MXPA03000001A - Nuevo metodo para obtener formulaciones acuosas con principios activos susceptibles a oxidacion y las soluciones acuosas obtenidas de este modo. - Google Patents

Nuevo metodo para obtener formulaciones acuosas con principios activos susceptibles a oxidacion y las soluciones acuosas obtenidas de este modo.

Info

Publication number
MXPA03000001A
MXPA03000001A MXPA03000001A MXPA03000001A MXPA03000001A MX PA03000001 A MXPA03000001 A MX PA03000001A MX PA03000001 A MXPA03000001 A MX PA03000001A MX PA03000001 A MXPA03000001 A MX PA03000001A MX PA03000001 A MXPA03000001 A MX PA03000001A
Authority
MX
Mexico
Prior art keywords
ppm
inert gas
active principles
aqueous formulations
obtaining
Prior art date
Application number
MXPA03000001A
Other languages
English (en)
Inventor
Franccedil Dietlin
Original Assignee
Scr Pharmatop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8851012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA03000001(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scr Pharmatop filed Critical Scr Pharmatop
Publication of MXPA03000001A publication Critical patent/MXPA03000001A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0005—Degasification of liquids with one or more auxiliary substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Removal Of Specific Substances (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

La invencion se refiere el campo de la quimica organica y mas particularmente a aquel de la quimica terapeutica. Mas precisamente, esta se refiere a un metodo para obtener formulaciones acuosas de principios activos facilmente oxidables, en particular fenoles, estables en un periodo prolongado, el cual consiste en que se someten a desoxigenacion por burbujeo con un gas inerte y/o se someten al vacio, mientras que se protegen contra posible captacion de oxigeno al mantenerlas bajo atmosfera de gas inerte, en llenado bajo las inerte en embotellas previamente libres de aire por burbujeo de gas inerte, luego sometiendolas cuando estan siendo cerradas a un vacio, para obtener en una botella una presion no mayor de 65,000 Pa, mediante lo cual se obtienen solutos que tienen una concentracion residual de oxigeno en la solucion, menor de 2 ppm, y preferentemente del orden de 1 ppm e incluso de 0.5 ppm. La invencion es util en particular para elaborar preparaciones de inyeccion que tienen un contenido de oxigeno la solucion, menor de 2 ppm.
MXPA03000001A 2000-06-06 2001-06-06 Nuevo metodo para obtener formulaciones acuosas con principios activos susceptibles a oxidacion y las soluciones acuosas obtenidas de este modo. MXPA03000001A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0007231A FR2809619B1 (fr) 2000-06-06 2000-06-06 Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
PCT/FR2001/001749 WO2001093830A1 (fr) 2000-06-06 2001-06-06 Procede d'obtention de formulations aqueuses de principes actifs sensibles a l'oxydation

Publications (1)

Publication Number Publication Date
MXPA03000001A true MXPA03000001A (es) 2004-03-19

Family

ID=8851012

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000001A MXPA03000001A (es) 2000-06-06 2001-06-06 Nuevo metodo para obtener formulaciones acuosas con principios activos susceptibles a oxidacion y las soluciones acuosas obtenidas de este modo.

Country Status (16)

Country Link
US (1) US6992218B2 (es)
CN (1) CN1556694A (es)
AP (1) AP1880A (es)
AU (1) AU2001266120A1 (es)
CA (1) CA2415403C (es)
CZ (1) CZ200313A3 (es)
DZ (1) DZ3384A1 (es)
FR (1) FR2809619B1 (es)
MA (1) MA26926A1 (es)
MX (1) MXPA03000001A (es)
NZ (1) NZ523458A (es)
PE (1) PE20030508A1 (es)
RU (1) RU2003100090A (es)
TW (1) TWI237570B (es)
WO (1) WO2001093830A1 (es)
YU (1) YU103A (es)

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FR2880807B1 (fr) * 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
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FR2894154B1 (fr) * 2005-12-06 2008-03-14 Pharmatop Scr Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation.
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US10022339B2 (en) 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
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EP2464332B1 (en) 2009-08-13 2016-03-02 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
AU2009353168B2 (en) 2009-09-24 2014-09-04 Kabushiki Kaisha Toshiba Carbon dioxide gas absorbent solution
CN102711726A (zh) 2009-12-10 2012-10-03 特克尼梅德医疗技术股份公司 用于制备扑热息痛稳定液体制剂的方法和组合物
US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
EP2672955A1 (en) 2011-02-10 2013-12-18 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
PT2680832T (pt) 2011-03-04 2019-10-28 Gruenenthal Gmbh Formulação farmacêutica aquosa de tapentadol para administração oral
ES2414557B1 (es) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
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Also Published As

Publication number Publication date
CA2415403A1 (fr) 2001-12-13
FR2809619B1 (fr) 2004-09-24
US20040054012A1 (en) 2004-03-18
NZ523458A (en) 2005-08-26
AP2002002711A0 (en) 2002-12-31
MA26926A1 (fr) 2004-12-20
FR2809619A1 (fr) 2001-12-07
WO2001093830A1 (fr) 2001-12-13
DZ3384A1 (fr) 2001-12-13
AP1880A (en) 2008-08-19
TWI237570B (en) 2005-08-11
AU2001266120A1 (en) 2001-12-17
US6992218B2 (en) 2006-01-31
YU103A (sh) 2006-05-25
CA2415403C (fr) 2011-05-24
RU2003100090A (ru) 2004-05-10
PE20030508A1 (es) 2003-06-25
CZ200313A3 (cs) 2003-11-12
CN1556694A (zh) 2004-12-22

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