WO2021025129A1 - 涙液分泌促進用眼科組成物 - Google Patents

涙液分泌促進用眼科組成物 Download PDF

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Publication number
WO2021025129A1
WO2021025129A1 PCT/JP2020/030231 JP2020030231W WO2021025129A1 WO 2021025129 A1 WO2021025129 A1 WO 2021025129A1 JP 2020030231 W JP2020030231 W JP 2020030231W WO 2021025129 A1 WO2021025129 A1 WO 2021025129A1
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WO
WIPO (PCT)
Prior art keywords
ophthalmic composition
salt
dergocitinib
eye
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/030231
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English (en)
French (fr)
Japanese (ja)
Inventor
良宏 高井
孝弘 黒瀬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rohto Pharmaceutical Co Ltd
Original Assignee
Rohto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohto Pharmaceutical Co Ltd filed Critical Rohto Pharmaceutical Co Ltd
Priority to CN202410802175.8A priority Critical patent/CN118903144A/zh
Priority to US17/632,419 priority patent/US20220280515A1/en
Priority to CN202080055566.8A priority patent/CN114173788A/zh
Priority to JP2021537387A priority patent/JP7597714B2/ja
Priority to EP20850966.1A priority patent/EP4011450A4/en
Priority to KR1020227005681A priority patent/KR20220044288A/ko
Publication of WO2021025129A1 publication Critical patent/WO2021025129A1/ja
Anticipated expiration legal-status Critical
Priority to JP2024207323A priority patent/JP2025019313A/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Definitions

  • the present invention relates to an ophthalmic composition for promoting tear secretion.
  • Corneal conjunctival epithelial disorder is a disease that occurs due to an intrinsic disease such as dry eye or an extrinsic disease caused by wearing contact lenses and presents symptoms such as lacrimation, foreign body sensation, eye pain, and hyperemia.
  • corneal epithelial disorders eye drops containing sodium hyaluronate, which has an action of promoting the growth of corneal epithelium and an action of retaining water, have been put on the market.
  • diquafosol sodium which is a therapeutic agent for dry eye, promoted tear secretion and improved corneal epithelial damage in a rat dry eye model (for example, non-patent literature). 1).
  • Janus kinase is a non-receptor tyrosine kinase that plays an important role in intracellular immune activation signal transduction, and drugs having Janus kinase inhibitory activity suppress excessive activation of the immune response. Therefore, it is expected to improve autoimmune diseases and allergic diseases.
  • An object of the present invention is to provide a new ophthalmic composition capable of promoting the secretion of tear fluid.
  • an ophthalmic composition capable of promoting the secretion of tear fluid.
  • Test Example 1 it is a graph which shows the tear secretion promoting effect by a single ophthalmic administration of dergocitinib using a normal rabbit.
  • Test Example 2 it is a graph which shows the tear secretion promoting effect by a single ophthalmic administration of dergocitinib using a normal mouse.
  • A is a graph showing the tear secretion promoting effect by a single ophthalmic administration of dergocitinib using normal rats in Test Example 3.
  • (B) is a graph showing the tear secretion promoting effect by a single ophthalmic administration of dergocitinib using a lacrimal gland-excised rat in Test Example 3.
  • Test Example 4 it is a graph which shows the tear volume increasing effect by repeated ophthalmic administration of dergocitinib using a lacrimal gland-excised rat.
  • Test Example 5 it is a graph which shows the effect of improving keratoconjunctival epithelial disorder by repeated instillation of dergocitinib using lacrimal gland-excised rats.
  • the ophthalmic composition according to this embodiment is 3-[(3S, 4R) -3-methyl-6- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1,6-diazaspiro [3]. .4] Octane-1-yl] -3-oxopropanenitrile or a salt thereof.
  • the salt of dergocitinib is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable.
  • Specific examples of such salts include salts with inorganic acids, salts with organic acids, salts with inorganic bases, salts with organic bases, salts with acidic amino acids, salts with basic amino acids, and the like. ..
  • Examples of the salt with the inorganic acid include salts with hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like.
  • Salts with organic acids include, for example, acetic acid, succinic acid, fumaric acid, maleic acid, tartaric acid, citric acid, lactic acid, stearic acid, benzoic acid, methanesulfonic acid (mesylic acid), ethanesulfonic acid, p-toluenesulfonic acid. And salt can be mentioned.
  • Examples of the salt with the inorganic base include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, aluminum salt and ammonium salt.
  • Examples of the salt with an organic base include salts with diethylamine, diethanolamine, meglumine, N, N-dibenzylethylenediamine and the like.
  • Examples of the salt with an acidic amino acid include a salt with aspartic acid, glutamic acid and the like.
  • Examples of the salt with a basic amino acid include a salt with arginine, lysine, ornithine and the like.
  • Delgocitinib or its salt has the effect of promoting the secretion of tears. Therefore, as an embodiment of the present invention, there is provided an ophthalmic composition for promoting tear secretion, which contains dergocitinib or a salt thereof. In addition, promotion of lacrimal secretion is considered to be a major factor in the improvement of keratoconjunctival epithelial disorders. Therefore, as an embodiment of the present invention, an ophthalmic composition for improving keratoconjunctival epithelial damage, which contains dergocitinib or a salt thereof, is provided. It has not been reported so far that inhibition of Janus kinase promotes tear secretion.
  • the ophthalmic composition according to the present embodiment is a keratoconjunctival epithelial disorder caused by an intrinsic disease such as dry eye (dry eye syndrome), Sjogren's syndrome, Stevens-Johnson syndrome, or postoperative, drug-induced, traumatic, contact lens. It can be used for any of the keratoconjunctival epithelial disorders caused by extrinsic diseases caused by wearing. Above all, since the ophthalmic composition according to the present embodiment promotes tear secretion by containing dergocitinib or a salt thereof, it is preferable to use it for ameliorating keratoconjunctival epithelial damage caused by an endogenous factor, and it is dry.
  • the dry eye that causes the keratoconjunctival epithelial disorder may be a dry eye caused by an autoimmune disease such as Sjogren's syndrome, or may be a dry eye caused by a factor other than the autoimmune disease.
  • the ophthalmic composition according to the present embodiment can be used for improving dry eye because it promotes tear secretion by containing dergocitinib or a salt thereof.
  • the dry eye may be a dry eye caused by an autoimmune disease such as Sjogren's syndrome, or may be a dry eye caused by a factor other than the autoimmune disease.
  • the content of dergocitinib or a salt thereof in the ophthalmic composition according to the present embodiment is not particularly limited, and is appropriately set according to the type and content of other compounding ingredients, the formulation form, and the like.
  • the content of the component (A) from the viewpoint of exerting the effect of the present invention more remarkably, for example, based on the total amount of the ophthalmic composition according to the present embodiment, the total content of dergocitinib or a salt thereof is 0.
  • various additives are appropriately selected according to a conventional method according to the formulation form thereof, as long as the effects of the present invention are not impaired, and one or more of them are used in combination. It may be contained in an appropriate amount.
  • the pH of the ophthalmic composition according to the present embodiment is not particularly limited as long as it is within a pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable range.
  • the ophthalmic composition according to the present embodiment can be prepared, for example, by adding and mixing dergocitinib or a salt thereof and, if necessary, other contained components so as to have a desired content. Specifically, for example, it can be prepared by dissolving or suspending the above components in purified water and sterilizing by filtration sterilization or the like.
  • the ophthalmic composition according to the present embodiment can take various dosage forms depending on the purpose, and examples thereof include liquid preparations, gel preparations, semi-solid preparations (ointments, etc.) and the like. Among these, a liquid agent is preferable, and an aqueous liquid agent is more preferable.
  • the ophthalmic composition according to the present embodiment is used, for example, as an eye drop (also referred to as an eye drop or an eye drop; the eye drop includes artificial tears and an eye drop that can be instilled while wearing contact lenses). Can be done.
  • an eye drop also referred to as an eye drop or an eye drop; the eye drop includes artificial tears and an eye drop that can be instilled while wearing contact lenses). Can be done.
  • the usage / dose thereof is not particularly limited as long as it is effective and has few side effects.
  • a method for promoting the secretion of tears which is administered to a subject with dergocitinib or a salt thereof, or an ophthalmic composition containing them.
  • a method for ameliorating keratoconjunctival epithelial damage which is administered to a subject with dergocitinib or a salt thereof, or an ophthalmic composition containing them.
  • the use of dergocitinib or a salt thereof for the production of an ophthalmic composition for promoting tear secretion is provided. Also, as an embodiment of the present invention, there is provided the use of dergocitinib or a salt thereof for the production of an ophthalmic composition for improving keratoconjunctival epithelial disorders.
  • dergocitinib or a salt thereof for use in promoting tear secretion is provided. Further, as an embodiment of the present invention, dergocitinib or a salt thereof for use in improving keratoconjunctival epithelial disorders is provided.
  • the tear volume was significantly increased in the dergocitinib solution group as compared with the PBS group (Student's t-test).
  • a phenol red thread (Zone Quick, AYUMI Pharmaceutical Corporation) was inserted into the conjunctival sac on the outer corner of the eye. After 15 seconds, the phenol red thread was withdrawn, the length of the wet portion of the phenol red thread was measured, and this measured value was taken as the tear volume. The results are shown in FIG.
  • the tear volume increased in the dergocitinib solution group at each concentration as compared with the PBS group, and a significant increase was confirmed especially in the 0.05% and 0.2% groups (Dunnett's test). ..
  • pilocarpine hydrochloride As a control substance, pilocarpine hydrochloride (Tokyo Chemical Industry Co., Ltd.) was dissolved in physiological saline (Otsuka Pharmaceutical Factory, Otsuka Pharmaceutical Factory) and stirred to prepare a 3% pilocarpine solution.
  • physiological saline Otsuka Pharmaceutical Factory, Otsuka Pharmaceutical Factory
  • SD rats Normal male Sprague-Dawley (SD) rats (Nippon SLC Co., Ltd.) and SD rats 1 week after removal of the main and accessory lacrimal glands were treated with saline and diquas ophthalmic solution 3% (Santen Pharmaceutical Co., Ltd.). ), 3% pilocarpine solution or 0.05% dergocitinib solution was instilled at a dose of 5 ⁇ L / eye.
  • the tear volume was significantly increased in the dergocitinib solution group at each concentration as compared with the PBS group. (Steel test).
  • Delgocitinib was dissolved in PBS (Kojin Bio Co., Ltd.) and stirred to prepare dergocitinib solutions (0.0125%, 0.05% and 0.2%) at each concentration.
  • Male SD rats (Nippon SLC Co., Ltd.) one week after the main lacrimal gland was removed were repeatedly instilled with PBS or a dergocitinib solution of each concentration four times a day at a dose of 5 ⁇ L / eye.
  • a 10 mg / mL fluorescein stain was instilled at a dose of 1 ⁇ L / eye.
  • the corneal epithelial injury score was significantly lower in the dergocitinib solution group at each concentration than in the PBS group. (Steel test).

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP2020/030231 2019-08-07 2020-08-06 涙液分泌促進用眼科組成物 Ceased WO2021025129A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN202410802175.8A CN118903144A (zh) 2019-08-07 2020-08-06 泪液分泌促进用眼科组合物
US17/632,419 US20220280515A1 (en) 2019-08-07 2020-08-06 Ophthalmic Composition for Promoting Tear Secretion
CN202080055566.8A CN114173788A (zh) 2019-08-07 2020-08-06 泪液分泌促进用眼科组合物
JP2021537387A JP7597714B2 (ja) 2019-08-07 2020-08-06 涙液分泌促進用眼科組成物
EP20850966.1A EP4011450A4 (en) 2019-08-07 2020-08-06 Ophthalmic composition for promoting tear secretion
KR1020227005681A KR20220044288A (ko) 2019-08-07 2020-08-06 누액 분비 촉진용 안과 조성물
JP2024207323A JP2025019313A (ja) 2019-08-07 2024-11-28 涙液分泌促進用眼科組成物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2019145670 2019-08-07
JP2019-145670 2019-08-07
JP2019239605 2019-12-27
JP2019-239605 2019-12-27

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WO2021025129A1 true WO2021025129A1 (ja) 2021-02-11

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US (1) US20220280515A1 (https=)
EP (1) EP4011450A4 (https=)
JP (2) JP7597714B2 (https=)
KR (1) KR20220044288A (https=)
CN (2) CN114173788A (https=)
TW (1) TW202120094A (https=)
WO (1) WO2021025129A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022025281A1 (https=) * 2020-07-30 2022-02-03
JPWO2022025279A1 (https=) * 2020-07-30 2022-02-03
WO2023100918A1 (ja) * 2021-11-30 2023-06-08 興和株式会社 新規ニコチンアミド化合物及びその用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4674401A3 (en) * 2019-12-27 2026-02-25 Rohto Pharmaceutical Co., Ltd Container accommodating an aqueous ophthalmic composition comprising delgocitinib

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JP2009046470A (ja) * 2007-07-11 2009-03-05 Pfizer Inc ドライアイ障害を治療する医薬組成物および方法
WO2011013785A1 (ja) * 2009-07-31 2011-02-03 日本たばこ産業株式会社 含窒素スピロ環化合物及びその医薬用途
WO2017006968A1 (ja) 2015-07-07 2017-01-12 日本たばこ産業株式会社 ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその中間体
WO2018117151A1 (ja) 2016-12-21 2018-06-28 日本たばこ産業株式会社 ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその共結晶

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KR102306276B1 (ko) * 2013-10-21 2021-09-30 니뽄 다바코 산교 가부시키가이샤 안질환의 치료제 또는 예방제
CA3044771A1 (en) * 2016-12-21 2018-06-28 Japan Tobacco Inc. Crystalline forms of a janus kinase inhibitor
JP7722931B2 (ja) * 2019-12-27 2025-08-13 ロート製薬株式会社 水性組成物
EP4674401A3 (en) * 2019-12-27 2026-02-25 Rohto Pharmaceutical Co., Ltd Container accommodating an aqueous ophthalmic composition comprising delgocitinib
US20230285564A1 (en) * 2020-07-30 2023-09-14 Rohto Pharmaceutical Co., Ltd. Aqueous Composition

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JP2009046470A (ja) * 2007-07-11 2009-03-05 Pfizer Inc ドライアイ障害を治療する医薬組成物および方法
WO2011013785A1 (ja) * 2009-07-31 2011-02-03 日本たばこ産業株式会社 含窒素スピロ環化合物及びその医薬用途
WO2017006968A1 (ja) 2015-07-07 2017-01-12 日本たばこ産業株式会社 ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその中間体
WO2018117151A1 (ja) 2016-12-21 2018-06-28 日本たばこ産業株式会社 ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその共結晶

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NAKAMURA, MASATSUGU: "Recent developments in the dry-eye field", FOLIA PHARMACOLOGICA JAPONICA, vol. 135, no. 4, 2010, pages 138 - 141, XP009526757, DOI: 10.1254/fpj.135.138 *
See also references of EP4011450A4

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022025281A1 (https=) * 2020-07-30 2022-02-03
JPWO2022025279A1 (https=) * 2020-07-30 2022-02-03
WO2022025279A1 (ja) * 2020-07-30 2022-02-03 ロート製薬株式会社 水性組成物
WO2023100918A1 (ja) * 2021-11-30 2023-06-08 興和株式会社 新規ニコチンアミド化合物及びその用途

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Publication number Publication date
JP2025019313A (ja) 2025-02-06
TW202120094A (zh) 2021-06-01
EP4011450A4 (en) 2023-08-09
CN118903144A (zh) 2024-11-08
KR20220044288A (ko) 2022-04-07
EP4011450A1 (en) 2022-06-15
CN114173788A (zh) 2022-03-11
US20220280515A1 (en) 2022-09-08
JP7597714B2 (ja) 2024-12-10
JPWO2021025129A1 (https=) 2021-02-11

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