WO2019098752A1 - 락토바실러스 플란타룸 배양물을 포함하는 항균용 화장료 조성물 - Google Patents

락토바실러스 플란타룸 배양물을 포함하는 항균용 화장료 조성물 Download PDF

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Publication number
WO2019098752A1
WO2019098752A1 PCT/KR2018/014096 KR2018014096W WO2019098752A1 WO 2019098752 A1 WO2019098752 A1 WO 2019098752A1 KR 2018014096 W KR2018014096 W KR 2018014096W WO 2019098752 A1 WO2019098752 A1 WO 2019098752A1
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Prior art keywords
culture
lactobacillus plantarum
skin
cosmetic composition
strain
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PCT/KR2018/014096
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English (en)
French (fr)
Korean (ko)
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백세희
서용기
신민경
Original Assignee
씨제이제일제당 (주)
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Priority to CN201880066809.0A priority Critical patent/CN111601584A/zh
Publication of WO2019098752A1 publication Critical patent/WO2019098752A1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a cosmetic composition having an antibacterial effect containing a single lactic acid bacterium culture, and more particularly to a cosmetic composition for skin antibiosis comprising a culture of Lactobacillus plantarum CJLP133 .
  • Skin protects the body from various oxidants, air pollution, heavy metals, ultraviolet radiation (UV), etc. It prevents bacteria, fungus and virus from invading the skin and acts as a protective barrier against moisture loss.
  • the structure of the skin is divided into three layers of epidermis, dermis and subcutaneous fat, and 90% of the dermis consists of collagen, elastin, hyaluronic acid and glycoprotein.
  • Major components Collagen is an important fibrous protein that accounts for about 25% of the total protein mass of the human body. It occupies most of the connective tissue and functions as intercellular matrix, structural support function, cell division and differentiation induction, skin tensile strength Provide important functions such as providing.
  • Lactic acid bacteria are beneficial in the human body to ferment carbohydrates and fiber to produce lactic acid (lactic acid). About 400 species have been found so far, of which 18 have been developed as products. When lactic acid bacteria enter the intestines of the human body, they secrete specific substances through their own metabolic activities. Since these substances have a beneficial effect on the human body, many studies on lactic acid bacteria have been made. Antimicrobial, antioxidant and immunological activities have been reported to date, and in recent years, whitening and moisturizing effects of lactic acid bacteria have been studied, and the possibility of becoming a flourishing material is increasing. Among the lactic acid bacteria, Lactobacillus has been reported to have a great effect on the immunity, antibacterial effect, skin whitening and atopic dermatitis.
  • POLAB Plant Originated Lactic Acid Bacteria
  • POLAB Plant Originated Lactic Acid Bacteria
  • the vegetable lactic acid bacterium is more than 10 times more than the conventional animal lactic acid bacteria, and has excellent adaptability to the external environment.
  • vegetable lactic acid bacteria isolated from kimchi which have high salt content, low pH, and high content of natural antimicrobial substances, are produced in a harsh environment, and thus produce various physiologically active substances.
  • the representative physiologically active substances include antimicrobial peptides, immunostimulating substances, and GABA (Gamma-Amino Butyric Acid), which exhibits anti-inflammatory and immunosuppressive effects among various physiological functions.
  • Lactic acid bacteria also produce bacteriocins that act as antimicrobial peptides as heat-stable peptides.
  • Bacteriocin is a natural antimicrobial protein or protein substance produced by microorganisms of various species, and generally refers to a substance having sterilizing activity against a species that is similar to the microorganism producing the same, or phylogenetically similar. Therefore, the development of cosmetic materials using the lactic acid bacteria culture fluid containing the above substances or the lactic acid bacteria fermentation plant extracts is active, which is in line with recent trends favoring environmentally friendly and safe substances.
  • Patent Document 1 KR 10-1486999 B1 (Jan. 21, 201)
  • Lactobacillus plantarum CJLP133 culture was found to have skin antimicrobial activity and the present application was completed.
  • One object of the present application is to provide a cosmetic composition for skin antibiosis comprising a Lactobacillus plantarum CJLP133 culture in which the cells of Lactobacillus plantarum CJLP133 deposited with the deposit number KCTC 11403BP are removed.
  • the present application provides a method for producing a lactobacillus plantarum culture which is safe without adverse effect on the skin by using a lactobacillus plantarum CJLP133 strain, which is a skin benefit bacterium, and which contains a culture of Lactobacillus plantarum CJLP133, To provide a cosmetic composition.
  • Figure 1 shows the results of the antibacterial activity test of the lactobacillus plantarum CJLP133 culture; 2a: Staphylococcus aureus , 2b: Staphylococcus epidermidis , 2c: E. coli O157: H7 , 2d: Pseudomonas aeruginosa , 2e: Propionibacterium acnes .
  • the present application is directed to a method for the treatment of skin antimicrobials comprising Lactobacillus plantarum CJLP133 cultures from which the cells of Lactobacillus plantarum CJLP133 deposited with accession number KCTC 11403BP have been removed,
  • the present invention provides a cosmetic composition.
  • Lactobacillus plantarum in the present application is one of microorganisms of the genus Lactobacillus, and is a gram-negative bacterium and a microorganism producing lactic acid. It is found in fermented food such as sour crout, pickle, kimchi.
  • the Lactobacillus plantarum strain may specifically be a strain of Lactobacillus plantarum CJLP133, which may be one deposited with the deposit number KCTC 11403BP.
  • Lactobacillus plantarum CJLP133 strain was deposited internationally on October 16, 2008 under the Budapest Treaty with the KCTC 11403BP as an international depositary to the KCTC, an international depository institution of the Korea Research Institute of Bioscience and Biotechnology.
  • culture product in the present application means a culture medium containing a by-product produced by culturing a strain in a culture medium and ingesting nutrients and metabolizing the culture medium.
  • the culture medium containing the diluted solution, concentrate, , A preparation of the culture medium, a preparation of the culture medium or a mixture thereof, and a culture of all the formulations which can be formed using the culture medium.
  • the culture may be a culture obtained by culturing a strain of Lactobacillus plantarum CJLP133, and may be obtained by removing the strain of the strain after culturing. That is, a culture medium in which the strain is removed from the strain after culturing the strain may be used as a culture.
  • the culture comprises (a) inoculating and culturing Lactobacillus plantarum strain CJLP133 in a medium; (b) centrifuging the result of step (a); And (c) recovering the supernatant from the product of step (b).
  • the culture medium may be any medium used in the art, provided that the culture can be cultured and the culture after cultivation is obtainable.
  • the medium may be a liquid medium, more specifically, have.
  • the step (a) may further include a step of culturing the Lactobacillus plantarum strain in a solid medium and culturing the strain in the presence of the step (a) so as to obtain a purely isolated strain, thereby obtaining a confirmed colonies .
  • the step (b) may be carried out at a temperature of 1 ° C to 7 ° C, specifically 2 ° C to 6 ° C, more specifically 3 ° C to 5 ° C, using a high speed centrifuge at 1,500 rpm to 3,500 rpm, specifically 2,000 rpm to 3,000 rpm , More specifically, centrifuging at a rotational force of 2,200 rpm to 2,800 rpm for 10 minutes to 30 minutes, specifically 15 minutes to 25 minutes, more specifically 17 minutes to 23 minutes.
  • the step (c) may further comprise filtering the supernatant.
  • the step (c) may further include a step of pulverizing the filtered supernatant using a freeze dryer.
  • antibacterial in the present application means the efficacy of inhibiting the growth of microorganisms such as skin disease-related bacteria.
  • the culture is a skin disease-associated bacterium, specifically Staphylococcus aureus , Staphylococcus epidermidis , E. coli O157: H7 , Pseudomonas aeruginosa , But is not limited to, one or more bacteria selected from the group consisting of Propionibacterium acnes .
  • composition of the present application may be to improve skin diseases caused by microorganisms through the above-mentioned antibacterial activity.
  • the cosmetic composition according to the present invention can be used as a cosmetic composition, a cosmetic composition, a cosmetic composition, a cosmetic composition, a cosmetic composition, a cosmetic composition, It may be formulated as a suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray, It is not limited.
  • the cosmetic composition may further comprise at least one cosmetically acceptable carrier mixed with a cosmetic composition for general skin.
  • a cosmetic composition include ordinary components such as oil, water, a surfactant, a moisturizer, a lower alcohol , A thickening agent, a chelating agent, a coloring agent, a preservative, a flavoring agent, and the like, but is not limited thereto.
  • the cosmetically acceptable carrier contained in the cosmetic composition of the present application varies depending on the formulation of the cosmetic composition.
  • formulations of the present application are ointments, pastes, creams or gels
  • an animal oil a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide May be used, but is not limited thereto. These may be used alone or in combination of two or more.
  • lactose When the formulation of the present application is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or the like may be used as a carrier component. But are not limited to, propellants such as rocaborn, propane / butane or dimethyl ether. These may be used alone or in combination of two or more.
  • a solvent, a dissolving agent or an emulsifying agent may be used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil and the like can be used, and particularly fatty acid esters of cottonseed oil, peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.
  • a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, but are not limited thereto. These may be used alone or in combination of two or more.
  • an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolizate, an isethionate, a lanolin derivative, an aliphatic alcohol, a vegetable oil, a glycerol, a sugar and the like are used as a carrier component But is not limited thereto. These may be used alone or in combination of two or more.
  • Another aspect of the present invention provides a skin antimicrobial method comprising the step of administering to a subject a Lactobacillus plantarum culture in which the cells of the Lactobacillus plantarum have been removed.
  • the skin antimicrobial method may be a method comprising a step of administering a cosmetic composition further comprising a Lactobacillus plantarum culture and an cosmetically acceptable carrier to an individual in need of skin antibiosis, Acceptable carriers are the same as described above.
  • the subject may include a human, or may exclude a human.
  • the subject may specifically include mammals, birds, etc., including cows, pigs, sheep, chickens, dogs, humans and the like.
  • the subject having skin antimicrobial activity by the administration of the composition of the present invention is not limited.
  • Another aspect of the present invention provides a use of a composition comprising a lactobacillus plantarum culture in which a bacterium of the genus Latobacillus plantarum has been removed, for producing a cosmetic having skin antimicrobial activity do.
  • the Lactobacillus plantarum CJLP133 strain deposited with accession number KCTC 11403BP was plated on MRS solid medium (BD Difco, Lactobacilli MRS Agar) and incubated at 37 ° C for about 18 hours.
  • the colonies identified as pure isolates were platinum loops and inoculated into MRS liquid medium (BD Difco, Lactobacilli MRS Broth) and incubated at 37 ° C for approximately 18 hours. After cultivation, the concentration of the culture was 1.0 * 10 9 CFU / mL.
  • the culture broth was centrifuged at 4 ° C and 2,500 rpm for 20 min using a high-speed centrifuge (LABOGENE 1248R) to separate the cells from the culture.
  • the supernatant of the culture was filtered, and the filtered supernatant was pulverized using a freeze dryer (HETO PL90000).
  • the culture prepared by the above method was called " Lactobacillus plantarum CJLP133 culture ".
  • Staphylococcus aureus Staphylococcus epidermidis , E. coli O157: H7 , and fungoides ( Pseudomonas aeruginosa ), which are commonly detected in the skin, , Acne bacteria ( Propionibacterium acnes ) were used. All five species were distributed at the Korea Biotechnology Research Center. Table 1 shows the details of the strain number, culture medium, culture temperature and incubation time for each strain.
  • Propionibacterium acnes was sealed in an anaerobic incubator using a gas pack system (MITSUBISHI GAS CHEMICAL, AnaeroPack) and anaerobically incubated.
  • a gas pack system MITSUBISHI GAS CHEMICAL, AnaeroPack
  • MRS liquid medium was lyophilized and pulverized, and sterilized distilled water was added at a concentration of 0.5 g / mL.
  • Each skin harmful bacterial strain was plated in 1.0 ⁇ 10 6 CFU / mL in TSA (BD Difco, Tryptic Soy Agar, RCM; BD Difco Reinforced Clostridial Medium).
  • TSA BD Difco, Tryptic Soy Agar, RCM; BD Difco Reinforced Clostridial Medium.
  • a sterilized paper disc (ADVANTEC, 8 mm) was placed on a plated plate of each strain, and 50 ⁇ L of the test substance and the control substance were added. After culturing according to the culture conditions of each strain (Table 1), the diameter of the clear zone around the disc was measured. The greater the circle, the greater the antimicrobial activity. Without antimicrobial activity, the inhibitory ring is not produced.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PCT/KR2018/014096 2017-11-16 2018-11-16 락토바실러스 플란타룸 배양물을 포함하는 항균용 화장료 조성물 WO2019098752A1 (ko)

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CN201880066809.0A CN111601584A (zh) 2017-11-16 2018-11-16 包括植物乳杆菌培养物的抗菌化妆品组合物

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KR1020170153344A KR102032546B1 (ko) 2017-11-16 2017-11-16 락토바실러스 플란타룸 배양물을 포함하는 항균용 화장료 조성물
KR10-2017-0153344 2017-11-16

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KR20110009560A (ko) * 2009-07-22 2011-01-28 씨제이제일제당 (주) 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물
KR101287126B1 (ko) * 2011-10-28 2013-07-17 대상에프앤에프 주식회사 식물성유산균발효액을 함유하는 질염 및 요로감염 예방 및 치료용 약학 조성물
KR20140023675A (ko) * 2012-08-17 2014-02-27 주식회사 바이오셀트란 락토바실러스 플란타룸의 배양액을 방부제 또는 기능성 성분으로 포함하는 화장료 조성물
KR101636014B1 (ko) * 2014-07-24 2016-07-04 수원대학교산학협력단 항바이러스 및 항세균 활성을 갖는 락토바실러스 및 그의 용도
KR20160026948A (ko) * 2016-02-19 2016-03-09 대한민국(농촌진흥청장) 락토바실러스 플란타룸 kcc-19 및 이를 포함하는 조성물

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CN114657106A (zh) * 2022-04-21 2022-06-24 青岛蔚蓝生物股份有限公司 一株植物乳植杆菌及其在防治痤疮中的应用
CN114657106B (zh) * 2022-04-21 2023-11-21 青岛蔚蓝生物股份有限公司 一株植物乳植杆菌及其在防治痤疮中的应用
CN114574408A (zh) * 2022-05-06 2022-06-03 山东锦鲤生物工程有限公司 益生菌seuneu-107及应用
CN114574408B (zh) * 2022-05-06 2022-07-22 山东锦鲤生物工程有限公司 益生菌seuneu-107及应用
CN114672443A (zh) * 2022-05-07 2022-06-28 山东百沃生物科技有限公司 一株具有预防或改善面部泛红和i型玫瑰痤疮功能的植物乳植杆菌
CN114672443B (zh) * 2022-05-07 2024-04-05 青岛蔚蓝生物集团有限公司 一株具有预防或改善面部泛红和i型玫瑰痤疮功能的植物乳植杆菌

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