WO2018077310A1 - Comprimé effervescent contenant du sodium de vitamine c et son procédé de préparation - Google Patents

Comprimé effervescent contenant du sodium de vitamine c et son procédé de préparation Download PDF

Info

Publication number
WO2018077310A1
WO2018077310A1 PCT/CN2017/114279 CN2017114279W WO2018077310A1 WO 2018077310 A1 WO2018077310 A1 WO 2018077310A1 CN 2017114279 W CN2017114279 W CN 2017114279W WO 2018077310 A1 WO2018077310 A1 WO 2018077310A1
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
sodium
parts
effervescent tablet
sucrose
Prior art date
Application number
PCT/CN2017/114279
Other languages
English (en)
Chinese (zh)
Inventor
黄爱强
钟文
黄爱毅
Original Assignee
广西圣保堂健康产业股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广西圣保堂健康产业股份有限公司 filed Critical 广西圣保堂健康产业股份有限公司
Publication of WO2018077310A1 publication Critical patent/WO2018077310A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Definitions

  • the invention belongs to the field of medicines, health foods and foods, and relates to a composition preparation and a preparation method thereof, in particular to an effervescent tablet containing vitamin C sodium and a preparation method thereof.
  • Vitamin C is a commonly used drug or nutritional supplement in the clinic. It is one of the antioxidant vitamins. It is involved in the hydroxylation reaction in the body and is necessary for the formation of bone, tooth, connective tissue and non-epithelial cells. The normal function of bones and blood vessels, increase the resistance to disease, and is one of the essential nutrients for the human body. It is widely used in the prevention and treatment of various diseases.
  • Effervescent tablets are a novel tablet developed and applied abroad in recent years. The difference between it and ordinary tablets is that it also contains an effervescent disintegrant.
  • effervescent tablet When the effervescent tablet is placed in drinking water, under the action of the effervescent disintegrant, a large amount of air bubbles are generated immediately, so that the tablet is quickly formed. Disintegration and melting, sometimes the bubbles generated by disintegration also cause the tablets to roll up and down in the water, accelerating their disintegration and melting. The gas generated when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has a soda-like beauty when it is drunk in the mouth.
  • Effervescent tablets have the following advantages: easy to store and carry; rapid disintegration, convenient taking, rapid onset; high bioavailability, can improve clinical efficacy; especially suitable for children, the elderly and patients who have difficulty swallowing pills; After the seasoning of the effervescent tablets, the taste is better, the medicine is no longer bitter, so that consumers or patients are more willing to accept.
  • Vitamin C effervescent tablets are included in the second edition of the 2015 Chinese Pharmacopoeia. They are commonly used drugs in clinical practice. Because of the oxidative failure of vitamin C, effervescent tablets are prone to moisture absorption and dampness. Therefore, the use effect of vitamin C effervescent tablets and The shelf life is greatly affected. And the pH value of the aqueous solution of vitamin C is close to 2, and the acidity is large. Oral use is more irritating to the oral cavity, throat esophagus and gastric mucosa. It is not suitable for long-term use, and it is not suitable for taking it with acidic drugs. It is used as a nutrient for daily use or as a nutrient. The treatment or prevention of clinical diseases is limited.
  • Vitamin C sodium is the sodium salt of vitamin C.
  • the pH of the aqueous solution is close to neutral. It has the same effect as vitamin C, but because it is sodium salt, the performance is more stable. At the same time, there is no longer strong acidity of vitamin C.
  • the drug is taken at the same time, which is better than vitamin C.
  • Vitamin C sodium is a vitamin C fortifier widely used at home and abroad and has been gradually replaced by vitamin C. The invention directly forms vitamin C sodium into effervescent tablets, and the preparation is safe and effective through clinical trials. At present, no relevant literature reports have been reported.
  • the invention aims at the problem that the existing vitamin C effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, the throat esophagus and the gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and damp.
  • the effervescent tablet containing vitamin C sodium and the preparation method thereof solve the problem that the quality of the clinical application of vitamin C is unstable and difficult to be taken for a long time.
  • the effervescent tablet containing vitamin C sodium has simple preparation and stable quality, and can be used for treating scurvy, infectious diseases, purpura, muscle weakness, paralysis, arrhythmia or renal dysfunction, or for malignancy. Prevention and treatment of tumors, cardiovascular and cerebrovascular diseases, infectious diseases or autoimmune diseases; or long-term use as a nutritional supplement.
  • An effervescent tablet containing vitamin C sodium comprising the following components by weight: 200-1120 parts of vitamin C sodium, 560-1300 parts of tartaric acid, 600-1500 parts of sodium hydrogencarbonate, and 200-600 parts of sucrose.
  • the above-mentioned vitamin C sodium-containing effervescent tablet preferably further comprises the following components by weight: 20-50 parts of a sweetener, 0.2-1 part of a pigment, and 2-8 parts of a flavor.
  • the above-mentioned vitamin C sodium-containing effervescent tablet further preferably further comprises 0.5 to 1.0% of trehalose and 0.2 to 0.4% of polyethylene glycol based on the total weight of the above components. 6000.
  • the above-mentioned vitamin C sodium-containing effervescent tablet preferably comprises the following components by weight: 850 parts of vitamin C sodium, 900 parts of tartaric acid, 1000 parts of sodium hydrogencarbonate, 350 parts of sucrose, 35 parts of sweetener,
  • the pigment was 0.6 parts and the fragrance was 5 parts, and further included trehalose which was 0.8% by weight based on the total weight of the above components and polyethylene glycol 6000 which was 0.3% by weight based on the total weight of the above components.
  • the above-mentioned vitamin C sodium-containing effervescent tablet is preferably aspartame, neotame or mogroside.
  • the pigment is preferably lemon yellow, amaranth, and bright blue.
  • the above-mentioned vitamin C sodium-containing effervescent tablet is preferably a sweet orange flavor or a blueberry flavor.
  • the above-mentioned vitamin C sodium-containing effervescent tablets, the acidity measurement and acidity value should preferably meet the following requirements: take the effervescent tablet, add cold water or warm water to disintegrate, make 1g solution per 100ml, to be collapsed After the solution is completely bubble free, the pH is determined to be 4.5 to 6.5; preferably the pH is 5.0 to 6.0.
  • a method for preparing an effervescent tablet containing the above vitamin C sodium comprises the following steps:
  • step S4 Take sodium bicarbonate, add the remaining 30-60% of the syrup pigment solution under step S3, mix, granulate, sieve, dry, and granulate to obtain an alkali agent;
  • drying temperature described in the steps S3 and S4 is preferably 80 ° C or lower, and the obtained particles have a moderate hardness, which is more favorable for tableting and facilitates disintegration; and the steps S3 and S4 are as described below.
  • the screen used for the sieving step is preferably 14-30 mesh.
  • the invention overcomes the problem that the existing vitamin C effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, throat esophagus and gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and damp.
  • the problem is to make the product more stable and more effective. It is suitable for long-term use by consumers or patients without side effects.
  • the invention can be used for treating diseases such as scurvy, infectious diseases and purpura, such as muscle weakness, paralysis, arrhythmia or renal dysfunction, and can also be used for malignant tumors, cardiovascular and cerebrovascular diseases, infectious diseases and autoimmunity. Prevention and treatment of major and difficult diseases such as sexually transmitted diseases; or long-term use as a nutritional supplement.
  • diseases such as scurvy, infectious diseases and purpura, such as muscle weakness, paralysis, arrhythmia or renal dysfunction
  • malignant tumors such as cardiovascular and cerebrovascular diseases, infectious diseases and autoimmunity.
  • Prevention and treatment of major and difficult diseases such as sexually transmitted diseases; or long-term use as a nutritional supplement.
  • the effervescent tablet containing vitamin C sodium of the invention has simple preparation, good fluidity of the particles, and the tablet is not sticky, and the prepared tablet has a smooth surface, is not easy to absorb moisture, has uniform effervescent gas production, and has short disintegration time. After disintegration, the solution is transparent and clear, the taste is sweet, the quality is stable, and the carrying is convenient. It has the characteristics of solid preparation and liquid preparation, especially suitable for children, the elderly and patients who cannot swallow solid preparations, with high bioavailability and safer use. effective.
  • the word "preferred" and variants refers to embodiments of the invention that are capable of providing a particular benefit in a particular environment. However, other embodiments may be preferred under the same or other circumstances. In addition, the detailed description of one or more preferred embodiments does not indicate that other embodiments are useless and are not intended to exclude other embodiments from the scope of the invention.
  • the acid sources commonly used in effervescent tablets are tartaric acid, citric acid, fumaric acid, adipic acid, malic acid, etc.; alkali sources include sodium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, calcium carbonate and the like.
  • the effervescent tablet prepared by using sodium hydrogencarbonate as an alkali source can rapidly disintegrate in water, and the pH of the effervescent solution is suitable for the stabilization of vitamin C sodium, so the alkali source of the present invention selects sodium hydrogencarbonate.
  • the fixed alkali source is sodium bicarbonate
  • the selection of tartaric acid, citric acid, fumaric acid, malic acid, adipic acid was tested to determine the best source of acid in the effervescent tablet.
  • the present invention uses tartaric acid mixed with vitamin C sodium, sodium hydrogencarbonate and sucrose to form granules, has a short disintegration time, clarifies the solution, and has a good mouthfeel, but has a sticking phenomenon when tableting.
  • the acid source of the present invention selects tartaric acid
  • the alkali source selects sodium hydrogencarbonate.
  • the invention compares the dry pressing tablet, the wet granulation and the re-pulling, the dry pressing tablet adopts the ordinary tableting machine has a poor effect and has high requirements on the equipment, so the invention adopts the wet granulation and the tableting.
  • 30% starch slurry, 40% sucrose syrup, 5% hypromellose aqueous solution, and 85% ethanol were used as binders. The results are shown in Table 2.
  • Vitamin C sodium is the sodium salt of vitamin C, which is more stable than vitamin C, but is prepared as an effervescent tablet in an acid agent.
  • the effects of alkaline agents, other excipients, and moisture and oxidation in the air must ensure that the quality of the product is stable during the shelf life, or that stabilizers need to be added.
  • 0.02% EDTA disodium, 1% trehalose, and 0.2% sodium sulfite were compared.
  • the samples prepared by the above stabilizers were respectively packaged with aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, the test results are shown in Table 4.
  • the material of the invention before the tableting has acid agent, vitamin C sodium, essence, alkali agent, material particle size and texture unevenness, poor particle flowability when tableting, and easy sticking when tableting.
  • the other formulas except the lubricant are the same.
  • the different amounts of dodecyl magnesium sulfate, polyethylene glycol 6000, mannitol are specifically compared, and the above lubricants are respectively used.
  • the prepared samples were packaged with aluminum-plastic composite film respectively, and the stability test was accelerated in the test chamber: temperature: 40 ⁇ 2°C, relative humidity: 75 ⁇ 5%, accelerated test for 3 months, and the results are shown in Table 6.
  • the effervescent tablet After the effervescent tablet disintegrates, it is a beverage-like liquid. Therefore, the flavor and taste are very important.
  • the effervescent tablet is small in volume, the sample loading is small, and the sweetness of simple sucrose is not enough.
  • the following sweeteners are compared: stevia, licorice Acid disodium, aspartame, sodium saccharin, sodium cyclamate, mogroside, neotame, and alitame, the results show that: the above sweeteners are aspartame, mogroside, neotame In the range of the components of the "sweetener 20-50 parts", the taste is good, the sweetness is moderate, and there is no discomfort, and the aspartame tastes best. Therefore, the present invention selects aspartame, mogroside, and neotame as sweeteners, and the amount thereof is 20-50 parts.
  • the preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:
  • step S3 Take tartaric acid, 12kg of sucrose and neotame in step S2, mix well, add appropriate 30% syrup pigment solution obtained under step S2, mix, granulate, pass 14 mesh sieve, dry at 80 °C, Whole grain, acidifier;
  • step S4 Take sodium bicarbonate, add the remaining 30% syrup pigment solution under step S3, mix well, then add the appropriate amount of 60% Ethanol granulation, passing through a 14 mesh sieve, drying at 80 ° C, granules, to obtain an alkali agent;
  • the preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:
  • step S3 Take tartaric acid, 10kg of sucrose, and sucrose glycosides under step S2, mix well, add appropriate amount of 60% syrup pigment solution obtained under step S2, mix, granulate, pass 30 mesh sieve, dry at 100 °C , whole grain, acidifier;
  • step S4 Take sodium bicarbonate, add the remaining 60% syrup pigment solution under step S3, mix well, then add appropriate amount of 100% ethanol granules, pass through a 30 mesh sieve, dry at 60 ° C, and granulate to obtain an alkali agent;
  • the preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:
  • step S3 Take tartaric acid, 20kg of sucrose and aspartame under step S2, mix well, add 40% syrup pigment solution obtained under step S2, mix, granulate, pass 20 mesh sieve, dry at 70 °C , whole grain, acidifier;
  • step S4 Take sodium bicarbonate, add the remaining 40% syrup pigment solution under step S3, mix well, then add appropriate amount of 60% ethanol granules, pass 20 mesh sieve, dry at 70 ° C, whole granules, get alkali agent;
  • the samples of the above Examples 1-3 were respectively packaged with an aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40 ⁇ 2° C., relative humidity: 75 ⁇ 5%, accelerated test for 3 months, and the results were as follows.
  • the appearance characteristics, moisture, effervescence reaction time, solution pH value, main component content and other stability of the 1-3 samples were compared with the results of the samples at 0, and there was no significant change, the sweetness was moderate, and the taste of the taste did not change.
  • the sample of the embodiment 1-3 of the invention is relatively stable in quality and can meet the stability requirements of storage, transportation and use.
  • the test results are shown in Table 7.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un comprimé effervescent contenant du sodium de vitamine C, comprenant les constituants suivants en parties en poids : de 200 à 1120 parties de sodium de vitamine C, de 560 à 1300 parties d'acide tartrique, de 600 à 1500 parties de bicarbonate de sodium, et de 200 à 600 parties de saccharose. La présente invention vise à résoudre des problèmes comme ceux liés au fait que les comprimés effervescents de vitamine C existants présentent une acidité élevée après dissolution, irritant ainsi la bouche, la gorge, l'œsophage et la muqueuse gastrique, sont impropres à une utilisation à long terme, perdent leur efficacité pendant le stockage en raison de l'oxydation facile de la vitamine C, et sont vulnérables à l'absorption d'humidité. Le comprimé effervescent contenant du sodium de vitamine C est une préparation simple, et présente une masse stable.
PCT/CN2017/114279 2016-10-24 2017-12-01 Comprimé effervescent contenant du sodium de vitamine c et son procédé de préparation WO2018077310A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610936055.2A CN106420655A (zh) 2016-10-24 2016-10-24 一种含维生素c钠的泡腾片及其制备方法
CN201610936055.2 2016-10-24

Publications (1)

Publication Number Publication Date
WO2018077310A1 true WO2018077310A1 (fr) 2018-05-03

Family

ID=58177777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/114279 WO2018077310A1 (fr) 2016-10-24 2017-12-01 Comprimé effervescent contenant du sodium de vitamine c et son procédé de préparation

Country Status (2)

Country Link
CN (1) CN106420655A (fr)
WO (1) WO2018077310A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110859757A (zh) * 2019-11-22 2020-03-06 广州康云生物科技有限公司 含溶菌酶的漱口水泡腾片及其制备方法
CN112335808A (zh) * 2020-11-20 2021-02-09 宣城柏维力生物工程有限公司 一种天然色素泡腾片及其生产工艺
CN114306129A (zh) * 2022-01-10 2022-04-12 山东中大药业有限公司 一种用于口腔清洁的泡腾片及其制备方法
CN114354812A (zh) * 2022-01-12 2022-04-15 济南同路医药科技发展有限公司 维生素c中草酸含量的检测方法
CN114432339A (zh) * 2022-02-18 2022-05-06 重庆希尔安药业有限公司 一种聚乙二醇钠钾散及其制备方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106420655A (zh) * 2016-10-24 2017-02-22 广西圣保堂健康产业股份有限公司 一种含维生素c钠的泡腾片及其制备方法
CN107049982A (zh) * 2017-06-01 2017-08-18 防城港圣保堂制药有限公司 一种离子vc丸剂及其制备方法
CN107184579A (zh) * 2017-06-01 2017-09-22 防城港圣保堂制药有限公司 一种离子vc颗粒剂及其制备方法
CN107361282A (zh) * 2017-06-30 2017-11-21 山东健康源生物工程有限公司 一种维生素ce泡腾片及其制备方法
CN107307424A (zh) * 2017-07-13 2017-11-03 防城港圣保堂制药有限公司 一种含酵素的离子vc组合物及其制备方法
CN107319243B (zh) * 2017-07-26 2021-04-20 西华大学 一种复方天然葛根黄酮降压保健泡腾片及其制备方法
CN109601810A (zh) * 2019-01-11 2019-04-12 河北农业大学 一种柿子泡腾片及其制备方法
CN112369544A (zh) * 2019-10-24 2021-02-19 广州富诺营养科技有限公司 一种维生素c泡腾片及其制备方法
CN112970998A (zh) * 2019-12-13 2021-06-18 湖南省博世康中医药有限公司 一种天麻多功能泡腾片的制备方法
CN114569631B (zh) * 2022-02-08 2023-06-27 杭州民生健康药业股份有限公司 一种抗潮维生素矿物质片及其抗潮处理方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104434864A (zh) * 2014-11-19 2015-03-25 峨眉山通惠制药有限公司 一种药物泡腾片及其制备方法
WO2016056648A1 (fr) * 2014-10-10 2016-04-14 株式会社林原 Procédé de stabilisation d'un acide ascorbique 2-o-α-d-glucosyl-l dans un milieu aqueux acide
CN106387918A (zh) * 2016-08-29 2017-02-15 广东工业大学 一种维生素c钠泡腾制剂及其制备方法
CN106420655A (zh) * 2016-10-24 2017-02-22 广西圣保堂健康产业股份有限公司 一种含维生素c钠的泡腾片及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824313B (zh) * 2012-09-18 2014-09-24 东北制药集团沈阳第一制药有限公司 一种维生素c泡腾颗粒及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016056648A1 (fr) * 2014-10-10 2016-04-14 株式会社林原 Procédé de stabilisation d'un acide ascorbique 2-o-α-d-glucosyl-l dans un milieu aqueux acide
CN104434864A (zh) * 2014-11-19 2015-03-25 峨眉山通惠制药有限公司 一种药物泡腾片及其制备方法
CN106387918A (zh) * 2016-08-29 2017-02-15 广东工业大学 一种维生素c钠泡腾制剂及其制备方法
CN106420655A (zh) * 2016-10-24 2017-02-22 广西圣保堂健康产业股份有限公司 一种含维生素c钠的泡腾片及其制备方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BI, DIANZHOU ET AL: "Studies on the Stability of Sodium Ascorbate Powders", JOURNAL OF SHENYANG COLLEGE OF PHARMACY, vol. 2, no. 4, 31 December 1985 (1985-12-31), pages 264 - 268 *
LI, YING ET AL.: "The Study of Major Content in Vitamin C Effervescence Tablet on Moisture Absorption", JOURNAL OF WUHAN INSTITUTE OF TECHNOLOGY, vol. 31, no. 5, 31 May 2009 (2009-05-31), pages 14 - 17 *
LOU, GUIQIN ET AL.: "Vitamin C Effersce: Prescription and Craft Preparation", CHINESE JOURNAL OF COAL INDUSTRY MEDICINE, vol. 13, no. 4, 30 April 2010 (2010-04-30), pages 542 - 543 *
ZHANG, LIFENG ET AL.: "Preparation of Vitamin C Effervescent Tablets", JOURNAL OF SHANXI MEDICAL UNIVERSITY, vol. 35, no. 1, 29 February 2004 (2004-02-29), pages 22 - 24 *
ZHI, SHITAO ET AL: "Synthetic Study of Sodium Ascorbate", TECHNOLOGY WIND, no. 17, 30 September 2015 (2015-09-30), pages 125 - 126 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110859757A (zh) * 2019-11-22 2020-03-06 广州康云生物科技有限公司 含溶菌酶的漱口水泡腾片及其制备方法
CN112335808A (zh) * 2020-11-20 2021-02-09 宣城柏维力生物工程有限公司 一种天然色素泡腾片及其生产工艺
CN114306129A (zh) * 2022-01-10 2022-04-12 山东中大药业有限公司 一种用于口腔清洁的泡腾片及其制备方法
CN114306129B (zh) * 2022-01-10 2024-06-07 山东中大药业有限公司 一种用于口腔清洁的泡腾片及其制备方法
CN114354812A (zh) * 2022-01-12 2022-04-15 济南同路医药科技发展有限公司 维生素c中草酸含量的检测方法
CN114354812B (zh) * 2022-01-12 2023-08-04 济南同路医药科技发展有限公司 维生素c中草酸含量的检测方法
CN114432339A (zh) * 2022-02-18 2022-05-06 重庆希尔安药业有限公司 一种聚乙二醇钠钾散及其制备方法
CN114432339B (zh) * 2022-02-18 2023-05-26 重庆希尔安药业有限公司 一种聚乙二醇钠钾散及其制备方法

Also Published As

Publication number Publication date
CN106420655A (zh) 2017-02-22

Similar Documents

Publication Publication Date Title
WO2018077310A1 (fr) Comprimé effervescent contenant du sodium de vitamine c et son procédé de préparation
CN106420643B (zh) 一种含维生素c钠的咀嚼片及其制备方法
WO2020078036A1 (fr) Comprimé buccal micro-effervescent et son procédé de préparation
AU2005239939B2 (en) BH4-responsive hyperphenylalaninemia remedies
CN106420808B (zh) 一种含有维生素d3和碳酸钙的制剂及其制备方法
WO2005112881A1 (fr) Comprime de montmorillonite dispersible et sa technique de preparation
CN103751327A (zh) 葡萄糖酸锌vc泡腾片
WO2018077311A1 (fr) Composition pour soulager la fatigue oculaire et son procédé de préparation
WO2015003478A2 (fr) Comprimé orodispersible pour nourrissons et enfants et procédé pour sa préparation
CN107126422A (zh) 一种氨磺必利片剂及其制备方法
CN100546571C (zh) 桑菊感冒泡腾片
CN101461788B (zh) 一种间苯三酚口腔崩解片及其制备方法
CN104644574B (zh) 一种枸橼酸西地那非掩味制剂
CN108815269A (zh) 叶酸葡萄糖酸亚铁维生素c泡腾片及其制备方法和应用
RU2563190C2 (ru) Лекарственное средство на основе сухих экстрактов лекарственных растений и способ его получения (варианты)
JP6092672B2 (ja) 口腔内速崩壊性錠剤
CN104490801A (zh) 一种适用于婴幼儿及儿童的可压碎片及其制备方法
CN102100902A (zh) 四逆泡腾片
RU2589507C1 (ru) Средство на основе сухого экстракта пустырника и способ его получения
JPH09175994A (ja) カルシウム液剤、カルシウム飲料及びその製造方法
CN107303395B (zh) 一种含有链霉蛋白酶的药物组合物及其制备方法
CN108853048A (zh) 有机硒泡腾片及其制备方法
CN100542521C (zh) 银黄泡腾片
CN113679675B (zh) 一种钙颗粒剂及其制备方法和用途
CN107951034A (zh) 维生素泡腾制剂及其制备方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17864100

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17864100

Country of ref document: EP

Kind code of ref document: A1