SI3287123T1 - Vodna farmacevtska formulacija tapentadola za peroralno uporabo - Google Patents

Vodna farmacevtska formulacija tapentadola za peroralno uporabo

Info

Publication number
SI3287123T1
SI3287123T1 SI201231778T SI201231778T SI3287123T1 SI 3287123 T1 SI3287123 T1 SI 3287123T1 SI 201231778 T SI201231778 T SI 201231778T SI 201231778 T SI201231778 T SI 201231778T SI 3287123 T1 SI3287123 T1 SI 3287123T1
Authority
SI
Slovenia
Prior art keywords
tapentadol
oral administration
pharmaceutical formulation
aqueous pharmaceutical
aqueous
Prior art date
Application number
SI201231778T
Other languages
English (en)
Inventor
Ulrich Reinhold
Marc Schiller
Eva Cornelia Wulsten
Sabine Karine Katrien Inghelbrecht
Roger Carolus Augusta Embrechts
Ulrich Feil
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44650617&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3287123(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of SI3287123T1 publication Critical patent/SI3287123T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SI201231778T 2011-03-04 2012-03-02 Vodna farmacevtska formulacija tapentadola za peroralno uporabo SI3287123T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449287P 2011-03-04 2011-03-04
EP11003601 2011-05-03
EP17189271.4A EP3287123B1 (en) 2011-03-04 2012-03-02 Aqueous pharmaceutical formulation of tapentadol for oral administration

Publications (1)

Publication Number Publication Date
SI3287123T1 true SI3287123T1 (sl) 2020-07-31

Family

ID=44650617

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201231677T SI2680832T1 (sl) 2011-03-04 2012-03-02 Vodna farmacevtska formulacija tapentadola za peroralno dovajanje
SI201231778T SI3287123T1 (sl) 2011-03-04 2012-03-02 Vodna farmacevtska formulacija tapentadola za peroralno uporabo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201231677T SI2680832T1 (sl) 2011-03-04 2012-03-02 Vodna farmacevtska formulacija tapentadola za peroralno dovajanje

Country Status (23)

Country Link
US (3) US20130022670A1 (sl)
EP (4) EP3597182A1 (sl)
JP (3) JP6046057B2 (sl)
KR (2) KR102051800B1 (sl)
CN (2) CN103501773A (sl)
AU (2) AU2012224952C1 (sl)
BR (1) BR112013022495A2 (sl)
CA (1) CA2828631C (sl)
CY (2) CY1125100T1 (sl)
DK (2) DK2680832T3 (sl)
EA (2) EA027290B1 (sl)
ES (1) ES2756776T3 (sl)
HR (2) HRP20191777T1 (sl)
HU (1) HUE046557T2 (sl)
IL (2) IL227824B (sl)
LT (2) LT3287123T (sl)
MX (2) MX351584B (sl)
PL (2) PL2680832T3 (sl)
PT (2) PT3287123T (sl)
RS (2) RS59491B1 (sl)
SI (2) SI2680832T1 (sl)
WO (1) WO2012119727A1 (sl)
ZA (1) ZA201306478B (sl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
ES2599031T3 (es) 2008-05-09 2017-01-31 Grünenthal GmbH Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
US20110020451A1 (en) 2009-07-22 2011-01-27 Grunenthal Gmbh Tamper-resistant dosage form for oxidation-sensitive opioids
AU2010275753B2 (en) 2009-07-22 2014-08-21 Grünenthal GmbH Hot-melt extruded controlled release dosage form
EP2611425B1 (en) 2010-09-02 2014-07-02 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
CN103269688A (zh) 2010-09-02 2013-08-28 格吕伦塔尔有限公司 包含无机盐的抗破碎剂型
CN103501773A (zh) 2011-03-04 2014-01-08 格吕伦塔尔有限公司 用于口服给予的他喷他多含水药物制剂
WO2013011477A1 (en) * 2011-07-20 2013-01-24 Torrent Pharmaceuticals Ltd Pharmaceutical invention of tapentadol
ES2655900T3 (es) 2011-07-29 2018-02-22 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
HUE034710T2 (hu) 2011-07-29 2018-02-28 Gruenenthal Gmbh Visszaéléssel szemben ellenálló, azonnali hatóanyagfelszabadulást biztosító tabletta
WO2013127831A1 (en) 2012-02-28 2013-09-06 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
SI2838512T1 (sl) 2012-04-18 2018-11-30 Gruenenthal Gmbh Pred posegi in prehitrim sproščanjem odporna farmacevtska oblika odmerka
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015026549A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem à prova de violação contendo uma ou mais partículas
WO2014191396A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
EP2845625A1 (en) 2013-09-04 2015-03-11 Grünenthal GmbH Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
AU2015261060A1 (en) * 2014-05-12 2016-11-03 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising Tapentadol
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
HUE042612T2 (hu) * 2015-03-27 2019-07-29 Gruenenthal Gmbh Parenterális alkalmazású stabil Tapentadol készítmény
MX2017013637A (es) 2015-04-24 2018-03-08 Gruenenthal Gmbh Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes.
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
CN105997862A (zh) * 2016-07-15 2016-10-12 蓝佳堂生物医药（福建）有限公司 一种口腔溃疡含漱液及其制备方法
PE20190908A1 (es) * 2016-09-23 2019-06-26 Gruenenthal Chemie Formulacion estable para la administracion parenteral de tapentadol
EP3585370A1 (en) 2017-02-23 2020-01-01 Grünenthal GmbH Tapentadol as local anesthetic
CN108434042A (zh) * 2018-05-31 2018-08-24 武汉新大地环保材料股份有限公司 一种新型日化防腐剂及其制备方法
EP4011369A1 (en) 2020-12-14 2022-06-15 G.L. Pharma GmbH Aqueous pharmaceutical composition comprising tapentadol tartrate

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334422D0 (en) 1983-12-23 1984-02-01 Sterwin Ag Composition
GB8334423D0 (en) 1983-12-23 1984-02-01 Sterwin Ag Composition
US4775678A (en) 1984-10-01 1988-10-04 Schering Corporation Clotrimazole cream
CA2013755C (en) 1989-04-05 1993-11-30 Simon Benita Medicinal emulsions
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
US6183758B1 (en) 1998-01-29 2001-02-06 Highland Laboratories, Inc. Phytochemicals, nutrients & medication absorption &/or treatment
US6211169B1 (en) 1999-09-29 2001-04-03 Aesgen, Inc. Stable calcitriol solution for packaging into vials
FR2809619B1 (fr) 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
US6594193B2 (en) * 2000-06-22 2003-07-15 Progressent Technologies, Inc. Charge pump for negative differential resistance transistor
US6399087B1 (en) 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
DE10109763A1 (de) 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
DE10112325A1 (de) 2001-03-13 2002-10-02 Fresenius Kabi De Gmbh Lagerstabile Fertiginfusionslösungen des Paracetamols
JP4905616B2 (ja) 2001-04-19 2012-03-28 ライオン株式会社 ソフトコンタクトレンズ用点眼剤
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
FR2832063B1 (fr) 2001-11-15 2004-08-27 Aguettant Lab Procede de production de solutions stables de substances phenoliques et les solutions en resultant
EP1485078B1 (en) * 2002-03-15 2012-09-26 Cypress Bioscience, Inc. Milnacipran for the treatment of irritable bowel syndrome
US20030191187A1 (en) 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
EP1545477A4 (en) * 2002-09-13 2006-11-22 Cydex Inc CAPSULES CONTAINING AQUEOUS FILLING COMPOSITIONS STABILIZED WITH DERIVED CYCLODEXTRIN
US6888993B2 (en) 2002-11-27 2005-05-03 Corning Incorporated Dispersion compensating optical fiber for SMF and transmission link including same
ITMI20022748A1 (it) 2002-12-23 2004-06-24 Eurand Int Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione.
JP2006515882A (ja) 2003-01-08 2006-06-08 カイロン コーポレイション 組織因子経路インヒビター（ｔｆｐｉ）または組織因子経路インヒビター改変体を含有する安定化水性組成物
US20040180915A1 (en) 2003-03-14 2004-09-16 Xanodyne Pharmacal, Inc. Methadone-containing compositions for parenteral administration and method of use thereof
US20060111382A1 (en) * 2004-05-17 2006-05-25 Pharmacofore, Inc. Compositions and methods for treating or preventing pain
PL1612203T3 (pl) 2004-06-28 2007-12-31 Gruenenthal Gmbh Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu
AR053304A1 (es) 2004-07-01 2007-05-02 Gruenenthal Gmbh Formas farmaceuticas orales protegidas frente al abuso con liberacion controlada de (1r,2r)-3-(3 dimetilamino-1-etil-2metil-propil)fenol y procedimiento para su produccion.
DE102004032103A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
CN101208081A (zh) 2005-04-28 2008-06-25 谢拉奎斯特生物科学有限公司 治疗疼痛的方法和组合物
TWI329334B (en) 2005-12-02 2010-08-21 Chung Shan Inst Of Science Manufacture method of electromagnetic interference layer for the plasma display panel
US20070166336A1 (en) * 2005-12-13 2007-07-19 David Delmarre Stable and palatable oral liquid sumatriptan compositions
US8176534B2 (en) 2005-12-30 2012-05-08 General Instrument Corporation Method and apparatus for provisioning a device to access digital rights management (DRM) services in a universal plug and play (UPnP) network
US20080039405A1 (en) 2006-04-25 2008-02-14 Croda, Inc. Modification of percutaneous absorption of topically active materials
DK2012764T3 (da) 2006-04-28 2011-02-28 Gruenenthal Gmbh Farmaceutisk kombination omfattende 3-(3-dimethylamino-1-ethyl-2methyl-propyl)-phenol og paracetamol
CA2649459C (en) 2006-04-28 2014-07-22 Gruenenthal Gmbh Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an nsaid
TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
JP5208933B2 (ja) 2006-07-24 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ （２ｒ，３ｒ）−３−（３−メトキシフェニル）−ｎ，ｎ，２−トリメチルペンタナミンの製造
EP1905440A1 (de) 2006-09-06 2008-04-02 Boehringer Ingelheim Pharma GmbH & Co. KG Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen
TWI394564B (zh) 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
DE102007012165A1 (de) * 2007-03-12 2008-09-18 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes
JP2008266168A (ja) 2007-04-18 2008-11-06 Teika Seiyaku Kk 眼科用剤
EP1985292A1 (en) 2007-04-23 2008-10-29 Grünenthal GmbH Titration of tapentadol
EP1992334A1 (en) 2007-05-08 2008-11-19 Docpharma NV/SA Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation
WO2009064505A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
CN102908339A (zh) * 2007-11-23 2013-02-06 格吕伦塔尔有限公司 他喷他多组合物
CA2959274C (en) * 2007-12-06 2019-07-09 Pain Therapeutics, Inc. Micronized opioid compositions, formulations and dosage forms and methods of making same
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
WO2009124586A1 (en) 2008-04-08 2009-10-15 Arpida Ag Aqueous pharmaceutical formulation
DK2352494T3 (da) * 2008-10-30 2019-10-28 Gruenenthal Gmbh Nye og potente tapentadoldoseringsformer
WO2010089767A1 (en) * 2009-01-09 2010-08-12 Panacea Biotec Ltd. Dual release pharmaceutical suspension
US20100227921A1 (en) * 2009-03-03 2010-09-09 Shire Llc Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
EP2246044A1 (en) 2009-04-21 2010-11-03 Pierre Fabre Dermo-Cosmétique Paediatric solutions comprising a beta-blocker
US20100272815A1 (en) * 2009-04-28 2010-10-28 Actavis Group Ptc Ehf Amorphous form of tapentadol hydrochloride
SG177752A1 (en) 2009-07-27 2012-03-29 Trigemina Inc Methods for treatment of pain
WO2011016487A1 (ja) * 2009-08-05 2011-02-10 ナガセ医薬品株式会社 インジゴカルミン製剤
US20120245230A1 (en) 2009-12-10 2012-09-27 Tecnimede-Sociedade Tecnico- Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
US20110190267A1 (en) 2010-01-05 2011-08-04 Shire Pharmaceuticals, Inc. Prodrugs of opioids and uses thereof
CN102821791B (zh) 2010-03-30 2015-06-17 磷肌酸有限公司 透皮递送贴剂
GB201006200D0 (en) 2010-04-14 2010-06-02 Ayanda As Composition
CN101948397A (zh) 2010-09-07 2011-01-19 天津泰普药品科技发展有限公司 镇痛药他喷他多重要中间体的制备方法
US20120270848A1 (en) 2010-10-22 2012-10-25 Galleon Pharmaceuticals, Inc. Novel Compositions and Therapeutic Methods Using Same
CN103501773A (zh) 2011-03-04 2014-01-08 格吕伦塔尔有限公司 用于口服给予的他喷他多含水药物制剂
MX348831B (es) 2011-03-04 2017-06-30 Gruenenthal Gmbh Administración parenteral de tapentadol.
ES2654407T3 (es) 2011-03-04 2018-02-13 Grünenthal GmbH Composición farmacéutica acuosa semisólida que contiene tapentadol
WO2013144814A1 (en) 2012-03-27 2013-10-03 Fresenius Kabi Oncology Ltd. Stable ready-to-use pharmaceutical composition of pemetrexed
CN103159633B (zh) 2012-07-06 2015-08-12 江苏恩华药业股份有限公司 他喷他多的制备方法及用于制备他喷他多的化合物
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
CN103735500B (zh) 2014-01-28 2016-01-20 江苏华泽医药科技有限公司 盐酸他喷他多注射液及其制备方法
HUE042612T2 (hu) 2015-03-27 2019-07-29 Gruenenthal Gmbh Parenterális alkalmazású stabil Tapentadol készítmény

Also Published As

Publication number Publication date
LT2680832T (lt) 2019-10-25
DK2680832T3 (da) 2019-10-14
RS59491B1 (sr) 2019-12-31
AU2012224952A1 (en) 2013-09-19
IL227824B (en) 2018-04-30
PT2680832T (pt) 2019-10-28
EP2680832A1 (en) 2014-01-08
KR101946790B1 (ko) 2019-02-13
AU2012224952C1 (en) 2017-03-09
AU2012224952B2 (en) 2016-09-22
EP3287123B1 (en) 2020-04-22
KR102051800B1 (ko) 2019-12-04
CA2828631A1 (en) 2012-09-13
MX2013010101A (es) 2013-10-01
CY1123023T1 (el) 2021-10-29
US20200054584A1 (en) 2020-02-20
US20130022670A1 (en) 2013-01-24
CN107308108A (zh) 2017-11-03
ES2756776T3 (es) 2020-04-27
EP3597182A1 (en) 2020-01-22
DK3287123T3 (da) 2020-06-02
MX369121B (es) 2019-10-30
JP2018162271A (ja) 2018-10-18
EA035750B1 (ru) 2020-08-05
JP6046057B2 (ja) 2016-12-14
CY1125100T1 (el) 2022-07-22
EA027290B1 (ru) 2017-07-31
LT3287123T (lt) 2020-06-10
US11547678B2 (en) 2023-01-10
EP3287123A1 (en) 2018-02-28
JP2017061521A (ja) 2017-03-30
JP2014506899A (ja) 2014-03-20
IL254854A0 (en) 2017-12-31
EP3685827A1 (en) 2020-07-29
HRP20191777T1 (hr) 2020-01-24
AU2016273858B2 (en) 2018-04-26
WO2012119727A1 (en) 2012-09-13
HRP20200898T1 (hr) 2020-10-02
PT3287123T (pt) 2020-05-22
EA201692443A1 (ru) 2017-08-31
JP6437984B2 (ja) 2018-12-12
CN103501773A (zh) 2014-01-08
IL254854B (en) 2022-03-01
RS60267B1 (sr) 2020-06-30
SI2680832T1 (sl) 2019-11-29
PL3287123T3 (pl) 2020-11-02
HUE046557T2 (hu) 2020-03-30
JP6735790B2 (ja) 2020-08-05
IL227824A0 (en) 2013-09-30
CA2828631C (en) 2019-10-15
EA201300989A1 (ru) 2014-02-28
EP2680832B1 (en) 2019-09-04
KR20190017056A (ko) 2019-02-19
ZA201306478B (en) 2014-05-28
PL2680832T3 (pl) 2020-03-31
KR20140017586A (ko) 2014-02-11
BR112013022495A2 (pt) 2016-12-06
US20160220516A1 (en) 2016-08-04
MX351584B (es) 2017-10-20
AU2016273858A1 (en) 2017-01-12

Similar Documents

Publication Publication Date Title
IL254854A0 (en) Aqueous pharmaceutical formulation of tapentadol for oral administration
EP2747563A4 (en) COMPOSITIONS AND METHODS FOR ORAL ADMINISTRATION OF MEDICINAL PRODUCTS
EP2906202A4 (en) DRUG FORMULATIONS FOR ORAL ADMINISTRATION
IL228709A0 (en) Dosage unit form for oral administration
EP2661273A4 (en) IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
HRP20160989T1 (hr) Otopina za oralnu primjenu
HK1199843A1 (en) Oral spray formulations and methods for administration of sildenafil
PT2665471T (pt) Formas de dosagem farmacêutica orais de libertação controlada que compreendem mgbg
EP2567710A4 (en) AQUEOUS PHARMACEUTICAL SYSTEM FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES ON THE NAILS
ZA201308905B (en) Nasal pharmaceutical formulation comprising fluticasone
AU2012265231A1 (en) Nasal pharmaceutical formulation
PL2702060T3 (pl) Kwasowe addycyjne sole risperidonu i ich kompozycje farmaceutyczne
IL227651A0 (en) Pharmaceutical formulations for local introduction containing 220b
PL2714042T3 (pl) Przeciwbólowa kompozycja farmaceutyczna do podawania doustnego
HK1250655A1 (zh) 用於口服給藥的他噴他多的水性藥物製劑
HUP0900482A2 (en) Pharmaceutical formulation for oral administration