YU13501A - POBOLJŠANA EKSPRESIJA INSEKTICIDNOG PROTEINA Cry 3B KOD BILJAKA - Google Patents
POBOLJŠANA EKSPRESIJA INSEKTICIDNOG PROTEINA Cry 3B KOD BILJAKAInfo
- Publication number
- YU13501A YU13501A YU13501A YU13501A YU13501A YU 13501 A YU13501 A YU 13501A YU 13501 A YU13501 A YU 13501A YU 13501 A YU13501 A YU 13501A YU 13501 A YU13501 A YU 13501A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- levels
- protein
- plants
- cry3b
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Insects & Arthropods (AREA)
- Pest Control & Pesticides (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Abstract
Predmetni pronalazak otkriva metode i jedinjenja koja sadrže grupu novih ekspresionih kaseta koje obezbedjuju značajno poboljšanje nivoa akumulacije za tvrdokrilce inhibitornih Cry3B i Cry3B varijanti sekvenci amino kiselina kada se one eksprimiraju u biljkama. Preferirani oblici pronalaska obezbedjuju najmanje do deset puta više nivoe proteina koji kontroliše insekte u odnosu na najviše nivoe dobijene korišćenjem prethodnih jedinjenja. U detaljima, transgeni kukuruz koji eksprimira visoke nivoe proteina dizajniran da pokazuje povećanu toksičnost prema štetnim tvrdokrilcima isporučuje superiorne nivoe zaštite od insekata i manje verovatno da podrži razvoj populacija ciljnih insekata koje su rezistentne na insekticidno aktivan protein.[The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B and Cry3B variant amino acid sequences when these are expressed in plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MEP-199/08A MEP19908A (en) | 1998-08-19 | 1999-08-19 | Improved expression of cry3b insecticidal protein in plants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9715098P | 1998-08-19 | 1998-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU13501A true YU13501A (sh) | 2005-06-10 |
Family
ID=22261516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU13501A YU13501A (sh) | 1998-08-19 | 1999-08-19 | POBOLJŠANA EKSPRESIJA INSEKTICIDNOG PROTEINA Cry 3B KOD BILJAKA |
Country Status (17)
| Country | Link |
|---|---|
| EP (5) | EP1104481B1 (sh) |
| CN (1) | CN100390284C (sh) |
| AR (2) | AR021465A1 (sh) |
| AT (3) | ATE506441T1 (sh) |
| AU (3) | AU5571699A (sh) |
| BR (2) | BRPI9913690B1 (sh) |
| CA (2) | CA2340286C (sh) |
| CZ (2) | CZ301915B6 (sh) |
| DE (3) | DE69943375D1 (sh) |
| DK (2) | DK1698699T3 (sh) |
| ES (3) | ES2365204T3 (sh) |
| ME (2) | MEP19908A (sh) |
| PL (1) | PL346650A1 (sh) |
| PT (2) | PT1121440E (sh) |
| WO (3) | WO2000011178A2 (sh) |
| YU (1) | YU13501A (sh) |
| ZA (1) | ZA200100874B (sh) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060594A (en) | 1997-12-18 | 2000-05-09 | Ecogen, Inc. | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
| GB9908788D0 (en) * | 1999-04-16 | 1999-06-09 | Univ London | Gene expression in eukaryotic cells |
| US6501009B1 (en) | 1999-08-19 | 2002-12-31 | Monsanto Technology Llc | Expression of Cry3B insecticidal protein in plants |
| HUP0303806A2 (hu) | 2001-02-22 | 2004-03-01 | Pioneer Hi-Bred International, Inc. | Szacharóz-szintetáz gének manipulálása a szár és a mag minőségének javítására |
| US7705216B2 (en) * | 2002-07-29 | 2010-04-27 | Monsanto Technology Llc | Corn event PV-ZMIR13 (MON863) plants and compositions and methods for detection thereof |
| AU2004299829B2 (en) | 2003-12-15 | 2007-08-16 | Monsanto Technology Llc | Corn plant MON88017 and compositions and methods for detection thereof |
| WO2005069986A2 (en) * | 2004-01-20 | 2005-08-04 | Monsanto Technology Llc | Chimeric promoters for use in plants |
| CN102524294B (zh) | 2004-04-09 | 2018-04-06 | 孟山都技术有限公司 | 用于在植物中控制昆虫侵袭的组合物和方法 |
| EP3508582B1 (en) | 2005-09-16 | 2021-01-13 | Monsanto Technology LLC | Methods for genetic control of insect infestations in plants and compositions thereof |
| BRPI0616848A8 (pt) | 2005-10-03 | 2017-09-19 | Monsanto Technology Llc | Semente de planta transgênica com maior teor de lisina |
| EP2184293B1 (en) * | 2007-06-08 | 2011-10-12 | Universidad Nacional Autonoma De Mexico | Suppression of resistance in insects to bacillus thuringiensis cry toxins, using toxins that do not require the cadherin receptor |
| CN104745603B (zh) * | 2007-06-08 | 2018-08-21 | 墨西哥国立大学 | 使用不需要钙黏着蛋白受体的毒素遏制昆虫对苏云金芽孢杆菌cry毒素的抗性 |
| ES2457218T3 (es) | 2008-04-07 | 2014-04-25 | Monsanto Technology Llc | Elementos reguladores de plantas y usos de los mismos |
| PE20110310A1 (es) * | 2008-07-02 | 2011-05-29 | Athenix Corp | Axmi-115, axmi-113, axmi-005, axmi-163 y axmi-184: proteinas insecticidas |
| CN102333439B (zh) * | 2009-03-30 | 2015-04-22 | 孟山都技术公司 | 水稻转基因事件17053及其使用方法 |
| EP2524045B1 (en) | 2010-01-14 | 2015-12-02 | Monsanto Technology LLC | Plant regulatory elements and uses thereof |
| CN103534267B (zh) | 2011-03-25 | 2017-07-14 | 孟山都技术公司 | 植物调控元件及其用途 |
| CA2997781C (en) | 2011-05-13 | 2020-05-26 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| US9663793B2 (en) | 2012-04-20 | 2017-05-30 | Monsanto Technology, Llc | Plant regulatory elements and uses thereof |
| WO2014004638A2 (en) * | 2012-06-29 | 2014-01-03 | Monsanto Technology Llc | Methods and compositions for enhancing gene expression |
| CN103194460B (zh) * | 2013-04-17 | 2015-04-08 | 中国农业大学 | 一种苏云金芽孢杆菌晶体融合蛋白Bt Cry3Bb的制备方法 |
| CN103884848B (zh) * | 2014-04-02 | 2015-08-05 | 江苏省农业科学院 | 一种预测转Bt基因棉花抗虫性强度的方法 |
| WO2016154631A1 (en) | 2015-03-26 | 2016-09-29 | The Texas A&M University System | Conversion of lignin into bioplastics and lipid fuels |
| CN109475124B (zh) * | 2015-08-27 | 2021-11-19 | 孟山都技术公司 | 新型昆虫抑制蛋白 |
| CA2998391C (en) | 2015-10-12 | 2023-09-12 | E. I. Du Pont De Nemours And Company | Fungal entomopathogen biocides and their use in plants |
| CN105936644B (zh) * | 2016-07-09 | 2021-11-16 | 河北省农林科学院植物保护研究所 | 一种杀虫蛋白及其核苷酸序列和应用 |
| US20200332311A1 (en) | 2018-01-12 | 2020-10-22 | The Texas A&M University System | Increasing plant bioproduct yield |
| WO2019143526A1 (en) | 2018-01-18 | 2019-07-25 | Pioneer Hi-Bred International, Inc. | Alginate encapsulation of fungal microsclerotia |
| US20240247279A1 (en) | 2018-04-27 | 2024-07-25 | Pioneer Hi-Bred International, Inc. | Maize event dp-023211-2 and methods for detection thereof |
| US20220015372A1 (en) | 2018-12-14 | 2022-01-20 | Pioneer Hi-Bred International, Inc. | Biologicals and their use in plants |
| CN109777823B (zh) * | 2019-01-28 | 2020-02-07 | 湖北大学 | 一种高抗柳蓝叶甲质体转Bt基因杨树新品种的获得方法 |
| WO2021076346A1 (en) | 2019-10-18 | 2021-04-22 | Pioneer Hi-Bred International, Inc. | Maize event dp-202216-6 and dp-023211-2 stack |
| CN112898388A (zh) * | 2020-06-16 | 2021-06-04 | 九圣禾种业股份有限公司 | 一种抗虫蛋白Cry1ABn39、编码基因和应用 |
| CN116056564A (zh) | 2020-09-10 | 2023-05-02 | 孟山都技术公司 | 利用减数分裂和种系启动子增加基因编辑和定点整合事件 |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| WO2022072718A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| UY39585A (es) * | 2020-12-23 | 2022-07-29 | Monsanto Technology Llc | Proteínas que exhiben actividad inhibidora de insectos frente a plagas con importancia agrícola de plantas de cultivo y semillas |
| WO2024009146A2 (en) | 2022-07-05 | 2024-01-11 | University Of Freiburg | Plant regulatory elements and uses thereof |
| WO2024052856A1 (en) | 2022-09-09 | 2024-03-14 | Friedrich Alexander Universität Erlangen-Nürnberg | Plant regulatory elements and uses thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3587718T2 (de) | 1984-03-06 | 1994-08-04 | Mgi Pharma Inc | Herbizide Resistenz in Pflanzen. |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US5639952A (en) * | 1989-01-05 | 1997-06-17 | Mycogen Plant Science, Inc. | Dark and light regulated chlorophyll A/B binding protein promoter-regulatory system |
| BR9007159A (pt) * | 1989-02-24 | 1991-12-10 | Monsanto Co | Genes sinteticos de plantas e processo para a preparacao dos mesmos |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US6127532A (en) * | 1989-09-12 | 2000-10-03 | Board Of Trustees Operating Michigan State University | Lectin cDNA and transgenic plants derived therefrom |
| GB8922007D0 (en) * | 1989-09-29 | 1989-11-15 | Cambridge Advanced Tech | Light-activatable plant promoter |
| US5187091A (en) * | 1990-03-20 | 1993-02-16 | Ecogen Inc. | Bacillus thuringiensis cryiiic gene encoding toxic to coleopteran insects |
| US5264364A (en) * | 1991-01-31 | 1993-11-23 | Ecogen Inc. | Bacillus thuringiensis cryIIIc(B) toxin gene and protein toxic to coleopteran insects |
| US5518908A (en) | 1991-09-23 | 1996-05-21 | Monsanto Company | Method of controlling insects |
| US5593874A (en) * | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| JP3594595B2 (ja) * | 1992-11-12 | 2004-12-02 | シンジェンタ リミテッド | 殺生物性のキチン結合性蛋白質 |
| US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
| US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
| FR2712302B1 (fr) * | 1993-11-10 | 1996-01-05 | Rhone Poulenc Agrochimie | Eléments promoteurs de gènes chimères de tubuline alpha. |
| US5659123A (en) | 1994-08-26 | 1997-08-19 | Plant Genetic Systems, N.V. | Diabrotica toxins |
| US5631152A (en) | 1994-10-26 | 1997-05-20 | Monsanto Company | Rapid and efficient regeneration of transgenic plants |
| ES2330168T3 (es) * | 1995-10-13 | 2009-12-04 | Dow Agrosciences Llc | Gen mopdificado de bacillus thuringiensis para combatir los lepidopteros en plantas. |
| ZA974176B (en) | 1996-05-16 | 1998-09-01 | Univ North Texas | A rapid in-vitro regeneration scheme of cotton (gossypium hirsutum l.) plants compatible with agrobacterium-mediated transformation |
| US5942664A (en) * | 1996-11-27 | 1999-08-24 | Ecogen, Inc. | Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants |
| US6023013A (en) | 1997-12-18 | 2000-02-08 | Monsanto Company | Insect-resistant transgenic plants |
| US6077824A (en) | 1997-12-18 | 2000-06-20 | Ecogen, Inc. | Methods for improving the activity of δ-endotoxins against insect pests |
| US6063597A (en) | 1997-12-18 | 2000-05-16 | Monsanto Company | Polypeptide compositions toxic to coleopteran insects |
| DK1040192T3 (da) * | 1997-12-18 | 2006-12-18 | Monsanto Technology Llc | Insekt-resistente transgene planter og fremgangsmåder til forbedring af delta-endotoksin-aktivitet mod insekter |
| US6060594A (en) | 1997-12-18 | 2000-05-09 | Ecogen, Inc. | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
| US9715098B2 (en) | 2012-05-31 | 2017-07-25 | The Board Of Trustees Of The University Of Illinois | Sparse deconvolution spatial light microscopy in two and three dimensions |
-
1999
- 1999-08-18 DE DE69943375T patent/DE69943375D1/de not_active Expired - Lifetime
- 1999-08-18 BR BRPI9913690A patent/BRPI9913690B1/pt active IP Right Grant
- 1999-08-18 CA CA2340286A patent/CA2340286C/en not_active Expired - Lifetime
- 1999-08-18 ES ES99942392T patent/ES2365204T3/es not_active Expired - Lifetime
- 1999-08-18 EP EP99942392A patent/EP1104481B1/en not_active Expired - Lifetime
- 1999-08-18 EP EP14181325.3A patent/EP2811024B1/en not_active Expired - Lifetime
- 1999-08-18 PL PL99346650A patent/PL346650A1/xx not_active IP Right Cessation
- 1999-08-18 AU AU55716/99A patent/AU5571699A/en not_active Abandoned
- 1999-08-18 WO PCT/US1999/018866 patent/WO2000011178A2/en active Application Filing
- 1999-08-18 WO PCT/US1999/019102 patent/WO2000011200A2/en active Application Filing
- 1999-08-18 EP EP09156877.4A patent/EP2080805B1/en not_active Expired - Lifetime
- 1999-08-18 CZ CZ20090604A patent/CZ301915B6/cs not_active IP Right Cessation
- 1999-08-18 AT AT99942392T patent/ATE506441T1/de not_active IP Right Cessation
- 1999-08-18 AU AU55783/99A patent/AU767146B2/en not_active Expired
- 1999-08-18 CZ CZ20010597A patent/CZ302074B6/cs not_active IP Right Cessation
- 1999-08-19 CA CA2340324A patent/CA2340324C/en not_active Expired - Fee Related
- 1999-08-19 ME MEP-199/08A patent/MEP19908A/xx unknown
- 1999-08-19 AT AT06113589T patent/ATE459717T1/de active
- 1999-08-19 ME MEP-2008-199A patent/ME00085B/me unknown
- 1999-08-19 BR BRPI9913089A patent/BRPI9913089B1/pt active IP Right Grant
- 1999-08-19 EP EP99942313A patent/EP1121440B1/en not_active Expired - Lifetime
- 1999-08-19 EP EP06113589A patent/EP1698699B1/en not_active Expired - Lifetime
- 1999-08-19 AT AT99942313T patent/ATE377080T1/de active
- 1999-08-19 PT PT99942313T patent/PT1121440E/pt unknown
- 1999-08-19 AU AU55719/99A patent/AU5571999A/en not_active Abandoned
- 1999-08-19 DE DE69942109T patent/DE69942109D1/de not_active Expired - Lifetime
- 1999-08-19 WO PCT/US1999/018883 patent/WO2000011185A2/en active IP Right Grant
- 1999-08-19 PT PT06113589T patent/PT1698699E/pt unknown
- 1999-08-19 AR ARP990104171A patent/AR021465A1/es not_active Application Discontinuation
- 1999-08-19 CN CNB99812169XA patent/CN100390284C/zh not_active Expired - Fee Related
- 1999-08-19 DK DK06113589.3T patent/DK1698699T3/da active
- 1999-08-19 ES ES06113589T patent/ES2340057T3/es not_active Expired - Lifetime
- 1999-08-19 DK DK99942313T patent/DK1121440T3/da active
- 1999-08-19 YU YU13501A patent/YU13501A/sh unknown
- 1999-08-19 DE DE69937459T patent/DE69937459T2/de not_active Expired - Lifetime
- 1999-08-19 ES ES99942313T patent/ES2294857T3/es not_active Expired - Lifetime
-
2001
- 2001-01-31 ZA ZA200100874A patent/ZA200100874B/en unknown
-
2010
- 2010-01-21 AR ARP100100133A patent/AR075146A2/es active IP Right Grant
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