WO2023151172A1 - Vaccin à vecteur adénoviral pour la prévention contre une souche omicron du sars-cov-2 - Google Patents

Vaccin à vecteur adénoviral pour la prévention contre une souche omicron du sars-cov-2 Download PDF

Info

Publication number
WO2023151172A1
WO2023151172A1 PCT/CN2022/085800 CN2022085800W WO2023151172A1 WO 2023151172 A1 WO2023151172 A1 WO 2023151172A1 CN 2022085800 W CN2022085800 W CN 2022085800W WO 2023151172 A1 WO2023151172 A1 WO 2023151172A1
Authority
WO
WIPO (PCT)
Prior art keywords
vector
vaccine
cov
omicron
nucleic acid
Prior art date
Application number
PCT/CN2022/085800
Other languages
English (en)
Chinese (zh)
Inventor
陈凌
杨臣臣
汪乾
关素华
Original Assignee
广州恩宝生物医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州恩宝生物医药科技有限公司 filed Critical 广州恩宝生物医药科技有限公司
Publication of WO2023151172A1 publication Critical patent/WO2023151172A1/fr

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)

Abstract

La présente invention concerne un vaccin à vecteur adénoviral pour la prévention contre une souche SARS-CoV-2 Omicron. Selon la présente invention, une nouvelle séquence du gène S est obtenue par optimisation en utilisant le biais d'usage des codons. La nouvelle séquence du gène S peut être exprimée efficacement dans les cellules humaines. Un organisme immunisé peut exprimer un antigène S de manière efficace et générer des anticorps neutralisants ciblant la souche SARS-CoV-2 Omicron, ce qui protège efficacement l'organisme contre l'infection par la souche Omicron.
PCT/CN2022/085800 2022-02-09 2022-04-08 Vaccin à vecteur adénoviral pour la prévention contre une souche omicron du sars-cov-2 WO2023151172A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210120315.4 2022-02-09
CN202210120315.4A CN114150005B (zh) 2022-02-09 2022-02-09 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗

Publications (1)

Publication Number Publication Date
WO2023151172A1 true WO2023151172A1 (fr) 2023-08-17

Family

ID=80450043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/085800 WO2023151172A1 (fr) 2022-02-09 2022-04-08 Vaccin à vecteur adénoviral pour la prévention contre une souche omicron du sars-cov-2

Country Status (2)

Country Link
CN (1) CN114150005B (fr)
WO (1) WO2023151172A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114150004B (zh) * 2022-02-09 2022-04-22 广州恩宝生物医药科技有限公司 表达SARS-CoV-2奥密克戎突变株病毒抗原肽的核酸序列及其应用
CN114150005B (zh) * 2022-02-09 2022-04-22 广州恩宝生物医药科技有限公司 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗
CN117567572A (zh) * 2022-04-01 2024-02-20 中国科学院微生物研究所 一种新冠病毒Delta和Omicron变异株嵌合抗原、其制备方法和应用
CN115453113A (zh) * 2022-04-13 2022-12-09 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种广谱性通用型新型冠状病毒双抗原夹心elisa抗体检测试剂盒及其应用
CN115716866A (zh) * 2022-09-30 2023-02-28 珠海丽凡达生物技术有限公司 新型冠状病毒疫苗及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112206318A (zh) * 2020-03-16 2021-01-12 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的Ad7载体疫苗
CN112220918A (zh) * 2020-03-16 2021-01-15 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的Ad35载体疫苗
CN113069540A (zh) * 2021-03-15 2021-07-06 广州恩宝生物医药科技有限公司 一种基于流感病毒载体的新型冠状病毒疫苗及其制备方法
CN113185613A (zh) * 2021-04-13 2021-07-30 武汉大学 新型冠状病毒s蛋白及其亚单位疫苗
CN113308493A (zh) * 2021-03-18 2021-08-27 广州恩宝生物医药科技有限公司 新型冠状病毒Ad26腺病毒载体疫苗及其制备方法与应用
CN114150005A (zh) * 2022-02-09 2022-03-08 广州恩宝生物医药科技有限公司 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200643171A (en) * 2005-06-07 2006-12-16 Temasek Life Sciences Lab Ltd Porcine circovirus type 2 vaccines
CA2866037C (fr) * 2007-04-23 2017-05-16 Siga Technologies, Inc. Produits chimiques, compositions et procedes de traitement et de prevention des infections a orthopoxvirus et des maladies associees
FI3110441T3 (fi) * 2014-02-24 2024-05-06 Glaxosmithkline Biologicals S A Uusi polysakkaridi ja sen käyttöjä
CN106916851A (zh) * 2017-03-01 2017-07-04 广州恩宝生物医药科技有限公司 一种复制缺陷型人14型腺病毒载体及其制备方法和应用
CN108210921A (zh) * 2017-12-29 2018-06-29 广州恩宝生物医药科技有限公司 一种寨卡病毒疫苗及其制备方法
CN110551757A (zh) * 2019-06-26 2019-12-10 广州恩宝生物医药科技有限公司 一种复制缺陷型重组人4型腺病毒及其制备方法和应用
CN111166875A (zh) * 2020-01-08 2020-05-19 广州恩宝生物医药科技有限公司 一种腺病毒二价疫苗
CN110974950B (zh) * 2020-03-05 2020-08-07 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗
WO2021000969A2 (fr) * 2020-02-23 2021-01-07 广州恩宝生物医药科技有限公司 Séquence d'acide nucléique exprimant un peptide antigénique du virus sars-cov-2 et son utilisation
CN110951756B (zh) * 2020-02-23 2020-08-04 广州恩宝生物医药科技有限公司 表达SARS-CoV-2病毒抗原肽的核酸序列及其应用
CN112300251B (zh) * 2020-02-24 2022-04-05 成都威斯克生物医药有限公司 抗SARS-CoV-2感染的蛋白及疫苗
CN111217917B (zh) * 2020-02-26 2020-10-23 康希诺生物股份公司 一种新型冠状病毒SARS-CoV-2疫苗及其制备方法
CN111218458B (zh) * 2020-02-27 2020-11-20 珠海丽凡达生物技术有限公司 编码SARS-CoV-2病毒抗原的mRNA和疫苗及疫苗的制备方法
MX2022011111A (es) * 2020-03-08 2023-03-02 Humanigen Inc Métodos para tratar infección de coronavirus y lesión pulmonar inducida por inflamación resultante.
CN111218459B (zh) * 2020-03-18 2020-09-11 中国人民解放军军事科学院军事医学研究院 一种以人复制缺陷腺病毒为载体的重组新型冠状病毒疫苗
CN111471103A (zh) * 2020-03-20 2020-07-31 唐山怡安生物工程有限公司 一种新冠病毒（2019-nCOV）的异源抗体及其制备方法
CN111330003A (zh) * 2020-03-23 2020-06-26 翁炳焕 一种新冠肺炎反义rna多价疫苗的制备方法
WO2021224946A1 (fr) * 2020-05-07 2021-11-11 Bharat Biotech International Limited Vaccin contre le coronavirus par immunisation nasale
WO2021243219A1 (fr) * 2020-05-29 2021-12-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vaccin contre le sars-cov-2 à base d'adénovirus
CN113750227A (zh) * 2020-06-01 2021-12-07 康希诺生物股份公司 一种SARS-CoV-2疫苗
CN111956797B (zh) * 2020-07-10 2022-05-13 清华大学 新型疫苗佐剂及其在新冠肺炎疫苗和其他疫苗中的应用
CN111778264B (zh) * 2020-07-14 2021-06-29 广州佰芮慷生物科技有限公司 基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎疫苗
CN112618707B (zh) * 2020-10-15 2023-07-04 广州达博生物制品有限公司 一种SARS-CoV-2冠状病毒疫苗及其制备方法
CN112386684B (zh) * 2020-11-12 2023-12-05 广东昭泰细胞生物科技有限公司 一种covid-19疫苗及其制备方法和应用
CN112552380B (zh) * 2020-12-10 2021-12-24 武汉博沃生物科技有限公司 一种SARS-CoV-2病毒的免疫原及其应用
CN114106166B (zh) * 2022-01-29 2022-05-06 中国疾病预防控制中心病毒病预防控制所 人源抗新冠病毒中和性抗体d2及其应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112206318A (zh) * 2020-03-16 2021-01-12 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的Ad7载体疫苗
CN112220918A (zh) * 2020-03-16 2021-01-15 广州恩宝生物医药科技有限公司 一种用于预防SARS-CoV-2感染的Ad35载体疫苗
CN113069540A (zh) * 2021-03-15 2021-07-06 广州恩宝生物医药科技有限公司 一种基于流感病毒载体的新型冠状病毒疫苗及其制备方法
CN113308493A (zh) * 2021-03-18 2021-08-27 广州恩宝生物医药科技有限公司 新型冠状病毒Ad26腺病毒载体疫苗及其制备方法与应用
CN113185613A (zh) * 2021-04-13 2021-07-30 武汉大学 新型冠状病毒s蛋白及其亚单位疫苗
CN114150005A (zh) * 2022-02-09 2022-03-08 广州恩宝生物医药科技有限公司 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine

Also Published As

Publication number Publication date
CN114150005A (zh) 2022-03-08
CN114150005B (zh) 2022-04-22

Similar Documents

Publication Publication Date Title
WO2023151172A1 (fr) Vaccin à vecteur adénoviral pour la prévention contre une souche omicron du sars-cov-2
CN110974950B (zh) 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗
Guo et al. Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector‐based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
WO2023151173A1 (fr) Séquence d'acide nucléique exprimant le peptide antigénique du virus de la souche mutante du sars-cov-2 omicron, et son utilisation
US10760096B2 (en) Human type 55 replication defective adenovirus vector, method for preparing same and uses thereof
US9750801B2 (en) Replicating recombinant adenovirus vectors, compositions, and methods of use thereof
US20210283244A1 (en) Adenovirus-vectored vaccine for preventing sars-cov-2 infection
CN111778264B (zh) 基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎疫苗
WO2022193552A1 (fr) Vaccin basé sur un vecteur d'adénovirus de type 26 (ad26) contre le sars-cov-2, son procédé de préparation et son application
Kim et al. A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice
WO2021139147A1 (fr) Vaccin à adénovirus bivalent
CN110616199A (zh) 一种复制缺陷型重组人7型腺病毒及其制备方法和应用
CN110551757A (zh) 一种复制缺陷型重组人4型腺病毒及其制备方法和应用
EP2855685A1 (fr) Vecteurs adénoviraux pour la transduction de tissus vasculaires
WO2023024525A1 (fr) Vaccin à vecteur adénovirus pour la prévention de la souche d'origine de sras-cov-2 et du variant bêta de sras-cov-2
WO2022007774A1 (fr) Nouveau vecteur d'adénovirus de chimpanzé, son procédé de construction et son application
CN115772528A (zh) 用于预防非洲猪瘟的腺病毒载体疫苗及其应用
Yamasaki et al. Development of a method for effective amplification of human adenovirus 40
KR20220012863A (ko) 아데노바이러스 유전자 요법 벡터 생산성 및 감염성을 증가시키는 아데노바이러스 폴리펩타이드 ix
CN115976078B (zh) 一种广谱的腺病毒载体新冠疫苗
WO2021184987A1 (fr) Vaccin à vecteur ad7 pour la prévention d'une infection par sras-cov-2
JP2011505837A (ja) アデノウイルス血清１４型に対するワクチン
EA045436B1 (ru) Аденовирусные векторы и пути их применения
Evans Regulation of adenovirus infection by E4ORF3-induced reorganization of PML nuclear domains
WO2004108939A2 (fr) Regions d'encapsidation d'adenovirus bovins et region de controle transcriptionnel e1

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22925533

Country of ref document: EP

Kind code of ref document: A1