YU103A - Postupak za dobijanje vodenih formulacija sa aktivnim sastojcima koji su osetljivi na oksidaciju - Google Patents

Postupak za dobijanje vodenih formulacija sa aktivnim sastojcima koji su osetljivi na oksidaciju

Info

Publication number
YU103A
YU103A YU103A YUP103A YU103A YU 103 A YU103 A YU 103A YU 103 A YU103 A YU 103A YU P103 A YUP103 A YU P103A YU 103 A YU103 A YU 103A
Authority
YU
Yugoslavia
Prior art keywords
ppm
inert gas
aqueous formulations
obtaining
priciples
Prior art date
Application number
YU103A
Other languages
English (en)
Serbo-Croatian (sh)
Inventor
Francois Dietlin
Daniele Fredj
Original Assignee
Pharmatop Scr.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8851012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU103(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmatop Scr. filed Critical Pharmatop Scr.
Publication of YU103A publication Critical patent/YU103A/sh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0005—Degasification of liquids with one or more auxiliary substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Removal Of Specific Substances (AREA)

Abstract

Predmetni pronalazak spada u oblast organske hemije, konkretnije u oblast terapeutske hemije. Preciznije, on se odnosi na postupak za dobijanje vodenih formulacija aktivnih sastojaka koji lako oksidišu, posebno fenola, koji su stabilni tokom dužeg vremenskog perioda, pri čemu postupak obuhvata deoksigenizaciju produvavanjem mehurićima inertnog gasa i/ili vakuumizacijom rastvora, uz istovremenu zaštitu od dejstva kiseonika na taj način što se rastvor drži u atmosferi inertnog gasa, putem punjenja boca sa rastvorom u atmosferi inertnog gasa, pri čemu je iz boca prethodno izbačen vazduh putem produvavanja inertnim gasom, nakon čega se zatvorene boce izlažu vakuumu, pri čemu se postiže pritisak u bocama ne veći od 65 000 Pa, čime se dobijaju rastvorene supstance sa koncentracijama rezidualnog kiseonika u rastvoru, manjem od 2 ppm, a poželjno reda 1 ppm i čak 0,5 ppm. Predmetni pronalazak je posebno koristan za pripremanje injektibilnih preparata koji imaju sadržaj kiseonika u rastvoru manji od 2 ppm.$The invention concerns the field of organic chemistry and more particularly that of therapeutic chemistry. More precisely, it concerns a method for obtaining aqueous formulations of easily oxidizable active principles, in particular phenols, stable over a prolonged period, which consists in advanced bubbling deoxygenation with an inert gas and/or vacuumizing them, while protecting them against possible oxygen uptake by maintaining them under inert gas atmosphere, by filling under inert gas into bottles previously made air-free by inert gas blowing, then in subjecting them when they are being closed to a vacuum so as to obtain in the bottle a pressure of not more than 65.000 Pa, thereby obtaining solutes having a residual oxygen concentration in the solution, less than 2 ppm, and preferably of the order of 1 ppm and even 0.5 ppm. The invention is useful in particular for preparing injection preparations having an oxygen content in the solution, less than 2 ppm.
YU103A 2000-06-06 2001-06-06 Postupak za dobijanje vodenih formulacija sa aktivnim sastojcima koji su osetljivi na oksidaciju YU103A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0007231A FR2809619B1 (fr) 2000-06-06 2000-06-06 Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention

Publications (1)

Publication Number Publication Date
YU103A true YU103A (sh) 2006-05-25

Family

ID=8851012

Family Applications (1)

Application Number Title Priority Date Filing Date
YU103A YU103A (sh) 2000-06-06 2001-06-06 Postupak za dobijanje vodenih formulacija sa aktivnim sastojcima koji su osetljivi na oksidaciju

Country Status (16)

Country Link
US (1) US6992218B2 (xx)
CN (1) CN1556694A (xx)
AP (1) AP1880A (xx)
AU (1) AU2001266120A1 (xx)
CA (1) CA2415403C (xx)
CZ (1) CZ200313A3 (xx)
DZ (1) DZ3384A1 (xx)
FR (1) FR2809619B1 (xx)
MA (1) MA26926A1 (xx)
MX (1) MXPA03000001A (xx)
NZ (1) NZ523458A (xx)
PE (1) PE20030508A1 (xx)
RU (1) RU2003100090A (xx)
TW (1) TWI237570B (xx)
WO (1) WO2001093830A1 (xx)
YU (1) YU103A (xx)

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FR2894154B1 (fr) * 2005-12-06 2008-03-14 Pharmatop Scr Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation.
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US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
JP2014505081A (ja) * 2011-02-10 2014-02-27 ネオジャン，エヌ．ヴェー． 貯蔵安定性のある水溶液中のパラセタモール配合物
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Also Published As

Publication number Publication date
TWI237570B (en) 2005-08-11
US20040054012A1 (en) 2004-03-18
NZ523458A (en) 2005-08-26
AP2002002711A0 (en) 2002-12-31
CA2415403C (fr) 2011-05-24
CA2415403A1 (fr) 2001-12-13
CZ200313A3 (cs) 2003-11-12
AU2001266120A1 (en) 2001-12-17
US6992218B2 (en) 2006-01-31
WO2001093830A1 (fr) 2001-12-13
FR2809619A1 (fr) 2001-12-07
MA26926A1 (fr) 2004-12-20
MXPA03000001A (es) 2004-03-19
DZ3384A1 (fr) 2001-12-13
CN1556694A (zh) 2004-12-22
PE20030508A1 (es) 2003-06-25
AP1880A (en) 2008-08-19
RU2003100090A (ru) 2004-05-10
FR2809619B1 (fr) 2004-09-24

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