 1998-11-17
AU2875297A (en) 1998-01-29
CO4900053A1 (es) 2000-03-27
KR980008228A (ko) 1998-04-30
NZ328331A (en) 1999-05-28
MX9705385A (es) 1998-04-30
TR199700653A2 (xx) 1998-02-21
ZA976222B (en) 1998-01-19
YU30297A (sh) 2000-10-30
PE91298A1 (es) 1998-12-31
US5958910A (en) 1999-09-28
EP0819681A2 (de) 1998-01-21

Similar Documents

Publication Publication Date Title
NO973338L (no) N-(4-aryl-tiazol-2-yl)-sulfonamid-derivater og deres anvendelse
HUP0301069A2 (hu) Új biaril-karboxamidok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
NO965334D0 (no) Nye 4,6-diarylpyrimidin-derivater og salter derav
CA2160444A1 (en) Aroyl-piperdine derivatives
AP2002002637A0 (en) Novel piperazine
AR007898A1 (es) Un compuesto derivado de la 4-hidroxi-piperidina, su empleo para la elaboracion de un medicamento, un procedimiento para prepararlo, y un medicamento que lo contiene.
NO986055D0 (no) Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
WO2000071510A3 (en) INHIBITORS OF FACTOR Xa
WO2001019788A3 (en) BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
NO990433L (no) Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet
HK1067963A1 (en) Alpha-(n-sulphonamido)acetamide derivatives as beta-amyloid inhibitors
DE69720709D1 (de) Substituierte tetracyclische tetrahydrofuranderivate
NO930783L (no) Kondenserte heterocykliske ketonderivater deres fremstilling og anveendelse
ATE211740T1 (de) Substituierte indazolderivate
ECSP930953A (es) Nuevos derivados de indol
DK0526313T3 (da) Nye ureaderivater, deres fremstilling og terapeutiske anvendelse
EP1382598A4 (en) NEW HETEROCYCLIC DERIVATIVES
HUP0203767A2 (hu) Új indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AP2002002595A0 (en) Heterocyclic amide derivatives.
DK0475352T3 (da) 3-(1H-Indazol-3-yl)-4-pyridinaminer, fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler
PE62299A1 (es) Derivados terapeuticos de naftaleno
NO20012538L (no) Anvendelse av N-substituerte azabicycloalkanderivater for behandling av forstyrrelser i sentralnervesystemet
AU3932297A (en) N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug
ECSP972192A (es) Derivados de sulfonamida de la formula n-(4-aril- thiazol-2-yl)-y su uso
WO2001074817A1 (fr) Derives d'hydrazide

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application