WO2020211088A1 - Composition de médecine chinoise traditionnelle et son utilisation - Google Patents

Composition de médecine chinoise traditionnelle et son utilisation Download PDF

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WO2020211088A1
WO2020211088A1 PCT/CN2019/083519 CN2019083519W WO2020211088A1 WO 2020211088 A1 WO2020211088 A1 WO 2020211088A1 CN 2019083519 W CN2019083519 W CN 2019083519W WO 2020211088 A1 WO2020211088 A1 WO 2020211088A1
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Prior art keywords
chinese medicine
traditional chinese
medicine composition
ethanol
acid
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PCT/CN2019/083519
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English (en)
Chinese (zh)
Inventor
吴以岭
吴相君
贾振华
吴瑞
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石家庄以岭药业股份有限公司
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Priority to PCT/CN2019/083519 priority Critical patent/WO2020211088A1/fr
Publication of WO2020211088A1 publication Critical patent/WO2020211088A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Definitions

  • This application relates to the field of medicine, in particular to a traditional Chinese medicine composition and its preparation method and application.
  • Traditional Chinese medicine is the most important material means for preventing and curing diseases in Chinese medicine. Improving the therapeutic effect of Chinese medicine is the key to the therapeutic effect of Chinese medicine. Regarding the characteristics of multi-component and multi-target effects of traditional Chinese medicine, increasing the content of multiple iconic components of traditional Chinese medicine can improve the quality of traditional Chinese medicine.
  • a Chinese medicine composition which is made of the following mass parts of Chinese medicine raw materials: Forsythia (Fructus Forsythia) 200-300, Ephedrae (Herba Ephedrae) 60-100, Rheum (rheum) 40-60, Houttuyniae (Herba Houttuyniae) 200-300, Honeysuckle (Flos Lonicerae) 200-300, Radix Isatidis (Radix Isatidis) 200-300, Huoxiang (Herba Pogostemonis) 60-100, Mianmaguan Public (Rhizoma Dryopteris Crassirhizomae) 200-300, Rhodiola (Rhodiola rosea L.) 60-100, Menthol (menthol) 5-9, Bitter almond (Semen Armeniacae Amarum) 60-100, Licorice (Radix Glycyrr
  • the traditional Chinese medicine composition contains the following ingredients:
  • the application also provides the use of the traditional Chinese medicine composition in the preparation of medicines for the treatment of colds and upper respiratory tract infections.
  • One or more embodiments of the present application provide a traditional Chinese medicine composition, which is made of the following mass parts of traditional Chinese medicine raw materials: forsythia (Fructus Forsythia) 200-300, ephedra (Herba Ephedrae) 60-100, rhubarb (rheum) 40 -60, Herba Houttuyniae 200-300, Flos Lonicerae 200-300, Radix Isatidis 200-300, Herba Pogostemonis 60-100, Rhizoma Dryopteris Crassirhizomae ) 200-300, Rhodiola rosea L. 60-100, Menthol 5-9, Semen Armeniacae Amarum 60-100, Radix Glycyrrhizae 60-100, Gypsum )200-300;
  • the traditional Chinese medicine composition contains the following ingredients:
  • the traditional Chinese medicine composition contains the following ingredients: 0.4-0.9mg/g ephedrine hydrochloride and pseudoephedrine hydrochloride, 2.2-4.3mg/g amygdalin, 0.25- 0.75mg/g chrysophanol, 0.15-0.40mg/g emodin, 2.4-5.4mg/g chlorogenic acid, 1.4-2.7mg/g neochlorogenic acid, 1.6-3.4mg/g cryptochlorogen Acid, 2.0-5.5mg/g isoficrin A, 1.65-2.90mg/g 4,5-di-O-caffeoylquinic acid, 2.7-3.8mg/g quercetin, 1.4- 2.9mg/g glycyrrhizic acid and 2.5-3.4mg/g forsythin.
  • the content of ephedrine hydrochloride and pseudoephedrine hydrochloride contained in the traditional Chinese medicine composition is 0.4 mg/g, 0.5 mg/g, 0.6 mg/g, 0.7 mg/g, 0.8 mg/g Or 0.9mg/g.
  • the content of amygdalin contained in the traditional Chinese medicine composition is 2.2 mg/g, 2.5 mg/g, 3 mg/g, 3.5 mg/g, 4 mg/g or 4.3 mg/g .
  • the content of chrysophanol contained in the traditional Chinese medicine composition is 0.25 mg/g, 0.3 mg/g, 0.4 mg/g, 0.5 mg/g, 0.6 mg/g, 0.7 mg/g g or 0.75mg/g.
  • the content of emodin contained in the traditional Chinese medicine composition is 0.15 mg/g, 0.2 mg/g, 0.3 mg/g or 0.40 mg/g.
  • the content of chlorogenic acid contained in the traditional Chinese medicine composition is 2.4 mg/g, 3 mg/g, 4 mg/g, 5 mg/g or 5.4 mg/g.
  • the content of neochlorogenic acid contained in the traditional Chinese medicine composition is 1.4 mg/g, 1.6 mg/g, 1.8 mg/g, 2 mg/g, 2.5 mg/g, or 2.7 mg/g. g.
  • the content of cryptochlorogenic acid contained in the traditional Chinese medicine composition is 1.6 mg/g, 2 mg/g, 2.5 mg/g, 3 mg/g or 3.4 mg/g.
  • the content of isoficrin A contained in the traditional Chinese medicine composition is 2.0 mg/g, 2.5 mg/g, 4 mg/g, 4.5 mg/g, 5 mg/g or 5.5 mg/g.
  • the content of di-O-caffeoylquinic acid contained in the traditional Chinese medicine composition is 0.65mg/g, 0.8mg/g, 1mg/g, 1.5mg/g, 1.7mg /g, 1.8mg/g or 1.90mg/g.
  • the content of quercetin contained in the traditional Chinese medicine composition is 2.7 mg/g, 3 mg/g, 3.2 mg/g, 3.5 mg/g or 3.8 mg/g.
  • the content of glycyrrhizic acid contained in the traditional Chinese medicine composition is 1.4 mg/g, 1.8 mg/g, 2 mg/g, 2.2 mg/g, 2.5 mg/g or 2.9 mg/g .
  • the content of forsythin contained in the traditional Chinese medicine composition is 2.5 mg/g, 3 mg/g, 3.1 mg/g, 3.2 mg/g, 3.3 mg/g, or 3.4 mg/g. g.
  • the traditional Chinese medicine composition contains the following ingredients: 4.0-5.4 mg/g chlorogenic acid, 2.0-2.7 mg/g neochlorogenic acid, 2.5-3.4 mg /g of cryptochlorogenic acid, 3.5-5.5mg/g of isoforsythoside A, 2.0-2.90mg/g of 4,5-di-O-caffeoylquinic acid, 3.0-3.8mg/g Quercetin and 2.5-2.9mg/g glycyrrhizic acid.
  • the ephedra is roasted ephedra
  • the bitter almond is fried bitter almond
  • the ageratum is patchouli
  • the honeysuckle, gypsum, Radix isatidis, Mianma Guanzhong, licorice and Rhodiola are boiled together with 7-11 weight-volume water, add bitter almonds, decoct for 1-4 hours, and combine the obtained extract with the Agastache Mix the clear ointment and concentrate the resulting mixture into a clear ointment, add 95% ethanol to the clear ointment until the ethanol concentration is 60-80%, leave it for 12-24 hours, filter through a ceramic membrane to obtain the filtrate, and recover the ethanol to obtain the second Clear cream
  • the second clearing paste is mixed with the first clearing paste, the mixture is concentrated under reduced pressure to obtain a paste with a relative density of 1.15 to 1.20, and the paste is vacuum belt dried and crushed to an appropriate particle size , To obtain a dry paste powder, and add menthol and the Huoxiang volatile oil to the dry paste powder to obtain the traditional Chinese medicine composition.
  • forsythia, ephedra, houttuynia cordata and rhubarb are extracted together with 6-10 weight-volume 70% ethanol for 1-2 times, each for 1-2 hours.
  • honeysuckle, gypsum, Isatis indigotica, Mianma Guanzhong, licorice and Rhodiola rosea are boiled together with water at a weight-volume ratio of 7-11, bitter almonds are added, and decocted for 1-2 Seconds, for 1-2 hours each time, mix the obtained extract with the Huoxiang clear ointment and concentrate the resulting mixture into a clear ointment with a relative density of 1.10-1.15.
  • 95% ethanol is added to the clear ointment until the ethanol concentration is 70%, and it is left at room temperature for 12-24 hours.
  • One or more embodiments of this application provide a method for preparing the traditional Chinese medicine composition of this application.
  • Forsythia Fratus Forsythia 200-300, Ephedrae (Herba) 60-100, Rheum (rheum) 40-60, Houttuyniae (Herba Houttuyniae) 200-300, Honeysuckle (Flos Lonicerae) 200-300, Radix Isatidis 200-300, Huoxiang (Herba Pogostemonis) 60-100, Rhizoma Dryopteris Crassirhizomae 200-300, Rhodiola Rosea L.) 60 -100, menthol (menthol) 5-9, bitter almond (Semen Armeniacae Amarum) 60-100, licorice (Radix Glycyrrhizae) 60-100, gypsum (gypsum) 200-300;
  • the honeysuckle, gypsum, Radix isatidis, Mianma Guanzhong, licorice and Rhodiola are boiled together with 7-11 weight-volume water, add bitter almonds, decoct for 1-4 hours, and combine the obtained extract with the Agastache
  • the clear paste is mixed and the resulting mixture is concentrated into a clear paste, 95% ethanol is added to the clear paste until the ethanol concentration is 60-80%, and it is left at room temperature for 12-24 hours.
  • the filtrate is filtered through a ceramic membrane, and the ethanol is recovered to obtain the third Erqing cream
  • the second clearing paste is mixed with the first clearing paste, the mixture is concentrated under reduced pressure to obtain a paste with a relative density of 1.15 to 1.20, and the paste is vacuum-belt dried and crushed to obtain a dry paste powder , Adding menthol and the volatile oil of Huoxiang to the dry powder to obtain the traditional Chinese medicine composition.
  • forsythia, ephedra, houttuynia cordata and rhubarb are extracted together with 6-10 weight-volume 70% ethanol for 1-2 times, each for 1-2 hours.
  • honeysuckle, gypsum, Isatis indigotica, Mianma Guanzhong, licorice and Rhodiola rosea are boiled together with water at a weight-volume ratio of 7-11, bitter almonds are added, and decocted for 1-2 Seconds, for 1-2 hours each time, mix the obtained extract with the Huoxiang clear ointment and concentrate the resulting mixture into a clear ointment with a relative density of 1.10-1.15.
  • 95% ethanol is added to the clear ointment until the ethanol concentration is 70%, and it is left at room temperature for 12-24 hours.
  • One or more embodiments of the present application provide the use of the traditional Chinese medicine composition of the present application in the preparation of a medicine for the treatment of colds and upper respiratory tract infections.
  • the common cold is influenza and the upper respiratory tract infection is tonsil inflammation.
  • the weight-to-volume ratio represents the volume (L or mL) of the solvent used for extraction corresponding to the weight (Kg or g) of the medicinal material.
  • the traditional Chinese medicine composition in one or more embodiments of the present application is used to treat a cold or upper respiratory tract infection.
  • the traditional Chinese medicine composition in one or more embodiments of the present application is used to treat influenza or tonsil inflammation.
  • the second clear paste is obtained by filtering through a ceramic membrane.
  • ceramic membrane filtration can be carried out by standing at room temperature. Using ceramic membrane filtration, the impurity removal effect is better, the extraction liquid filtration effect is better, and the content of active ingredients is increased. Using it to filter the original liquid has better filtering effect and better impurity removal effect.
  • the paste is obtained by filtration under reduced pressure.
  • the temperature in the vacuum filtration process is reduced, the time is shortened, and the active ingredient is less damaged.
  • the vacuum belt drying temperature is low and the speed is high, so the effective ingredients can be protected well.
  • Fructus Forsythia is the dried fruit of Forsythia suspensa (Thunb.) Vahl, a plant of the family Oleaceae.
  • Ephedrae (Herba Ephedrae) is a dry grass stem of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A. Mey. or Ephedra equiisetina Bge.
  • rheum is the dried root of Rheum palmatum L., Rheum tanguticum Maxim. ex Balf. or medicinal Rheum officinale Baill. rhizome.
  • Houttuyniae (Herba Houttuyniae) is the dry aerial part of Houttuynia cordata Thunb.
  • Flos Lonicerae is Lonicera japonica Thunb., Lonicera hypoglauca Miq., Lonicera confusa DC. or Hairy style.
  • Radix Isatidis is the dry root of Isatis indigotica Fort., a cruciferous plant.
  • Herba Pogostemonis is Pogostemon cablin (Blanco) Benth. or Agastache rugosa (Fisch.et Mey.) O. Ktze.) The dry aerial part.
  • Rhizoma Dryopteris Crassirhizomae is the dry rhizome and petiole residues of Dryopteris Crassirhizoma Nakai, a plant of the Dryopteris family.
  • Rhodiola rosea is the dry aerial part of Rhodiola saera (Prain) Fu, a plant of the genus Rhodiola of the Crassulaceae family.
  • menthol is an aromatic oil obtained by distillation of fresh stems and leaves of Mentha haplocalyx Briq.
  • bitter almond is a Rosaceae plant Prunus armeniaca L.var.ansu Maxim.
  • Siberian apricot Prunus sibirica L.
  • the dried mature seeds of Prunus mandshurica (Maxim.) Koehne or Prunus armeniaca L..
  • licorice is the dried root of the legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the leguminous family.
  • gypsum is a sulfate mineral anhydrite group gypsum, and the main component is hydrous calcium sulfate (CaSO 4 ⁇ 2H 2 O).
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • step 6 Dissolve the menthol and the patchouli volatile oil obtained in step 2 with an appropriate amount of ethanol and spray them into the dry particles obtained in step 5, mix them, and fill them into capsules to obtain capsules of traditional Chinese medicine composition.
  • ephedrine hydrochloride and pseudoephedrine hydrochloride reference substance Take an appropriate amount of ephedrine hydrochloride and pseudoephedrine hydrochloride reference substance, accurately weigh it, add methanol-water (containing 0.092% phosphoric acid, 0.04% triethylamine and 0.02% di-n-butylamine) 10:90 to make 30 ⁇ g ephedrine hydrochloride per 1mL And 8 ⁇ g pseudoephedrine hydrochloride mixed solution, that is.
  • sample A group Taking cold, influenza and tonsillitis patients in the outpatient clinic of Yiling Hospital of Hebei province as the research object, they were randomly divided into sample A group and sample B group with 84 cases each by using the digital table method.
  • Sample group A 54 males and 30 females; aged 15-63 years old, with an average age of 37 years.
  • Sample group B 52 males and 32 females; age 13-64 years old, average age 38 years old.
  • the two groups of patients were given corresponding care and the doctor ordered to drink more water.
  • Patients in the sample group A were given sample A; patients in the sample B group were given sample B; both groups were treated for 7 consecutive days.
  • the scores of TCM syndromes, the time of medicine to relieve fever and the disappearance time of pus spots were recorded and compared before and after treatment. .
  • the onset time is the time required for the body temperature to decrease by 0.5°C after taking the medicine.
  • Antipyretic time is the time required for body temperature to drop to 37°C after taking the medicine.
  • the recovery time is the time required for the clinical symptoms to disappear completely after taking the medicine.
  • the sample B group has more clinical advantages than the sample A group, and the difference is statistically significant (P ⁇ 0.05).
  • the total effective rate of sample B group was significantly better than that of sample A group, and the difference was statistically significant (P ⁇ 0.05).

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Abstract

L'invention concerne une composition de médecine chinoise traditionnelle, préparée à partir des médicaments bruts de médecine chinoise traditionnelle suivants en partie en poids : de 200 à 300 parties de fructus forsythia, de 60 à 100 parties de herba ephedrae, de 40 à 60 parties de rheum, de 200 à 300 parties de herba houttuyniae, de 200 à 300 parties de flos lonicerae, de 200 à 300 parties de radix isatidis, de 60 à 100 parties de herba pogostemonis, de 200 à 300 parties de rhizome de dryopteris crassirhizomae, de 60 à 100 parties de rhodiola rosea L., de 5 à 9 parties de menthol, de 60 à 100 parties de semen armeniacae amarum, de 60 à 100 parties de radix glycyrrhizae, et de 200 à 300 parties de gypse. La composition de médecine chinoise traditionnelle comprend les composants suivants : de 0,4 à 0,9 mg/g de chlorhydrate d'éphédrine et de chlorhydrate de pseudoéphédrine, de 2,2 à 4,3 mg/g d'amygdaline, de 0,25 à 0,75 mg/g de chrysophanol, de 0,15 à 0,40 mg/g d'émodine, de 2,4 à 5,4 mg/g d'acide chlorogénique, de 1,4 à 2,7 mg/g d'acide néochlorogénique, de 1,6 à 3,4 mg/g d'acide cryptochlorogénique, de 2,0 à 5,5 mg/g d'isopsythioside A, de 1,65 à 2,90 mg/g d'acide 4,5-di-o-caféoylquinique, de 2,7 à 3,8 mg/g de quercitrine, de 1,4 à 2,9 mg/g d'acide glycyrrhizique, et de 2,5 à 3,4 mg/g de phillyrine. La composition de médecine chinoise traditionnelle a pour effet de traiter le rhume et l'infection des voies respiratoires supérieures.
PCT/CN2019/083519 2019-04-19 2019-04-19 Composition de médecine chinoise traditionnelle et son utilisation WO2020211088A1 (fr)

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CN113648378A (zh) * 2021-06-25 2021-11-16 浙江省立同德医院 治疗新冠肺炎早期的中药复方及治疗呼吸道感染的应用
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