PE20030508A1 - Un proceso nuevo para obtener formulaciones acuosas de principios activos sensibles a la oxidacion y las soluciones asi obtenidas - Google Patents

Un proceso nuevo para obtener formulaciones acuosas de principios activos sensibles a la oxidacion y las soluciones asi obtenidas

Info

Publication number
PE20030508A1
PE20030508A1 PE2001000715A PE2001000715A PE20030508A1 PE 20030508 A1 PE20030508 A1 PE 20030508A1 PE 2001000715 A PE2001000715 A PE 2001000715A PE 2001000715 A PE2001000715 A PE 2001000715A PE 20030508 A1 PE20030508 A1 PE 20030508A1
Authority
PE
Peru
Prior art keywords
deoxygenation
oxidation
solution
concentration
solutions
Prior art date
Application number
PE2001000715A
Other languages
English (en)
Inventor
Daniele Fredj
Francois Dietlin
Original Assignee
Pharmatop Scr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8851012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030508(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmatop Scr filed Critical Pharmatop Scr
Publication of PE20030508A1 publication Critical patent/PE20030508A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0005—Degasification of liquids with one or more auxiliary substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Removal Of Specific Substances (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE UNA SOLUCION ACUOSA DE UN PRINCIPIO ACTIVO DE NATURALEZA FENOLICA COMO PARACETAMOL, SENSIBLE A LA OXIDACION, CONSERVANDOLA POR UN PERIODO PROLONGADO, CARACTERIZADO POR LA DESOXIGENACION DE LA SOLUCION SE DA MEDIANTE EL BURBUJEO DE AL MENOS UN GAS INERTE (NITROGENO) Y PONIENDOLA BAJO VACIO, JUSTO HASTA CONTENER UNA CONCENTRACION DE OXIGENO DE MENOS DE 2ppm EN QUE LA SOLUCION ACUOSA PRECIPITADA DEL PRINCIPIO ESTA CUBIERTA DE UNA ATMOSFERA DE GAS INERTE (ARGON) SE LA PONE EN UN ENVASE ENCERRADO EN QUE LA PRESION ACTUAL ES UN MAXIMO DE 65000 Pa; DE MODO QUE LA CONCENTRACION DE OXIGENO ES MENOS DE O IGUAL A 2ppm, SE EMPLEA EL EFECTO DE DESOXIGENACION ANADIENDO UN AGENTE ANTIOXIDANTE (TIOLES, ACIDO ASCORBICO, AZUCARES REDUCTORES) A LA SOLUCION; SE COMPLETA EL EFECTO DE LA DESOXIGENACION POR ADICION DE ACIDO HIDROXIPOLICARBOXILICO COMO ACIDO CITRICO, ACIDO TARTARICO, GLUCONICO, SACARICO, CITRAMALICO, MALICO, EN UNA CONCENTRACION DE 5mg/100ml A 20mg/100ml
PE2001000715A 2000-06-06 2001-07-16 Un proceso nuevo para obtener formulaciones acuosas de principios activos sensibles a la oxidacion y las soluciones asi obtenidas PE20030508A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0007231A FR2809619B1 (fr) 2000-06-06 2000-06-06 Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention

Publications (1)

Publication Number Publication Date
PE20030508A1 true PE20030508A1 (es) 2003-06-25

Family

ID=8851012

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000715A PE20030508A1 (es) 2000-06-06 2001-07-16 Un proceso nuevo para obtener formulaciones acuosas de principios activos sensibles a la oxidacion y las soluciones asi obtenidas

Country Status (16)

Country Link
US (1) US6992218B2 (es)
CN (1) CN1556694A (es)
AP (1) AP1880A (es)
AU (1) AU2001266120A1 (es)
CA (1) CA2415403C (es)
CZ (1) CZ200313A3 (es)
DZ (1) DZ3384A1 (es)
FR (1) FR2809619B1 (es)
MA (1) MA26926A1 (es)
MX (1) MXPA03000001A (es)
NZ (1) NZ523458A (es)
PE (1) PE20030508A1 (es)
RU (1) RU2003100090A (es)
TW (1) TWI237570B (es)
WO (1) WO2001093830A1 (es)
YU (1) YU103A (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809619B1 (fr) * 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
ITMI20012135A1 (it) 2001-10-16 2003-04-16 Bioren S A Soluzioni iniettabili pronte all'uso di paracetamolo
FR2832063B1 (fr) * 2001-11-15 2004-08-27 Aguettant Lab Procede de production de solutions stables de substances phenoliques et les solutions en resultant
FR2851164B1 (fr) 2003-02-14 2005-04-22 Xuan Tho Nguyen Formulation liquide injectable de paracetamol
US20050020554A1 (en) * 2003-06-06 2005-01-27 Ahmed Salah U. Stability of hormone formulations
FR2880807B1 (fr) * 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
AU2006213673A1 (en) 2005-02-09 2006-08-17 Santen Pharmaceutical Co., Ltd. Formulations for ocular treatment
DE102005037653A1 (de) * 2005-08-05 2007-02-15 Theraselect Gmbh Stabile, flüssige Formulierung von Paracetamol
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
FR2894154B1 (fr) * 2005-12-06 2008-03-14 Pharmatop Scr Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation.
CA2635797C (en) 2006-02-09 2015-03-31 Macusight, Inc. Stable formulations, and methods of their preparation and use
JP5506378B2 (ja) 2006-03-23 2014-05-28 参天製薬株式会社 血管透過性に関連する疾患または病気のための製剤および方法
US20070249727A1 (en) 2006-04-21 2007-10-25 The Proctor & Gamble Company Compositions and kits useful for treatment of respiratory illness
US10022339B2 (en) 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
AU2006346318B2 (en) 2006-07-18 2011-02-10 Genfarma Laboratorio S.L. Injectable liquid paracetamol formulation
EP1992334A1 (en) * 2007-05-08 2008-11-19 Docpharma NV/SA Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation
DE102007026975A1 (de) * 2007-06-01 2008-12-04 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Antioxidationsmittel für Lebensmittel
WO2009081283A2 (en) * 2007-06-18 2009-07-02 Combino Pharm, S.L. Aqueous formulations of acetaminophen for injection
EP2170313A2 (en) * 2007-06-18 2010-04-07 Combino Pharm, S.L. Aqueous formulations of acetaminophen for injection
US9399012B2 (en) 2007-11-13 2016-07-26 Mallinckrodt Ip Reduced dose intravenous acetaminophen
WO2009098716A2 (en) * 2008-01-17 2009-08-13 Aptuit Laurus Private Limited Stable pharmaceutical aqueous compositions
FR2926992B1 (fr) * 2008-02-06 2011-01-14 Moly Pharma Formulation d'une solution de paracetamol injectable,procede de preparation et de conditionnement d'une telle solution et dispositif de conditionnement d'une telle solution
US20110097470A1 (en) * 2008-06-11 2011-04-28 Joerg Kowalczyk Highly active antioxidant based on trehalulose
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
US8404748B2 (en) * 2009-08-13 2013-03-26 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
EP2464332B1 (en) 2009-08-13 2016-03-02 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
CN102548639B (zh) * 2009-09-24 2015-04-29 株式会社东芝 二氧化碳吸收液
US20120245230A1 (en) 2009-12-10 2012-09-27 Tecnimede-Sociedade Tecnico- Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
CN103476395A (zh) * 2011-02-10 2013-12-25 尼奥根公司 在水溶液中贮存稳定的扑热息痛制剂
LT3287123T (lt) 2011-03-04 2020-06-10 Grünenthal GmbH Vandeninė farmacinė tapentadolio kompozicija, skirta gerti
ES2414557B1 (es) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
ITMI20121154A1 (it) 2012-06-29 2013-12-30 Sint Sa Soluzione iniettabile di acetaminofene per la somministrazione spinale
CN103006550A (zh) * 2012-12-11 2013-04-03 哈药集团三精制药股份有限公司 一种胞磷胆碱钠注射液及其制备方法
US20140303254A1 (en) * 2013-04-08 2014-10-09 InnoPharma Licensing LLC Process Of Manufacturing A Stable, Ready To Use Infusion Bag For An Oxidation Sensitive Formulation
UY35988A (es) 2014-02-27 2015-09-30 Sint Sa Proceso para la producción de una solución inyectable de noradrenalina de baja concentración
BR102014005885B1 (pt) 2014-03-13 2021-04-13 Biotec Biológica Indústria Farmacêutica Ltda E.P.P Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso
WO2016008546A1 (en) * 2014-07-18 2016-01-21 Everbright Pharmaceuticals S.A.R.L. Aqueous formulation comprising paracetamol and ibuprofen
CN104288099B (zh) * 2014-09-25 2017-02-15 西安仁仁药业有限公司 一种布洛芬注射液的制备方法
MX2017012312A (es) * 2015-03-27 2018-01-18 Gruenenthal Gmbh Formulacion estable para administracion parenteral de tapentadol.
RS62844B1 (sr) 2015-06-18 2022-02-28 Estetra Srl Orodisperzibilna dozna jedinica koja sadrži komponentu estetrola
CA2988498C (en) 2015-06-18 2022-02-08 Mithra Pharmaceuticals S.A. Orodispersible dosage unit containing an estetrol component
EP3120837A1 (de) 2015-07-22 2017-01-25 Stada Arzneimittel Ag Verfahren zur herstellung einer bortezomibester-lösung
PT3411004T (pt) 2016-02-05 2021-05-11 Innopharma Inc Processo de fabrico de um saco de perfusão estável e pronto para utilização para uma formulação sensível à oxidação
MX2019003257A (es) 2016-09-23 2019-06-10 Gruenenthal Gmbh Formulacion estable para la administracion parenteral de tapentadol.
WO2018140894A1 (en) 2017-01-30 2018-08-02 Nevakar, Inc Norepinephrine compositions and methods therefor
WO2018192664A1 (en) * 2017-04-20 2018-10-25 Hyloris Developments Sa METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF
WO2019150381A1 (en) * 2018-02-01 2019-08-08 Joshi Mahendra R A stable pharmaceutical composition and process for production of isoproterenol hydrochloride injection
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
CA3100314A1 (en) 2018-05-16 2019-11-21 Bayer Healthcare Llc High concentration suspension formulation for cold and flu soft gel capsule medications
EP3863589A1 (en) * 2018-10-08 2021-08-18 Merz Pharma GmbH & Co. KGaA Neurotoxin prefilled vial
US10478453B1 (en) 2019-01-15 2019-11-19 Exela Pharma Sciences, LLC Stable, highly pure L-cysteine compositions for injection and methods of use
CN113105040A (zh) * 2021-04-02 2021-07-13 武汉工控工业技术研究院有限公司 一种自然水体无菌处理及长期保存技术
CN116803376B (zh) * 2023-08-04 2024-02-13 广州白云山星群(药业)股份有限公司 一种复方愈创木酚磺酸钾口服溶液的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3443004A (en) * 1965-04-08 1969-05-06 Ciba Geigy Corp Injectable solution containing 6-chloroor 6-trifluoromethyl-7-sulfamyl - 1,2,4-benzothiodiazine-1,1-dioxide diuretic
DD153578A1 (de) * 1980-10-22 1982-01-20 Hans Meffert Stabilisierung von oxydationsempfindlichen wirkstoffen,vorrangig dithranol in arzneizubereitungen
RO93391B (ro) * 1984-12-20 1988-03-31 Eli Lilly And Company Procedeu pentru prepararea unor saruri de dobutamina
JPH07502544A (ja) * 1992-10-21 1995-03-16 アルコン　ラボラトリーズ，インコーポレイテッド 眼内組織潅注用および眼内外科処置中の瞳孔散大維持用組成物
WO1994013274A1 (en) * 1992-12-10 1994-06-23 Abbott Laboratories Stabilized catecholamine solutions
FR2740338B1 (fr) * 1995-12-01 1997-12-05 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees contenant de la dobutamine
FR2751875B1 (fr) * 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
FR2809619B1 (fr) * 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention

Also Published As

Publication number Publication date
CA2415403A1 (fr) 2001-12-13
TWI237570B (en) 2005-08-11
CZ200313A3 (cs) 2003-11-12
CN1556694A (zh) 2004-12-22
YU103A (sh) 2006-05-25
AU2001266120A1 (en) 2001-12-17
FR2809619A1 (fr) 2001-12-07
MA26926A1 (fr) 2004-12-20
AP2002002711A0 (en) 2002-12-31
RU2003100090A (ru) 2004-05-10
WO2001093830A1 (fr) 2001-12-13
CA2415403C (fr) 2011-05-24
DZ3384A1 (fr) 2001-12-13
MXPA03000001A (es) 2004-03-19
US6992218B2 (en) 2006-01-31
AP1880A (en) 2008-08-19
NZ523458A (en) 2005-08-26
US20040054012A1 (en) 2004-03-18
FR2809619B1 (fr) 2004-09-24

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